OC(=O)CCC1NC=NC1=O>>OC(=O)CCC(NC=N)C(=O)O  Imidazolone propionase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Dephospho-CoA kinase
CC(C)C(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)C)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Valyl-tRNA ligase
*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*>>*C(=O)OCC(O)COP(=O)(O)OCC[N+](C)(C)C.*C(=O)O  Phospholipase A2
OCC(O)COP(=O)(O)O>>OCC(=O)COP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Glycerol 3-P dehydrogenase
OCC(O)COP(=O)(O)O>>OCC(=O)COP(=O)(O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Glycerol 3-P dehydrogenase
CC(=O)OC(CC(=O)O)C[N+](C)(C)C>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.C[N+](C)(C)CC(O)CC(=O)O  Carnitine acetyltransferase
OC(COP(=O)(O)O)C(O)c1c[nH]c2ccccc12>>c1cc2ccccc2[nH]1.OC(COP(=O)(O)O)C=O  Tryptophan synthase
*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(CO)OC(=O)*.NCCOP(=O)(O)O  Phospholipase C
*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(COP(=O)(O)O)OC(=O)*.NCCO  Phospholipase D
*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(O)COP(=O)(O)OCCN.*C(=O)O  Phospholipase A2
*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+]  Phosphatidylethanolamine methyltransferase
*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(O)C(O)C1O)OC(=O)*>[Mg+2]>*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O)OC(=O)*.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  1-Phosphatidylinositol kinase
Nc1ccc(CC(O)C(O)C(O)CO)cc1>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3=Nc4c(NC3C)nc(N)[nH]c4=O.OP(=O)(O)OP(=O)(O)O.O
CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NC(CS)C(=O)O>>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS.O=C=O  P-Pantothenoylcysteine decarboxylase
CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)O>>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NC(CS)C(=O)O.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1.OP(=O)(O)OP(=O)(O)O  P-Pantothenatecysteine ligase
CC(O)C(=O)C>>CC(O)C(C)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (R,R)-Butanediol dehydrogenase
CC(C)(CO)C(O)C(=O)O>>CC(C)(CO)C(O)C(=O)NCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Pantothenate-beta-alanine ligase
CC(C)(CO)C(O)C(=O)NCCC(=O)O>[Mg+2]>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Pantothenate kinase
CC(C)(CO)C(O)C(=O)NCCC(=O)O>>CC(C)(CO)C(O)C(=O)O.NCCC(=O)O  Pantothenase
CC(=O)C(C)(O)C(=O)O>>CC(O)C(=O)C.O=C=O  Acetolactate decarboxylase
CC(=O)C(C)(O)C(=O)O>[Mg+2]>CC(C)(O)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Ketol-acid reductoisomerase
CC(CO)C(=O)O>>CC(C=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3-Hydroxyisobutyrate dehydrogenase
CC(CO)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(CO)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  3-Hydroxyisobutyryl-CoA hydrolase
OC(=O)C1CC(=O)NC(=O)N1>[Fe+2].[Zn+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>OC(=O)c1cc(=O)[nH]c(=O)[nH]1.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Dihydro-orotate dehydrogenase
OC(=O)C1CC(=O)NC(=O)N1>[Fe+2].[Zn+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>OC(=O)c1cc(=O)[nH]c(=O)[nH]1.OO  Dihydro-orotate dehydrogenase
NC1CCC(=O)OC1O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCC(=O)CCC(=O)O  Glutamate-1-semialdehyde-2,1-aminomutase
CC(C=O)C(=O)O>>CC(CN)C(=O)O.CC(=O)C(=O)O  beta-Alanine-(=3-aminoisobutyrate)-pyruvate transaminase
CC(C=O)C(=O)O>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Malonate semialdehyde dehydrogenase (acylating)
CC(C=O)C(=O)O>>CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  Methylmalonate semialdehyde dehydrogenase (acylating)
CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1OC1(C)C)C)C)C>>CC(CCC=C(C)C)C1CCC2(C)C3CCC4C5(CC35CCC12C)CCC(O)C4(C)C  Cycloarterenol synthase
CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1OC1(C)C)C)C)C>>CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3  Lanosterol synthase
*O>>*OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  3-Methyl-2-oxobutanoate dehydrogenase kinase
*OP(=O)(O)O>[Mg+2]>*O.OP(=O)(O)O  Glycogen synthase D phosphatase
*OP(=O)(O)OP(=O)(O)O>>*O.OP(=O)(O)O.OP(=O)(O)O  3-Methyl-2-oxobutanoate dehydrogenase phosphatase
*O>[Mg+2]>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Protein kinase A (Phosphorylase kinase kinase)
*C(=O)OCC(O)COP(=O)(O)OCC[N+](C)(C)C>>*C(=O)O.C[N+](C)(C)CCOP(=O)(O)OCC(O)CO  Lysophospholipase
OC(COP(=O)(O)O)C(=O)OP(=O)(O)O>[Mg+2]>OC(=O)C(COP(=O)(O)O)OP(=O)(O)O  Bisphosphoglycerate mutase
OC(=O)c1cc(O)c2ccccc2c1O>>CC(=CCCC(=CCc1c(C)c(O)c2ccccc2c1O)C)C.OP(=O)(O)OP(=O)(O)O.O=C=O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]
CCCCCC(=O)OCC(O)CO>>OCC(O)CO.CCCCCC(=O)O  Lipases
CCCCCC(=O)OCC(O)CO>>CCCCCC(=O)OCC(CO)OC(=O)CCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Acylglycerol acyltransferase
OC(COP(=O)(O)O)C(O)C(=O)CNc1ccccc1C(=O)O>>OC(COP(=O)(O)O)C(O)c1c[nH]c2ccccc12.O=C=O.O  Indole 3-glycerol P-synthase
*C(=O)OCC(O)COP(=O)(O)OCC[N+](C)(C)C>>*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CCCCCC(=O)OCC(O)CO>[Mg+2]>CCCCCC(=O)OCC(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Acylglycerol kinase
CCCCCCO>>CCCCCC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Alcohol dehydrogenase
CCCCCCO>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>CCCCCC=O.[*H2]  Alkan-1-ol dehydrogenase (acceptor)
OC(=O)C1=NCCC1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Pyrroline-2-carboxylate reductase
OC(=O)C1=NCCC1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Pyrroline-2-carboxylate reductase
OC1CN=C(C1)C(=O)O>>NCC(O)CC(=O)C(=O)O  non-enzymatic
OC1CN=C(C1)C(=O)O>>OC(=O)C(=O)CCC=O.N  1-Pyrroline-4-hydroxy-2-carboxylate deaminase 
OC1CN=C(C1)C(=O)O>>OC(=O)c1ccc[nH]1.O  non-enzymatic
Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.O  Methenyl-THF-cyclohydrolase
Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.OC=O  Formyl-THF-deformylase
Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1NC=O  P-Ribosylaminoimidazolecarboxamide formyltransferase
CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.*  3-Oxo-5beta-steroid delta4 dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Steroid delta-isomerase 
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Steroid delta-isomerase 
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.O.*  Steroid 11beta-monooxygenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.O.*  Steroid 11beta-monooxygenase
CC(=CC=O)C=CC=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C
CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  11beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  11beta-Hydroxysteroid dehydrogenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C>*>CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C.O.*  Steroid 17alpha-monooxygenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.O.*  Steroid 21-monooxygenase
CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3>>CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)CC4CC3.O=C=O.O=C=O.O.O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CC(O)C1=O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O.OC=O
CC12CCC3C(CC=C4CC(O)CCC34C)C2CC(O)C1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Steroid-delta-isomerase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CC(O)C1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Steroid-delta-isomerase
CC(C)CCCC(C)(O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C>*.*>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.CC(C)CCC=O.O
CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O.O.CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.O.*  Steroid 21-monooxygenase
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Steroid delta-isomerase 
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Steroid delta-isomerase 
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>*.*>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O.CC=O  17alpha-Hydroxyprogesterone aldolase
CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CO)CC(O)C31>>CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.[H].[H]
CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1=O>*>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OC=O.O
CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O.OC=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1=O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O>>*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  active Phosphorylase kinase 
Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2>>Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O
Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)O)O2>>Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O
Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3>>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)O)O3.*O
Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3>>Nc1ncnc2[nH]cnc12.OCC1OC(CC1O)OP(=O)(O)O  Purine nucleoside phosphorylase
Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3>>Nc1ncnc2[nH]cnc12.OCC1OC(CC1O)OP(=O)(O)O  Purine nucleoside phosphorylase
Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)O)O3>[Mg+2].[Co+2].[Ca+2]>Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3.OP(=O)(O)O  5'-Nucleotidase
Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>>Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1.OP(=O)(O)O
Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]>*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4ccc(N)nc4=O)O1.OP(=O)(O)OP(=O)(O)O  DNA-directed DNA polymerase
Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>>Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)O)O2.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1  Deoxycytidylate hydroxymethyltransferase
Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>>OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.N  Deoxycytidilate deaminase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3>>Nc1nc2[nH]cnc2c(=O)[nH]1.OCC1OC(CC1O)OP(=O)(O)O  Purine nucleoside phosphorylase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3>>Nc1nc2[nH]cnc2c(=O)[nH]1.Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O  Nucleoside deoxyribosyltransferase
OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1CC(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Nucleoside monophosphate kinase
OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O  Thymidylate synthase
OC1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.OP(=O)(O)OP(=O)(O)O  (Deoxy-UTP-pyrophosphatase)
OC(=O)C1CC=CC(=N1)C(=O)O>>OC(=O)C1CCCC(=N1)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Dihydrodipicolinate reductase
CCC(C)(O)C(O)C(=O)O>[Mg+2]>CCC(C)C(=O)C(=O)O.O  Dihydroxyacid dehydratase
CC(C)(O)C(O)C(=O)O>[Mg+2]>CC(C)C(=O)C(=O)O.O  Dihydroxyacid dehydratase
OCC(O)C(O)C(=O)C(=O)C(=O)O>>OCC(O)C(O)C(O)C(=O)O.O=C=O
OCC(O)C(O)C(=O)C(=O)C(=O)O>>OCC(O)C(O)C(O)C(=O)O.O=C=O
Nc1nc(NCC(=O)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(N)c(=O)[nH]1>>Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O.O
Nc1nc(NCC(=O)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(N)c(=O)[nH]1>>CC1Nc2nc(N)[nH]c(=O)c2N=C1C(C)(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O.O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+]
Oc1ccc(O)nc1>>NC(=O)C=CC(=O)O.OC=O
*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC=O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N  Pyruvate decarboxylase
*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS  Pyruvate dehydrogenase
*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(C)(O)C(=O)O>>*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O
*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>*.CC(=O)SC(CCS)CCCCC(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N  Pyruvate dehydrogenase (lipoamide) complex
CCC(O)(C(=O)C)C(=O)O>[Mg+2]>CCC(C)(O)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Ketol-acid reductoisomerase
NC(=C(C=CC=O)C(=O)O)C(=O)O>>NC(=CC=CC=O)C(=O)O.O=C=O  Aminocarboxymuconate semialdehyde decarboxylase
NC(C(=O)O)C(=O)CCC(=O)O>>NCC(=O)CCC(=O)O.O=C=O  5-Aminolevulinate synthase
NC(CCCC=O)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  Saccharopine dehydrogenase (NAD+, L-glutamate forming)
NC(CCCC=O)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  Saccharopine dehydrogenase (NADP+, L-glutamate forming)
NC(CCCC=O)C(=O)O>>OC(=O)C1CCCC=N1.O  non-enzymatic
NC(=CC=CC=O)C(=O)O>>NC(=CC=CC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  2-Aminomuconate semialdehyde dehydrogenase
NC(=CC=CC=O)C(=O)O>>OC(=O)c1ccccn1.O  non-enzymatic
CC(C)(CO)C(=O)C(=O)O>>CC(C)(CO)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  2-Dehydropantoate reductase
CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1O>>COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]
CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1=O>>COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]
COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1O>>COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1OC5OC(C(O)C(O)C5O)C(=O)O
COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1O>>COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1OS(=O)(=O)O
COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1O>>COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1OC5OC(C(O)C(O)C5O)C(=O)O
COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1O>>COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1OS(=O)(=O)O
CC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3-Hydroxyacyl-CoA dehydrogenase
CCC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC=C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Acyl-CoA dehydrogenase
CCC(C)C(=O)C(=O)O>>*.CCC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O  3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)
NCCCC(=O)C(=O)O>>OC(=O)C1=NCCC1.O  non-enzymatic
CC(=O)NCCCCC(=O)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O
CC(=O)NCCCCC(=O)C(=O)O>>NCCCCC(=O)C(=O)O.CC(=O)O  Acyl-lysine deacylase 
CCC(=O)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[Mg+2]>CCC(O)(C(=O)C)C(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N  Acetolactate synthase
CCC(=O)C(=O)O>>CCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  L-Lactate dehydrogenase
NC(=O)CCC(=O)C(=O)O>>OC(=O)CCC(=O)C(=O)O.N  omega-Amidase
OC(=O)CCC(=O)C(=O)O>>NC(CCC(=O)O)C(=O)O.NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Glutamate synthase (NADPH)
OC(=O)C(=O)CCC=O>>OC(=O)CCC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  (2-Oxoglutarate semialdehyde dehydrogenase)
OC(=O)CCC(=O)C(=O)O>>OC(CCC(=O)O)C(=O)O.*  2-Hydroxyglutairate dehydrogenase
OC(=O)CCC(=O)C(=O)O>>OC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Malate dehydrogenase
OC(=O)CCC(=O)C(=O)O>>OC(=O)CCC(O)(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Homocitrate synthase
OC(=O)CCC(=O)C(=O)O>[Zn+2].Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  Glutamate dehydrogenase 
OC(=O)CCC(=O)C(=O)O>[Zn+2].Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  Glutamate dehydrogenase 
OC(=O)CCC(=O)C(=O)O>Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N>OC(=O)CCC=O.O=C=O  Oxoglutarate decarboxylase
CC(C)CC(=O)C(=O)O>>CC(C)CC(N)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  L-Leucine dehydrogenase
CC(C)CC(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(C)CC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O  Branched-chain-amino-acid transaminase
CC(C)CC(=O)C(=O)O>>*.CC(C)CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O  3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)
CC(C)C(=O)C(=O)O>>CC(C)(CO)C(=O)C(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1  3-Methyl-2-oxobutanoate hydroxymethyltransferase
CC(C)C(=O)C(=O)O>[K+]>CC(C)C(O)(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  2-Isopropylmalate synthase
CC(C)C(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(C)C(N)C(=O)O.OC(=O)CCC(=O)C(=O)O  Branched-chain-amino acid transaminase
CC(C)C(=O)C(=O)O>>*.CC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O  3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)
OC(=O)C(=O)CC=C>>CC(O)CC(=O)C(=O)O  2-Oxopent-4-enoate hydratase
OCC(OP(=O)(O)O)C(=O)O>[Zn+2].[Mg+2]>OC(=O)C(=C)OP(=O)(O)O.O  Enolase
CC(=CCCC(=CCc1ccccc1O)C)C>>CC(=CCCC(=CCc1cccc(O)c1O)C)C
OC(=O)CCC(=O)c1ccccc1C(=O)O>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS>OC(=O)c1cc(O)c2ccccc2c1O.OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O
NC(=C(C=CC=O)C(=O)O)C(=O)O>>OC(=O)c1cccnc1C(=O)O.O  non-enzymatic
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)CO>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CO.OCC=O  Dihydroneopterin aldolase
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)CO>>Nc1nc(=O)c2nc(cnc2[nH]1)C(O)C(O)CO
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>[Mg+2]>CC(=O)C(=O)C1CNc2nc(N)[nH]c(=O)c2N1.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O  (6-Pyruvoyltetrahydropterin synthase)
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>[Mg+2]>Nc1nc2NC3OC(COP(=O)(O)O)C(=C(S)C3Nc2c(=O)[nH]1)S.OP(=O)(O)O.OP(=O)(O)O
Nc1nc2NCC(=Nc2c(=O)[nH]1)CO>[Mg+2]>Nc1nc2NCC(=Nc2c(=O)[nH]1)COP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O  2-Amino-4-hydroxy-6-hydroxymetyldihydropteridine pyrophosphokinase
Nc1nc2NCC(=Nc2c(=O)[nH]1)COP(=O)(O)OP(=O)(O)O>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)O.OP(=O)(O)OP(=O)(O)O  Dihydropteroate synthase
NC(=CC=CC(=O)O)C(=O)O>>OC(=O)CCCC(=O)C(=O)O.N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
NC(=CC=CC(=O)O)C(=O)O>>OC(=O)CCCC(=O)C(=O)O.N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
OCC(O)C(O)CC(=O)C(=O)O>[Mg+2]>OC(COP(=O)(O)O)C(O)CC(=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  2-Dehydro-3-deoxygluconokinase
CC(O)CC(=O)C(=O)O>>CC(=O)C(=O)O.CC=O  4-Hydroxy-2-oxovalerate aldolase
NC(CC(=O)c1cccc(O)c1N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)c1cc(O)c2cccc(O)c2n1.O.NC(CCC(=O)O)C(=O)O  Kynurenine transaminase
OC(=O)C(=CC=CC=O)O>>OC(=O)C(=O)CC=C.OC=O  (Hydroxymuconate semialdehyde hydrolase)
CC(O)C=O>>CC(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Aldehyde dehydrogenase
OC(=O)CCCC(=O)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O.O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  2-Oxoglutarate dehydrogenase
NC(=O)CCC(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCC(=O)N)C(=O)O.*C(=O)C(=O)O  Glutamine-oxoacid transaminase
OC(=O)CCC(=O)C(=O)O>[Mg+2]>*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(O)(CCC(=O)O)C(=O)O
CC(C)CCC(O)C(C)(O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.CC(C)CCC=O.*.O.O  Cholesterol monooxygenase (side-chain cleaving)
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.O.*  Steroid 21-monooxygenase
CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC(C)CCCC(C)(O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Steroid 17alpha-monooxygenase
CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCC(O)C(C)(O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.O.*  Cholesterol monooxygenase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O.*OS(=O)(=O)O  Estrone sulfotransferase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OS(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O  (Phosphoadenylsulfate reductase)
*C(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)*>>*C(N)C(=O)OCC(O)COP(=O)(O)OCC(COC(=O)*)OC(=O)*.*C1OC(COP(=O)(O)OC2C(O)C(*)OC2COP(=O)(O)OC3C(O)C(*)OC3CO)C(O)C1O
*C(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)*>>*C(=O)CC(COP(=O)(O)OCC(O)COP(=O)(O)OCC(COC(=O)*)OC(=O)*)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1
OC1CC(O)(CC(=O)C1O)C(=O)O>>OC1CC(=CC(=O)C1O)C(=O)O.O  3-Dehydroquinate dehydratase
OC1CC(O)(CC(=O)C1O)C(=O)O>>OC1CC(O)(CC(O)C1O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Quinate dehydrogenase
OC1CC(=CC(=O)C1O)C(=O)O>>OC1CC(=CC(O)C1O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Shikimate dehydrogenase
OCCC(=O)O>>OC(=O)CC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3-Hydroxypropionate dehydrogenase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCO>>OCCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  3-hydroxyisobutyryl-CoA hydrolase
CC(C)C(C(O)C(=O)O)C(=O)O>>CC(C)CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  3-Isopropylmalate dehydrogenase
CC(C)C(C(O)C(=O)O)C(=O)O>>CC(C)C(=CC(=O)O)C(=O)O.O
OC(=O)C(=O)CS>>CC(=O)C(=O)O.SC#N  3-Mercaptopyruvate sulfurtransferase
OC(=O)C(=O)CS>>CC(=O)C(=O)O.OS(=O)(=O)S  3-Mercaptopyruvate sulfurtransferase
CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C>>CC(C)(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Enoyl-CoA hydratase
CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C>>CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)CC(=O)O.[*H].OC(=O)CCCCC1SCC2NC(=O)NC12  Methylcrotonyl-CoA carboxylase
CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)CC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O  3-Methylglutaconyl-CoA hydratase
CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Acetyl-CoA acyltransferase
OC(=O)CCC(=O)CC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(=O)O.OC(=O)CCC(=O)O  3-Oxoadipate-CoA transferase
OC(=O)CC1=CCC(=O)O1>>OC(=O)CCC(=O)CC(=O)O  3-Oxoadipate enol-lactonase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23
OC(COP(=O)(O)O)C(=O)O>>OCC(OP(=O)(O)O)C(=O)O  Phosphoglyceromutase
OC(COP(=O)(O)O)C(=O)O>>OCC(OP(=O)(O)O)C(=O)O  Phosphoglycerate phosphomutase
OC(COP(=O)(O)O)C(=O)O>>OC(=O)C(=O)COP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  D-3-Phosphoglycerate dehydrogenase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O.OS(=O)(=O)O  Phosphoadenylyl sulfatase
OC(=O)C(=O)COP(=O)(O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(COP(=O)(O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O  Phosphoserine transaminase
NC(COP(=O)(O)O)C(=O)O>[Mg+2]>NC(CO)C(=O)O.OP(=O)(O)O  Phosphoserine phosphatase
NC(CS(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)C(=O)CS(=O)O.NC(CCC(=O)O)C(=O)O  Aspartate transaminase
NC(CS(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCS(=O)O.O=C=O  Sulfinoaniline decarboxylase
NC(CS(=O)O)C(=O)O>>NC(CS(=O)(=O)O)C(=O)O
OC(=O)C(=O)CS(=O)O>>CC(=O)C(=O)O.OS(=O)O  non-enzymatic?
