OC(=O)CCC1NC=NC1=O>>OC(=O)CCC(NC=N)C(=O)O Imidazolone propionase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Dephospho-CoA kinase CC(C)C(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)C)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Valyl-tRNA ligase *C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*>>*C(=O)OCC(O)COP(=O)(O)OCC[N+](C)(C)C.*C(=O)O Phospholipase A2 OCC(O)COP(=O)(O)O>>OCC(=O)COP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glycerol 3-P dehydrogenase OCC(O)COP(=O)(O)O>>OCC(=O)COP(=O)(O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Glycerol 3-P dehydrogenase CC(=O)OC(CC(=O)O)C[N+](C)(C)C>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.C[N+](C)(C)CC(O)CC(=O)O Carnitine acetyltransferase OC(COP(=O)(O)O)C(O)c1c[nH]c2ccccc12>>c1cc2ccccc2[nH]1.OC(COP(=O)(O)O)C=O Tryptophan synthase *C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(CO)OC(=O)*.NCCOP(=O)(O)O Phospholipase C *C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(COP(=O)(O)O)OC(=O)*.NCCO Phospholipase D *C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(O)COP(=O)(O)OCCN.*C(=O)O Phospholipase A2 *C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+] Phosphatidylethanolamine methyltransferase *C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(O)C(O)C1O)OC(=O)*>[Mg+2]>*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O)OC(=O)*.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 1-Phosphatidylinositol kinase Nc1ccc(CC(O)C(O)C(O)CO)cc1>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3=Nc4c(NC3C)nc(N)[nH]c4=O.OP(=O)(O)OP(=O)(O)O.O CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NC(CS)C(=O)O>>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS.O=C=O P-Pantothenoylcysteine decarboxylase CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)O>>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NC(CS)C(=O)O.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1.OP(=O)(O)OP(=O)(O)O P-Pantothenatecysteine ligase CC(O)C(=O)C>>CC(O)C(C)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (R,R)-Butanediol dehydrogenase CC(C)(CO)C(O)C(=O)O>>CC(C)(CO)C(O)C(=O)NCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Pantothenate-beta-alanine ligase CC(C)(CO)C(O)C(=O)NCCC(=O)O>[Mg+2]>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Pantothenate kinase CC(C)(CO)C(O)C(=O)NCCC(=O)O>>CC(C)(CO)C(O)C(=O)O.NCCC(=O)O Pantothenase CC(=O)C(C)(O)C(=O)O>>CC(O)C(=O)C.O=C=O Acetolactate decarboxylase CC(=O)C(C)(O)C(=O)O>[Mg+2]>CC(C)(O)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Ketol-acid reductoisomerase CC(CO)C(=O)O>>CC(C=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxyisobutyrate dehydrogenase CC(CO)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(CO)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 3-Hydroxyisobutyryl-CoA hydrolase OC(=O)C1CC(=O)NC(=O)N1>[Fe+2].[Zn+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>OC(=O)c1cc(=O)[nH]c(=O)[nH]1.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dihydro-orotate dehydrogenase OC(=O)C1CC(=O)NC(=O)N1>[Fe+2].[Zn+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>OC(=O)c1cc(=O)[nH]c(=O)[nH]1.OO Dihydro-orotate dehydrogenase NC1CCC(=O)OC1O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCC(=O)CCC(=O)O Glutamate-1-semialdehyde-2,1-aminomutase CC(C=O)C(=O)O>>CC(CN)C(=O)O.CC(=O)C(=O)O beta-Alanine-(=3-aminoisobutyrate)-pyruvate transaminase CC(C=O)C(=O)O>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase (acylating) CC(C=O)C(=O)O>>CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Methylmalonate semialdehyde dehydrogenase (acylating) CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1OC1(C)C)C)C)C>>CC(CCC=C(C)C)C1CCC2(C)C3CCC4C5(CC35CCC12C)CCC(O)C4(C)C Cycloarterenol synthase CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1OC1(C)C)C)C)C>>CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 Lanosterol synthase *O>>*OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 3-Methyl-2-oxobutanoate dehydrogenase kinase *OP(=O)(O)O>[Mg+2]>*O.OP(=O)(O)O Glycogen synthase D phosphatase *OP(=O)(O)OP(=O)(O)O>>*O.OP(=O)(O)O.OP(=O)(O)O 3-Methyl-2-oxobutanoate dehydrogenase phosphatase *O>[Mg+2]>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase A (Phosphorylase kinase kinase) *C(=O)OCC(O)COP(=O)(O)OCC[N+](C)(C)C>>*C(=O)O.C[N+](C)(C)CCOP(=O)(O)OCC(O)CO Lysophospholipase OC(COP(=O)(O)O)C(=O)OP(=O)(O)O>[Mg+2]>OC(=O)C(COP(=O)(O)O)OP(=O)(O)O Bisphosphoglycerate mutase OC(=O)c1cc(O)c2ccccc2c1O>>CC(=CCCC(=CCc1c(C)c(O)c2ccccc2c1O)C)C.OP(=O)(O)OP(=O)(O)O.O=C=O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] CCCCCC(=O)OCC(O)CO>>OCC(O)CO.CCCCCC(=O)O Lipases CCCCCC(=O)OCC(O)CO>>CCCCCC(=O)OCC(CO)OC(=O)CCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acylglycerol acyltransferase OC(COP(=O)(O)O)C(O)C(=O)CNc1ccccc1C(=O)O>>OC(COP(=O)(O)O)C(O)c1c[nH]c2ccccc12.O=C=O.O Indole 3-glycerol P-synthase *C(=O)OCC(O)COP(=O)(O)OCC[N+](C)(C)C>>*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS CCCCCC(=O)OCC(O)CO>[Mg+2]>CCCCCC(=O)OCC(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Acylglycerol kinase CCCCCCO>>CCCCCC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Alcohol dehydrogenase CCCCCCO>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>CCCCCC=O.[*H2] Alkan-1-ol dehydrogenase (acceptor) OC(=O)C1=NCCC1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-2-carboxylate reductase OC(=O)C1=NCCC1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-2-carboxylate reductase OC1CN=C(C1)C(=O)O>>NCC(O)CC(=O)C(=O)O non-enzymatic OC1CN=C(C1)C(=O)O>>OC(=O)C(=O)CCC=O.N 1-Pyrroline-4-hydroxy-2-carboxylate deaminase OC1CN=C(C1)C(=O)O>>OC(=O)c1ccc[nH]1.O non-enzymatic Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.O Methenyl-THF-cyclohydrolase Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.OC=O Formyl-THF-deformylase Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1NC=O P-Ribosylaminoimidazolecarboxamide formyltransferase CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.* 3-Oxo-5beta-steroid delta4 dehydrogenase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.O.* Steroid 11beta-monooxygenase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.O.* Steroid 11beta-monooxygenase CC(=CC=O)C=CC=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C>*>CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C.O.* Steroid 17alpha-monooxygenase CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.O.* Steroid 21-monooxygenase CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3>>CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)CC4CC3.O=C=O.O=C=O.O.O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O CC12CCC3C(CCC4=CC(=O)CCC34C)C2CC(O)C1=O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O.OC=O CC12CCC3C(CC=C4CC(O)CCC34C)C2CC(O)C1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Steroid-delta-isomerase CC12CCC3C(CC=C4CC(O)CCC34C)C2CC(O)C1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Steroid-delta-isomerase CC(C)CCCC(C)(O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C>*.*>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.CC(C)CCC=O.O CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O.O.CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.O.* Steroid 21-monooxygenase CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>*.*>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O.CC=O 17alpha-Hydroxyprogesterone aldolase CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CO)CC(O)C31>>CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.[H].[H] CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1=O>*>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OC=O.O CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O.OC=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1=O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O *.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O>>*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O active Phosphorylase kinase Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2>>Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)O)O2>>Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3>>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)O)O3.*O Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3>>Nc1ncnc2[nH]cnc12.OCC1OC(CC1O)OP(=O)(O)O Purine nucleoside phosphorylase Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3>>Nc1ncnc2[nH]cnc12.OCC1OC(CC1O)OP(=O)(O)O Purine nucleoside phosphorylase Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)O)O3>[Mg+2].[Co+2].[Ca+2]>Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3.OP(=O)(O)O 5'-Nucleotidase Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>>Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1.OP(=O)(O)O Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]>*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4ccc(N)nc4=O)O1.OP(=O)(O)OP(=O)(O)O DNA-directed DNA polymerase Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>>Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)O)O2.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Deoxycytidylate hydroxymethyltransferase Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>>OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.N Deoxycytidilate deaminase Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3>>Nc1nc2[nH]cnc2c(=O)[nH]1.OCC1OC(CC1O)OP(=O)(O)O Purine nucleoside phosphorylase Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3>>Nc1nc2[nH]cnc2c(=O)[nH]1.Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O Nucleoside deoxyribosyltransferase OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1CC(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside monophosphate kinase OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O Thymidylate synthase OC1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.OP(=O)(O)OP(=O)(O)O (Deoxy-UTP-pyrophosphatase) OC(=O)C1CC=CC(=N1)C(=O)O>>OC(=O)C1CCCC(=N1)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrodipicolinate reductase CCC(C)(O)C(O)C(=O)O>[Mg+2]>CCC(C)C(=O)C(=O)O.O Dihydroxyacid dehydratase CC(C)(O)C(O)C(=O)O>[Mg+2]>CC(C)C(=O)C(=O)O.O Dihydroxyacid dehydratase OCC(O)C(O)C(=O)C(=O)C(=O)O>>OCC(O)C(O)C(O)C(=O)O.O=C=O OCC(O)C(O)C(=O)C(=O)C(=O)O>>OCC(O)C(O)C(O)C(=O)O.O=C=O Nc1nc(NCC(=O)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(N)c(=O)[nH]1>>Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O.O Nc1nc(NCC(=O)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(N)c(=O)[nH]1>>CC1Nc2nc(N)[nH]c(=O)c2N=C1C(C)(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O.O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+] Oc1ccc(O)nc1>>NC(=O)C=CC(=O)O.OC=O *.