$SMI<CN1CCC23C4Oc5c3c(CC1C2C=CC4O)ccc5O>
$EXNO<BCN23>
$UKEY<00015197- -00>
EXNO<BCN23>
ENTR<00015197>
PROG<Entry under review>
NAME<Morphine, British Approved Name>
DOCN<M-005112 in Dictionary of Organic Compounds, 6th Edn., 1996>
DOCN<M-01696 in Dictionary of Natural Products, 1994>
DOCN<M-00536 in Dictionary of Pharmacological Agents, 1997>
SYNS<7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol, Chemical Abstracts 9th Collective Index>
SYNS<Meconium>
SYNS<Morfine>
INDX<Morphine>
CASM<    57272>
XCAS<    64313>
MOLF<C17H19NO3>
MOLW<285.342>
LGPE<Log P 0.76SR (exp)>
LGPC<Log P 0.24 (uncertain value)  (calc)>
SIGM<M3762>
RKEY<00015197-01>
RTAG<isol, bibl, uv>
RKEY<00015197-02>
RTAG<synth>
RKEY<00015197-03>
RTAG<synth, pharmacol>
RKEY<00015197-04>
RTAG<ms>
RKEY<00015197-05>
RTAG<cryst struct, abs config>
RKEY<00015197-06>
RTAG<pharmacol>
RKEY<00015197-07>
RKEY<00015197-08>
RTAG<ord>
RKEY<00015197-09>
RTAG<metab>
RKEY<00015197-10>
RTAG<Heterocodeine>
RKEY<00015197-11>
RTAG<biosynth>
RKEY<00015197-12>
RTAG<cryst struct>
RKEY<00015197-13>
RTAG<cmr>
RKEY<00015197-14>
RTAG<oxide>
RKEY<00015197-15>
RTAG<rev, glc>
RKEY<00015197-16>
RKEY<00015197-17>
RKEY<00015197-18>
RKEY<00015197-19>
RTAG<revs, pharmacol>
RKEY<00015197-20>
RKEY<00015197-21>
RKEY<00015197-22>
RTAG<rev, synth>
RKEY<00015197-23>
RKEY<00015197-24>
RTAG<rev>
RKEY<00015197-25>
RKEY<00015197-26>
RKEY<00015197-27>
RKEY<00015197-28>
RKEY<00015197-29>
RKEY<00015197-30>
RTAG<synonyms>
RKEY<00015197-31>
RKEY<00015197-32>
RKEY<00015197-33>
RTAG<rev, bibl>
RKEY<00015197-34>
RKEY<00015197-35>
RKEY<00015197-36>
RKEY<00015197-37>
$EXNO<NDD84>
$UKEY<00015197-A-00>
EXNO<NDD84>
VARD<(-)>
INDX<"Morphine; (-)-form">
SORC<Principal alkaloid of opium (Papaver somniferum) (Papaveraceae)>
UIMP<Powerful opioid analgesic. Psychotomimetic agent. A drug of abuse. Acts as a stimulant to horses, has been used in horse doping>
PHYS<Prisms + 1H2O (EtOH aq.), anhyd. prisms (anisole)>
SOLP<"V. sol. EtOAc, Me2CO; sol. EtOH; spar. sol. H2O, Et2O, CHCl3">
MELT<Mp 254-256.4 dec. (anhyd.)>
OPTR<23, -130.9 (MeOH)>
PKAS<pKa2 9.9 (25 deg C)>
HAZF<Hazard data available>
RTEC<QC7875000>
HAZD<Gastrointestinal effects when used therapeutically. Human and exp. reprod. effects. Abuse leads to habituation or addiction. Larger doses produce respiratory depression leading to coma. Can cause death. LD50 (rat, orl) 335 mg/kg>
TOCN<XA0600>
TOCN<XA0670>
TOCN<XA5730>
TOCN<XA6070>
SPEC<Papaver somniferum>
$EXNO<MSH78>
$UKEY<00015197-B-00>
EXNO<MSH78>
VARD<(+)>
INDX<"Morphine; (+)-form">
SORC<Synthetic>
OPTR<25, +118 (c, 0.25 in CHCl3)>
|