CC(CNC(=O)N)C(=O)O>>CC(CN)C(=O)O.O=C=O.N  3-Ureidopropionase
NC(=O)NCCC(=O)O>>NCCC(=O)O.O=C=O.N  3-Ureidopropionase
CC(C)C(O)(CC(=O)O)C(=O)O>>CC(C)C(C(O)C(=O)O)C(=O)O  3-Isopropylmalate dehydratase
CC(C)C(O)(CC(=O)O)C(=O)O>>CC(C)C(=CC(=O)O)C(=O)O.O
OCC(O)C(O)C(=O)C(O)C(=O)O>>OCC(O)C(O)C(=O)CO.O=C=O  dehydro-L-Gulonate decarboxylase
CCCCCCCCCCCCCCCC(=O)C(N)CO>>CCCCCCCCCCCCCCCC(O)C(N)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3-Dehydrosphinganine reductase
Nc1c(O)cccc1C(=O)O>[Fe+2]>NC(=C(C=CC=O)C(=O)O)C(=O)O  3-Hydroxyanthranilate oxygenase
NC(CC(=O)c1cccc(O)c1N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>Nc1c(O)cccc1C(=O)O.CC(N)C(=O)O  Kynureninase
CC12CCC(O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3alpha-Hydroxysteroid dehydrogenase
CC12CCC(O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3alpha-Hydroxysteroid dehydrogenase
CC12CCC(O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O)OC5OC(C(O)C(O)C5O)C(=O)O
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C
CC(CCC(=O)O)C1CCC2C3C=CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Delta6-steroid reductase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  20beta-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3alpha-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3alpha-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  11beta-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  11beta-Hydroxysteroid dehydrogenase
CC(CCCC(C)C(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>[Mg+2]>CC(CCC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  24-monooxygenase
CC(CCC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>[Mg+2]>CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
CC(CCC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>[Mg+2]>CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
CC(CO)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCCC(CO)COS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C
CC(CO)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCCC(C)C(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+]  Cholestane tetraol 26-dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CO)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  Cholestanetriol 26-monooxygenase
CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3alpha-Hydroxysteroid dehydrogenase
CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3alpha-Hydroxysteroid dehydrogenase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3beta-hydroxy-D5-Steroid dehydrogenase 
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3beta-hydroxy-D5-Steroid dehydrogenase 
CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS>[Mg+2]>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.OP(=O)(O)OP(=O)(O)O  Pantetheine-P adenylyltransferase
Nc1ccc(cc1)C(=O)O>>Nc1ccc(CC(O)C(O)C(O)CO)cc1.O=C=O.[O]
NCCCC=O>>NCCCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Aminobutyraldehyde dehydrogenase
NC(CC(=O)OP(=O)(O)O)C(=O)O>>NC(CC=O)C(=O)O.OP(=O)(O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Aspartate semialdehyde dehydrogenase
OC(=O)CC(=O)CC(=O)C=CC(=O)O>>CC(=O)CC(=O)O.OC(=O)C=CC(=O)O  Fumarylacetoacetase
NC(=N)NCCCC(=O)N>>NC(=N)NCCCC(=O)O.N  L-Guanidinobutanamide deaminase
NC(=N)NCCCC(=O)O>>NCCCC(=O)O.NC(=O)N  4-Guanidobutyrase
OC(=O)c1ccc(O)cc1>[Mg+2]>CC(=CCCC(=CCc1ccccc1O)C)C.OP(=O)(O)OP(=O)(O)O.O=C=O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCO>>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O
OC(=O)C(=O)Cc1ccc(O)cc1>OCC(O)C1OC(=O)C(=C1O)O>OC(=O)Cc1cc(O)ccc1O.O=C=O  4-Hydroxyphenylpyruvate hydroxylase
OC(=O)C(=O)Cc1ccc(O)cc1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(Cc1ccc(O)cc1)C(=O)O.OC(=O)CCC(=O)C(=O)O  Tyrosine transaminase
OC(=O)CCC1NC=NC1=O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OC(=O)CCC1NC(=O)NC1=O  Aldehyde oxidase
OC(=O)CC(=O)CC(=O)C=CC(=O)O>>OC(=O)CC(=O)CC(=O)C=CC(=O)O  Maleyl-acetoacetate isomerase
OCCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCO.*O
OC1C(O)C(NC(=O)CNC=O)OC1COP(=O)(O)O>>OC1C(O)C(NC(=N)CNC=O)OC1COP(=O)(O)O.NC(CCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Phosphoribosyl-formylglycinamide synthase
OC1C(O)C(NC(=N)CNC=O)OC1COP(=O)(O)O>[K+].[Mg+2]>Nc1cncn1C2OC(COP(=O)(O)O)C(O)C2O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Phosphoribosylformylglycinamidine cyclo-ligase
NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N>>NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1NC=O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1  Phosphoribosyl-aminoimidazole carboxamide formyltransferase
NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1NC=O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.O  IMP Cyclohydrolase
Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)NC(CC(=O)O)C(=O)O>>NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N.OC(=O)C=CC(=O)O  Adenylosuccinate lyase
Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)O>[Mg+2]>Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)NC(CC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Phosphoribosyl-aminoimidazole-succinocarboxamide synthetase
Nc1cncn1C2OC(COP(=O)(O)O)C(O)C2O>[Mg+2]>Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)O  Phosphoribosylaminoimidazole carboxylase
NCC(=O)NC1OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(NC(=O)CNC=O)OC1COP(=O)(O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1  Phosphoribosylglycineamide formyltransferase
Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Methylene-THF-dehydrogenase
Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>NCC(=O)O>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=O)c2c(=O)[nH]1.[H+]  Aminomethyltransferase
CC1C2C(C)Nc3nc(N)[nH]c(=O)c3[N+]2=CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4>>CC1C2C(C)Nc3nc(N)[nH]c(=O)c3N2CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4.CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2cc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O.[H+]  5,10-Methylene-THMPT dehydrogenase
Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>>CN1C(CNc2ccc(cc2)C(=O)NC(CCC(=O)O)C(=O)O)CNc3nc(N)[nH]c(=O)c13.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Methylene-THF-reductase (NAD(P)+)
Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>>CN1C(CNc2ccc(cc2)C(=O)NC(CCC(=O)O)C(=O)O)CNc3nc(N)[nH]c(=O)c13.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Methylene-THF-reductase (NAD(P)+)
CC1C2C(C)Nc3nc(N)[nH]c(=O)c3N2CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C.CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2nc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O.O  5,10-Methylene-THMPT reductase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>[Mg+2]>Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Formate-THF ligase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NCC(=O)NC1OC(COP(=O)(O)O)C(O)C1O  P-Ribosylglycinamide formyltransferase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.N.*.OC(=O)CCCCC(S)CCS  Aminomethyl transferase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1.NC(CCC(=O)O)C(=O)O  Glutamate formiminotransferase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1.NCC(=O)O  Glutamate formiminotransferase
CC1CNC(=O)NC1=O>>CC(CNC(=O)N)C(=O)O  Dihydropyrimidinase
O=C1CCNC(=O)N1>>NC(=O)NCCC(=O)O  Dihydropyrimidinase
Nc1[nH]cnc1C(=O)O>>Nc1cnc[nH]1.O=C=O
NCC(=O)CCC(=O)O>[Mg+2].[Zn+2].[K+]>NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.O.O  Porphobilinogen synthase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1>>Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.N  Formimino-THF cyclodeaminase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=O)c2c(=O)[nH]1>>Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  5-Formyl-THF-cycloligase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=O)c2c(=O)[nH]1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.OC(=O)CCC(NC=O)C(=O)O  Glutamate fromiminotransferase
CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C=O>>CC1C2C(C)Nc3nc(N)[nH]c(=O)c3[N+]2=CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4.O  5,10-Methenyl-THMPT cyclohydrolase
CC(=CCCC(=CCc1cccc(O)c1O)C)C>>COc1c(O)c(C)c(CC=C(C)CCC=C(C)C)c(O)c1OC.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+].[H+]
Oc1ccc2[nH]cc(CC=O)c2c1>>OC(=O)Cc1c[nH]c2ccc(O)cc12.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Aldehyde dehydrogenase
NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O>>Oc1ccc2[nH]cc(C3=CC(=C4C(=O)Nc5ccccc45)C(=O)N3)c2c1
CC(O)C(=O)SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O>>CC(O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O  Hydroxyacyl-glutathione hydrolase (glyoxylase II)
CN1C(CNc2ccc(cc2)C(=O)NC(CCC(=O)O)C(=O)O)CNc3nc(N)[nH]c(=O)c13>>*C.CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1  Methyl-THF-B12 methyltransferase
CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C>>CSCCS(=O)(=O)O.CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3Nc4c(NC3C)nc(N)[nH]c4=O
NC1OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>NCC(=O)NC1OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Phosphoribosylamine-glycine ligase
NC(=O)Nc1[nH]cnc1C(=O)O>>Nc1[nH]cnc1C(=O)O.O=C=O.N
CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC(CCCC(CO)COS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(O)C(CO)COS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C
CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1>>CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Dihydropteridine reductase
CC(=O)C(=O)C1CNc2nc(N)[nH]c(=O)c2N1>>CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Sepiapterin reductase 
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1
CC1Nc2nc(N)[nH]c(=O)c2N=C1C(C)(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>>CC(O)C1=Nc2c(NC1C)nc(N)[nH]c2=O.OCC=O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O
*.CC(=O)SC(CCS)CCCCC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.OC(=O)CCCCC(S)CCS  Dihydrolipoamide acetyltransferase
OC(=O)c1ccc(O)nc1>>Oc1ccc(O)nc1.O=C=O
Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Dihydrofolate reductase
Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Dihydrofolate reductase
Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Dihydrofolate reductase
Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)O>[Mg+2].[K+]>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Dihydrofolate synthase
CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C(=CC=C3CC(O)CCC3=C)CCCC12C
CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  7-Dehydrocholesterol reductase
CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  7-Dehydrocholesterol reductase
OC(COP(=O)(O)O)C(O)C(O)CC(=O)C(=O)O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[Co+2]>OC1CC(O)(CC(=O)C1O)C(=O)O.OP(=O)(O)O  3-Dehydroquinate synthase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C.*  3-Oxo-5beta-steroid delta4 dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3-Oxo-5beta-steroid delta4 dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CC(O)C12C.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  12alpha-monooxygenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C.*  3-Oxo-5beta-steroid delta4 dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3-Oxo-5beta-steroid delta4 dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3alpha-Hydroxysteroid dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)C=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O  Glucose-1-P-adenylyltransferase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC4COP(=O)(O)OC4C3O.OP(=O)(O)OP(=O)(O)O  Adenylate cyclase
[*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>*.O
[*H2]>>*.O
[*H2]>>*.O
[*H2]>>*.O  Choline dehydrogenase
*OS(=O)(=O)O>>*O.OS(=O)(=O)O  Arylsulfatase
CC=O>>CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Aldehyde dehydrogenase
CC=O>>CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Aldehyde dehydrogenase
CC=O>>CCO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Alcohol dehydrogenase
CC(=O)O>[Mg+2]>CC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)OP(=O)(O)O  Acetyl-CoA ligase
CC(=O)CC(=O)O>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)O  Acetoacetyl-CoA: Acetate-CoA transferase
CC(=O)CC(=O)O>>CC(=O)C.O=C=O  Acetoacetate decarboxylase
CC(=O)CC(=O)O>>CC(O)CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3-Hydroxybutyrate dehydrogenase
CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Acetoacetyl-CoA hydrolase
CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O  3-Oxoacid-CoA transferase
CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Acetyl-CoA acetyltransferase
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)C(N)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  5-Aminolevulinate synthase
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Acetyl-CoA acetyltransferase (thiolase)
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Hydroxymethyl-glutaryl-CoA synthase
CC(=O)S*S>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.S*S  Enzyme/ACP acetyltransferase
CC(=O)S*S>>CC(=O)S*S
CC(=O)S*SC(=O)CC(=O)O>>CC(=O)CC(=O)S*S.O=C=O  3-Oxoacyl-E/ACP synthase
CC(=O)S*SC(=O)CC(=O)O>>CC(=O)S*S.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O  Enzyme/ACP malonyltransferase
CC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23>[Mg+2]>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O  Acetate-CoA ligase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=C>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCO  Enoyl-CoA hydratase
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>[Mg+2].[K+]>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Acyl-CoA-ligases (several)
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>[Mg+2].[K+]>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Acyl-CoA-ligases (several)
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCC(=O)OC(CC(=O)O)C[N+](C)(C)C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Carnitine palmitoyltransferase
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCC(=O)OCC(O)COP(=O)(O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  (active) Glycerol-3-phospho-acyltransferase
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC=CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.O.O  (Acyl-CoA-desaturase)
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Acyl-CoA dehydroenase (NADP)
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Acyl-CoA-dehydrogenases (2 known)
*.CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS>>*.CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS  ACP Phosphodiesterase
*C(=O)S*S>>CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.S*S  (Palmitoyl-CoA-enzyme palmitoyl transferase)
*C(=O)S*S>>*C(=O)O.S*S  Oleyl-ACP hydrolase
CCCCCC(=O)OCC(O)COP(=O)(O)O>>CCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  1-Acylglycerol-3P-acyltransferase
Nc1ncnc2[nH]cnc12>[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Adenine P-ribosyltransferase
Nc1ncnc2[nH]cnc12>>O=c1[nH]cnc2[nH]cnc12.N  Adenine deaminase
Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O>[Mg+2]>Nc1ncnc2[nH]cnc12.OCC1OC(O)C(O)C1O  Purine nucleosidase
Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Adenosine kinase
Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O>>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23.N  Adenosine deaminase
Nc1ncnc2n(cnc12)C3OC4COP(=O)(O)OC4C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O  3,5-Cyclic nucleotide phosphodiesterase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Fe+2]>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.*.O  Ribonucleoside-diphosphate reductase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Ca+2].[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Apyrase (Potato/Insects)
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.O.[H+].[H+].[H+]  (Oxidative phosphorylation)
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O  Adenylate kinase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(N)ncnc45)C(O)C1O.OP(=O)(O)O  Polyribonucleotide nucleotidyltransferase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O>[Zn+2]>Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O.OP(=O)(O)O  5'-Nucleotidase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O>[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Adenylate kinase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.N  AMP deaminase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.*.O  Ribonucleoside triphosphate reductase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  ATPases (several known)
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>[Ca+2].[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Apyrase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(NC(CC(=O)O)C(=O)O)ncnc23>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OC(=O)C=CC(=O)O  Adenylosuccinate lyase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O>>OS(=O)(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O  Adenylsulfatase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O>>OS(=O)O.*.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O  Adenylsulfate reductase
NCCCCNC(=N)N>>NCCCCN.NC(=O)N  Agmatinase
CCCCCC=O>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>CCCCCC(=O)O.[*H2]  Aldehyde dehydrogenase (PQQ)
CCCCCC=O>>CCCCCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Aldehyde dehydrogenase
CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C54CC(OC5O)C31>>CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.*.*  3-Oxo-5beta-steroid delta4dehydrogenase
CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C54CC(OC5O)C31  non-enzymatic
CCCCCC>>CCCCCCO.O.*  Alkane-1-monooxygenase
NC(=O)NC1NC(=O)NC1=O>>NC(=O)NC(NC(=O)N)C(=O)O  Allantoinase
OC(=O)CCCC(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCCC(=O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O  2-Aminoadipate transaminase
OP(=O)(O)OCC(=O)Cc1cnc[nH]1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(COP(=O)(O)O)Cc1cnc[nH]1.OC(=O)CCC(=O)C(=O)O  Histidinol-P transaminase
CC(=O)CN>[K+]>CC(O)CN.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  1-Aminopropan-2-ol dehydrogenase
CC(=O)CN>>CC(=O)C=O.N.OO  Monoamine oxidase
*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O>>CC(C)C(NC(=O)C(CS)NC(=O)CCCC(N)C(=O)O)C(=O)O.O.*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS  d(L-2-Aminoadipyl-)L-cysteinyl-D-valinesynthase
Nc1cnc[nH]1>>OC(=O)CNC=N.N  Aminoimidazolase
OCC1OC(OC2C(O)C(O)C(OCC3OC(OC4C(O)C(O)C(O)OC4CO)C(O)C(O)C3OC5OC(CO)C(O)C(O)C5O)OC2CO)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OCC1OC(OC2C(O)C(O)C(OC3C(O)C(O)C(O)OC3CO)OC2CO)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O  (alpha-Glucan) phosphorylase