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC=O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N Pyruvate decarboxylase *.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS Pyruvate dehydrogenase *.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(C)(O)C(=O)O>>*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O *.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>*.CC(=O)SC(CCS)CCCCC(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N Pyruvate dehydrogenase (lipoamide) complex CCC(O)(C(=O)C)C(=O)O>[Mg+2]>CCC(C)(O)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Ketol-acid reductoisomerase NC(=C(C=CC=O)C(=O)O)C(=O)O>>NC(=CC=CC=O)C(=O)O.O=C=O Aminocarboxymuconate semialdehyde decarboxylase NC(C(=O)O)C(=O)CCC(=O)O>>NCC(=O)CCC(=O)O.O=C=O 5-Aminolevulinate synthase NC(CCCC=O)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Saccharopine dehydrogenase (NAD+, L-glutamate forming) NC(CCCC=O)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Saccharopine dehydrogenase (NADP+, L-glutamate forming) NC(CCCC=O)C(=O)O>>OC(=O)C1CCCC=N1.O non-enzymatic NC(=CC=CC=O)C(=O)O>>NC(=CC=CC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 2-Aminomuconate semialdehyde dehydrogenase NC(=CC=CC=O)C(=O)O>>OC(=O)c1ccccn1.O non-enzymatic CC(C)(CO)C(=O)C(=O)O>>CC(C)(CO)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 2-Dehydropantoate reductase CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1O>>COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1=O>>COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1O>>COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1OC5OC(C(O)C(O)C5O)C(=O)O COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1O>>COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1OS(=O)(=O)O COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1O>>COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1OC5OC(C(O)C(O)C5O)C(=O)O COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1O>>COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1OS(=O)(=O)O CC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxyacyl-CoA dehydrogenase CCC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC=C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenase CCC(C)C(=O)C(=O)O>>*.CCC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O 3-Methyl-2-oxobutanoate dehydrogenase (lipoamide) NCCCC(=O)C(=O)O>>OC(=O)C1=NCCC1.O non-enzymatic CC(=O)NCCCCC(=O)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O CC(=O)NCCCCC(=O)C(=O)O>>NCCCCC(=O)C(=O)O.CC(=O)O Acyl-lysine deacylase CCC(=O)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[Mg+2]>CCC(O)(C(=O)C)C(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N Acetolactate synthase CCC(=O)C(=O)O>>CCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O L-Lactate dehydrogenase NC(=O)CCC(=O)C(=O)O>>OC(=O)CCC(=O)C(=O)O.N omega-Amidase OC(=O)CCC(=O)C(=O)O>>NC(CCC(=O)O)C(=O)O.NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glutamate synthase (NADPH) OC(=O)C(=O)CCC=O>>OC(=O)CCC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] (2-Oxoglutarate semialdehyde dehydrogenase) OC(=O)CCC(=O)C(=O)O>>OC(CCC(=O)O)C(=O)O.* 2-Hydroxyglutairate dehydrogenase OC(=O)CCC(=O)C(=O)O>>OC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Malate dehydrogenase OC(=O)CCC(=O)C(=O)O>>OC(=O)CCC(O)(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Homocitrate synthase OC(=O)CCC(=O)C(=O)O>[Zn+2].Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Glutamate dehydrogenase OC(=O)CCC(=O)C(=O)O>[Zn+2].Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Glutamate dehydrogenase OC(=O)CCC(=O)C(=O)O>Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N>OC(=O)CCC=O.O=C=O Oxoglutarate decarboxylase CC(C)CC(=O)C(=O)O>>CC(C)CC(N)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O L-Leucine dehydrogenase CC(C)CC(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(C)CC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O Branched-chain-amino-acid transaminase CC(C)CC(=O)C(=O)O>>*.CC(C)CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O 3-Methyl-2-oxobutanoate dehydrogenase (lipoamide) CC(C)C(=O)C(=O)O>>CC(C)(CO)C(=O)C(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 3-Methyl-2-oxobutanoate hydroxymethyltransferase CC(C)C(=O)C(=O)O>[K+]>CC(C)C(O)(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 2-Isopropylmalate synthase CC(C)C(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(C)C(N)C(=O)O.OC(=O)CCC(=O)C(=O)O Branched-chain-amino acid transaminase CC(C)C(=O)C(=O)O>>*.CC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O 3-Methyl-2-oxobutanoate dehydrogenase (lipoamide) OC(=O)C(=O)CC=C>>CC(O)CC(=O)C(=O)O 2-Oxopent-4-enoate hydratase OCC(OP(=O)(O)O)C(=O)O>[Zn+2].[Mg+2]>OC(=O)C(=C)OP(=O)(O)O.O Enolase CC(=CCCC(=CCc1ccccc1O)C)C>>CC(=CCCC(=CCc1cccc(O)c1O)C)C OC(=O)CCC(=O)c1ccccc1C(=O)O>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS>OC(=O)c1cc(O)c2ccccc2c1O.OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O NC(=C(C=CC=O)C(=O)O)C(=O)O>>OC(=O)c1cccnc1C(=O)O.O non-enzymatic Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)CO>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CO.OCC=O Dihydroneopterin aldolase Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)CO>>Nc1nc(=O)c2nc(cnc2[nH]1)C(O)C(O)CO Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>[Mg+2]>CC(=O)C(=O)C1CNc2nc(N)[nH]c(=O)c2N1.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O (6-Pyruvoyltetrahydropterin synthase) Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>[Mg+2]>Nc1nc2NC3OC(COP(=O)(O)O)C(=C(S)C3Nc2c(=O)[nH]1)S.OP(=O)(O)O.OP(=O)(O)O Nc1nc2NCC(=Nc2c(=O)[nH]1)CO>[Mg+2]>Nc1nc2NCC(=Nc2c(=O)[nH]1)COP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O 2-Amino-4-hydroxy-6-hydroxymetyldihydropteridine pyrophosphokinase Nc1nc2NCC(=Nc2c(=O)[nH]1)COP(=O)(O)OP(=O)(O)O>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)O.OP(=O)(O)OP(=O)(O)O Dihydropteroate synthase NC(=CC=CC(=O)O)C(=O)O>>OC(=O)CCCC(=O)C(=O)O.N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O NC(=CC=CC(=O)O)C(=O)O>>OC(=O)CCCC(=O)C(=O)O.N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O OCC(O)C(O)CC(=O)C(=O)O>[Mg+2]>OC(COP(=O)(O)O)C(O)CC(=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 2-Dehydro-3-deoxygluconokinase CC(O)CC(=O)C(=O)O>>CC(=O)C(=O)O.CC=O 4-Hydroxy-2-oxovalerate aldolase NC(CC(=O)c1cccc(O)c1N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)c1cc(O)c2cccc(O)c2n1.O.NC(CCC(=O)O)C(=O)O Kynurenine transaminase OC(=O)C(=CC=CC=O)O>>OC(=O)C(=O)CC=C.OC=O (Hydroxymuconate semialdehyde hydrolase) CC(O)C=O>>CC(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aldehyde dehydrogenase OC(=O)CCCC(=O)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O.O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 2-Oxoglutarate dehydrogenase NC(=O)CCC(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCC(=O)N)C(=O)O.*C(=O)C(=O)O Glutamine-oxoacid transaminase OC(=O)CCC(=O)C(=O)O>[Mg+2]>*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(O)(CCC(=O)O)C(=O)O CC(C)CCC(O)C(C)(O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.CC(C)CCC=O.*.O.O Cholesterol monooxygenase (side-chain cleaving) CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.O.* Steroid 21-monooxygenase CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC(C)CCCC(C)(O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid 17alpha-monooxygenase CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCC(O)C(C)(O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.O.* Cholesterol monooxygenase Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O.*OS(=O)(=O)O Estrone sulfotransferase Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OS(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O (Phosphoadenylsulfate reductase) *C(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)*>>*C(N)C(=O)OCC(O)COP(=O)(O)OCC(COC(=O)*)OC(=O)*.*C1OC(COP(=O)(O)OC2C(O)C(*)OC2COP(=O)(O)OC3C(O)C(*)OC3CO)C(O)C1O *C(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)*>>*C(=O)CC(COP(=O)(O)OCC(O)COP(=O)(O)OCC(COC(=O)*)OC(=O)*)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 OC1CC(O)(CC(=O)C1O)C(=O)O>>OC1CC(=CC(=O)C1O)C(=O)O.O 3-Dehydroquinate dehydratase OC1CC(O)(CC(=O)C1O)C(=O)O>>OC1CC(O)(CC(O)C1O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Quinate dehydrogenase OC1CC(=CC(=O)C1O)C(=O)O>>OC1CC(=CC(O)C1O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Shikimate dehydrogenase OCCC(=O)O>>OC(=O)CC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxypropionate dehydrogenase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCO>>OCCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 3-hydroxyisobutyryl-CoA hydrolase CC(C)C(C(O)C(=O)O)C(=O)O>>CC(C)CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O 3-Isopropylmalate dehydrogenase CC(C)C(C(O)C(=O)O)C(=O)O>>CC(C)C(=CC(=O)O)C(=O)O.O OC(=O)C(=O)CS>>CC(=O)C(=O)O.SC#N 3-Mercaptopyruvate sulfurtransferase OC(=O)C(=O)CS>>CC(=O)C(=O)O.OS(=O)(=O)S 3-Mercaptopyruvate sulfurtransferase CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C>>CC(C)(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Enoyl-CoA hydratase CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C>>CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)CC(=O)O.[*H].OC(=O)CCCCC1SCC2NC(=O)NC12 Methylcrotonyl-CoA carboxylase CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)CC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O 3-Methylglutaconyl-CoA hydratase CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Acetyl-CoA acyltransferase OC(=O)CCC(=O)CC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(=O)O.OC(=O)CCC(=O)O 3-Oxoadipate-CoA transferase OC(=O)CC1=CCC(=O)O1>>OC(=O)CCC(=O)CC(=O)O 3-Oxoadipate enol-lactonase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 OC(COP(=O)(O)O)C(=O)O>>OCC(OP(=O)(O)O)C(=O)O Phosphoglyceromutase OC(COP(=O)(O)O)C(=O)O>>OCC(OP(=O)(O)O)C(=O)O Phosphoglycerate phosphomutase OC(COP(=O)(O)O)C(=O)O>>OC(=O)C(=O)COP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] D-3-Phosphoglycerate dehydrogenase Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O.OS(=O)(=O)O Phosphoadenylyl sulfatase OC(=O)C(=O)COP(=O)(O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(COP(=O)(O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O Phosphoserine transaminase NC(COP(=O)(O)O)C(=O)O>[Mg+2]>NC(CO)C(=O)O.OP(=O)(O)O Phosphoserine phosphatase NC(CS(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)C(=O)CS(=O)O.NC(CCC(=O)O)C(=O)O Aspartate transaminase NC(CS(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCS(=O)O.O=C=O Sulfinoaniline decarboxylase NC(CS(=O)O)C(=O)O>>NC(CS(=O)(=O)O)C(=O)O OC(=O)C(=O)CS(=O)O>>CC(=O)C(=O)O.OS(=O)O non-enzymatic? CC(CNC(=O)N)C(=O)O>>CC(CN)C(=O)O.O=C=O.N 3-Ureidopropionase NC(=O)NCCC(=O)O>>NCCC(=O)O.O=C=O.N 3-Ureidopropionase CC(C)C(O)(CC(=O)O)C(=O)O>>CC(C)C(C(O)C(=O)O)C(=O)O 3-Isopropylmalate dehydratase CC(C)C(O)(CC(=O)O)C(=O)O>>CC(C)C(=CC(=O)O)C(=O)O.O OCC(O)C(O)C(=O)C(O)C(=O)O>>OCC(O)C(O)C(=O)CO.O=C=O dehydro-L-Gulonate decarboxylase CCCCCCCCCCCCCCCC(=O)C(N)CO>>CCCCCCCCCCCCCCCC(O)C(N)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3-Dehydrosphinganine reductase Nc1c(O)cccc1C(=O)O>[Fe+2]>NC(=C(C=CC=O)C(=O)O)C(=O)O 3-Hydroxyanthranilate oxygenase NC(CC(=O)c1cccc(O)c1N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>Nc1c(O)cccc1C(=O)O.CC(N)C(=O)O Kynureninase CC12CCC(O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase CC12CCC(O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase CC12CCC(O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O)OC5OC(C(O)C(O)C5O)C(=O)O CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C CC(CCC(=O)O)C1CCC2C3C=CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Delta6-steroid reductase CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 20beta-Hydroxysteroid dehydrogenase CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 11beta-Hydroxysteroid dehydrogenase CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 11beta-Hydroxysteroid dehydrogenase CC(CCCC(C)C(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>[Mg+2]>CC(CCC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C 24-monooxygenase CC(CCC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>[Mg+2]>CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] CC(CCC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>[Mg+2]>CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] CC(CO)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCCC(CO)COS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C CC(CO)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCCC(C)C(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+] Cholestane tetraol 26-dehydrogenase CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CO)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Cholestanetriol 26-monooxygenase CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3beta-hydroxy-D5-Steroid dehydrogenase CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3beta-hydroxy-D5-Steroid dehydrogenase CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS>[Mg+2]>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.OP(=O)(O)OP(=O)(O)O Pantetheine-P adenylyltransferase Nc1ccc(cc1)C(=O)O>>Nc1ccc(CC(O)C(O)C(O)CO)cc1.O=C=O.[O] NCCCC=O>>NCCCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aminobutyraldehyde dehydrogenase NC(CC(=O)OP(=O)(O)O)C(=O)O>>NC(CC=O)C(=O)O.OP(=O)(O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aspartate semialdehyde dehydrogenase OC(=O)CC(=O)CC(=O)C=CC(=O)O>>CC(=O)CC(=O)O.OC(=O)C=CC(=O)O Fumarylacetoacetase NC(=N)NCCCC(=O)N>>NC(=N)NCCCC(=O)O.N L-Guanidinobutanamide deaminase NC(=N)NCCCC(=O)O>>NCCCC(=O)O.NC(=O)N 4-Guanidobutyrase OC(=O)c1ccc(O)cc1>[Mg+2]>CC(=CCCC(=CCc1ccccc1O)C)C.OP(=O)(O)OP(=O)(O)O.O=C=O CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCO>>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O OC(=O)C(=O)Cc1ccc(O)cc1>OCC(O)C1OC(=O)C(=C1O)O>OC(=O)Cc1cc(O)ccc1O.O=C=O 4-Hydroxyphenylpyruvate hydroxylase OC(=O)C(=O)Cc1ccc(O)cc1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(Cc1ccc(O)cc1)C(=O)O.OC(=O)CCC(=O)C(=O)O Tyrosine transaminase OC(=O)CCC1NC=NC1=O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OC(=O)CCC1NC(=O)NC1=O Aldehyde oxidase OC(=O)CC(=O)CC(=O)C=CC(=O)O>>OC(=O)CC(=O)CC(=O)C=CC(=O)O Maleyl-acetoacetate isomerase OCCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCO.*O OC1C(O)C(NC(=O)CNC=O)OC1COP(=O)(O)O>>OC1C(O)C(NC(=N)CNC=O)OC1COP(=O)(O)O.NC(CCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Phosphoribosyl-formylglycinamide synthase OC1C(O)C(NC(=N)CNC=O)OC1COP(=O)(O)O>[K+].[Mg+2]>Nc1cncn1C2OC(COP(=O)(O)O)C(O)C2O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Phosphoribosylformylglycinamidine cyclo-ligase NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N>>NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1NC=O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Phosphoribosyl-aminoimidazole carboxamide formyltransferase NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1NC=O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.O IMP Cyclohydrolase Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)NC(CC(=O)O)C(=O)O>>NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N.OC(=O)C=CC(=O)O Adenylosuccinate lyase Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)O>[Mg+2]>Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)NC(CC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Phosphoribosyl-aminoimidazole-succinocarboxamide synthetase Nc1cncn1C2OC(COP(=O)(O)O)C(O)C2O>[Mg+2]>Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)O Phosphoribosylaminoimidazole carboxylase NCC(=O)NC1OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(NC(=O)CNC=O)OC1COP(=O)(O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Phosphoribosylglycineamide formyltransferase Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Methylene-THF-dehydrogenase Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>NCC(=O)O>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=O)c2c(=O)[nH]1.[H+] Aminomethyltransferase CC1C2C(C)Nc3nc(N)[nH]c(=O)c3[N+]2=CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4>>CC1C2C(C)Nc3nc(N)[nH]c(=O)c3N2CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4.CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2cc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O.[H+] 5,10-Methylene-THMPT dehydrogenase Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>>CN1C(CNc2ccc(cc2)C(=O)NC(CCC(=O)O)C(=O)O)CNc3nc(N)[nH]c(=O)c13.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Methylene-THF-reductase (NAD(P)+) Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>>CN1C(CNc2ccc(cc2)C(=O)NC(CCC(=O)O)C(=O)O)CNc3nc(N)[nH]c(=O)c13.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Methylene-THF-reductase (NAD(P)+) CC1C2C(C)Nc3nc(N)[nH]c(=O)c3N2CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C.CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2nc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O.O 5,10-Methylene-THMPT reductase Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>[Mg+2]>Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Formate-THF ligase Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NCC(=O)NC1OC(COP(=O)(O)O)C(O)C1O P-Ribosylglycinamide formyltransferase Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.N.*.OC(=O)CCCCC(S)CCS Aminomethyl transferase Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1.NC(CCC(=O)O)C(=O)O Glutamate formiminotransferase Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1.NCC(=O)O Glutamate formiminotransferase CC1CNC(=O)NC1=O>>CC(CNC(=O)N)C(=O)O Dihydropyrimidinase O=C1CCNC(=O)N1>>NC(=O)NCCC(=O)O Dihydropyrimidinase Nc1[nH]cnc1C(=O)O>>Nc1cnc[nH]1.O=C=O NCC(=O)CCC(=O)O>[Mg+2].[Zn+2].[K+]>NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.O.O Porphobilinogen synthase Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1>>Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.N Formimino-THF cyclodeaminase Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=O)c2c(=O)[nH]1>>Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O 5-Formyl-THF-cycloligase Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=O)c2c(=O)[nH]1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.OC(=O)CCC(NC=O)C(=O)O Glutamate fromiminotransferase CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C=O>>CC1C2C(C)Nc3nc(N)[nH]c(=O)c3[N+]2=CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4.O 5,10-Methenyl-THMPT cyclohydrolase CC(=CCCC(=CCc1cccc(O)c1O)C)C>>COc1c(O)c(C)c(CC=C(C)CCC=C(C)C)c(O)c1OC.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+].[H+] Oc1ccc2[nH]cc(CC=O)c2c1>>OC(=O)Cc1c[nH]c2ccc(O)cc12.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O>>Oc1ccc2[nH]cc(C3=CC(=C4C(=O)Nc5ccccc45)C(=O)N3)c2c1 CC(O)C(=O)SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O>>CC(O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O Hydroxyacyl-glutathione hydrolase (glyoxylase II) CN1C(CNc2ccc(cc2)C(=O)NC(CCC(=O)O)C(=O)O)CNc3nc(N)[nH]c(=O)c13>>*C.CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Methyl-THF-B12 methyltransferase CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C>>CSCCS(=O)(=O)O.CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3Nc4c(NC3C)nc(N)[nH]c4=O NC1OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>NCC(=O)NC1OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Phosphoribosylamine-glycine ligase NC(=O)Nc1[nH]cnc1C(=O)O>>Nc1[nH]cnc1C(=O)O.O=C=O.N CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC(CCCC(CO)COS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(O)C(CO)COS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1>>CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dihydropteridine reductase CC(=O)C(=O)C1CNc2nc(N)[nH]c(=O)c2N1>>CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Sepiapterin reductase Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 CC1Nc2nc(N)[nH]c(=O)c2N=C1C(C)(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>>CC(O)C1=Nc2c(NC1C)nc(N)[nH]c2=O.OCC=O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O *.CC(=O)SC(CCS)CCCCC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.OC(=O)CCCCC(S)CCS Dihydrolipoamide acetyltransferase OC(=O)c1ccc(O)nc1>>Oc1ccc(O)nc1.O=C=O Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)O>[Mg+2].[K+]>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Dihydrofolate synthase CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C(=CC=C3CC(O)CCC3=C)CCCC12C CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 7-Dehydrocholesterol reductase CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 7-Dehydrocholesterol reductase OC(COP(=O)(O)O)C(O)C(O)CC(=O)C(=O)O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[Co+2]>OC1CC(O)(CC(=O)C1O)C(=O)O.OP(=O)(O)O 3-Dehydroquinate synthase CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C.* 3-Oxo-5beta-steroid delta4 dehydrogenase CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3-Oxo-5beta-steroid delta4 dehydrogenase CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CC(O)C12C.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 12alpha-monooxygenase CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C.