OCC1OC(OC2C(O)C(O)C(OCC3OC(OC4C(O)C(O)C(O)OC4CO)C(O)C(O)C3OC5OC(CO)C(O)C(O)C5O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(OC3C(O)C(O)C(O)OC3CO)OC2CO)C(O)C(O)C1O.OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O  alpha-Amylase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC2OC3C(O)C(O)C(OC3CO)OC4C(O)C(O)C(OC4CO)OC5C(O)C(O)C(OC5CO)OC1C(O)C2O  Cyclomaltodextrin glucanotransferase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(OCC3OC(OC4C(O)C(O)C(O)OC4CO)C(O)C(O)C3OC5OC(CO)C(O)C(O)C5O)OC2CO)C(O)C(O)C1O  1,4-alpha-Glucan branching enzyme (Q-enzyme)
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Glycogen (starch) synthases
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Starch (bacterial glycogen) synthase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  I-Form (active) Glycogen (starch) synthase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Starch (bacterial glycogen) synthase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O  Glucan-1,4-alpha-glucosidase (glucoamylase)
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O  alpha Amylase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O  Glycogen phosphorylase a
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O.O.*  Steroid 11beta-monooxygenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Steroid 19-hydroxylase)
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O.*  3-Oxo-5beta-steroid delta4 dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O.*  3-Oxo-5beta-steroid delta4 dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3(or 17)beta-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3(or 17)beta-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1=O
Nc1ccccc1C(=O)O>>Nc1ccccc1C(=O)OC2OC(C(O)C(O)C2O)C(=O)O
Nc1ccccc1C(=O)O>[Fe+2]>Oc1ccccc1O.O=C=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.N  Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
Nc1ccccc1C(=O)O>[Fe+2]>Oc1ccccc1O.O=C=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.N  Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
Nc1ccccc1C(=O)O>>OC1C(O)C(Nc2ccccc2C(=O)O)OC1COP(=O)(O)O.OP(=O)(O)OP(=O)(O)O  Anthranilate-phosphoribosyltranferase
*>[Mg+2]>*.CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O  Holo-ACP synthase
*>>*[Fe+3]  Transferrin reductase
C[N+](C)(C)CC=O>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>C[N+](C)(C)CC(=O)O.[*H2]  Choline dehydrogenase
C[N+](C)(C)CC=O>[Mg+2]>C[N+](C)(C)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Betaine aldehyde dehydrogenase
C[N+](C)(C)CC(=O)O>>CN(C)CC(=O)O.CSCCC(N)C(=O)O.[H+]  Betaine-homocysteine methyltransferase
[NH4+]>>NC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Carbamoylphosphate synthase
OC(=O)[O-]>>NC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Carbamoylphosphate synthase
CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)OC5OC(C(O)C(O)C5O)C(=O)O)c(CCC(=O)OC6OC(C(O)C(O)C6O)C(=O)O)c2C)NC1=O>>CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C.OC1OC(C(O)C(O)C1O)C(=O)O.OC1OC(C(O)C(O)C1O)C(=O)O  beta-Glucuronidase + further reactions
CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)OC5OC(C(O)C(O)C5O)C(=O)O)c(CCC(=O)OC6OC(C(O)C(O)C6O)C(=O)O)c2C)NC1=O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Glucuronosyltransferase
CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O.O  Bilirubin oxidase
CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Biliverdin reductase
CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Biliverdin reductase
CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CCC1=C(C)C(=CC2=NC(=Cc3[nH]c(C=C4NC(=O)C(C)C4=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CCC1=C(C)C(=CC2=NC(=Cc3[nH]c(C=C4NC(=O)C(C)C4=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O.*.*
CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)OP(=O)(O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Phosphate butyryl-transferase
*C(=O)S*S>>*C(=O)S*SC(=O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
*C(=O)S*SC(=O)CC(=O)O>>*C(=O)CC(=O)S*S.O=C=O
*C(=O)OCC(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCC(O)COP(=O)(O)O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1  CDP-Diacylglycerolglycerol-3P 3-phosphatidyltransferase
*C(=O)OCC(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O)OC(=O)*>[K+].[Mg+2]>*C(=O)OCC(COP(=O)(O)O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1  Phosphatidate cytidyltransferase
C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O>[Mg+2]>*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1  Choline phosphotransferase
NCCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O>[Mg+2]>*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1  Ethanolamine-phosphotransferase
O=C=O>>*.[C-]#[O+].*.O  CO-dehydrogenase
OC(=O)[O-]>[Mg+2]>NC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.O  Carbamate kinase
OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  P-Gluconate dehydrogenase (decarboxylating)
OCC(O)C(O)C(O)CO>>OCC1(O)OCC(O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Ribitoldehydrogenase
NCCC(=O)NC(Cc1cnc[nH]1)C(=O)O>[Zn+2]>NCCC(=O)O.NC(Cc1c[nH]cn1)C(=O)O  Carnosinase
Oc1ccccc1O>[Fe+2]>OC(=O)C(=CC=CC=O)O  Catechol 2,3-dioxygenase
Oc1ccccc1O>[Fe+2]>OC(=O)C=CC=CC(=O)O  Catechol 1,2-dioxygenase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O  beta-Glucosidase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O  Cellobiose phosphorylase
OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.O  Cellulose-1,4-cellobiosidase
OCC1OC(O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Cellulose synthase (UDP-forming)
*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  (N-Acylsphingosine glucosyltransferase)
*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(COP(=O)(O)OCC[N+](C)(C)C)C(O)C=CCCCCCCCCCCCCC.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1  Ceramide cholinephosphotransferase
*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC>>CCCCCCCCCCCCCC=CC(O)C(N)CO.*C(=O)O  Acylsphingosine deacylase
CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C>>CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C
CC(=O)NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2NC(=O)C)C1O>>CC(=O)NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2NC(=O)C)C1O
CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C>>CCc1c(C=O)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C.O
CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C.CC(C)CCCC(C)CCCC(C)CCCC(=CCO)C  Chlorophyllase
CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C>>CCc1c(C)c2cc3[nH]c(cc4nc(C(CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C4C)c5C(C(=O)OC)C(=O)c6c(C)c(cc1n2)[nH]c65)c(C)c3C=C.[Mg+2]
CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C>>CCC1C(C)C2=[N+]3[Mg+2][N+]4=C(C=c5[n-]c(=C2)c(C(=O)C)c5C)C(C)C(CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C4=C6C(C(=O)OC)C(=O)c7c(C)c(C=C13)[n-]c67.OP(=O)(O)OP(=O)(O)O
CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C.OP(=O)(O)OP(=O)(O)O
CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3C=CC4CC(O)CCC4(C)C3CC(O)C12C.O  7alpha-dehydroxylase
CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Cholate-CoA ligase
CC(C)CCCC(C)C1CCC2C(=CC=C3CC(O)CCC3=C)CCCC12C>>CC(CCCC(C)(C)O)C1CCC2C(=CC=C3CC(O)CC(O)C3=C)CCCC12C
*C(=O)OC1CCC2(C)C3CCC4(C)C(CCC4C3CC=C2C1)C(C)CCCC(C)C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.*C(=O)O  Cholesterol esterase
*C(=O)OC1CCC2(C)C3CCC4(C)C(CCC4C3CC=C2C1)C(C)CCCC(C)C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.*C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Cholesterol acyltransferase
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.O.*  Cholesterol monooxygenase (side chain cleaving)
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*>CC(C)CCCC(C)C1CCC2C3C(O)C=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  Cholesterol 7alpha-monooxygenase
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C.OO  Cholesterol oxidase
C[N+](C)(C)CCO>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>C[N+](C)(C)CC=O.[*H2]
C[N+](C)(C)CCO>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>C[N+](C)(C)CC=O.O  Choline oxidase
C[N+](C)(C)CCO>>CC(=O)OCC[N+](C)(C)C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Choline acetyltransferase
CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>>CC(CCC(=O)NCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Glycine-N-choloyltransferase
CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>>CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Glycine-N-choloyltransferase
OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>>Nc1ccc(cc1)C(=O)O
OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>>OC(=O)c1ccc(O)cc1.CC(=O)C(=O)O  (Chorismate lyase)
OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>[Mg+2]>Nc1ccccc1C(=O)O.NC(CCC(=O)O)C(=O)O.CC(=O)C(=O)O  Anthranilate synthase
OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>>OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O  Chorismate mutase
OC(=O)CC(O)(CC(=O)O)C(=O)O>[Mg+2]>OC(=O)CC(=O)C(=O)O.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  ATP Citrate lyase
OC(=O)CC(O)(CC(=O)O)C(=O)O>>OC(C(CC(=O)O)C(=O)O)C(=O)O
CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)O
CC(O)CNC(=O)CCC1(C)C(CC(=O)N)C2N3C1=C(C)C4=[N+]5C(=CC6=[N+]7C(=C(C)C8=[N+](C2(C)C(C)(CC(=O)N)C8CCC(=O)N)[Co+2]375)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(C)C4CCC(=O)N>>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O
CC1=C2[N+]3=C(C=C4[N+]5=C(C(CCC(=O)O)C4(C)C)C(=C6N7C(C(CC(=O)O)C6(C)CCC(=O)O)C8(C)[N+](=C1C(CCC(=O)O)C8(C)CC(=O)O)[Co+2]735)C)C(CCC(=O)O)C2(C)CC(=O)O>>CC(O)CNC(=O)CCC1(C)C(CC(=O)N)C2N3C1=C(C)C4=[N+]5C(=CC6=[N+]7C(=C(C)C8=[N+](C2(C)C(C)(CC(=O)N)C8CCC(=O)N)[Co+2]375)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(C)C4CCC(=O)N.O.O.O.O.O.O.O
CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2nc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O>>CC(OP(=O)(O)OCC(O)C(O)C(O)CN1C2NC(=O)NC(=O)C2Nc3ccc(O)cc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O  Hydrogenase
OC(=O)CC(=O)C(=O)O>>OC(=O)CC(O)(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Citrate synthase
Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5C)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C>>Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(=O)O)c5C)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.[H].[H].[H].[H].[H].[H]
Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C>>Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.[H].[H].[H].[H].[H].[H]
Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C>>Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(=O)O.O=C=O.O=C=O.O.O  Coproporphyrinogen oxidase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  11beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  11beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.*  3-Oxo-5beta-steroid delta4 dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CO)CC(O)C31.O.*  Corticosterone 18-monooxygenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Cortisone beta-reductase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  11beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  11beta-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Cortisone beta-reductase
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO>>CC12CC(O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(O)CO
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO>>CC12CC(=O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(O)CO
CN(CC(=O)O)C(=N)N>>CN1CC(=O)NC1=N.O  Creatininase
CN(CC(=O)O)C(=N)N>>NC(=O)N.CNCC(=O)O  Creatinase
CN1CC(=O)NC1=N>>CN1CC(=O)NC1=O.N  Creatinine deiminase
CC=CC(=O)S*S>>CCCC(=O)S*S.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C  Enoyl-E/ACP reductase
CC=CC(=O)S*S>>CCCC(=O)S*S.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Enoyl-E/ACP reductase
CC(CCC=C(C)C)C1CCC2(C)C3CCC4C5(CC35CCC12C)CCC(O)C4(C)C>>CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)CC4CC3
Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>>Nc1cc[nH]c(=O)n1.OCC1OC(OP(=O)(O)O)C(O)C1O  Pyrimidine nucleoside phosphorylase
Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>>Nc1cc[nH]c(=O)n1.OCC1OC(O)C(O)C1O  Nucleosidase
Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>>OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O.N  Cytidine deaminase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>[Fe+2]>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.*.O  Ribonucleoside-diphosphate reductase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>[Mg+2]>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Nucleoside diphosphate kinase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(N)nc4=O)C(O)C1O.OP(=O)(O)O  Polyribonucleotide nucleotidyltransferase
Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1>>Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1.OP(=O)(O)O  5'-Nucleotidase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.*.O  Ribonucleoside triphosphate reductase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(N)nc4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O  DNA-directed RNA polymerase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(N)nc4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O  RNA-directed DNA polymerase
Nc1cc[nH]c(=O)n1>>O=c1cc[nH]c(=O)[nH]1.N  Cytosine deaminase
CCCCCC(=O)OCC(CO)OC(=O)CCCCC>>CCCCCC(=O)OCC(COC(=O)CCCCC)OC(=O)CCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Diacylglycerol acyltransferase
CCCCCC(=O)OCC(CO)OC(=O)CCCCC>>CCCCCC(=O)OCC(O)CO.CCCCCC(=O)O  Lipases
*C(O)CC(=O)S*S>>*C(=O)CC(=O)S*S.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
*C(O)CC(=O)S*S>>*C(=O)CC=CCCCCCC.O.*CCC(=O)S*S
CC(O)CC(=O)S*S>>CC(=O)CC(=O)S*S.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3-Oxoacyl-E/ACP reductase
CC(O)CC(=O)S*S>>CC=CC(=O)S*S.O  (3-Hydroxyacyl-E/ACP dehydratases)
OC(CC(=O)C(=O)O)C(=O)O>>OC(=O)C=O.CC(=O)C(=O)O  4-hydroxy-2-Oxoglutarate aldolase
OC1C(O)C(COP(=O)(O)O)OC(=O)C1O>>OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O  6-P-Gluconolactonase
OC(COP(=O)(O)O)C(O)C=O>>OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)COP(=O)(O)O
OC(COP(=O)(O)O)C(O)C=O>>OC(COP(=O)(O)O)C(O)C(O)CC(=O)C(=O)O.OP(=O)(O)O
*OP(=O)(O)O>>*O.OP(=O)(O)O  Glycogen synthase D phosphatase
OCC1OC(O)C(O)C(O)C1O>[Mg+2]>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Galactokinase
OC1OC(C(O)C(O)C1O)C(=O)O>>OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Galacturonokinase
OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C(O)CC(=O)C(=O)O
OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C1OC(=O)C(=C1O)O.O
OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1OC(C(O)C(O)C1O)C(=O)O.OP(=O)(O)O
OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O.OP(=O)(O)OP(=O)(O)O
OCC(O)C(O)C(O)C(O)C(=O)O>>OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Gluconokinase
OCC1OC(=O)C(O)C(O)C1O>[Mg+2]>OCC(O)C(O)C(O)C(O)C(=O)O  Gluconolactonase
OCC1OC(=O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Glucose dehydrogenase
OCC1OC(=O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Glucose dehydrogenase
NC1C(O)OC(CO)C(O)C1O>>NC(C(O)C(O)C(O)CO)C(=O)O.OO
NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Glucosamine-P-acetyltranferase
OCC(=O)C(O)C(O)C(O)C=O.OP(=O)=O>>OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  myo-Inositol-1-P synthase
OCC1OC(O)C(O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O  Xylose isomerase
OCC1OC(O)C(O)C(O)C1O>>OCC1OC(=O)C(O)C(O)C1O.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Glucose oxidase
OCC1OC(O)C(O)C(O)C1O>>OCC(O)C(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Aldehyde reductase
OC1OC(C(O)C(O)C1O)C(=O)O>>OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Glucuronokinase
OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C(O)C(O)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Glucuronate reductase
OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C(O)CC(=O)C(=O)O
OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1OC(C(O)C(O)C1O)C(=O)O.OP(=O)(O)O
OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O.OP(=O)(O)OP(=O)(O)O  Glucuronate 1-P Uridylyltransferase
OC(C=O)C1OC(=O)C(O)C1O>>OC(C(O)C(O)C(=O)O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Aldehyde dehydrogenase
OC(C=O)C1OC(=O)C(O)C1O>>OCC(O)C1OC(=O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Glucuronolactone reductase
OC(C=O)C1OC(=O)C(O)C1O>>OC1OC(C(O)C(O)C1O)C(=O)O  Uronolactonase
OC(COP(=O)(O)O)C=O>>OC(=O)c1cccnc1C(=O)O.O.O.OP(=O)(O)O
OCC(O)C=O>[Mg+2]>OC(COP(=O)(O)O)C=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Triokinase
OCC(O)C=O>>OCC(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Aldehyde (NAD+) dehydrogenase
OC(COP(=O)(O)O)C=O>>OC(COP(=O)(O)O)C(=O)OP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Glyceraldehyde-phosphate dehydrogenase
OC(COP(=O)(O)O)C=O>>OC(COP(=O)(O)O)C(=O)OP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Glyceraldehyde-phosphate dehydrogenase (NADP)
OC(COP(=O)(O)O)C=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC1OC(COP(=O)(O)O)C(O)C1O.OCC(=O)C(O)C(O)COP(=O)(O)O  Transketolase
OC(COP(=O)(O)O)C=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OCC(=O)C(O)C(O)COP(=O)(O)O.OC(COP(=O)(O)O)C(O)C=O  Transketolase
CC(O)C(=O)O>>CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  D-Lactate dehydrogenase
CC(O)C(=O)O>>CC(=O)C(=O)O.*[Fe+2].*[Fe+2]  D-Lactate dehydrogenase
OCC1OC(O)C(O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O  Mannose isomerase
OC(=O)C1CCCN1>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OC(=O)C1=NCCC1.OO  D-Aminoacid oxidase
OC(=O)C1CCCN1>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>NCCCCC(=O)O.OC(=O)CCCCC1CCSS1  D-Proline reductase (dithiol)
OC1OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O  Ribose-phosphate pyrophosphokinase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(O)C(=O)C(O)C(O)COP(=O)(O)O  Hexulose-6-P synthase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OC1OC(COP(=O)(O)O)C(O)C1O  Ribose-phosphate isomerase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O  Ribose-phosphate isomerase
OCC(O)C(O)C(O)C(O)CO>>OCC1OC(O)(CO)C(O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  L-Iditol dehydrogenase
OCC(O)C(O)C(O)C=O>>OCC1(O)OCC(O)C1O  Xylose isomerase
OCC(O)C(O)C(O)C=O>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Aldehyde reductase
OCC(O)C(O)C(O)C=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O
OCC1(O)OCC(O)C1O>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  D-Xylulose reductase
OCC1(O)OCC(O)C1O>[Mg+2]>OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Xylulokinase
OC(COP(=O)(O)O)C(O)c1cnc[nH]1>>OP(=O)(O)OCC(=O)Cc1cnc[nH]1.O  Imidazoleglycerol-P dehydratase
NC(CCCC(=O)NC1C2SCC(=C(N2C1=O)C(=O)O)CO)C(=O)O>>CC(=O)OCC1=C(N2C(SC1)C(NC(=O)CCCC(N)C(=O)O)C2=O)C(=O)O.O