* 3-Oxo-5beta-steroid delta4 dehydrogenase CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3-Oxo-5beta-steroid delta4 dehydrogenase CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase CC(C)CCCC(C)C1CCC2C3C(O)C=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Glucose-1-P-adenylyltransferase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC4COP(=O)(O)OC4C3O.OP(=O)(O)OP(=O)(O)O Adenylate cyclase [*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>*.O [*H2]>>*.O [*H2]>>*.O [*H2]>>*.O Choline dehydrogenase *OS(=O)(=O)O>>*O.OS(=O)(=O)O Arylsulfatase CC=O>>CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase CC=O>>CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase CC=O>>CCO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Alcohol dehydrogenase CC(=O)O>[Mg+2]>CC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)OP(=O)(O)O Acetyl-CoA ligase CC(=O)CC(=O)O>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)O Acetoacetyl-CoA: Acetate-CoA transferase CC(=O)CC(=O)O>>CC(=O)C.O=C=O Acetoacetate decarboxylase CC(=O)CC(=O)O>>CC(O)CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3-Hydroxybutyrate dehydrogenase CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acetoacetyl-CoA hydrolase CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O 3-Oxoacid-CoA transferase CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Acetyl-CoA acetyltransferase CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)C(N)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 5-Aminolevulinate synthase CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acetyl-CoA acetyltransferase (thiolase) CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Hydroxymethyl-glutaryl-CoA synthase CC(=O)S*S>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.S*S Enzyme/ACP acetyltransferase CC(=O)S*S>>CC(=O)S*S CC(=O)S*SC(=O)CC(=O)O>>CC(=O)CC(=O)S*S.O=C=O 3-Oxoacyl-E/ACP synthase CC(=O)S*SC(=O)CC(=O)O>>CC(=O)S*S.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O Enzyme/ACP malonyltransferase CC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23>[Mg+2]>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Acetate-CoA ligase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=C>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCO Enoyl-CoA hydratase CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>[Mg+2].[K+]>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acyl-CoA-ligases (several) CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>[Mg+2].[K+]>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acyl-CoA-ligases (several) CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCC(=O)OC(CC(=O)O)C[N+](C)(C)C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Carnitine palmitoyltransferase CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCC(=O)OCC(O)COP(=O)(O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS (active) Glycerol-3-phospho-acyltransferase CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC=CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.O.O (Acyl-CoA-desaturase) CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Acyl-CoA dehydroenase (NADP) CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA-dehydrogenases (2 known) *.CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS>>*.CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS ACP Phosphodiesterase *C(=O)S*S>>CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.S*S (Palmitoyl-CoA-enzyme palmitoyl transferase) *C(=O)S*S>>*C(=O)O.S*S Oleyl-ACP hydrolase CCCCCC(=O)OCC(O)COP(=O)(O)O>>CCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 1-Acylglycerol-3P-acyltransferase Nc1ncnc2[nH]cnc12>[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Adenine P-ribosyltransferase Nc1ncnc2[nH]cnc12>>O=c1[nH]cnc2[nH]cnc12.N Adenine deaminase Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O>[Mg+2]>Nc1ncnc2[nH]cnc12.OCC1OC(O)C(O)C1O Purine nucleosidase Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Adenosine kinase Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O>>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23.N Adenosine deaminase Nc1ncnc2n(cnc12)C3OC4COP(=O)(O)OC4C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O 3,5-Cyclic nucleotide phosphodiesterase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Fe+2]>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.*.O Ribonucleoside-diphosphate reductase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Ca+2].[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)O Apyrase (Potato/Insects) Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.O.[H+].[H+].[H+] (Oxidative phosphorylation) Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Adenylate kinase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(N)ncnc45)C(O)C1O.OP(=O)(O)O Polyribonucleotide nucleotidyltransferase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O>[Zn+2]>Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O.OP(=O)(O)O 5'-Nucleotidase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O>[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Adenylate kinase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.N AMP deaminase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.*.O Ribonucleoside triphosphate reductase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O ATPases (several known) Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>[Ca+2].[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Apyrase OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(NC(CC(=O)O)C(=O)O)ncnc23>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OC(=O)C=CC(=O)O Adenylosuccinate lyase Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O>>OS(=O)(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Adenylsulfatase Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O>>OS(=O)O.*.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Adenylsulfate reductase NCCCCNC(=N)N>>NCCCCN.NC(=O)N Agmatinase CCCCCC=O>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>CCCCCC(=O)O.[*H2] Aldehyde dehydrogenase (PQQ) CCCCCC=O>>CCCCCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C54CC(OC5O)C31>>CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.*.* 3-Oxo-5beta-steroid delta4dehydrogenase CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C54CC(OC5O)C31 non-enzymatic CCCCCC>>CCCCCCO.O.* Alkane-1-monooxygenase NC(=O)NC1NC(=O)NC1=O>>NC(=O)NC(NC(=O)N)C(=O)O Allantoinase OC(=O)CCCC(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCCC(=O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O 2-Aminoadipate transaminase OP(=O)(O)OCC(=O)Cc1cnc[nH]1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(COP(=O)(O)O)Cc1cnc[nH]1.OC(=O)CCC(=O)C(=O)O Histidinol-P transaminase CC(=O)CN>[K+]>CC(O)CN.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 1-Aminopropan-2-ol dehydrogenase CC(=O)CN>>CC(=O)C=O.N.OO Monoamine oxidase *.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O>>CC(C)C(NC(=O)C(CS)NC(=O)CCCC(N)C(=O)O)C(=O)O.O.*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS d(L-2-Aminoadipyl-)L-cysteinyl-D-valinesynthase Nc1cnc[nH]1>>OC(=O)CNC=N.N Aminoimidazolase OCC1OC(OC2C(O)C(O)C(OCC3OC(OC4C(O)C(O)C(O)OC4CO)C(O)C(O)C3OC5OC(CO)C(O)C(O)C5O)OC2CO)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OCC1OC(OC2C(O)C(O)C(OC3C(O)C(O)C(O)OC3CO)OC2CO)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O (alpha-Glucan) phosphorylase OCC1OC(OC2C(O)C(O)C(OCC3OC(OC4C(O)C(O)C(O)OC4CO)C(O)C(O)C3OC5OC(CO)C(O)C(O)C5O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(OC3C(O)C(O)C(O)OC3CO)OC2CO)C(O)C(O)C1O.OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O alpha-Amylase OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC2OC3C(O)C(O)C(OC3CO)OC4C(O)C(O)C(OC4CO)OC5C(O)C(O)C(OC5CO)OC1C(O)C2O Cyclomaltodextrin glucanotransferase OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(OCC3OC(OC4C(O)C(O)C(O)OC4CO)C(O)C(O)C3OC5OC(CO)C(O)C(O)C5O)OC2CO)C(O)C(O)C1O 1,4-alpha-Glucan branching enzyme (Q-enzyme) OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Glycogen (starch) synthases OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Starch (bacterial glycogen) synthase OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O I-Form (active) Glycogen (starch) synthase OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Starch (bacterial glycogen) synthase OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O Glucan-1,4-alpha-glucosidase (glucoamylase) OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O alpha Amylase OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O Glycogen phosphorylase a CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>*.*>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O.O.* Steroid 11beta-monooxygenase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 19-hydroxylase) CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O.* 3-Oxo-5beta-steroid delta4 dehydrogenase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O.* 3-Oxo-5beta-steroid delta4 dehydrogenase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3(or 17)beta-Hydroxysteroid dehydrogenase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3(or 17)beta-Hydroxysteroid dehydrogenase CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1=O Nc1ccccc1C(=O)O>>Nc1ccccc1C(=O)OC2OC(C(O)C(O)C2O)C(=O)O Nc1ccccc1C(=O)O>[Fe+2]>Oc1ccccc1O.O=C=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.N Anthranilate 1,2-dioxygenase (deaminating, decarboxylating) Nc1ccccc1C(=O)O>[Fe+2]>Oc1ccccc1O.O=C=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.N Anthranilate 1,2-dioxygenase (deaminating, decarboxylating) Nc1ccccc1C(=O)O>>OC1C(O)C(Nc2ccccc2C(=O)O)OC1COP(=O)(O)O.OP(=O)(O)OP(=O)(O)O Anthranilate-phosphoribosyltranferase *>[Mg+2]>*.CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O Holo-ACP synthase *>>*[Fe+3] Transferrin reductase C[N+](C)(C)CC=O>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>C[N+](C)(C)CC(=O)O.[*H2] Choline dehydrogenase C[N+](C)(C)CC=O>[Mg+2]>C[N+](C)(C)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Betaine aldehyde dehydrogenase C[N+](C)(C)CC(=O)O>>CN(C)CC(=O)O.CSCCC(N)C(=O)O.[H+] Betaine-homocysteine methyltransferase [NH4+]>>NC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Carbamoylphosphate synthase OC(=O)[O-]>>NC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Carbamoylphosphate synthase CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)OC5OC(C(O)C(O)C5O)C(=O)O)c(CCC(=O)OC6OC(C(O)C(O)C6O)C(=O)O)c2C)NC1=O>>CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C.OC1OC(C(O)C(O)C1O)C(=O)O.OC1OC(C(O)C(O)C1O)C(=O)O beta-Glucuronidase + further reactions CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)OC5OC(C(O)C(O)C5O)C(=O)O)c(CCC(=O)OC6OC(C(O)C(O)C6O)C(=O)O)c2C)NC1=O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Glucuronosyltransferase CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O.O Bilirubin oxidase CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Biliverdin reductase CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Biliverdin reductase CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CCC1=C(C)C(=CC2=NC(=Cc3[nH]c(C=C4NC(=O)C(C)C4=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CCC1=C(C)C(=CC2=NC(=Cc3[nH]c(C=C4NC(=O)C(C)C4=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O.*.* CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)OP(=O)(O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Phosphate butyryl-transferase *C(=O)S*S>>*C(=O)S*SC(=O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS *C(=O)S*SC(=O)CC(=O)O>>*C(=O)CC(=O)S*S.O=C=O *C(=O)OCC(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCC(O)COP(=O)(O)O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 CDP-Diacylglycerolglycerol-3P 3-phosphatidyltransferase *C(=O)OCC(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O)OC(=O)*>[K+].[Mg+2]>*C(=O)OCC(COP(=O)(O)O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1 Phosphatidate cytidyltransferase C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O>[Mg+2]>*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 Choline phosphotransferase NCCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O>[Mg+2]>*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 Ethanolamine-phosphotransferase O=C=O>>*.[C-]#[O+].*.O CO-dehydrogenase OC(=O)[O-]>[Mg+2]>NC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.O Carbamate kinase OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O P-Gluconate dehydrogenase (decarboxylating) OCC(O)C(O)C(O)CO>>OCC1(O)OCC(O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Ribitoldehydrogenase NCCC(=O)NC(Cc1cnc[nH]1)C(=O)O>[Zn+2]>NCCC(=O)O.NC(Cc1c[nH]cn1)C(=O)O Carnosinase Oc1ccccc1O>[Fe+2]>OC(=O)C(=CC=CC=O)O Catechol 2,3-dioxygenase Oc1ccccc1O>[Fe+2]>OC(=O)C=CC=CC(=O)O Catechol 1,2-dioxygenase OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O beta-Glucosidase OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O Cellobiose phosphorylase OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.O Cellulose-1,4-cellobiosidase OCC1OC(O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Cellulose synthase (UDP-forming) *C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O (N-Acylsphingosine glucosyltransferase) *C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(COP(=O)(O)OCC[N+](C)(C)C)C(O)C=CCCCCCCCCCCCCC.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 Ceramide cholinephosphotransferase *C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC>>CCCCCCCCCCCCCC=CC(O)C(N)CO.*C(=O)O Acylsphingosine deacylase CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C>>CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C CC(=O)NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2NC(=O)C)C1O>>CC(=O)NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2NC(=O)C)C1O CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C>>CCc1c(C=O)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C.O CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C.CC(C)CCCC(C)CCCC(C)CCCC(=CCO)C Chlorophyllase CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C>>CCc1c(C)c2cc3[nH]c(cc4nc(C(CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C4C)c5C(C(=O)OC)C(=O)c6c(C)c(cc1n2)[nH]c65)c(C)c3C=C.[Mg+2] CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C>>CCC1C(C)C2=[N+]3[Mg+2][N+]4=C(C=c5[n-]c(=C2)c(C(=O)C)c5C)C(C)C(CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C4=C6C(C(=O)OC)C(=O)c7c(C)c(C=C13)[n-]c67.OP(=O)(O)OP(=O)(O)O CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C.OP(=O)(O)OP(=O)(O)O CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3C=CC4CC(O)CCC4(C)C3CC(O)C12C.O 7alpha-dehydroxylase CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Cholate-CoA ligase CC(C)CCCC(C)C1CCC2C(=CC=C3CC(O)CCC3=C)CCCC12C>>CC(CCCC(C)(C)O)C1CCC2C(=CC=C3CC(O)CC(O)C3=C)CCCC12C *C(=O)OC1CCC2(C)C3CCC4(C)C(CCC4C3CC=C2C1)C(C)CCCC(C)C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.*C(=O)O Cholesterol esterase *C(=O)OC1CCC2(C)C3CCC4(C)C(CCC4C3CC=C2C1)C(C)CCCC(C)C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.*C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Cholesterol acyltransferase CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.O.* Cholesterol monooxygenase (side chain cleaving) CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*>CC(C)CCCC(C)C1CCC2C3C(O)C=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Cholesterol 7alpha-monooxygenase CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C.OO Cholesterol oxidase C[N+](C)(C)CCO>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>C[N+](C)(C)CC=O.[*H2] C[N+](C)(C)CCO>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>C[N+](C)(C)CC=O.O Choline oxidase C[N+](C)(C)CCO>>CC(=O)OCC[N+](C)(C)C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Choline acetyltransferase CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>>CC(CCC(=O)NCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Glycine-N-choloyltransferase CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>>CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Glycine-N-choloyltransferase OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>>Nc1ccc(cc1)C(=O)O OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>>OC(=O)c1ccc(O)cc1.CC(=O)C(=O)O (Chorismate lyase) OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>[Mg+2]>Nc1ccccc1C(=O)O.NC(CCC(=O)O)C(=O)O.CC(=O)C(=O)O Anthranilate synthase OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>>OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O Chorismate mutase OC(=O)CC(O)(CC(=O)O)C(=O)O>[Mg+2]>OC(=O)CC(=O)C(=O)O.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O ATP Citrate lyase OC(=O)CC(O)(CC(=O)O)C(=O)O>>OC(C(CC(=O)O)C(=O)O)C(=O)O CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)O CC(O)CNC(=O)CCC1(C)C(CC(=O)N)C2N3C1=C(C)C4=[N+]5C(=CC6=[N+]7C(=C(C)C8=[N+](C2(C)C(C)(CC(=O)N)C8CCC(=O)N)[Co+2]375)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(C)C4CCC(=O)N>>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O CC1=C2[N+]3=C(C=C4[N+]5=C(C(CCC(=O)O)C4(C)C)C(=C6N7C(C(CC(=O)O)C6(C)CCC(=O)O)C8(C)[N+](=C1C(CCC(=O)O)C8(C)CC(=O)O)[Co+2]735)C)C(CCC(=O)O)C2(C)CC(=O)O>>CC(O)CNC(=O)CCC1(C)C(CC(=O)N)C2N3C1=C(C)C4=[N+]5C(=CC6=[N+]7C(=C(C)C8=[N+](C2(C)C(C)(CC(=O)N)C8CCC(=O)N)[Co+2]375)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(C)C4CCC(=O)N.O.O.O.O.O.O.O CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2nc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O>>CC(OP(=O)(O)OCC(O)C(O)C(O)CN1C2NC(=O)NC(=O)C2Nc3ccc(O)cc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O Hydrogenase OC(=O)CC(=O)C(=O)O>>OC(=O)CC(O)(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Citrate synthase Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5C)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C>>Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(=O)O)c5C)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.[H].[H].[H].[H].[H].[H] Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C>>Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.[H].[H].[H].[H].[H].[H] Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C>>Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(=O)O.O=C=O.O=C=O.O.O Coproporphyrinogen oxidase CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.* 3-Oxo-5beta-steroid delta4 dehydrogenase CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CO)CC(O)C31.O.* Corticosterone 18-monooxygenase CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Cortisone beta-reductase CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Cortisone beta-reductase CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO>>CC12CC(O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(O)CO CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO>>CC12CC(=O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(O)CO CN(CC(=O)O)C(=N)N>>CN1CC(=O)NC1=N.O Creatininase CN(CC(=O)O)C(=N)N>>NC(=O)N.CNCC(=O)O Creatinase CN1CC(=O)NC1=N>>CN1CC(=O)NC1=O.N Creatinine deiminase CC=CC(=O)S*S>>CCCC(=O)S*S.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C Enoyl-E/ACP reductase CC=CC(=O)S*S>>CCCC(=O)S*S.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Enoyl-E/ACP reductase CC(CCC=C(C)C)C1CCC2(C)C3CCC4C5(CC35CCC12C)CCC(O)C4(C)C>>CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)CC4CC3 Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>>Nc1cc[nH]c(=O)n1.OCC1OC(OP(=O)(O)O)C(O)C1O Pyrimidine nucleoside phosphorylase Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>>Nc1cc[nH]c(=O)n1.OCC1OC(O)C(O)C1O Nucleosidase Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>>OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O.N Cytidine deaminase Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>[Fe+2]>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.*.O Ribonucleoside-diphosphate reductase Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>[Mg+2]>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(N)nc4=O)C(O)C1O.OP(=O)(O)O Polyribonucleotide nucleotidyltransferase Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1>>Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1.OP(=O)(O)O 5'-Nucleotidase Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.*.O Ribonucleoside triphosphate reductase Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(N)nc4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O DNA-directed RNA polymerase Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(N)nc4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O RNA-directed DNA polymerase Nc1cc[nH]c(=O)n1>>O=c1cc[nH]c(=O)[nH]1.N Cytosine deaminase CCCCCC(=O)OCC(CO)OC(=O)CCCCC>>CCCCCC(=O)OCC(COC(=O)CCCCC)OC(=O)CCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Diacylglycerol acyltransferase CCCCCC(=O)OCC(CO)OC(=O)CCCCC>>CCCCCC(=O)OCC(O)CO.CCCCCC(=O)O Lipases *C(O)CC(=O)S*S>>*C(=O)CC(=O)S*S.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] *C(O)CC(=O)S*S>>*C(=O)CC=CCCCCCC.O.*CCC(=O)S*S CC(O)CC(=O)S*S>>CC(=O)CC(=O)S*S.