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)[n+]5cccc(c5)C(=O)O)C(O)C3O>[Mg+2]>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.NC(CCC(=O)O)C(=O)O  NAD-Synthase (glutamine hydrolyzing)
NC(CCO)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CCC(=O)C(=O)O.N  Cystathionine gamma-lyase
NC(CO)C(=O)O>[K+].Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)C(=O)O.N  L-Serine dehydratase
CC(O)C(N)C(=O)O>>CCC(=O)C(=O)O.N  Threonine dehydratase
NC(=O)c1cccnc1>>OC(=O)c1cccnc1.N  Nicotine amidase
NCCc1c[nH]c2ccc(O)cc12>[Cu+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>Oc1ccc2[nH]cc(CC=O)c2c1.N.OO  Monoamine oxidase
NCCc1c[nH]c2ccccc12>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[Cu+2]>O=CCc1c[nH]c2ccccc12.N.OO  Monoamine oxidase
NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCc1c[nH]c2ccc(O)cc12.O=C=O  Aromatic L-amino acid decarboxylase
CC(=O)CC(=O)O>>CC(=O)C.O=C=O  Acetoacetate decarboxylase
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>OC(=O)CCCCC1SCC2NC(=O)NC12.[Co+2].[Zn+2]>CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.OC(=O)CC(=O)C(=O)O  Methylmalonyl-CoA carboxyltransferase
CC(C(=O)C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Acetyl-CoA-acyltransferase
OC(COP(=O)(O)O)C(O)CC(=O)C(=O)O>>CC(=O)C(=O)O.OC(COP(=O)(O)O)C=O  2-dehydro-3-deoxyphospho-Gluconate aldolase
OC(CC(=O)C(=O)O)C(O)C(=O)O>>CC(=O)C(=O)O.OC(C=O)C(=O)O  2-dehydro-3-deoxy-D-Glucarate aldolase
NC(=O)NC(NC(=O)N)C(=O)O>>NC(=O)N.NC(=O)NC(O)C(=O)O  Allantoinase
O=C1CC(=O)NC(=O)N1>>OC(=O)CC(=O)O.NC(=O)N  Barbiturase
CC(=O)NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2NC(=O)C)C1O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.CC(=O)NC1C(O)OC(CO)C(O)C1O  N-Acetyl-beta-glucosaminidase
OC(=O)CC(O)(CC(=O)O)C(=O)O>>OC(=O)CC(=O)C(=O)O.CC(=O)O  Citrate lyase
NC(CCSCC(N)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CCC(=O)C(=O)O.NC(CS)C(=O)O.N  Cystathionine gamma-lyase
CC(O)C(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCC(=O)O.CC=O  Threonine aldolase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1cccnc1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(O)C(O)C4O)C(O)C3OP(=O)(O)O.[H+]  NAD(P) nucleosidase
NC(=O)NC(O)C(=O)O>>OC(=O)C=O.NC(=O)N  Ureidoglycolate lyase
*OC1OC(C(O)C(O)C1O)C(=O)O>>OC1OC(C(O)C(O)C1O)C(=O)O.*O  beta-Glucuronidase
OC(C(CC(=O)O)C(=O)O)C(=O)O>[Mg+2]>OC(=O)CCC(=O)O.OC(=O)C=O  Isocitrate lyase
CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O  3-hydroxybutyryl-CoA dehydratase
OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O>>OC(COP(=O)(O)O)C(O)CC(=O)C(=O)O.O  P-Gluconate dehydratase
OC(C(O)C(O)C(=O)O)C(O)C(=O)O>>OC(CC(=O)C(=O)O)C(O)C(=O)O.O  D-Glucarate dehydratase
OC(C(O)C(O)C(=O)O)C(O)C(=O)O>>OC(CC(=O)C(=O)O)C(O)C(=O)O.O  D-Glucarate dehydratase
OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OC1C(O)C(COP(=O)(O)O)OC(=O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Glucose 6-P dehydrogenase
CC=CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCC=CCC=CCC=CCC=CCCCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CC=CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCCCCC(C)CCCCCCCCC(=O)O.NC(CCS)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>CC(CCOP(=O)(O)OP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C
CC12CCC3C(CC=C4CC(CCC34C)OS(=O)(=O)O)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O.OS(=O)(=O)O  Sterylsulfatase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CC(O)C1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Steroid 16alpha-hydroxylase)
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3(or 17)beta-Hydroxysteroid dehydrogenase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  3(or 17)beta-Hydroxysteroid dehydrogenase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Steroid delta-isomerase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Steroid delta-isomerase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(CCC34C)OS(=O)(=O)O)C2CCC1=O.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O  Alcohol sulfotransferase
CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3-Hydroxybutyryl-CoA dehydrogenase
CCCCO>[Zn+2]>CCCC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Butanol dehydrogenase
CC(C)O>>CC(=O)C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  (2-Propanol dehydrogenase (NAD+))
CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Butyraldehyde dehydrogenase
CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Butyryl-CoA dehydrogenase
OCC(O)C(O)C(=O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  dehydro-L-Gulonate dehydrogenase
OCC(O)C(O)C(=O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  dehydro-L-Gulonate dehydrogenase
OCC(O)C(O)C(O)CO>>OCC(O)C(O)C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  L-Arabinitol dehydrogenase
OCC(O)C1OC(=O)C(=C1O)O>>OCC(O)C1OC(=O)C(=O)C1=O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O  Glutathione dehydrogenase (ascorbate)
OCC(O)C(O)C(O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  L-Gulonate dehydrogenase
OCC(O)C(O)C(O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  L-Gulonate dehydrogenase
OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Malonate semialdehyde dehydrogenase
OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Malonate semialdehyde dehydrogenase
CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(=O)C12C
OC(COP(=O)(O)O)C(=O)OP(=O)(O)O>[Mg+2]>OC(COP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O  3-Phosphoglycerate kinase
OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(O)C(O)C(O)C1O.OP(=O)(O)O  1-L-myo-Inositol phosphatase
Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>>Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1.OP(=O)(O)OP(=O)(O)O  dCTP-Pyrophosphatase
Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>>Nc1ccn(C2CC(O)C(CO)O2)c(=O)n1.OP(=O)(O)O  5'-Nucleotidase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)O)O3>[Mg+2].[Co+2].[Ca+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3.OP(=O)(O)O  5'-Nucleotidase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3>>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3.OP(=O)(O)OP(=O)(O)OP(=O)(O)O  dGTPase
OC(=O)C(COP(=O)(O)O)OP(=O)(O)O>>OC(COP(=O)(O)O)C(=O)O.OP(=O)(O)O  Bisphosphoglycerate phosphatase
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>>Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)CO.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>[Mg+2]>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O  Adenylylsulfate kinase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O.OP(=O)(O)O  3'-Phosphoadenylsulfate 3'-phosphatase
*C(=O)OCC(COP(=O)(O)OCC(O)COP(=O)(O)O)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)*.OP(=O)(O)O  Phosphatase
CCCC(=O)OP(=O)(O)O>>CCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O  Butyrate kinase
OCC1(OP(=O)(O)O)OC(COP(=O)(O)O)C(O)C1O>>OCC1(O)OC(COP(=O)(O)O)C(O)C1O.OP(=O)(O)O  Fructose-2,6 bisphosphatase
OCC1OC(O)(CO)C(O)C1O>[Mg+2]>OCC1(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Hexokinase
NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>NC1C(O)OC(CO)C(O)C1O.OP(=O)(O)O
OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)COP(=O)(O)O>[Mg+2]>OCC(=O)C(O)C(O)C(O)C(O)COP(=O)(O)O.OP(=O)(O)O  Fructose bisphosphatase
CCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCC>[Mg+2]>CCCCCC(=O)OCC(CO)OC(=O)CCCCC.OP(=O)(O)O  Phosphatidate phosphatase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23>[Mg+2].[Co+2].[Ca+2]>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23.OP(=O)(O)O  5'-Nucleotidase
NC(COP(=O)(O)O)Cc1cnc[nH]1>>NC(CO)Cc1cnc[nH]1.OP(=O)(O)O  Histidinol phosphatase
CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.OP(=O)(O)O
CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)COP(=O)(O)O)C(=O)O>[Mg+2]>CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O.OP(=O)(O)O  (N-Acetylneuraminate-9-phosphatase)
NC(CCOP(=O)(O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(O)C(N)C(=O)O.OP(=O)(O)O  Threonine synthase
OC(=O)C(=C)OP(=O)(O)O>[Mg+2].[K+]>CC(=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O  Pyruvate kinase
OC(=O)C(=C)OP(=O)(O)O>[Mg+2].[K+]>CC(=O)C(=O)O.*C1OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C1O  Pyruvate kinase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O.OP(=O)(O)OP(=O)(O)O  Phosphoribosyl-ATP pyrophosphatase
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O>>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.OP(=O)(O)O  Thymidine triphosphatase
OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O.OP(=O)(O)O  5'-Nucleotidase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23>[Mg+2].[Co+2].[Ca+2]>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]c(=O)[nH]c23.OP(=O)(O)O  5'-Nucleotidase
OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OP(=O)(O)O  Glucose-6-phosphatase
OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O>[Mg+2]>OCC1(O)OC(COP(=O)(O)O)C(O)C1O.OP(=O)(O)O  Hexosediphosphatase
OCC1OC(O)(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  1-Phosphofructokinase
OCC(O)COP(=O)(O)O>>OCC(O)CO.OP(=O)(O)O  Glycerol kinase
*>>OCC(O)C(O)C(O)C=O.*  Xylosidases
*>>OCC(O)C(O)C(O)C=O.*
CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O>>CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Phenylalanine 4-monooxygenase
NC(Cc1cc(I)c(O)c(I)c1)C(=O)O>>NC(Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O.NC(=C)C(=O)O.O.O
NC(Cc1cc(I)c(O)c(I)c1)C(=O)O>>NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O.O.O.NC(=C)C(=O)O
CN(C)CC(=O)O>[Fe+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CNCC(=O)O.[*H2].C=O  Dimethylglycine dehydrogenase
CC(CCOP(=O)(O)OP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C>>CC(CCOP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C.OP(=O)(O)O
CC(CCOP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C>>CC(CCO)CCC=C(C)CCC=C(C)CCC=C(C)C.OP(=O)(O)O  Dolichyl phosphatase
NCCc1ccc(O)c(O)c1>>CN1CCC23C4Oc5c3c(CC1C2C=CC4O)ccc5O
NCCc1ccc(O)c(O)c1>[Cu+2].OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>NCC(O)c1ccc(O)c(O)c1.O.OCC(O)C1OC(=O)C(=O)C1=O  Dopamine beta-monooxygenase
*C.CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N
[*H].OC(=O)CCCCC1SCC2NC(=O)NC12>[Mg+2].[K+]>*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Biotin carboxylase
[*H].OC(=O)CCCCC1SCC2NC(=O)NC12>[Mg+2]>*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O
*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12>[Mg+2]>[*H].OC(=O)CCCCC1SCC2NC(=O)NC12.OC(=O)[O-].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O
*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12>[Mg+2]>[*H].OC(=O)CCCCC1SCC2NC(=O)NC12.OC(=O)[O-].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Dihydrolipoamide dehydrogenase
*.OC(=O)CCCCC1CCSS1>>*.OC(=O)CCCCC(S)CCS.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Dihydrolipoamide dehydrogenase
*.OC(=O)CCCCC(S)CCSC(=O)CCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O.*.OC(=O)CCCCC(S)CCS  Dihydrolipoamide succinyltransferase
*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(O)(CCC(=O)O)C(=O)O>>*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc(C(O)CCC(=O)O)[n+]1Cc2cnc(C)nc2N.O=C=O  2-Oxoglutarate decarboxylase
*.OC(=O)CCCCC(S)CCS>>*.OC(=O)CCCCC1CCSS1.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Dihydrolipoamide dehydrogenase
*.OC(=O)CCCCC(S)CCS>>*.OC(=O)CCCCC1CCSS1.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.O=C=O  Acetyl-CoA acyltransferase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O  UDPG-4-epimerase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O  UDP-Glucuronate-4-epimerase
CC(C)C(=C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)C(C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C
CC(C)C(C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)C(C)C=CC(C)C1CCC2C(=CC=C3CC(O)CCC3=C)CCCC12C
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Estriol 2-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Estriol 2-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CCC1O
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(=O)O)ccc34)C2CC(O)C1O
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Steroid 16a-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Estradiol 17beta-dehydrogenase
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Estradiol 17beta-dehydrogenase
CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(OC5OC(C(O)C(O)C5O)C(=O)O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Glucuronosyltransferase
CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Estradiol 17beta-dehydrogenase
CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Estradiol 17beta-dehydrogenase
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Steroid 16a-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Estriol 2-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Estriol 2-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(=O)O)ccc34)C2CCC1=O
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CCC1=O.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O  Estrone sulfotransferase
NCCO>>NCCOP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Ethanolamine kinase
CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1=O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.O=O  2-Hydroxyacid dehydrogenase
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*  Acyl-CoA dehydrogenase
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*  Acyl-CoA dehydrogenases (2 known) 
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.OO
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[*H2]  Glycerol 3-P dehydrogenase
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[*H2]
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.OO  (S)-2-Hydroxyacid oxidase
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.OO
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.OO
CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C>[Mg+2]>CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)OP(=O)(O)O  Farnesyl-bisphospho-farnesyltransferase
CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C>[Mg+2]>CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C.OP(=O)(O)OP(=O)(O)O  Farnesyl-trans-transferase
CCCCCC(=O)O>>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)OP(=O)(O)O  Acyl-CoA ligases
CCCCCC(=O)O>>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)O  Acyl-CoA ligases
[Fe+2]>>[Fe+3].O.[Fe+3]  Ferroxidase (ceruloplasmin)
[*H2]>>*.[H][H]  Hydrogenase
*[Fe+3]>>*.[Fe+2]  Transferrin reductase
Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)cnc2[nH]1>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Dihydrofolate reductase
Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)cnc2[nH]1>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Dihydrofolate reductase
C=O>>OC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Formaldehyde dehydrogenase
OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Formate dehydrogenase
OC=O>Nc1nc2NCC(Nc2c(=O)[nH]1)C3=C(S[Mo](=O)(=O)S3)C(O)COP(=O)(O)O>O=C=O.*[Fe+2].*[Fe+2].[H+].[H+]  Formate dehydrogenase (cytochrome)
OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Formate dehydrogenase
OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Formate dehydrogenase
OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Formate dehydrogenase
OC(=O)CNC=N>>NCC(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1  Glycine formimino transferase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC=O>>OC=O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Formyl-CoA hydrolase
OC(=O)CCC(C(CCC(=O)NC(CCC(=O)NC(CCC(=O)NCCc1ccc(OCc2coc(CNC=O)c2)cc1)C(=O)O)C(=O)O)C(=O)O)C(=O)O>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C=O.NCc1cc(COc2ccc(CCNC(=O)CCC(NC(=O)CCC(NC(=O)CCC(C(CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)O)cc2)co1  Formylmethanofuran-THMPT formyltransferase
OC(=O)C=CC(=O)O>>OC(CC(=O)O)C(=O)O  Fumarate hydratase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Cellulose synthase (GDP-forming)
CC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C>[Mg+2]>CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C.OP(=O)(O)OP(=O)(O)O  Geranyl-trans-transferase
NC(C(O)C(O)C(O)CO)C(=O)O>O>OCC(O)C(O)CC(=O)C(=O)O.N  Aminodeoxygluconate dehydratase
*C(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC.OCC1OC(O)C(O)C(O)C1O  Glucosylceramidase
*C(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC>>CCCCCCCCCCCCCCCCCC(=O)NCC(OC1OC(CO)C(OC2OC(CO)C(OC3OC(CO)C(O)C(OC4OC(CO)C(O)C(O)C4O)C3NC(=O)C)C(OC5(CC(O)C(N)C(O5)C(O)C(O)CO)C(=O)O)C2O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=CCC(=O)O>OC(=O)CCCCC1SCC2NC(=O)NC12>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O  Glutaryl-CoA dehydrogenase
OC(=O)CCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Glutarate-CoA ligase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=CCC(=O)O.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Glutaryl-CoA dehydrogenase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=CCC(=O)O.[*H2]  Glutaryl-CoA dehydrogenase
NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Glutathione reductase
NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>>*SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O.*SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O.[H+].[H+]  Glutathione transferases (Detoxification reactions)
NCCOP(=O)(O)OCC(O)CO>>OCC(O)COP(=O)(O)O.NCCO  Glycerophosphocholine phosphodiesterase
OCC(O)CO>>CC(O)C=O.O  Glycerol dehydratase
OCC(O)CO>>OCC(O)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Glycerol hydrogenase (NADP+) 
OCC(O)CO>>OCC(O)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Glycerol hydrogenase (NADP+) 
OCC(=O)COP(=O)(O)O>>OC(COP(=O)(O)O)C=O  Triose-P isomerase
NCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>*.NCSC(CCS)CCCCC=O.O=C=O  Glycine dehydrogenase (decarboxylating)
NCC(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)CN)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Glycine-tRNA ligase
NCC(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OC(=O)C=O.OO.N  D-Amino acid oxidase
NCC(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OC(=O)C=O.N.OO  D-Aminoacid oxidase
NCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)C=O.NC(CCC(=O)O)C(=O)O  Glycine transaminase
NCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)C=O.CC(N)C(=O)O  Glycine transaminase
NCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CO)C(=O)O.OC(=O)C=O  Serineglyoxylate transaminase
CC(CCC(=O)NCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NCC(=O)O  Choloylglycine hydrolase
*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O>>*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O  Phosphorylase phosphatase