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Oxoacyl-E/ACP reductase CC(O)CC(=O)S*S>>CC=CC(=O)S*S.O (3-Hydroxyacyl-E/ACP dehydratases) OC(CC(=O)C(=O)O)C(=O)O>>OC(=O)C=O.CC(=O)C(=O)O 4-hydroxy-2-Oxoglutarate aldolase OC1C(O)C(COP(=O)(O)O)OC(=O)C1O>>OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O 6-P-Gluconolactonase OC(COP(=O)(O)O)C(O)C=O>>OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)COP(=O)(O)O OC(COP(=O)(O)O)C(O)C=O>>OC(COP(=O)(O)O)C(O)C(O)CC(=O)C(=O)O.OP(=O)(O)O *OP(=O)(O)O>>*O.OP(=O)(O)O Glycogen synthase D phosphatase OCC1OC(O)C(O)C(O)C1O>[Mg+2]>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Galactokinase OC1OC(C(O)C(O)C1O)C(=O)O>>OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Galacturonokinase OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C(O)CC(=O)C(=O)O OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C1OC(=O)C(=C1O)O.O OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1OC(C(O)C(O)C1O)C(=O)O.OP(=O)(O)O OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O.OP(=O)(O)OP(=O)(O)O OCC(O)C(O)C(O)C(O)C(=O)O>>OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Gluconokinase OCC1OC(=O)C(O)C(O)C1O>[Mg+2]>OCC(O)C(O)C(O)C(O)C(=O)O Gluconolactonase OCC1OC(=O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glucose dehydrogenase OCC1OC(=O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glucose dehydrogenase NC1C(O)OC(CO)C(O)C1O>>NC(C(O)C(O)C(O)CO)C(=O)O.OO NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Glucosamine-P-acetyltranferase OCC(=O)C(O)C(O)C(O)C=O.OP(=O)=O>>OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O myo-Inositol-1-P synthase OCC1OC(O)C(O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O Xylose isomerase OCC1OC(O)C(O)C(O)C1O>>OCC1OC(=O)C(O)C(O)C1O.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Glucose oxidase OCC1OC(O)C(O)C(O)C1O>>OCC(O)C(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aldehyde reductase OC1OC(C(O)C(O)C1O)C(=O)O>>OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glucuronokinase OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C(O)C(O)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glucuronate reductase OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C(O)CC(=O)C(=O)O OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1OC(C(O)C(O)C1O)C(=O)O.OP(=O)(O)O OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O.OP(=O)(O)OP(=O)(O)O Glucuronate 1-P Uridylyltransferase OC(C=O)C1OC(=O)C(O)C1O>>OC(C(O)C(O)C(=O)O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase OC(C=O)C1OC(=O)C(O)C1O>>OCC(O)C1OC(=O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glucuronolactone reductase OC(C=O)C1OC(=O)C(O)C1O>>OC1OC(C(O)C(O)C1O)C(=O)O Uronolactonase OC(COP(=O)(O)O)C=O>>OC(=O)c1cccnc1C(=O)O.O.O.OP(=O)(O)O OCC(O)C=O>[Mg+2]>OC(COP(=O)(O)O)C=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Triokinase OCC(O)C=O>>OCC(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde (NAD+) dehydrogenase OC(COP(=O)(O)O)C=O>>OC(COP(=O)(O)O)C(=O)OP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glyceraldehyde-phosphate dehydrogenase OC(COP(=O)(O)O)C=O>>OC(COP(=O)(O)O)C(=O)OP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glyceraldehyde-phosphate dehydrogenase (NADP) OC(COP(=O)(O)O)C=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC1OC(COP(=O)(O)O)C(O)C1O.OCC(=O)C(O)C(O)COP(=O)(O)O Transketolase OC(COP(=O)(O)O)C=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OCC(=O)C(O)C(O)COP(=O)(O)O.OC(COP(=O)(O)O)C(O)C=O Transketolase CC(O)C(=O)O>>CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] D-Lactate dehydrogenase CC(O)C(=O)O>>CC(=O)C(=O)O.*[Fe+2].*[Fe+2] D-Lactate dehydrogenase OCC1OC(O)C(O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O Mannose isomerase OC(=O)C1CCCN1>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OC(=O)C1=NCCC1.OO D-Aminoacid oxidase OC(=O)C1CCCN1>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>NCCCCC(=O)O.OC(=O)CCCCC1CCSS1 D-Proline reductase (dithiol) OC1OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Ribose-phosphate pyrophosphokinase OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(O)C(=O)C(O)C(O)COP(=O)(O)O Hexulose-6-P synthase OCC(=O)C(O)C(O)COP(=O)(O)O>>OC1OC(COP(=O)(O)O)C(O)C1O Ribose-phosphate isomerase OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O Ribose-phosphate isomerase OCC(O)C(O)C(O)C(O)CO>>OCC1OC(O)(CO)C(O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Iditol dehydrogenase OCC(O)C(O)C(O)C=O>>OCC1(O)OCC(O)C1O Xylose isomerase OCC(O)C(O)C(O)C=O>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aldehyde reductase OCC(O)C(O)C(O)C=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O OCC1(O)OCC(O)C1O>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O D-Xylulose reductase OCC1(O)OCC(O)C1O>[Mg+2]>OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Xylulokinase OC(COP(=O)(O)O)C(O)c1cnc[nH]1>>OP(=O)(O)OCC(=O)Cc1cnc[nH]1.O Imidazoleglycerol-P dehydratase NC(CCCC(=O)NC1C2SCC(=C(N2C1=O)C(=O)O)CO)C(=O)O>>CC(=O)OCC1=C(N2C(SC1)C(NC(=O)CCCC(N)C(=O)O)C2=O)C(=O)O.O Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)[n+]5cccc(c5)C(=O)O)C(O)C3O>[Mg+2]>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.NC(CCC(=O)O)C(=O)O NAD-Synthase (glutamine hydrolyzing) NC(CCO)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CCC(=O)C(=O)O.N Cystathionine gamma-lyase NC(CO)C(=O)O>[K+].Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)C(=O)O.N L-Serine dehydratase CC(O)C(N)C(=O)O>>CCC(=O)C(=O)O.N Threonine dehydratase NC(=O)c1cccnc1>>OC(=O)c1cccnc1.N Nicotine amidase NCCc1c[nH]c2ccc(O)cc12>[Cu+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>Oc1ccc2[nH]cc(CC=O)c2c1.N.OO Monoamine oxidase NCCc1c[nH]c2ccccc12>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[Cu+2]>O=CCc1c[nH]c2ccccc12.N.OO Monoamine oxidase NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCc1c[nH]c2ccc(O)cc12.O=C=O Aromatic L-amino acid decarboxylase CC(=O)CC(=O)O>>CC(=O)C.O=C=O Acetoacetate decarboxylase CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>OC(=O)CCCCC1SCC2NC(=O)NC12.[Co+2].[Zn+2]>CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.OC(=O)CC(=O)C(=O)O Methylmalonyl-CoA carboxyltransferase CC(C(=O)C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Acetyl-CoA-acyltransferase OC(COP(=O)(O)O)C(O)CC(=O)C(=O)O>>CC(=O)C(=O)O.OC(COP(=O)(O)O)C=O 2-dehydro-3-deoxyphospho-Gluconate aldolase OC(CC(=O)C(=O)O)C(O)C(=O)O>>CC(=O)C(=O)O.OC(C=O)C(=O)O 2-dehydro-3-deoxy-D-Glucarate aldolase NC(=O)NC(NC(=O)N)C(=O)O>>NC(=O)N.NC(=O)NC(O)C(=O)O Allantoinase O=C1CC(=O)NC(=O)N1>>OC(=O)CC(=O)O.NC(=O)N Barbiturase CC(=O)NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2NC(=O)C)C1O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.CC(=O)NC1C(O)OC(CO)C(O)C1O N-Acetyl-beta-glucosaminidase OC(=O)CC(O)(CC(=O)O)C(=O)O>>OC(=O)CC(=O)C(=O)O.CC(=O)O Citrate lyase NC(CCSCC(N)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CCC(=O)C(=O)O.NC(CS)C(=O)O.N Cystathionine gamma-lyase CC(O)C(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCC(=O)O.CC=O Threonine aldolase NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1cccnc1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(O)C(O)C4O)C(O)C3OP(=O)(O)O.[H+] NAD(P) nucleosidase NC(=O)NC(O)C(=O)O>>OC(=O)C=O.NC(=O)N Ureidoglycolate lyase *OC1OC(C(O)C(O)C1O)C(=O)O>>OC1OC(C(O)C(O)C1O)C(=O)O.*O beta-Glucuronidase OC(C(CC(=O)O)C(=O)O)C(=O)O>[Mg+2]>OC(=O)CCC(=O)O.OC(=O)C=O Isocitrate lyase CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O 3-hydroxybutyryl-CoA dehydratase OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O>>OC(COP(=O)(O)O)C(O)CC(=O)C(=O)O.O P-Gluconate dehydratase OC(C(O)C(O)C(=O)O)C(O)C(=O)O>>OC(CC(=O)C(=O)O)C(O)C(=O)O.O D-Glucarate dehydratase OC(C(O)C(O)C(=O)O)C(O)C(=O)O>>OC(CC(=O)C(=O)O)C(O)C(=O)O.O D-Glucarate dehydratase OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OC1C(O)C(COP(=O)(O)O)OC(=O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glucose 6-P dehydrogenase CC=CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCC=CCC=CCC=CCC=CCCCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS CC=CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCCCCC(C)CCCCCCCCC(=O)O.NC(CCS)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>CC(CCOP(=O)(O)OP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C CC12CCC3C(CC=C4CC(CCC34C)OS(=O)(=O)O)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O.OS(=O)(=O)O Sterylsulfatase CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CC(O)C1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 16alpha-hydroxylase) CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3(or 17)beta-Hydroxysteroid dehydrogenase CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3(or 17)beta-Hydroxysteroid dehydrogenase CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Steroid delta-isomerase CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Steroid delta-isomerase CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(CCC34C)OS(=O)(=O)O)C2CCC1=O.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O Alcohol sulfotransferase CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxybutyryl-CoA dehydrogenase CCCCO>[Zn+2]>CCCC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Butanol dehydrogenase CC(C)O>>CC(=O)C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] (2-Propanol dehydrogenase (NAD+)) CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Butyraldehyde dehydrogenase CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Butyryl-CoA dehydrogenase OCC(O)C(O)C(=O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] dehydro-L-Gulonate dehydrogenase OCC(O)C(O)C(=O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] dehydro-L-Gulonate dehydrogenase OCC(O)C(O)C(O)CO>>OCC(O)C(O)C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Arabinitol dehydrogenase OCC(O)C1OC(=O)C(=C1O)O>>OCC(O)C1OC(=O)C(=O)C1=O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O Glutathione dehydrogenase (ascorbate) OCC(O)C(O)C(O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Gulonate dehydrogenase OCC(O)C(O)C(O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Gulonate dehydrogenase OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(=O)C12C OC(COP(=O)(O)O)C(=O)OP(=O)(O)O>[Mg+2]>OC(COP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O 3-Phosphoglycerate kinase OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(O)C(O)C(O)C1O.OP(=O)(O)O 1-L-myo-Inositol phosphatase Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>>Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1.OP(=O)(O)OP(=O)(O)O dCTP-Pyrophosphatase Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>>Nc1ccn(C2CC(O)C(CO)O2)c(=O)n1.OP(=O)(O)O 5'-Nucleotidase Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)O)O3>[Mg+2].[Co+2].[Ca+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3.OP(=O)(O)O 5'-Nucleotidase Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3>>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3.OP(=O)(O)OP(=O)(O)OP(=O)(O)O dGTPase OC(=O)C(COP(=O)(O)O)OP(=O)(O)O>>OC(COP(=O)(O)O)C(=O)O.OP(=O)(O)O Bisphosphoglycerate phosphatase Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>>Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)CO.