OCC(=O)O>>OC(=O)C=O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C  (S)-2-Hydroxy-acid oxidase
OCC(=O)O>>OC(=O)C=O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C  (S)-2-Hydroxyacid oxidase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)CN)C1O>>*
OC(=O)C=O>>OCC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Glyoxylate reductase
OC(=O)C=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCC(=O)O.OC(=O)CCC(=O)C(=O)O.CC(=O)C(=O)O  Alanine glyoxylate transaminase
OC(=O)C=O>>OCC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Glyoxylate reductase
OC(=O)C=O>>OC(=O)C(=O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C  (S)-3-Hydroxyacid ester dehydrogenase
OC(=O)C=O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Glyoxylate dehydrogenase (acylating)
OC(=O)C=O>>OC(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Malate synthase
OC(=O)C=O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.[Mg+2]>OC(C=O)C(=O)O.O=C=O  Tartronate-semialdehyde synthase
NC(=N)NCC(=O)O>>CN(CC(=O)O)C(=N)N.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]  Guanidinoacetate methyl-transferase
NC(=N)NCC(=O)O>>OC(=O)CNC(=N)NP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Guanidinoacetate kinase
Nc1nc2[nH]cnc2c(=O)[nH]1>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(CO)C(O)C3O.OP(=O)(O)O  Purine nucleoside phosphorylase
Nc1nc2[nH]cnc2c(=O)[nH]1>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Hypoxanthine P-ribosyltransferase
Nc1nc2[nH]cnc2c(=O)[nH]1>>O=c1[nH]c(=O)c2nc[nH]c2[nH]1.N  Guanine deaminase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(CO)C(O)C3O>>Nc1nc2[nH]cnc2c(=O)[nH]1.OCC1OC(O)C(O)C1O  Purine nucleosidase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Nucleoside diphosphatase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Nucleoside diphosphate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.*  Nucleoside diphosphate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(=O)[nH]c(N)nc45)C(O)C1O.OP(=O)(O)O  Polyribonucleotide nucleotidyltransferase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O>[Zn+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(CO)C(O)C3O.OP(=O)(O)O  5'-Nucleotidase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O>[K+].[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Guanylate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  GMP reductase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.[Mg+2].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.*.O  Ribonucleoside triphosphate reductase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1nc(NCC(=O)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(N)c(=O)[nH]1.OC=O  GTP Cyclohydrolase I
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  ATPases (several known)
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(=O)[nH]c(N)nc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O  DNA-directed RNA polymerase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(=O)[nH]c(N)nc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O  RNA-directed RNA polymerase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Fe+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.*.O  Ribonucleoside-diphosphate reductase
OS(=O)(=O)S>>SC#N.OS(=O)=O  Thiosulfate sulfurtransferase
*>>CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O.CCC1=C(C)C(=CC2=NC(=Cc3[nH]c(C=C4NC(=O)C(C)C4=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O.O.O.O.[C-]#[O+].*.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*  Heme oxygenase (decycling)
*S[Fe+2]12([N+]3=C4C=c5c(CCC(=O)O)c(C)c6=CC7=[N+]2C(=Cc8c(C)c(C=C)c(C=C3C(=C4CCC(=O)O)C)n81)C(=C7C)C=C)n65>>*  Heme oxygenase (decycling)
*S[Fe+2]12([N+]3=C4C=c5c(CCC(=O)O)c(C)c6=CC7=[N+]2C(=Cc8c(C)c(C=C)c(C=C3C(=C4CCC(=O)O)C)n81)C(=C7C)C=C)n65>>*
NCCc1cnc[nH]1>[Cu+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>O=CCc1c[nH]cn1.N.OO  Amine oxidase (Cu++)
NCCc1cnc[nH]1>>CNCCc1c[nH]cn1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]  Histamine methyltransferase
OC(=O)CCC(=CC(=O)O)C(=O)O>>OC(C(CCC(=O)O)C(=O)O)C(=O)O  Homoaconitate hydratase
OC(=O)CCC(O)(CC(=O)O)C(=O)O>>OC(=O)CCC(=CC(=O)O)C(=O)O.O
OC(=O)Cc1cc(O)ccc1O>[Fe+2]>OC(=O)CC(=O)CC(=O)C=CC(=O)O  Homogentisate 1,2-dioxygenase
OC(=O)Cc1cc(O)ccc1O>>CC(=CCCC(=CCC1=CC(=O)C(=C(C)C1=O)C)C)C
OC(=O)Cc1cc(O)ccc1O>>CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.OP(=O)(O)OP(=O)(O)O.O=C=O.[H+].[H+]
OC(C(CCC(=O)O)C(=O)O)C(=O)O>[Mg+2]>OC(=O)CCC(C(=O)O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  (Homoisocitrate dehydrogenase)
OC(=O)CCC1NC(=O)NC1=O>>NC(=O)NC(CCC(=O)O)C(=O)O
I>>II.O.O  Iodide peroxidase
I>>II.O.O  Iodide peroxidase
OCC(=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Hydroxypuruvate reductase
OCC(=O)C(=O)O>>OCC(O)C(=O)O.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  2-Hydroxyacid dehydrogenase
OCC(=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Hydroxypuruvate reductase
NCCS(=O)O>>NCCS(=O)(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Hypotaurine dehydrogenase
O=c1[nH]cnc2[nH]cnc12>>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23.OP(=O)(O)O  Purine nucleoside phosphorylase
O=c1[nH]cnc2[nH]cnc12>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.OP(=O)(O)OP(=O)(O)O  Hypoxanthine P-ribosyltransferase
O=c1[nH]cnc2[nH]cnc12>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>O=c1[nH]c(=O)c2nc[nH]c2[nH]1.OO  Xanthine oxidase
*O>>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Protein kinase A
O=CCc1c[nH]c2ccccc12>>OC(=O)Cc1c[nH]c2ccccc12.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Aldehyde dehydrogenase
OC(=O)C(=O)Cc1c[nH]c2ccccc12>>O=CCc1c[nH]c2ccccc12.O=C=O
OC(=O)C(=O)Cc1c[nH]c2ccccc12>>OC(O)C(=O)Cc1c[nH]c2ccccc12
c1cc2ccccc2[nH]1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.[NH4+]>NC(Cc1c[nH]c2ccccc12)C(=O)O.O  Tryptophan synthase
OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23>>O=c1[nH]cnc2[nH]cnc12.OCC1OC(O)C(O)C1O  Nucleosidase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(NC(CC(=O)O)C(=O)O)ncnc23.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Adenylosuccinate synthase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23>[K+].NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  IMP dehydrogenase
CC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Acyl-CoA dehydrogenase
OC1C(OC(=C)C(=O)O)C=CC=C1C(=O)O>Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N>OC(=O)CCC(=O)c1ccccc1C(=O)O.CC(=O)C(=O)O.O=C=O.O
OC1C(OC(=C)C(=O)O)C=CC=C1C(=O)O>>OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O  Isochorismate synthase
CC1(C)SC2C(NC(=O)CCCC(N)C(=O)O)C(=O)N2C1C(=O)O>>NC(CCCC(=O)NC1C2SCC(=C(N2C1=O)C(=O)O)CO)C(=O)O.O.OC(=O)CCC(=O)O.OC(=O)CCC(=O)O.O=C=O.O=C=O  (Expandase + hydroxylase)
CC1(C)SC2C(NC(=O)CCCC(N)C(=O)O)C(=O)N2C1C(=O)O>>CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O.NC(CCCC(=O)O)C(=O)O
CC(C)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Acyl-CoA dehydrogenase
OC(=O)c1cc(O)c2ccccc2n1>>OC(=O)CCC(=O)C(=O)O.OC(=O)CC(=O)C(=O)O
*C(=O)OCC(O)COP(=O)(O)OCCN>>*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
*C(=O)OCC(O)COP(=O)(O)OCCN>>NCCOP(=O)(O)OCC(O)CO.*C(=O)O  Lysophospholipase
C[N+](C)(C)CCOP(=O)(O)OCC(O)CO>>OCC(O)COP(=O)(O)O.C[N+](C)(C)CCO  Glycerophosphocholine phosphodiesterase
OC1CC(N=C1)C(=O)O>>OC1CNC(C1)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Pyrroline-5-carboxylate reductase
OC1CC(N=C1)C(=O)O>>OC1CNC(C1)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Pyrroline-5-carboxylate reductase
OC1CC(N=C1)C(=O)O>>NC(CC(O)C(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  1-Pyrroline-5-carboxylate dehydrogenase
OC1CC(N=C1)C(=O)O>>NC(CC(O)C(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  1-Pyrroline-5-carboxylate dehydrogenase
OC(=O)C1CCC=N1>>NC(CCC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  1-Pyrroline-5-carboxylate dehydrogenase
OC(=O)C1CCC=N1>>NC(CCC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  1-Pyrroline-5-carboxylate dehydrogenase
OC(=O)C1CCC=N1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Pyrroline-5-carboxylate reductase
OC(=O)C1CCC=N1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Pyrroline-5-carboxylate reductase
CC(=O)C(N)C(=O)O>>CC(=O)CN.O=C=O  5-Aminolevulinate synthase
NC(CCCC(=O)O)C(=O)O>NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>NC(CCCC=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (2-Aminoadipate reductase)
NC(CCCC(=O)O)C(=O)O>>NC(CCCC=O)C(=O)O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Aminoadipate semialdehyde dehydrogenase
NC(CCCC=O)C(=O)O>>NC(CCCC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Aminoadipate semialdehyde dehydrogenase
NC(CCCC(=O)O)C(=O)O>>NC(CCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.OP(=O)(O)OP(=O)(O)O
CCCC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3-Hydroxyacyl-CoA dehydrogenase
OC1CNC(C1)C(=O)O>>OC1CC(N=C1)C(=O)O.[*H2]  L-Proline dehydrogenase
OC1CNC(C1)C(=O)O>>OC1CNC(C1)C(=O)O  4-Hydroxyproline epimerase
OC1CC(N=C1)C(=O)O>>NC(CC(O)C=O)C(=O)O  non-enzymatic
CC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(C)N)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Alanine tRNA ligase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(C)N)C1O>>*
NC(CCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O>>*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O
OCC(O)C(O)C(O)C=O>>OCC1(O)OCC(O)C1O  L-Arabinose isomerase
OCC(O)C(O)C(O)C=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O
OCC(O)C(O)C(O)CO>>OCC1(O)OCC(O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  L-Arabitol dehydrogenase (Ribulose-forming)
NC(CCCNC(=N)N)C(=O)O>[Mg+2]>NC(CCCNC(=N)NP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Arginine kinase
NC(CCCNC(=N)N)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>NC(=N)NCCCC(=O)N.O.O=C=O  Arginine 2-monooxygenase
NC(CCCNC(=N)N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCCCNC(=N)N.O=C=O  Arginine decarboxylase
NC(CCCNC(=N)N)C(=O)O>>[NH4+].NC(CCCNC(=O)N)C(=O)O  Arginine deiminase
NC(CCCNC(=N)N)C(=O)O>>NC(CCCNC(=N)NC(CC(=O)O)C(=O)O)C(=O)O  Argininosuccinate lyase
NC(CCCNC(=N)N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCNC(=N)N)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  L-Arginyl-tRNA ligase
NC(CCCNC(=N)N)C(=O)O>[Co+2]>NCCCC(N)C(=O)O.NC(=O)N  Arginase
NC(CCCNC(=N)N)C(=O)O>>NCCCC(N)C(=O)O.NC(=N)NCC(=O)O  Glycine amidinotransferase
NC(CCCNC(=N)N)C(=O)O.NC(CCCNC(=N)N)C(=O)O>CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>[N]=O.[N]=O.O.O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(CCCNC(=O)N)C(=O)O.NC(CCCNC(=O)N)C(=O)O  Nitric oxide synthase
NC(CCCNC(=N)NC(CC(=O)O)C(=O)O)C(=O)O>[Mg+2]>NC(CCCNC(=O)N)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.NC(CC(=O)O)C(=O)O  Argininosuccinate synthetase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCNC(=N)N)C1O>>*
OCC(O)C1OC(=O)C(=C1O)O>>OCC(O)C1OC(=O)C(=O)C1O  non-enzymatic
OCC(O)C1OC(=O)C(=C1O)O>[Cu+2]>OCC(O)C1OC(=O)C(=O)C1=O.O  Ascorbate oxidase
OCC(O)C1OC(=O)C(=C1O)O>[Fe+2]>OCC(O)C(O)C(=O)O.OC(=O)C(=O)O  Ascorbate-2,3-dioxygenase
NC(CC(=O)N)C(=O)O>>NC(CC(=O)O)C(=O)O.N  Asparaginase
NC(CC(=O)N)C(=O)O>>NC(=O)CC(=O)C(=O)O.NCC(=O)O  Asparagine-oxo acid transaminase
NC(CC(=O)O)C(=O)O>>NC(CCC(=O)O)C(=O)O.OC(=O)CC(=O)C(=O)O  Aspartate transaminase
NC(CC(=O)O)C(=O)O>[Co+2]>OC(=O)C=CC(=O)O.N  Aspartate ammonia-lyase
NC(CC(=O)O)C(=O)O>[Mg+2]>NC(CC(=O)N)C(=O)O.OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O  Aspartate ammonialigase
NC(CC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(N)C(=O)O.O=C=O  Aspartate-4-decarboxylase
NC(CC(=O)O)C(=O)O>>NC(=O)NC(CC(=O)O)C(=O)O.OP(=O)(O)O  Aspartate carbamoyltransferase
NC(CC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)CC(=O)C(=O)O.NC(CCC(=O)O)C(=O)O  Aspartate transaminase
NC(CC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCC(=O)O.O=C=O  Aspartate-1-decarboxylase
NC(CC=O)C(=O)O>>OC(=O)C1CC=CC(=N1)C(=O)O.O.O  (Dihydrodipicolinate synthase)
NC(CC=O)C(=O)O>[K+]>NC(CCO)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Homoserine dehydrogenase
NC(CC=O)C(=O)O>[K+]>NC(CCO)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Homoserine dehydrogenase
NC(CCSCC(N)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCS)C(=O)O.N.CC(=O)C(=O)O  Cystathionine beta-lyase
NC(CS(=O)(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCS(=O)(=O)O.O=C=O  Sulfinoaniline decarboxylase
NC(CS)C(=O)O>[Fe+2].NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>NC(CS(=O)O)C(=O)O  Cysteine dioxygenase
NC(CS)C(=O)O>>OC(=O)C(=O)CS.NC(CCC(=O)O)C(=O)O  Cysteine transaminase
NC(CS)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCSCC(N)C(=O)O)C(=O)O.OC(=O)CCC(=O)O  O-Succinylhomoserine (thiol)-lyase
NC(CS)C(=O)O>>NC(CS(=O)(=O)O)C(=O)O.S  Cysteine lyase
NC(CS)C(=O)O>>CC(=O)C(=O)O.N.S  Cystathionine beta-lyase
NC(CSSCC(N)C(=O)O)C(=O)O>>CC(=O)C(=O)O.NC(CSS)C(=O)O.N  Cystathionine beta-lyase
OCC(O)C1OC(=O)C(=O)C1=O>>OCC(O)C(O)C(=O)C(=O)C(=O)O
NC(Cc1ccc(O)c(O)c1)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>NCCc1ccc(O)c(O)c1.O=C=O  (DOPA decarboxylase) aromatic L-amino acid decarboxylase
CNCC(O)c1ccc(O)c(O)c1>>COc1cc(ccc1O)C(O)C(=O)O  Catechol methyltransferase
NC(CCC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>NCCCC(=O)O.O=C=O  Glutamate decarboxylase
NC(CCC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O  Alanine transaminase
NC(CCC(=O)O)C(=O)O>[Mg+2]>NC(CCC(=O)N)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Glutamate ammonia ligase
NC(CCC(=O)O)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCC(=O)O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Glutamate-tRNA ligase
NC(CCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CS)C(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Glutamatecysteine ligase
NC(CCC(=O)O)C(=O)O>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>CC(C(N)C(=O)O)C(=O)O  Methylaspartate mutase
NC(CCC(=O)O)C(=O)O>>CC(=O)NC(CCC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Aminoacid acetyltransferase
NC(CCC=O)C(=O)O>>OC(=O)C1CCC=N1.O  non-enzymatic
NC(CCC(=O)N)C(=O)O>>NC(CCC(=O)O)C(=O)O.N  Glutaminase
NC(CCC(=O)OP(=O)(O)O)C(=O)O>>NC(CCC=O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)O  Glutamate-5-semialdehyde dehydrogenase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCC(=O)O)C1O>>NC1CCC(=O)OC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.*C1OC(COP(=O)(O)OC2C(O)C(*)OC2COP(=O)(O)OC3C(O)C(*)OC3CO)C(O)C1O  (Glutamyl-tRNA(Glu) reductase)
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCC(=O)O)C1O>>*
OCC(O)C1OC(=O)C(O)C1O>>OCC(O)C1OC(=O)C(=O)C1O.OO  L-Gulonolactone oxidase
OCC(O)C1OC(=O)C(O)C1O>>OCC(O)C(O)C(O)C(O)C(=O)O  Glucono-3-lactonase
NC(Cc1c[nH]cn1)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCc1cnc[nH]1.O=C=O  Histidine decarboxylase
NC(Cc1c[nH]cn1)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4cnc[nH]4)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O
NC(Cc1c[nH]cn1)C(=O)O>[Zn+2]>OC(=O)C=Cc1cnc[nH]1.N  Histidine ammonia lyase
NC(CO)Cc1cnc[nH]1>>NC(Cc1c[nH]cn1)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+]  Histidinol dehydrogenase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4cnc[nH]4)C1O>>*
NC(CCS)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.[K+]>NC(CCSCC(N)C(=O)O)C(=O)O.O  Cystathionine beta-synthase
NC(CCS)C(=O)O>C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23.[Mg+2]>CSCCC(N)C(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1  5-Methyl-THF-homocysteine methyltransferase
NC(CCS)C(=O)O>OP(=O)(O)O.[Mg+2]>CSCCC(N)C(=O)O.CC(OC(=O)C(N)CCC(=O)O)C(OC(=O)C(N)CCC(=O)O)C1=CNc2nc(N)nc(OC(=O)C(N)CCC(=O)O)c2N1  5-Methyltetrahydropteroyl-(Glu)3-homocysteine methyltransferase
NC(CCS)C(=O)O>>CSCCC(N)C(=O)O.CN(C)CC(=O)O.[H+]  Betaine-homocysteine methyltransferase
NC(CCS)C(=O)O>>NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.O  Adenosylhomocysteinase
NC(CCO)C(=O)O>>NC(CCOC(=O)CCC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  (Homoserine succinyltransferase)
CCC(C)C(N)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CCC(C)C(=O)C(=O)O.N.OO  L-Amino acid oxidase
CCC(C)C(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CCC(C)C(=O)C(=O)O.NC(CCC(=O)O)C(=O)O  Branched-chain-amino acid transaminase
CCC(C)C(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)CC)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Isoleucyl-tRNA ligase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)CC)C1O>>*
NC(CC(=O)c1ccccc1N)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>NC(CC(=O)c1cccc(O)c1N)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  Kynurenine 3-monooxygenase
NC(CC(=O)c1ccccc1N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>Nc1ccccc1C(=O)O.CC(N)C(=O)O  Kynureninase
NC(CC(=O)c1ccccc1N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)c1cc(O)c2ccccc2n1.NC(CCC(=O)O)C(=O)O.O  Kynurenine transaminase
CC(O)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>CC(=O)O.O=C=O.O  Lactate 2-monooxygenase
CC(O)C(=O)O>>CC(O)C(=O)O  Lactate racemase
CC(O)C(=O)O>>CC(=O)C(=O)O.[*H][Fe+2].[*H][Fe+2]  Lactate dehydrogenase (cytochrome)
CC(C)CC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CC(C)C)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Leucyl-tRNA ligase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CC(C)C)C1O>>*
NCCCCC(N)C(=O)O>>NCCCCCN.O=C=O  Lysine decarboxylase
NCCCCC(N)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O
NCCCCC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCCN)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Lysine-tRNA ligase
NCCCCC(N)C(=O)O>>CC(=O)NCCCCC(N)C(=O)O.OP(=O)(O)O  epsilon-Lysine acetyltransferase
NCCCCC(N)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Saccharopine dehydrogenase (NAD+, L-Lysine forming)
NCCCCC(N)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  Saccharopine dehydrogenase (NADP+, L-Lysine forming)
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCCN)C1O>>*NC(=O)C(CCCCN)NC(=O)*.*C1OC(COP(=O)(O)OC2C(O)C(*)OC2COP(=O)(O)OC3C(O)C(*)OC3CO)C(O)C1O
OCC(O)C(O)C(O)C(=O)O>>OCC1OC(=O)C(=C1O)O.O.O
CS(=O)CCC(N)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*>CSCCC(N)C(=O)O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Mehionine S-oxide reductase
CSCCC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCSC)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Methionine-tRNA ligase
CSCCC(N)C(=O)O>[Mg+2].[K+]>C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)O  Methionine adenosyltranferase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCSC)C1O>[Mg+2]>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(CCSC)NC=O)C1O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1  Methionyl-tRNA formyltransferase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCSC)C1O>>*
NCC(O)c1ccc(O)c(O)c1>>CNCC(O)c1ccc(O)c(O)c1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]  (Phenylethanolamine N-methyltransferase)
NCC(O)c1ccc(O)c(O)c1>>COc1cc(ccc1O)C(O)C(=O)O
NCCCC(N)C(=O)O>>NC(CCCNC(=O)N)C(=O)O.OP(=O)(O)O  Ornithine carbamoyltransferase
NCCCC(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCC=O)C(=O)O.NC(CCC(=O)O)C(=O)O  Ornithineoxoacid transaminase
NCCCC(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCCCN.O=C=O  Ornithine decarboxylase
NC(=O)CC(=O)C(=O)O>>OC(=O)CC(=O)C(=O)O.N  omega-Amidase
NC(Cc1ccccc1)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccccc4)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O
NC(Cc1ccccc1)C(=O)O>[Fe+2]>NC(Cc1ccc(O)cc1)C(=O)O.O.CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O  Phenylalanine 4-monooxygenase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccccc4)C1O>>*
OC(=O)C1CCCCN1>>OC(=O)C1CCCC=N1.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  (L-Pipecolate dehydrogenase)
OC(=O)C1CCCN1>>OC(=O)C1CCC=N1.[*H2]  L-Proline dehydrogenase
OC(=O)C1CCCN1>OCC(O)C1OC(=O)C(=C1O)O>OC1CNC(C1)C(=O)O.O=C=O.OC(=O)CCC(=O)O  Procollagenproline-2-oxoglutarate dioxygenase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O  Ribulose-P 3-epimerase
OCC1(O)OCC(O)C1O>[Mg+2]>OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Ribulokinase
NC(CO)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCC(=O)O.Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.O  Glycine (Serine) Hydroxymethyl transferase
NC(CO)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CCCCCCCCCCCCCCCC(=O)C(N)CO.O=C=O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Serine palmitoyl transferase
NC(CO)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OCC(=O)C(=O)O.CC(N)C(=O)O  Alanine-oxoacid transaminase
NC(CO)C(=O)O>[Mg+2]>*C(=O)OCC(COP(=O)(O)OCC(N)C(=O)O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1  CDP-Diacylglycerol-serine phosphatidyltransferase
NC(CO)C(=O)O>>CC(=O)C(=O)O.N  2-Serine dehydratase
OCC(O)C(O)C(=O)O>>OCC(=O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  L-Threonate dehydrogenase
CC(O)C(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.O>CCC(=O)C(=O)O.N  Threonine dehydratase
CC(O)C(N)C(=O)O>>CC(=O)C(N)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  L-Threonine 3-dehydrogenase
NC(Cc1c[nH]c2ccccc12)C(=O)O>[Fe+2]>NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O.O.CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O  Tryptophan 5-monooxygenase
NC(Cc1c[nH]c2ccccc12)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.[K+]>c1cc2ccccc2[nH]1.CC(=O)C(=O)O.N  Tryptophanase
NC(Cc1c[nH]c2ccccc12)C(=O)O>>OC(=O)C(=O)Cc1c[nH]c2ccccc12.OO.N  L-Amino acid oxidase
NC(Cc1c[nH]c2ccccc12)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)C(=O)Cc1c[nH]c2ccccc12.NC(CCC(=O)O)C(=O)O  Tryptophan transaminase
NC(Cc1c[nH]c2ccccc12)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4c[nH]c5ccccc45)C1O.OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O
NC(Cc1c[nH]c2ccccc12)C(=O)O>>NC(CC(=O)c1ccccc1NC=O)C(=O)O  Tryptophan 2,3-dioxygenase)-pyrrolase
NC(Cc1c[nH]c2ccccc12)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>NCCc1c[nH]c2ccccc12.O=C=O  Aromatic L-amino acid decarboxylase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4c[nH]c5ccccc45)C1O>>*
NC(Cc1ccc(O)cc1)C(=O)O>[Fe+2]>NC(Cc1ccc(O)c(O)c1)C(=O)O.CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O.O  Tyrosine 3-monooxygenase
NC(Cc1ccc(O)cc1)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccc(O)cc4)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O
NC(Cc1ccc(O)cc1)C(=O)O>[Cu+2]>NC(Cc1ccc(O)c(I)c1)C(=O)O.I  Iodide peroxidase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccc(O)cc4)C1O>>*
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)C)C1O>>*
OCC(O)C(O)C(O)C(=O)O>>OCC1OC(=O)C(=C1O)O.O.O
OCC(O)C(O)C(=O)CO>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  L-Xylulose reductase
OCC(O)C(O)C(=O)CO>[Mg+2]>OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  L-Xylulokinase
OCC(=O)C(O)C(O)COP(=O)(O)O>Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.[Mg+2]>OC(COP(=O)(O)O)C=O.CC(=O)OP(=O)(O)O.O  Phosphoketolase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O  Ribulose-P-4-epimerase
NC(CC(O)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(CC(=O)C(=O)O)C(=O)O.NC(CCC(=O)O)C(=O)O  Aspartate transaminase
NC(CCC(=O)NC(CS)C(=O)O)C(=O)O>>NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  Glutathione synthase
CC(C(N)C(=O)O)C(=O)O>[Mg+2].[K+]>CC(=CC(=O)O)C(=O)O.N  Methylaspartate ammonia lyase
NC(CCCC(N)C(=O)O)C(=O)O>>NC(CCCC(N)C(=O)O)C(=O)O  Diaminopimelate epimerase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O  beta-Galactosidase
CC(O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=C.O  Lactoyl-CoA dehydratase
CC(O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Lactoyl-CoA dehydrogenase
CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3>NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3.OC=O
*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*>>*C(=O)OCC(CO)OC(=O)*.C[N+](C)(C)CCOP(=O)(O)O  Phospholipase C
*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*>>*C(=O)OCC(COP(=O)(O)O)OC(=O)*.C[N+](C)(C)CCO  Phospholipase D
CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2C(=CCCC2(C)C)C.[H].[H]
CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2=C(C)CCCC2(C)C.[H].[H]
CC1C(CCC(=O)O)C2=CC3=[N+]4[Mg+2][N+]5=C(C=C1N2)C(=C(C=C)C5=Cc6[nH]c(C=C4C(=C3CCC(=O)O)C)c(C=C)c6C)C>>COC(=O)CCC1=C(C)C2=Cc3[nH]c(C=C4C(=C(C)C5=[N+]4[Mg+2][N+]2=C1C=C6NC(=C5)C(C)C6CCC(=O)O)C=C)c(C)c3C=C.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]  Magnesium protoporphyrin methyltransferase
NC(=O)C=CC(=O)O>>OC(=O)C=CC(=O)O.N
OC(=O)C=CC(=O)O>>OC(=O)C=CC(=O)O
OC(=O)CC=O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  Malonate semialdehyde dehydrogenase (acetylating)
OC(=O)CC=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  Malonate semialdehyde dehydrogenase (acylating)
OC(=O)CC=O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Malonate semialdehyde dehydrogenase (acetylating)
OC(=O)CC=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  Malonate semialdehyde dehydrogenase (acylating)
OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Malonate semialdehyde dehydrogenase
OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Malonate semialdehyde dehydrogenase
OC(=O)CC=O>>NCCC(=O)O.OC(=O)CCC(=O)C(=O)O  4-Aminobutyrate transaminase
OC(=O)CC=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCC(=O)O.CC(=O)C(=O)O  beta-Alanine-puruvate transaminase
OC(=O)CC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O.CC(=O)O  Malonyl-CoA transferase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O  Malonyl-CoA decarboxylase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.OC(=O)CC(=O)O  Malonate-CoA transferase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O  Malonyl-CoA decarboxylase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12.[H+]  (active) Acetyl-CoA carboxylase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.O=C=O
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O  alpha-Glucosidase (maltase)
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O  Maltose phosphorylase
CC(=CCCC(=CCc1c(C)c(O)c2ccccc2c1O)C)C>>CC(=CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C)C.[H].[H]
CC(=CC(=O)O)C(=O)O>[Fe+2]>CC(O)(CC(=O)O)C(=O)O  (S)-2-Methylmalate dehydratase
CC(=C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(CO)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Enoyl-CoA hydratase
C>[Cu+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CO.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Methane monooxygenase
NCc1cc(COc2ccc(CCNC(=O)CCC(NC(=O)CCC(NC(=O)CCC(C(CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)O)cc2)co1>OS(=O)(=O)CCS>OC(=O)CCC(C(CCC(=O)NC(CCC(=O)NC(CCC(=O)NCCc1ccc(OCc2coc(CNC=O)c2)cc1)C(=O)O)C(=O)O)C(=O)O)C(=O)O.O
CO>>C=O.OC(=O)c1cc2c(O)c(O)c3nc(cc(C(=O)O)c3c2[nH]1)C(=O)O  Alcohol dehydrogenase (Acc)
CSCCS(=O)(=O)O>CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2nc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>C.CC(OP(=O)(O)O)C(NC(=O)CCCCCCSSCCS(=O)(=O)O)C(=O)O  Methyl-CoenzymeM reductase
CC(=O)C=O>>CC(O)C(=O)SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O  Lactoyl-glutathione lyase (glyoxylase I)
CC(C(=O)O)C(=O)C(=O)O>>CCC(=O)C(=O)O.O=C=O
CC(C(=O)O)C(=O)C(=O)O>>CC(C(N)C(=O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O
CC(O)(CCO)CC(=O)O>[Mg+2]>CC(O)(CCOP(=O)(O)O)CC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Mevalonate kinase
CC(O)(CCOP(=O)(O)OP(=O)(O)O)CC(=O)O>[Mg+2]>CC(=C)CCOP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O.O=C=O  Diphosphomevalonate decarboxylase
CC(O)(CCOP(=O)(O)O)CC(=O)O>[Mg+2]>CC(O)(CCOP(=O)(O)OP(=O)(O)O)CC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Phosphomevalonate kinase
COC(=O)C1C(=O)C2=C(C)C3=Cc4[nH]c(C=C5C(=C(C)C6=[N+]5[Mg+2][N+]3=C2C1=C7NC(=C6)C(C)C7CCC(=O)O)C=C)c(C)c4C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Protochlorophyllide reductase (2 steps)
COC(=O)C1C(=O)C2=C(C)C3=Cc4[nH]c(C=C5C(=C(C)C6=[N+]5[Mg+2][N+]3=C2C1=C7NC(=C6)C(C)C7CCC(=O)O)C=C)c(C)c4C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Protochlorophyllide reductase (2 steps)
COC(=O)CCC1=C(C)C2=Cc3[nH]c(C=C4C(=C(C)C5=[N+]4[Mg+2][N+]2=C1C=C6NC(=C5)C(C)C6CCC(=O)O)C=C)c(C)c3C=C>>COC(=O)C1C(=O)C2=C(C)C3=Cc4[nH]c(C=C5C(=C(C)C6=[N+]5[Mg+2][N+]3=C2C1=C7NC(=C6)C(C)C7CCC(=O)O)C=C)c(C)c4C=C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O
NC(Cc1ccc(O)c(I)c1)C(=O)O>[Cu+2]>NC(Cc1cc(I)c(O)c(I)c1)C(=O)O.I  Iodide peroxidase
OC1C(O)C(Nc2ccccc2C(=O)O)OC1COP(=O)(O)O>>OC(COP(=O)(O)O)C(O)C(=O)CNc1ccccc1C(=O)O  Phosphoribosylanthranilate isomerase
CC(=O)NC(CCCN)C(=O)O>>NCCCC(N)C(=O)O.CC(=O)O  Acetylornithine deacetylase
CC(=O)NC(CCCN)C(=O)O>>NCCCC(N)C(=O)O.CC(=O)NC(CCC(=O)O)C(=O)O  Glutamate acetyltransferase
CC(=O)NC(CCCN)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)NC(CCC=O)C(=O)O.NC(CCC(=O)O)C(=O)O  Acetylornithine transaminase
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)O>[Mg+2]>CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O.OP(=O)(O)OP(=O)(O)O  UDP-N-Acetylglucosamine pyrophosphorylase
NC1C(O)OC(CO)C(O)C1O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Glucosamine acetyltransferase
CC(=O)NC1C(O)OC(CO)C(O)C1O>>NC1C(O)OC(CO)C(O)C1O.CC(=O)O
CC(=O)NC1C(O)OC(CO)C(O)C1O>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3>CC(=O)NC1C(O)OC(CO)C(O)C1O  N-Acylglucosamine 2-epimerase
CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O  N-Acylglucosamine 6-P 2-epimerase
CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)O  Phoshoacetylglucosamine mutase
CC(=O)NC1C(O)OC(CO)C(O)C1O>[Mg+2]>CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O.OP(=O)(O)O  N-Acetylneuraminate synthase
CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)COP(=O)(O)O)C(=O)O.OP(=O)(O)O  N-Acyl neuraminate 9-P-synthase
CC(=O)NC(CCC(=O)O)C(=O)O>>CC(=O)NC(CCC(=O)OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  N-Acetylglutamate kinase
CC(=O)NC(CCC(=O)OP(=O)(O)O)C(=O)O>>CC(=O)NC(CCC=O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)O  N-Acetyl-gamma-glutamyl-P reductase
CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O>>CC(=O)NC1C(O)CC(OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(N)nc3=O)(OC1C(O)C(O)CO)C(=O)O.OP(=O)(O)OP(=O)(O)O  Acylneuraminate cytidylyltransferase
CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.CC(=O)C(=O)O  N-Acetylneuraminate lyase 
NC(=O)NC(CC(=O)O)C(=O)O>>OC(=O)C1CC(=O)NC(=O)N1.O  Dihydroorotase
NC(=O)NC(CC(=O)O)C(=O)O>>NC(CC(=O)O)C(=O)O.O=C=O.N  Ureidosuccinate
CN(CC(=O)O)C(=O)N>>CNCC(=O)O.O=C=O.N  N-Carbamoylsarcosine amidase
NC(=O)NC(CCC(=O)O)C(=O)O>>NC(CCC(=O)O)C(=O)O.N.O=C=O
OC(=O)CCC(NC=N)C(=O)O>>NC(CCC(=O)O)C(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1  Glutamate formiminotransferase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(CCSC)NC=O)C1O>>*
NC(CC(=O)c1ccccc1NC=O)C(=O)O>>NC(CC(=O)c1ccccc1N)C(=O)O.OC=O  Formamidase
CN1CC(=O)NC1=O>>CN(CC(=O)O)C(=O)N.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O  N-Methylhydantoinase (ATP hydrolyzing)
CC(C)(CO)C(O)C(=O)NCCC(=O)NC(CS)C(=O)O>>CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS.O=C=O  Pantothenoylcysteine decarboxylase
OC(=O)CCC(=O)NC(CCCC(=O)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCCC(NC(=O)CCC(=O)O)C(=O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O  Succinyl-diaminopimelate transaminase
NC(CCCC(NC(=O)CCC(=O)O)C(=O)O)C(=O)O>[Co+2]>NC(CCCC(N)C(=O)O)C(=O)O.OC(=O)CCC(=O)O  Succinyl-diaminopimelate desuccinylase
CC(=O)NCCCCC(N)C(=O)O>>CC(=O)NCCCCC(=O)C(=O)O.NC(CCC(=O)O)C(=O)O  N6-Acetyl-beta-L-lysine transaminase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Dehydrogenases
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1cccnc1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(O)C(O)C4O)C(O)C3O.[H+]  NAD(P) nucleosidase
NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O.O  NADH peroxidase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Dehydrogenases
NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  NAD(P) transhydrogenase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O>[Mg+2]>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)OP(=O)(O)O  NMN-Adenyltransferase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(CO)C(O)C2O.OP(=O)(O)O
NC(=O)c1ccc[n+](c1)C2OC(CO)C(O)C2O>>NC(=O)c1cccnc1.OCC1OC(O)C(O)C1O.[H+]
NC(=O)c1cccnc1>[Mg+2]>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O.OP(=O)(O)OP(=O)(O)O
OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(c2)C(=O)O>[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)[n+]5cccc(c5)C(=O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Nicotinamide nucleotide adenylyltransferase
OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(c2)C(=O)O>[Mg+2]>OC(=O)c1cccnc1.OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.[H+]  Nicotinate phosphoribosyltransferase
OC(=O)c1cccnc1>>OC(=O)c1ccc(O)nc1
N#N>>[NH4+].[NH4+].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.*.*.*.*.*.*  Nitrogenase
CC(=O)OCC[N+](C)(C)C>>C[N+](C)(C)CCO.CC(=O)O  Acetylcholin esterase
CC(=O)OCC(N)C(=O)O>>NC(CS)C(=O)O.CC(=O)O  O-Acetylserine (thiol)lyase
CC(=O)OCC(N)C(=O)O>>NC(CO)C(=O)O.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Serine acetyltransferase
C[N+](C)(C)CCOP(=O)(O)O>[Mg+2]>C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O.OP(=O)(O)OP(=O)(O)O  Phosphorylcholine cytidylyltransferase
NCCOP(=O)(O)O>[Mg+2]>NCCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O.OP(=O)(O)OP(=O)(O)O  Ethanolamine-P cytidylyltransferase
NC(CCOC(=O)CCC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCS)C(=O)O.OC(=O)CCC(=O)O  O-Succinylhomoserine (thiol)-lyase
*C(=O)OCC(COP(=O)(O)OCC(N)C(=O)O)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*.O=C=O  Phosphatidylserine decarboxylase
OC1C(CC(=CC1OP(=O)(O)O)C(=O)O)OC(=C)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O.OP(=O)(O)O  Chorismate synthase
OC(=O)c1cc(=O)[nH]c(=O)[nH]1>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)O)n2c(cc(=O)[nH]c2=O)C(=O)O.OP(=O)(O)OP(=O)(O)O  Orotate P-ribosyltransferase
OC1C(O)C(OC1COP(=O)(O)O)n2c(cc(=O)[nH]c2=O)C(=O)O>>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.O=C=O  Orotidine-5'-P decarboxylase
OC(=O)C(=O)O>>OC=O.O=C=O  Oxalate decarboxylase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C(=O)O>>OC(=O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O  Oxalate CoA-transferase
OC(=O)CCC(C(=O)O)C(=O)C(=O)O>[Mg+2]>OC(=O)CCCC(=O)C(=O)O.O=C=O  (Homoisocitrate dehydrogenase)
OC(=O)CC(C(=O)O)C(=O)C(=O)O>>OC(=O)CCC(=O)C(=O)O.O=C=O  Isocitrate dehydrogenase (NADP)
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC=O.O=C=O  Oxalyl-CoA decarboxylase
OC1C(O)C(O)C(O)C(O)C1O>[Fe+2]>OC1OC(C(O)C(O)C1O)C(=O)O  myo-Inositol oxygenase
OC1C(O)C(O)C(O)C(O)C1O>[Fe+2]>OC1OC(C(O)C(O)C1O)C(=O)O  myo-Inositol oxygenase
OP(=O)(O)OP(=O)(O)O>[Mg+2]>OP(=O)(O)O.OP(=O)(O)O  Pyrophosphatase
OC(=O)c1cc2c(O)c(O)c3nc(cc(C(=O)O)c3c2[nH]1)C(=O)O>>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O.[H+].[H+].*[Fe+2].*[Fe+2]
CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS>[Mg+2]>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Pantetheine kinase
*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O>>*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O
CC(C)(CO)C(O)C(=O)NCCCO>>CC(C)(CO)C(O)C(=O)NCCC(=O)O
CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O>>CC1(C)SC2C(N)C(=O)N2C1C(=O)O.OC(=O)Cc1ccccc1  Penicillin amidase
CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O>>CC1(C)SC(NC1C(=O)O)C(NC(=O)Cc2ccccc2)C(=O)O  beta-Lactamase
OC(=O)C(=O)Cc1ccccc1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(Cc1ccccc1)C(=O)O.OC(=O)CCC(=O)C(=O)O  Tyrosine transaminase
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.OP(=O)(O)O  Phosphoenolpyruvate carboxylase
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.OP(=O)(O)OP(=O)(O)O  Phosphoenolpyruvate carboxykinase (pyrophosphate)
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O  Phosphoenolpyruvate carboxykinase (ATP)
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O  Phosphoenolpyruvate carboxykinase (GTP)
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2cnc3c(=O)[nH]cnc23  Phosphoenolpyruvate carboxykinase (GTP)
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O>>NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N=CNC3OC(COP(=O)(O)O)C(O)C3O  Phosphoribosyl-AMP cyclohydrolase
NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N=CNC3OC(COP(=O)(O)O)C(O)C3O>>NC(=O)c1ncn(C2OC(OP(=O)(O)O)C(O)C2O)c1N=CNCCC(=O)C(O)C(O)COP(=O)(O)O  P-Ribosylformimino-AICAR phosphoisomerase
NC(=O)c1ncn(C2OC(OP(=O)(O)O)C(O)C2O)c1N=CNCCC(=O)C(O)C(O)COP(=O)(O)O>>OC(COP(=O)(O)O)C(O)c1cnc[nH]1.NC(CCC(=O)O)C(=O)O.NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N
Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3>[Mg+2]>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Nucleoside diphosphate kinase
Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)O)O3>[Mg+2]>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  (Deoxy) adenylate kinase
Nc1ccn(C2CC(O)C(CO)O2)c(=O)n1>[Mg+2]>Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  (Deoxycytidine kinase)
Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>[Mg+2]>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Nucleoside diphosphate kinase
Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>[Mg+2]>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Cytidylate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Nucleoside diphosphate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)O)O3>[K+].[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Guanylate kinase
OC1CC(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Nucleoside diphosphate kinase
CC(=O)O>[Mg+2]>CC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Acetate kinase
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)OP(=O)(O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Phosphate acetyltransferase
C[N+](C)(C)CCO>>C[N+](C)(C)CCOP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Choline kinase
CN(CC(=O)O)C(=N)N>[Mg+2]>CN(CC(=O)O)C(=N)NP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Creatine kinase
Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>[Mg+2]>Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Uridine kinase
Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1>[Mg+2]>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Cytidylate kinase
CCCCCC(=O)OCC(CO)OC(=O)CCCCC>[Mg+2]>CCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCC.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Diacylglycerol kinase
OCC1OC(O)(CO)C(O)C1O>[Mg+2]>OCC1OC(O)(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Ketohexokinase
OCC1OC(O)(CO)C(O)C1O>[Mg+2]>OCC1(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Fructokinase
NC1C(O)OC(CO)C(O)C1O>[Mg+2]>NC1C(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Hexokinase
OCC1OC(O)C(O)C(O)C1O>[Mg+2]>OC1OC(COP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Hexokinase
OCC(O)C(=O)O>[Mg+2]>OCC(OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Glycerate kinase
OCC(O)C(=O)O>[Mg+2]>OC(COP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Glycerate kinase
OCC1OC(O)C(O)C(O)C1O>[Mg+2]>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Hexokinase
OCC1OC(O)C(O)C(O)C1O>[Mg+2]>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Mannokinase
OCC1OC(O)C(O)C1O>[Mg+2]>OC1OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Ribokinase
OCC1(O)OCC(O)C1O>[Mg+2]>OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  D-Ribulokinase
CC(CCO)CCC=C(C)CCC=C(C)CCC=C(C)C>>CC(CCOP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1  Dolichyl kinase
OCC(O)CO>[Mg+2]>OCC(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Glycerol kinase
NC(CC(=O)O)C(=O)O>[Mg+2]>NC(CC(=O)OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Aspartate kinase
NC(CCC(=O)O)C(=O)O>>NC(CCC(=O)OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Glutamate 5-kinase
NC(CCO)C(=O)O>[Mg+2]>NC(CCOP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Homoserine kinase
CC(=O)NC1C(O)OC(CO)C(O)C1O>>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  N-Acetylglucosamine kinase
CC(=O)NC1C(O)OC(CO)C(O)C1O>[Mg+2].[K+]>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  N-acyl-D-Mannosamine kinase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>[Mg+2]>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  NAD kinase
NCC(O)CCC(N)C(=O)O>[Mg+2]>NCC(CCC(N)C(=O)O)OP(=O)(O)O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Hydroxylysine kinase
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Thymidine kinase
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O  Thymidine kinase
OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Uridine kinase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Nucleoside diphosphate kinase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>[Mg+2]>OC1C(O)C(COP(=O)(O)O)OC(OP(=O)(O)O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Phosphoglucokinase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>[Mg+2]>OC1C(O)C(COP(=O)(O)O)OC(OP(=O)(O)O)C1O.OCC1OC(O)C(O)C(O)C1O  Glucose-1-P-phosphodismutase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>OCC1(OP(=O)(O)O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  6-Phosphofructo-2-kinase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.*  6-Phosphofructo-1-kinase
CC(C)CCCC(C)CCCC(C)CCCC(=CCC12OC2(C)C(=O)c3ccccc3C1=O)C>>CC(=CCCC(=CCCC(=CCCC(=CCc1c(C)c(O)c2ccccc2c1O)C)C)C)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OC1CSSCC1O.O
CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C.OP(=O)(O)OP(=O)(O)O
CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C>>CC(C)CCCC(C)CCCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C.OP(=O)(O)OP(=O)(O)O
CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C>>CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.OP(=O)(O)OP(=O)(O)O
CCCCCC=CCC=CCC=CCC=CCCCC(=O)O>>CCCCCC(O)C=CC1C(O)CC2OC(=CCCCC(=O)O)CC12
Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]>*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4cnc5c(N)ncnc45)O1.OP(=O)(O)OP(=O)(O)O  DNA-directed DNA polymerase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]>*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4cnc5c(=O)[nH]c(N)nc45)O1.OP(=O)(O)OP(=O)(O)O  DNA-directed DNA polymerase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(N)ncnc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O  RNA-directed RNA polymerase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(N)ncnc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O  DNA-directed RNA polymerase
CC(=O)NC1C(O)CC(OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(N)nc3=O)(OC1C(O)C(O)CO)C(=O)O>>*
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]>*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4cc(C)c(=O)[nH]c4=O)O1.OP(=O)(O)OP(=O)(O)O  DNA-directed DNA polymerase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>*C1OC(C(OC2OC(C(*)C(O)C2O)C(=O)OC)C(O)C1O)C(=O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O>>*.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O>>*.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(=O)[nH]c4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O  RNA-directed RNA polymerase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(=O)[nH]c4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O  DNA-directed RNA polymerase
NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.NCc1[nH]cc(CCC(=O)O)c1CC(=O)O>>OCc1[nH]c(Cc2[nH]c(Cc3[nH]c(Cc4[nH]cc(CCC(=O)O)c4CC(=O)O)c(CCC(=O)O)c3CC(=O)O)c(CCC(=O)O)c2CC(=O)O)c(CCC(=O)O)c1CC(=O)O.N.N.N.N  Porphobilinogen deaminase
CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O>>CC1(C(CCC(=O)O)C2CC34NC(=O)CC4(C)C(CCC(=O)O)C(=N3)C=C5C(CC(=O)O)C(CCC(=O)O)C(=C6C7=NC(CC1=N2)C(CC(=O)O)C7CCC6=O)N5[Ni+])C(=O)N
CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O>>CC1=C2N=C(C=C3NC(=Cc4[nH]c(Cc5[nH]c1c(CC(=O)O)c5CCC(=O)O)c(CCC(=O)O)c4CC(=O)O)C(CCC(=O)O)C3(C)CC(=O)O)C(CCC(=O)O)C2(C)CC(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]
CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O>>CC1(CC(=O)O)C(CCC(=O)O)C2=CC3=[N+]4C(=Cc5c(CCC(=O)O)c(CC(=O)O)c6C=C7[N+]8=C(C=C1N2[Fe+2]84n56)C(CCC(=O)O)C7(C)CC(=O)O)C(=C3CC(=O)O)CCC(=O)O.[H].[H].[H].[H]
CC1=C2N=C(C=C3NC(=Cc4[nH]c(Cc5[nH]c1c(CC(=O)O)c5CCC(=O)O)c(CCC(=O)O)c4CC(=O)O)C(CCC(=O)O)C3(C)CC(=O)O)C(CCC(=O)O)C2(C)CC(=O)O>>CC(=O)O.O=C=O.CC1=C2[N+]3=C(C=C4[N+]5=C(C(CCC(=O)O)C4(C)C)C(=C6N7C(C(CC(=O)O)C6(C)CCC(=O)O)C8(C)[N+](=C1C(CCC(=O)O)C8(C)CC(=O)O)[Co+2]735)C)C(CCC(=O)O)C2(C)CC(=O)O
CC(O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  20beta-Hydroxysteroid dehydrogenase
CC(O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(=O)O
CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.O.*  Steroid 17alpha-monooxygenase
CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1C(=O)CO.O.*  Steroid 21-monooxygenase
OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O>>OC(=O)C(=O)Cc1ccc(O)cc1.O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Prephenate dehydrogenase
OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O>>OC(=O)C(=O)Cc1ccc(O)cc1.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  Prephenate dehydrogenase
OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O>>OC(=O)C(=O)Cc1ccccc1.O=C=O.O  Prephenate dehydratase
OCc1[nH]c(Cc2[nH]c(Cc3[nH]c(Cc4[nH]cc(CCC(=O)O)c4CC(=O)O)c(CCC(=O)O)c3CC(=O)O)c(CCC(=O)O)c2CC(=O)O)c(CCC(=O)O)c1CC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.O  Spontaneously
OCc1[nH]c(Cc2[nH]c(Cc3[nH]c(Cc4[nH]cc(CCC(=O)O)c4CC(=O)O)c(CCC(=O)O)c3CC(=O)O)c(CCC(=O)O)c2CC(=O)O)c(CCC(=O)O)c1CC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.O  Uroporphyrinogen III synthase
NCC(O)CCC(N)C(=O)O>>NCC(CCC(N)C(=O)O)OC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Procollagen galactosyl transferase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>*.*>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.O.*  Steroid 21-monooxygenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>*.*>CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C.O.*  Steroid 11beta-monooxygenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>*.*>CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C.O.*  Steroid 17alpha-monooxygenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C.*  3-Oxo-5beta-steroid delta4 dehydrogenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Steroid delta-isomerase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Steroid delta-isomerase
CCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23>[Mg+2].[K+]>CCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O  Acetate-CoA ligase
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=C.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Acyl-CoA dehydrogenase
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O  Succinate propionate CoA transferase
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Acetate ligase
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.[*H].OC(=O)CCCCC1SCC2NC(=O)NC12  Propionyl-CoA carboxylase
*.CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.*
*NC(=O)C(CCCCN)NC(=O)*>[Fe+2].OCC(O)C1OC(=O)C(=C1O)O>NCC(O)CCC(N)C(=O)O.OC(=O)CCC(=O)O.O=C=O  Procollagenlysine-2-oxoglutarate 5-dioxygenase
*>>NC(CC(C(=O)O)C(=O)O)C(=O)O.CC(C)CCCC(C)CCCC(C)CCCC(=CCC12OC2(C)C(=O)c3ccccc3C1=O)C.O  Phylloquinone monooxygenase
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>*SC(C)C1=C(C)C2=[N+]3C1=Cc4c(C)c(C(C)S*)c5C=C6C(=C(CCC(=O)O)C7=[N+]6[Fe+2]3(n45)n8c(=C7)c(CCC(=O)O)c(C=O)c8=C2)C  Cytochrome-heme lyase
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>CC(C)CCC(C)CCC(C)CCC(O)C1=C(C)C2=[N+]3C1=Cc4c(C)c(C=C)c5C=C6C(=C(CCC(=O)O)C7=[N+]6[Fe+2]3(n45)n8c(=C7)c(CCC(=O)O)c(C=O)c8=C2)C
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*S[Fe+2]12([N+]3=C4C=c5c(CCC(=O)O)c(C)c6=CC7=[N+]2C(=Cc8c(C)c(C=C)c(C=C3C(=C4CCC(=O)O)C)n81)C(=C7C)C=C)n65
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*.CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C
Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>CC1C(CCC(=O)O)C2=CC3=[N+]4[Mg+2][N+]5=C(C=C1N2)C(=C(C=C)C5=Cc6[nH]c(C=C4C(=C3CCC(=O)O)C)c(C=C)c6C)C.[H].[H]  (Mg chelatase)
Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O>>CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C
Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O>>CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C.[H+].[H+]  Ferrochelatase
Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(=O)O>>Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O.O.O.O  Protoporphyrinogen oxidase
NCCCCN>>NCCCC=O.OO.N  Amine oxidase (Cu++)
NCCCCN>>NCCCCNCCCN.CSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.[H+]  Spermidine synthase
CC(=O)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[Mg+2]>CC(=O)C(C)(O)C(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N  Acetolactate synthase
CC(=O)C(=O)O>>*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O  Pyruvate dehydrogenase
CC(=O)C(=O)O>>*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(C)(O)C(=O)O
CC(=O)C(=O)O>>CC(=O)O.O=C=O.*[Fe+2].*[Fe+2].[H+].[H+]  Pyruvate dehydrogenase (cytochrome)
CC(=O)C(=O)O>Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.[*H2].O=C=O  Pyruvate synthase
CC(=O)C(=O)O>C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.OC=O  active Formate acetyltransferase
CC(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O  Alanine transaminase
CC(=O)C(=O)O>[Zn+2]>CC(N)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O  Alanine dehydrogenase
CC(=O)C(=O)O>[Zn+2]>CC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Lactate dehydrogenase
CC(=O)C(=O)O>OC(=O)CCCCC1SCC2NC(=O)NC12.[Co+2].[Zn+2]>OC(=O)CC(=O)C(=O)O.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Methylmalonyl-CoA carboxyltransferase
CC(=O)C(=O)O>>OC(=O)CC(=O)C(=O)O.[*H].OC(=O)CCCCC1SCC2NC(=O)NC12  Pyruvate carboxylase
OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(C(=O)O)c2C(=O)O>>OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(c2)C(=O)O.O=C=O  Quinolinate phosphoribosyltransferase (decarboxylating)
OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(C(=O)O)c2C(=O)O>[Mg+2]>OC(=O)c1cccnc1C(=O)O.OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.[H+]  Quinolinate phosphoribosyltransferase (decarboxylating)
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Methylmalonyl-CoA-epimerase
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Methylmalonyl-CoA-epimerase
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O  L-Methylmalonyl-CoA mutase
CC(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CC(N)C(=O)O  Alanine racemase
OC(=O)C1CCCN1>>OC(=O)C1CCCN1  Proline racemase
NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O.OCC(O)C1OC(=O)C(=C1O)O  Glutathione dehydrogenase
NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O.*S.*S  Glutathione transhydrogenases
OCC(O)C(O)C(O)C=O>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Aldehyde reductase
CC(=CC=CC(=CC(=O)O)C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=CC(=CC(=O)OC1OC(C(O)C(O)C1O)C(=O)O)C)C=CC2=C(C)CCCC2(C)C
CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.CCCCCCCCCCCCCCCC(=O)O  Retinylpalmitate esterase
*>>[*H2].NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Rubredoxin-NAD reductase
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>OC(=O)CCCCC1SCC2NC(=O)NC12>CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.[Na+].O=C=O  Methylmalonyl-CoA decarboxylase
OC(CC(=O)O)C(=O)O>>CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  Malate dehydrogenase (decarboxylating)("malic enzyme")
OC(CC(=O)O)C(=O)O>>CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  Malate dehydrogenase (decarboxylating)("malic enzyme")
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O>>CC(O)(CCO)CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Hydroxymethylglutaryl-CoA reductase (active)
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O>>CC(O)(CCO)CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Hydroxymethylglutaryl-CoA reductase (active)
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O>[Mg+2].[Mg+2]>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)CC(=O)O  Hydroxymethyl-glutaryl-CoA lyase
C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23>>NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.C[n+]1cccc(c1)C(=O)O  Nicotinate methyltransferase and other methyltransferases
C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23>>NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.Cc1c[nH]c(=O)nc1N.[H+]  DNA (cytosine-5)-Methyltransferase
CC(O)(CC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)C(=O)O.CC(=O)O  Citramalate lyase
OC(CC(=O)O)C(=O)O>>OC(=O)CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Malate dehydrogenase
CNCC(=O)O>[Fe+2]>NCC(=O)O.[*H2].C=O  Sarcosine dehydrogenase
NCCc1c[nH]c2ccc(O)cc12>>CN(C)CCc1c[nH]c2ccc(O)cc12
NCCc1c[nH]c2ccc(O)cc12>>COc1ccc2[nH]cc(CCNC(=O)C)c2c1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.[H+]
OC1CC(=CC(O)C1O)C(=O)O>[Mg+2]>OC1CC(=CC(OP(=O)(O)O)C1O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Shikimate kinase
OC1CC(=CC(OP(=O)(O)O)C1O)C(=O)O>>OC1C(CC(=CC1OP(=O)(O)O)C(=O)O)OC(=C)C(=O)O.OP(=O)(O)O  3-P-Shikimate-1-carboxyvinyltransferase
NCCCCNCCCN>>NCCCNCCCCNCCCN.CSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.[H+]  Spermine synthase
CCCCCCCCCCCCCCCC(O)C(N)CO>>CCCCCCCCCCCCCC=CC(O)C(N)CO.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C
*C(=O)NC(COP(=O)(O)OCC[N+](C)(C)C)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC.C[N+](C)(C)CCOP(=O)(O)O  Sphingomyelin phosphodiesterase
CCCCCCCCCCCCCC=CC(O)C(N)CO>>*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Sphingosine acetyltransferase
CCCCCCCCCCCCCC=CC(O)C(N)CO>>CCCCCCCCCCCCCC=CC(O)C(N)COC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Sphingosine galactosyltransferase
CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C>>CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1OC1(C)C)C)C)C.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Squalene monooxygenase
OC(=O)CCC(=O)O>>OC(=O)C=CC(=O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Succinate dehydrogenase
OC(=O)CCC=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCCC(=O)O.OC(=O)CCC(=O)C(=O)O  Aminobutyrate transaminase
OC(=O)CCC=O>[Zn+2]>OCCCC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  4-Hydroxybutyrate dehydrogenase
OC(=O)CCC=O>>OC(=O)CCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Succinate semialdehyde dehydrogenase (NAD(P)+)
OC(=O)CCC=O>>OC(=O)CCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Succinate semialdehyde dehydrogenase (NAD(P)+)
OC(=O)CCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O.OP(=O)(O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2cnc3c(=O)[nH]cnc23  Succinyl-CoA ligases
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(C(=O)O)C(=O)CCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  5-Aminolevulinate synthase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>>OC(=O)CCC(=O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.*  2-Oxoglutarate synthase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>>OC(=O)CCC(=O)O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Succinyl-CoA ligases
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>[Mg+2]>OC(=O)CCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Succinyl-CoA ligases
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>>OC(=O)CCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Succinyl-CoA hydrolase
OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.*OCC1OC(CO)(OCC2OC(*)(CO)C(O)C2O)C(O)C1O  Levansucrase
OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O.*OCC1OC(OCC2OC(OCC3OC(O*)C(O)C(O)C3O)C(O)C(O)C2O)C(O)C(O)C1O  Dextransucrase
OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O.OCC1OC(O)C(O)C(O)C1O  alpha-Glucosidase
OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O  Sucrose phosphorylase
OCC1OC(OC2(CO)OC(COP(=O)(O)O)C(O)C2O)C(O)C(O)C1O>>OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O.OP(=O)(O)O
OS(=O)(=O)O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Sulfate adenylyltransferase
CC12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.OS(=O)(=O)O  Arylsulfatase
OS(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>S.O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Sulfite reductase (NADPH)
OS(=O)O>>OS(=O)(=O)O.OO  Sulfite oxidase
OS(=O)O>>OS(=O)(=O)O.[*H2]  Sulfite dehydrogenase
NC(CS)C(=O)O>>NC(CSSCC(N)C(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Cystine reductase (NADH)
NC(CS)C(=O)O>>NC(CSSCC(N)C(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O  GSH-Cystine transhydrogenase
*>>*
CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3Nc4c(NC3C)nc(N)[nH]c4=O>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3=Nc4c(NC3C)nc(N)[nH]c4=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
OC(C=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  2-Hydroxy-3-oxopropionate reductase
OC(C=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  2-Hydroxy-3-oxopropionate reductase
CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NCCS(=O)(=O)O  Choloylglycine hydrolase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Steroid 19-hydroxylase)
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1O.*  3-oxo-5beta-Steroid D4 dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1OC5OC(C(O)C(O)C5O)C(=O)O
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3alpha-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  3alpha-Hydroxysteroid dehydrogenase
*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc(C(O)CCC(=O)O)[n+]1Cc2cnc(C)nc2N>>*.OC(=O)CCCCC(S)CCSC(=O)CCC(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N  2-oxoglutarate dehydrogenase system
[*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Thioredoxin reductase (NADP)
[*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Thioredoxin reductase (NADP)
[*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Thioredoxin reductase (NADP)
[*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Thioredoxin reductase (NADP)
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>>Cc1c[nH]c(=O)[nH]c1=O.OCC1OC(CC1O)OP(=O)(O)O  Thymidine phosphorylase
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>>Cc1c[nH]c(=O)[nH]c1=O.OCC1OC(O)CC1O  Nucleosidase
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>>Cc1c[nH]c(=O)[nH]c1=O.*CC1CC(O)C(O)O1  Nucleoside deoxyribosyltransferase
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Nucleoside diphosphate kinase
Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O>>Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O.OP(=O)(O)O  5'-Nucleotidase
Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  dTMP kinase
Cc1c[nH]c(=O)[nH]c1=O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CC1CNC(=O)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Dihydrouracil dehydrogenase (NADP)
Cc1c[nH]c(=O)[nH]c1=O>>CC1C(=O)NC(=O)NC1=O.[*H2]  Uracil dehydrogenase
CC=C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Enoyl-CoA hydratase
[Fe+3]*[Fe+3]>>*.[Fe+2].NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Transferrin reductase
[Fe+3]*[Fe+3]>>*.[Fe+3].[Fe+3]  Transferrin reductase
CCCCCC(=O)OCC(COC(=O)CCCCC)OC(=O)CCCCC>>CCCCCC(=O)OCC(CO)OC(=O)CCCCC.CCCCCC(=O)O  Triacylglycerol lipase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Lactose synthase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O=C=O
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Sucrose synthase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(OC2(CO)OC(COP(=O)(O)O)C(O)C2O)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Sucrose-P-synthase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O  UDPG-Hexose-1-P-uridyltransferase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+]  UDPG-dehydrogenase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  (other Glucosyltransferases)
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>[Mg+2]>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  UTP-Glucose-1-P-uridylyltransferase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O=C=O  UDP-Glucuronate decarboxylase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>*OC1OC(C(O)C(O)C1O)C(=O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  Glucuronosyltransferase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O  UDP-Arabinose epimerase
CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(C)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
CC(OC1C(O)C(CO)OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C1NC(=O)C)C(=O)O>>*
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O  UDP-N-Acetylglucosamine 4-epimerase
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O  UDP-N-Acetyl-D-glucosamine-4-epimerase
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>CC(=O)NC1C(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)OC(CO)C(O)C1OC(=C)C(=O)O.OP(=O)(O)O  UDP-N-Acetylglucosamine 1-carboxyvinyl transferase
CC(=O)NC1C(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)OC(CO)C(O)C1OC(=C)C(=O)O>>CC(OC1C(O)C(CO)OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C1NC(=O)C)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  UDP-N-Acetylmuramate dehydrogenase
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>*
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>*
COc1c(O)c(C)c(CC=C(C)CCC=C(C)C)c(O)c1OC>>COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)CCC=C(C)C.[H].[H]
COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)C>>COc1c(O)c(C)c(CC=C(C)C)c(O)c1OC.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C
O=c1cc[nH]c(=O)[nH]1>[Fe+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>O=C1CCNC(=O)N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Dihydrouracildehydrogenase (NADP)
O=c1cc[nH]c(=O)[nH]1>>O=C1CCNC(=O)N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Dihydrouracil dehydrogenase (NAD)
O=c1cc[nH]c(=O)[nH]1>>O=C1CC(=O)NC(=O)N1.[*H2]  Uracil dehydrogenase
O=c1cc[nH]c(=O)[nH]1>>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.OP(=O)(O)OP(=O)(O)O  Uracil phosphoribosyltransferase
O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1>[Cu+2]>NC(=O)NC1NC(=O)NC1=O.OO.O=C=O  Urate oxidase
NC(=O)N>>[NH4+].OC(=O)[O-].[NH4+]  Urease
OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O>>O=c1cc[nH]c(=O)[nH]1.OCC1OC(OP(=O)(O)O)C(O)C1O  Uridine phosphorylase
OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O>>O=c1cc[nH]c(=O)[nH]1.OCC1OC(O)C(O)C1O  Uridine nucleosidase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Fe+2]>OC1CC(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.*.O  Ribonucleoside-diphosphate reductase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(=O)[nH]c4=O)C(O)C1O.OP(=O)(O)O  Polyribonucleotide nucleotidyltransferase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.OP(=O)(O)O  Nucleoside diphosphatase
OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Cytidylate kinase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OC1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.*.O  Ribonucleoside triphosphate reductase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.NC(CCC(=O)O)C(=O)O  CTP synthase
OC(=O)C=Cc1cnc[nH]1>>OC(=O)CCC1NC=NC1=O  Urocanate hydratase
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (R) 20beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(=O)CO
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (R) 20beta-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(=O)CO
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5C)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.O=C=O.O=C=O.O=C=O.O=C=O  Uroporphyrinogen decarboxylase
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.[H].[H].[H].[H].[H].[H]
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.O=C=O.O=C=O.O=C=O.O=C=O  Uroporphyrinogen decarboxylase
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O  Uroporphyrinogen III methyltransferase
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.[H].[H].[H].[H].[H].[H]
O=c1[nH]c(=O)c2nc[nH]c2[nH]1>>NC(=O)Nc1[nH]cnc1C(=O)O
O=c1[nH]c(=O)c2nc[nH]c2[nH]1>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1.OO  Xanthine oxidase
O=c1[nH]c(=O)c2nc[nH]c2[nH]1>>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]c(=O)[nH]c23.OP(=O)(O)O  Purine nucleoside phosphorylase
O=c1[nH]c(=O)c2nc[nH]c2[nH]1>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23.OP(=O)(O)OP(=O)(O)O  Hypoxanthine P-ribosyltransferase
OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]c(=O)[nH]c23>>O=c1[nH]c(=O)c2nc[nH]c2[nH]1.OCC1OC(O)C(O)C1O  Purine nucleosidase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  GMP synthase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.NC(CCC(=O)O)C(=O)O  GMP synthase
*O>[Mg+2]>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Protein kinase A (+others?)
*O>[Mg+2]>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Protein kinase
*O>>*OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  [Hydroxymethylglutaryl-CoA reductase] kinase
*O>>*OP(=O)(O)OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  [Pyruvate dehydrogenase (lipoamide)] kinase
*O>[Mg+2]>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O  Protein kinase A
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>CC1(CCCC2(C)C3CCC4CC3(CC4(O)CO)CCC12)C(=O)O
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>[Mg+2]>CC(=CCCC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C)C.OP(=O)(O)OP(=O)(O)O  (Polyprenyl-cis-transferases) e.g.Di-trans-poly-cis-decarpenyl transferase
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)C.CC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C  Polyprenyl-trans-transferases
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>[Mg+2]>CC(C)CCCC(=CCCC(=CCCC(=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)OP(=O)(O)O  Geranylgeranyl-bisphospho-geranylgeranyltransferase
CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=O)C=CC=CC=C(C)C=CC1=C(C)CCCC1(C)C  Retinene isomerase
CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=CC(=CC(=O)O)C)C=CC1=C(C)CCCC1(C)C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Retinal dehydrogenase
CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  Retinol dehydrogenase
CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS  Retinol fattyacyltransferase
OC1CNC(C1)C(=O)O>>OC1CN=C(C1)C(=O)O.OO  D-Aminoacid oxidase
CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2C(=CCCC2(C)C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CC(O)CC1(C)C)C=CC=C(C)C=CC2C(=CC(O)CC2(C)C)C
OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O>[Mg+2]>NC1OC(COP(=O)(O)O)C(O)C1O.NC(CCC(=O)O)C(=O)O.OP(=O)(O)OP(=O)(O)O  Amido-P-ribosyltransferase
OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O.OP(=O)(O)OP(=O)(O)O  ATP-Phosphoribosyl transferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.OP(=O)(O)OP(=O)(O)O  UTP-Hexose-1-P uridylyltransferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O.OP(=O)(O)OP(=O)(O)O  Galactose-1-P-thymidylyltransferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Glucose-1-P-guanylyl-transferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>[Mg+2]>OC1OC(COP(=O)(O)O)C(O)C(O)C1O  Phosphoglucomutase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O.OP(=O)(O)OP(=O)(O)O  Glucose-1-P-thymidylyltransferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OC1OC(COP(=O)(O)O)C(O)C(O)C1O
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O  UDPG-Hexose-1-P-uridyltransferase
OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OCC(=O)C(O)C(O)C(O)C=O.OP(=O)=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  myo-Inositol-1-P synthase
OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OCC1(O)OC(COP(=O)(O)O)C(O)C1O  Glucosephosphate isomerase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OCC1(O)OC(COP(=O)(O)O)C(O)C1O  Mannose-6-P isomerase
OC1OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O  Ribose-P-pyrophosphokinase
*OC1OC(CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.*O  alpha-Galactosidase
*OC1OC(CO)C(O)C(O)C1NC(=O)C>>CC(=O)NC1C(O)OC(CO)C(O)C1O.*  N-Acetyl-beta-glucosaminidase
NCCC(=O)O>>CC(C)(CO)C(O)C(=O)NCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Pantoate-beta-alanineligase
NCCC(=O)O>>NCCC(=O)NC(Cc1cnc[nH]1)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O  Carnosine synthase
CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2=C(C)CCCC2(C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CC(O)CC1(C)C)C=CC=C(C)C=CC2C(=CC(O)CC2(C)C)C
CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2=C(C)CCCC2(C)C>[Fe+2]>CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C  beta-Carotene 15.15'-dioxygenase
OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O>>OC(COP(=O)(O)O)C=O.OCC(=O)COP(=O)(O)O  Fructose bisphosphate aldolase
OCC1OC(O)(COP(=O)(O)O)C(O)C1O>>OCC(=O)COP(=O)(O)O.OCC(O)C=O  Fructose bisphosphate aldolase (aldolase 6)
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>OCC(O)C(=O)C(O)C(O)COP(=O)(O)O  Hexulose-6-P isomerase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>NC1C(O)OC(COP(=O)(O)O)C(O)C1O.NC(CCC(=O)O)C(=O)O  Glutaminefructose-6P-transaminase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>NC1C(O)OC(COP(=O)(O)O)C(O)C1O.O  Glucosamine-P isomerase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>OCC(=O)C(O)C(O)C(O)C(O)COP(=O)(O)O.OC(COP(=O)(O)O)C=O  Transaldolase
*OC1OC(CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.*O  beta-Glucosidase
*C(=O)CC=CCCCCCC>>CCCCCCC=CCCCCCCCCCC(=O)O.*
OC(=O)CC(=CC(=O)O)C(=O)O>>OC(=O)CC(=C)C(=O)O.O=C=O  Aconitate decarboxylase
OC(=O)CC(=CC(=O)O)C(=O)O>>OC(=O)CC(O)(CC(=O)O)C(=O)O  Aconitate hydratase
OC(=O)CC(=CC(=O)O)C(=O)O>>OC(C(CC(=O)O)C(=O)O)C(=O)O  Aconitate hydratase
CC(C)CCCC(=CCCC(=CCCC(=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CC(=CCCC(=CCCC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C.[H].[H].[H].[H].[H].[H]
OC(=O)C=CC=CC(=O)O>>OC(=O)CC1=CCC(=O)O1  Muconate cycloisomerase
CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1=C(C)C(=O)NC1Cc2[nH]c(C=C3N=C(CC4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C.O  non-enzymatically
CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O  UDPG-4-epimerase
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(CC2O)n3cc(C)c(=O)[nH]c3=O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(CC2O)n3cc(C)c(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(C)C(O)C(O)C1O.Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O
CC(C)C(NC(=O)C(CS)NC(=O)CCCC(N)C(=O)O)C(=O)O>[Fe+2]>CC1(C)SC2C(NC(=O)CCCC(N)C(=O)O)C(=O)N2C1C(=O)O.O.O  Isopenicillin synthase
OC(=O)C1CCCC(=N1)C(=O)O>>OC(=O)CCC(=O)NC(CCCC(=O)C(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
OC(=O)C1=NCCCC1>>NCCCCC(=O)C(=O)O  non-enzymatic
OC(=O)C1=NCCCC1>>OC(=O)C1CCCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  delta1-Piperideine-2-carboxylate reductase
OC(=O)C1=NCCCC1>>OC(=O)C1CCCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  delta1-Piperideine-2-carboxylate reductase
CC(=C)CCOP(=O)(O)OP(=O)(O)O>[Mg+2]>CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C.OP(=O)(O)OP(=O)(O)O
CC(=C)CCOP(=O)(O)OP(=O)(O)O>[Mg+2]>CC(=CCOP(=O)(O)OP(=O)(O)O)C  Isopentenyldiphosphate isomerase
CC(=C)CCOP(=O)(O)OP(=O)(O)O>[Mg+2]>CC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C.OP(=O)(O)OP(=O)(O)O  Dimethylallyl-trans-transferase
CC(=C)CCOP(=O)(O)OP(=O)(O)O>>*C(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C.OP(=O)(O)OP(=O)(O)O  Rubber cis-polyprenyl cis-transferase
CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O  (Desmosterol reductase)
CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)C(=C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+].[H+]
CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CCC(C=CC(C)C1CCC2C3CC=C4CC(O)CC(C)C4C3CCC12C)C(C)C.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+]
CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.*.O
CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC(C)CCCC(C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C.OO  Lathosterol oxidase
CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)CC4CC3>>CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C
CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1=C(C)C(=O)NC1Cc2[nH]c(C=C3N=C(CC4NC(=O)C(=C4C)CC)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C.O  non-enzymatically
CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(CC)C4C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C
*OP(=O)(O)O>>*O.OP(=O)(O)O  [Acetyl-CoA carboxylase] phosphatase
*>[Fe+2]>*
*OP(=O)(O)O>>*O.OP(=O)(O)O
*OP(=O)(O)OP(=O)(O)O>>*O.OP(=O)(O)O.OP(=O)(O)O  [Hydroxymethylglutaryl-CoA reductase (NADPH)] phosphatase
*OP(=O)(O)OP(=O)(O)OP(=O)(O)O>>*O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O  [Pyruvate dehydrogenase (lipoamide)] phosphatase
*OP(=O)(O)O>>*O.OP(=O)(O)O  [Pyruvate kinase] phophatase
CCC1C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(CC)C4C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1C(C)C(=O)NC1Cc2[nH]c(C=C3N=C(CC4NC(=O)C(CC)C4C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C.O  non-enzymatically
OCC1OC(OC2C(O)C(O)C(OC3C(O)C(O)C(O)OC3CO)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O  alpha-dextrin-endo-1,4-Glucosidase
NC(CCCC(N)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCCCC(N)C(=O)O.O=C=O  Diaminopimelate decarboxylase
OC1C(O)C(O)C(O)C(O)C1O>>*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(O)C(O)C1O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1  CDP-Diacylglycerolinositol-3-phosphatidyltransferase
OC1C(O)C(O)C(O)C(O)C1O>>*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(O)C(O)C1O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1  CDP-diacyl-glycerol-inositol phosphadyltransferase
CC(OP(=O)(O)O)C(NC(=O)CCCCCCSSCCS(=O)(=O)O)C(=O)O>>OS(=O)(=O)CCS.CC(OP(=O)(O)O)C(NC(=O)CCCCCCS)C(=O)O  Heterodisulfide reductase, hydrogenase
*.CC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS
*.CC(C)CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC(C)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS
CC(O)C1=Nc2c(NC1C)nc(N)[nH]c2=O>[Mg+2]>CC(OP(=O)(O)OP(=O)(O)O)C1=Nc2c(NC1C)nc(N)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O
*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O)OC(=O)*>>OC1C(O)C(OP(=O)(O)O)C(O)C(O)C1OP(=O)(O)O.*C(=O)OCC(CO)OC(=O)*  Phospholipase C
OC(C(CC(=O)O)C(=O)O)C(=O)O>>OC(=O)CC(C(=O)O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]  Isocitrate dehydrogenase (NADP)
OC(C(CC(=O)O)C(=O)O)C(=O)O>>OC(=O)CCC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O  Isocitrate dehydrogenase (NAD+)
*.CCC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CCC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS
CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23
CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C  Acyl-CoA dehydrogenases (2 known) 
CCCC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23  Enoyl-CoA hydratase
*C=CC(=O)S*S>>*C(=O)S*S.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C
*C=CC(=O)S*S>>*C(=O)S*S.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*C=CC(=O)S*S>>*C(O)CC(=O)S*S
CC(=CCCC(=CCCC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C>[Mg+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C.[H].[H]