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>[Mg+2]>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Adenylylsulfate kinase Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O.OP(=O)(O)O 3'-Phosphoadenylsulfate 3'-phosphatase *C(=O)OCC(COP(=O)(O)OCC(O)COP(=O)(O)O)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)*.OP(=O)(O)O Phosphatase CCCC(=O)OP(=O)(O)O>>CCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Butyrate kinase OCC1(OP(=O)(O)O)OC(COP(=O)(O)O)C(O)C1O>>OCC1(O)OC(COP(=O)(O)O)C(O)C1O.OP(=O)(O)O Fructose-2,6 bisphosphatase OCC1OC(O)(CO)C(O)C1O>[Mg+2]>OCC1(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hexokinase NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>NC1C(O)OC(CO)C(O)C1O.OP(=O)(O)O OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)COP(=O)(O)O>[Mg+2]>OCC(=O)C(O)C(O)C(O)C(O)COP(=O)(O)O.OP(=O)(O)O Fructose bisphosphatase CCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCC>[Mg+2]>CCCCCC(=O)OCC(CO)OC(=O)CCCCC.OP(=O)(O)O Phosphatidate phosphatase OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23>[Mg+2].[Co+2].[Ca+2]>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23.OP(=O)(O)O 5'-Nucleotidase NC(COP(=O)(O)O)Cc1cnc[nH]1>>NC(CO)Cc1cnc[nH]1.OP(=O)(O)O Histidinol phosphatase CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.OP(=O)(O)O CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)COP(=O)(O)O)C(=O)O>[Mg+2]>CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O.OP(=O)(O)O (N-Acetylneuraminate-9-phosphatase) NC(CCOP(=O)(O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(O)C(N)C(=O)O.OP(=O)(O)O Threonine synthase OC(=O)C(=C)OP(=O)(O)O>[Mg+2].[K+]>CC(=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Pyruvate kinase OC(=O)C(=C)OP(=O)(O)O>[Mg+2].[K+]>CC(=O)C(=O)O.*C1OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C1O Pyruvate kinase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O.OP(=O)(O)OP(=O)(O)O Phosphoribosyl-ATP pyrophosphatase Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O>>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.OP(=O)(O)O Thymidine triphosphatase OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O.OP(=O)(O)O 5'-Nucleotidase OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23>[Mg+2].[Co+2].[Ca+2]>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]c(=O)[nH]c23.OP(=O)(O)O 5'-Nucleotidase OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OP(=O)(O)O Glucose-6-phosphatase OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O>[Mg+2]>OCC1(O)OC(COP(=O)(O)O)C(O)C1O.OP(=O)(O)O Hexosediphosphatase OCC1OC(O)(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 1-Phosphofructokinase OCC(O)COP(=O)(O)O>>OCC(O)CO.OP(=O)(O)O Glycerol kinase *>>OCC(O)C(O)C(O)C=O.* Xylosidases *>>OCC(O)C(O)C(O)C=O.* CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O>>CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Phenylalanine 4-monooxygenase NC(Cc1cc(I)c(O)c(I)c1)C(=O)O>>NC(Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O.NC(=C)C(=O)O.O.O NC(Cc1cc(I)c(O)c(I)c1)C(=O)O>>NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O.O.O.NC(=C)C(=O)O CN(C)CC(=O)O>[Fe+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CNCC(=O)O.[*H2].C=O Dimethylglycine dehydrogenase CC(CCOP(=O)(O)OP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C>>CC(CCOP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C.OP(=O)(O)O CC(CCOP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C>>CC(CCO)CCC=C(C)CCC=C(C)CCC=C(C)C.OP(=O)(O)O Dolichyl phosphatase NCCc1ccc(O)c(O)c1>>CN1CCC23C4Oc5c3c(CC1C2C=CC4O)ccc5O NCCc1ccc(O)c(O)c1>[Cu+2].OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>NCC(O)c1ccc(O)c(O)c1.O.OCC(O)C1OC(=O)C(=O)C1=O Dopamine beta-monooxygenase *C.CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N [*H].OC(=O)CCCCC1SCC2NC(=O)NC12>[Mg+2].[K+]>*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Biotin carboxylase [*H].OC(=O)CCCCC1SCC2NC(=O)NC12>[Mg+2]>*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O *C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12>[Mg+2]>[*H].OC(=O)CCCCC1SCC2NC(=O)NC12.OC(=O)[O-].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O *C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12>[Mg+2]>[*H].OC(=O)CCCCC1SCC2NC(=O)NC12.OC(=O)[O-].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O *.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dihydrolipoamide dehydrogenase *.OC(=O)CCCCC1CCSS1>>*.OC(=O)CCCCC(S)CCS.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Dihydrolipoamide dehydrogenase *.OC(=O)CCCCC(S)CCSC(=O)CCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O.*.OC(=O)CCCCC(S)CCS Dihydrolipoamide succinyltransferase *.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(O)(CCC(=O)O)C(=O)O>>*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc(C(O)CCC(=O)O)[n+]1Cc2cnc(C)nc2N.O=C=O 2-Oxoglutarate decarboxylase *.OC(=O)CCCCC(S)CCS>>*.OC(=O)CCCCC1CCSS1.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Dihydrolipoamide dehydrogenase *.OC(=O)CCCCC(S)CCS>>*.OC(=O)CCCCC1CCSS1.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.O=C=O Acetyl-CoA acyltransferase OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O UDPG-4-epimerase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O UDP-Glucuronate-4-epimerase CC(C)C(=C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)C(C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C CC(C)C(C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)C(C)C=CC(C)C1CCC2C(=CC=C3CC(O)CCC3=C)CCCC12C CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Estriol 2-hydroxylase) CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Estriol 2-hydroxylase) CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CCC1O CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(=O)O)ccc34)C2CC(O)C1O CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 16a-hydroxylase) CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Estradiol 17beta-dehydrogenase CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Estradiol 17beta-dehydrogenase CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(OC5OC(C(O)C(O)C5O)C(=O)O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Glucuronosyltransferase CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Estradiol 17beta-dehydrogenase CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Estradiol 17beta-dehydrogenase CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 16a-hydroxylase) CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Estriol 2-hydroxylase) CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Estriol 2-hydroxylase) CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(=O)O)ccc34)C2CCC1=O CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CCC1=O.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O Estrone sulfotransferase NCCO>>NCCOP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Ethanolamine kinase CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1=O *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.O=O 2-Hydroxyacid dehydrogenase *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.* Acyl-CoA dehydrogenase *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.* *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.* *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.* *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.* Acyl-CoA dehydrogenases (2 known) *.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.OO *.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[*H2] Glycerol 3-P dehydrogenase *.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[*H2] *.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.OO (S)-2-Hydroxyacid oxidase *.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.OO *.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.OO CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C>[Mg+2]>CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)OP(=O)(O)O Farnesyl-bisphospho-farnesyltransferase CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C>[Mg+2]>CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C.OP(=O)(O)OP(=O)(O)O Farnesyl-trans-transferase CCCCCC(=O)O>>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)OP(=O)(O)O Acyl-CoA ligases CCCCCC(=O)O>>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)O Acyl-CoA ligases [Fe+2]>>[Fe+3].O.[Fe+3] Ferroxidase (ceruloplasmin) [*H2]>>*.[H][H] Hydrogenase *[Fe+3]>>*.[Fe+2] Transferrin reductase Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)cnc2[nH]1>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)cnc2[nH]1>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase C=O>>OC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formaldehyde dehydrogenase OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formate dehydrogenase OC=O>Nc1nc2NCC(Nc2c(=O)[nH]1)C3=C(S[Mo](=O)(=O)S3)C(O)COP(=O)(O)O>O=C=O.*[Fe+2].*[Fe+2].[H+].[H+] Formate dehydrogenase (cytochrome) OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formate dehydrogenase OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formate dehydrogenase OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formate dehydrogenase OC(=O)CNC=N>>NCC(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1 Glycine formimino transferase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC=O>>OC=O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Formyl-CoA hydrolase OC(=O)CCC(C(CCC(=O)NC(CCC(=O)NC(CCC(=O)NCCc1ccc(OCc2coc(CNC=O)c2)cc1)C(=O)O)C(=O)O)C(=O)O)C(=O)O>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C=O.NCc1cc(COc2ccc(CCNC(=O)CCC(NC(=O)CCC(NC(=O)CCC(C(CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)O)cc2)co1 Formylmethanofuran-THMPT formyltransferase OC(=O)C=CC(=O)O>>OC(CC(=O)O)C(=O)O Fumarate hydratase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Cellulose synthase (GDP-forming) CC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C>[Mg+2]>CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C.OP(=O)(O)OP(=O)(O)O Geranyl-trans-transferase NC(C(O)C(O)C(O)CO)C(=O)O>O>OCC(O)C(O)CC(=O)C(=O)O.N Aminodeoxygluconate dehydratase *C(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC.OCC1OC(O)C(O)C(O)C1O Glucosylceramidase *C(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC>>CCCCCCCCCCCCCCCCCC(=O)NCC(OC1OC(CO)C(OC2OC(CO)C(OC3OC(CO)C(O)C(OC4OC(CO)C(O)C(O)C4O)C3NC(=O)C)C(OC5(CC(O)C(N)C(O5)C(O)C(O)CO)C(=O)O)C2O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=CCC(=O)O>OC(=O)CCCCC1SCC2NC(=O)NC12>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O Glutaryl-CoA dehydrogenase OC(=O)CCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutarate-CoA ligase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=CCC(=O)O.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Glutaryl-CoA dehydrogenase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=CCC(=O)O.[*H2] Glutaryl-CoA dehydrogenase NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Glutathione reductase NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>>*SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O.*SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O.[H+].[H+] Glutathione transferases (Detoxification reactions) NCCOP(=O)(O)OCC(O)CO>>OCC(O)COP(=O)(O)O.NCCO Glycerophosphocholine phosphodiesterase OCC(O)CO>>CC(O)C=O.O Glycerol dehydratase OCC(O)CO>>OCC(O)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glycerol hydrogenase (NADP+) OCC(O)CO>>OCC(O)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glycerol hydrogenase (NADP+) OCC(=O)COP(=O)(O)O>>OC(COP(=O)(O)O)C=O Triose-P isomerase NCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>*.NCSC(CCS)CCCCC=O.O=C=O Glycine dehydrogenase (decarboxylating) NCC(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)CN)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Glycine-tRNA ligase NCC(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OC(=O)C=O.OO.N D-Amino acid oxidase NCC(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>OC(=O)C=O.N.OO D-Aminoacid oxidase NCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)C=O.NC(CCC(=O)O)C(=O)O Glycine transaminase NCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)C=O.CC(N)C(=O)O Glycine transaminase NCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CO)C(=O)O.OC(=O)C=O Serineglyoxylate transaminase CC(CCC(=O)NCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NCC(=O)O Choloylglycine hydrolase *.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O>>*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O Phosphorylase phosphatase OCC(=O)O>>OC(=O)C=O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C (S)-2-Hydroxy-acid oxidase OCC(=O)O>>OC(=O)C=O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C (S)-2-Hydroxyacid oxidase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)CN)C1O>>* OC(=O)C=O>>OCC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glyoxylate reductase OC(=O)C=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCC(=O)O.OC(=O)CCC(=O)C(=O)O.CC(=O)C(=O)O Alanine glyoxylate transaminase OC(=O)C=O>>OCC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glyoxylate reductase OC(=O)C=O>>OC(=O)C(=O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C (S)-3-Hydroxyacid ester dehydrogenase OC(=O)C=O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glyoxylate dehydrogenase (acylating) OC(=O)C=O>>OC(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Malate synthase OC(=O)C=O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.[Mg+2]>OC(C=O)C(=O)O.O=C=O Tartronate-semialdehyde synthase NC(=N)NCC(=O)O>>CN(CC(=O)O)C(=N)N.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] Guanidinoacetate methyl-transferase NC(=N)NCC(=O)O>>OC(=O)CNC(=N)NP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Guanidinoacetate kinase Nc1nc2[nH]cnc2c(=O)[nH]1>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(CO)C(O)C3O.OP(=O)(O)O Purine nucleoside phosphorylase Nc1nc2[nH]cnc2c(=O)[nH]1>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Hypoxanthine P-ribosyltransferase Nc1nc2[nH]cnc2c(=O)[nH]1>>O=c1[nH]c(=O)c2nc[nH]c2[nH]1.N Guanine deaminase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(CO)C(O)C3O>>Nc1nc2[nH]cnc2c(=O)[nH]1.OCC1OC(O)C(O)C1O Purine nucleosidase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)O Nucleoside diphosphatase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.* Nucleoside diphosphate kinase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(=O)[nH]c(N)nc45)C(O)C1O.OP(=O)(O)O Polyribonucleotide nucleotidyltransferase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O>[Zn+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(CO)C(O)C3O.OP(=O)(O)O 5'-Nucleotidase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O>[K+].[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Guanylate kinase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O GMP reductase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.[Mg+2].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.*.O Ribonucleoside triphosphate reductase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1nc(NCC(=O)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(N)c(=O)[nH]1.OC=O GTP Cyclohydrolase I Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O ATPases (several known) Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(=O)[nH]c(N)nc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O DNA-directed RNA polymerase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(=O)[nH]c(N)nc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O RNA-directed RNA polymerase Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>[Fe+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.*.O Ribonucleoside-diphosphate reductase OS(=O)(=O)S>>SC#N.OS(=O)=O Thiosulfate sulfurtransferase *>>CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O.CCC1=C(C)C(=CC2=NC(=Cc3[nH]c(C=C4NC(=O)C(C)C4=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O.O.O.O.[C-]#[O+].*.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.* Heme oxygenase (decycling) *S[Fe+2]12([N+]3=C4C=c5c(CCC(=O)O)c(C)c6=CC7=[N+]2C(=Cc8c(C)c(C=C)c(C=C3C(=C4CCC(=O)O)C)n81)C(=C7C)C=C)n65>>* Heme oxygenase (decycling) *S[Fe+2]12([N+]3=C4C=c5c(CCC(=O)O)c(C)c6=CC7=[N+]2C(=Cc8c(C)c(C=C)c(C=C3C(=C4CCC(=O)O)C)n81)C(=C7C)C=C)n65>>* NCCc1cnc[nH]1>[Cu+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>O=CCc1c[nH]cn1.N.OO Amine oxidase (Cu++) NCCc1cnc[nH]1>>CNCCc1c[nH]cn1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] Histamine methyltransferase OC(=O)CCC(=CC(=O)O)C(=O)O>>OC(C(CCC(=O)O)C(=O)O)C(=O)O Homoaconitate hydratase OC(=O)CCC(O)(CC(=O)O)C(=O)O>>OC(=O)CCC(=CC(=O)O)C(=O)O.O OC(=O)Cc1cc(O)ccc1O>[Fe+2]>OC(=O)CC(=O)CC(=O)C=CC(=O)O Homogentisate 1,2-dioxygenase OC(=O)Cc1cc(O)ccc1O>>CC(=CCCC(=CCC1=CC(=O)C(=C(C)C1=O)C)C)C OC(=O)Cc1cc(O)ccc1O>>CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.OP(=O)(O)OP(=O)(O)O.O=C=O.[H+].[H+] OC(C(CCC(=O)O)C(=O)O)C(=O)O>[Mg+2]>OC(=O)CCC(C(=O)O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] (Homoisocitrate dehydrogenase) OC(=O)CCC1NC(=O)NC1=O>>NC(=O)NC(CCC(=O)O)C(=O)O I>>II.O.O Iodide peroxidase I>>II.O.O Iodide peroxidase OCC(=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Hydroxypuruvate reductase OCC(=O)C(=O)O>>OCC(O)C(=O)O.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C 2-Hydroxyacid dehydrogenase OCC(=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Hydroxypuruvate reductase NCCS(=O)O>>NCCS(=O)(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Hypotaurine dehydrogenase O=c1[nH]cnc2[nH]cnc12>>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23.OP(=O)(O)O Purine nucleoside phosphorylase O=c1[nH]cnc2[nH]cnc12>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.OP(=O)(O)OP(=O)(O)O Hypoxanthine P-ribosyltransferase O=c1[nH]cnc2[nH]cnc12>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>O=c1[nH]c(=O)c2nc[nH]c2[nH]1.OO Xanthine oxidase *O>>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase A O=CCc1c[nH]c2ccccc12>>OC(=O)Cc1c[nH]c2ccccc12.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase OC(=O)C(=O)Cc1c[nH]c2ccccc12>>O=CCc1c[nH]c2ccccc12.O=C=O OC(=O)C(=O)Cc1c[nH]c2ccccc12>>OC(O)C(=O)Cc1c[nH]c2ccccc12 c1cc2ccccc2[nH]1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.[NH4+]>NC(Cc1c[nH]c2ccccc12)C(=O)O.O Tryptophan synthase OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23>>O=c1[nH]cnc2[nH]cnc12.OCC1OC(O)C(O)C1O Nucleosidase OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(NC(CC(=O)O)C(=O)O)ncnc23.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Adenylosuccinate synthase OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23>[K+].NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] IMP dehydrogenase CC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenase OC1C(OC(=C)C(=O)O)C=CC=C1C(=O)O>Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N>OC(=O)CCC(=O)c1ccccc1C(=O)O.CC(=O)C(=O)O.O=C=O.O OC1C(OC(=C)C(=O)O)C=CC=C1C(=O)O>>OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O Isochorismate synthase CC1(C)SC2C(NC(=O)CCCC(N)C(=O)O)C(=O)N2C1C(=O)O>>NC(CCCC(=O)NC1C2SCC(=C(N2C1=O)C(=O)O)CO)C(=O)O.O.OC(=O)CCC(=O)O.OC(=O)CCC(=O)O.O=C=O.O=C=O (Expandase + hydroxylase) CC1(C)SC2C(NC(=O)CCCC(N)C(=O)O)C(=O)N2C1C(=O)O>>CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O.NC(CCCC(=O)O)C(=O)O CC(C)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenase OC(=O)c1cc(O)c2ccccc2n1>>OC(=O)CCC(=O)C(=O)O.OC(=O)CC(=O)C(=O)O *C(=O)OCC(O)COP(=O)(O)OCCN>>*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS *C(=O)OCC(O)COP(=O)(O)OCCN>>NCCOP(=O)(O)OCC(O)CO.*C(=O)O Lysophospholipase C[N+](C)(C)CCOP(=O)(O)OCC(O)CO>>OCC(O)COP(=O)(O)O.C[N+](C)(C)CCO Glycerophosphocholine phosphodiesterase OC1CC(N=C1)C(=O)O>>OC1CNC(C1)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-5-carboxylate reductase OC1CC(N=C1)C(=O)O>>OC1CNC(C1)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-5-carboxylate reductase OC1CC(N=C1)C(=O)O>>NC(CC(O)C(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 1-Pyrroline-5-carboxylate dehydrogenase OC1CC(N=C1)C(=O)O>>NC(CC(O)C(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 1-Pyrroline-5-carboxylate dehydrogenase OC(=O)C1CCC=N1>>NC(CCC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 1-Pyrroline-5-carboxylate dehydrogenase OC(=O)C1CCC=N1>>NC(CCC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 1-Pyrroline-5-carboxylate dehydrogenase OC(=O)C1CCC=N1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-5-carboxylate reductase OC(=O)C1CCC=N1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-5-carboxylate reductase CC(=O)C(N)C(=O)O>>CC(=O)CN.O=C=O 5-Aminolevulinate synthase NC(CCCC(=O)O)C(=O)O>NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>NC(CCCC=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (2-Aminoadipate reductase) NC(CCCC(=O)O)C(=O)O>>NC(CCCC=O)C(=O)O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aminoadipate semialdehyde dehydrogenase NC(CCCC=O)C(=O)O>>NC(CCCC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aminoadipate semialdehyde dehydrogenase NC(CCCC(=O)O)C(=O)O>>NC(CCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.OP(=O)(O)OP(=O)(O)O CCCC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxyacyl-CoA dehydrogenase OC1CNC(C1)C(=O)O>>OC1CC(N=C1)C(=O)O.[*H2] L-Proline dehydrogenase OC1CNC(C1)C(=O)O>>OC1CNC(C1)C(=O)O 4-Hydroxyproline epimerase OC1CC(N=C1)C(=O)O>>NC(CC(O)C=O)C(=O)O non-enzymatic CC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(C)N)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Alanine tRNA ligase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(C)N)C1O>>* NC(CCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O>>*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O OCC(O)C(O)C(O)C=O>>OCC1(O)OCC(O)C1O L-Arabinose isomerase OCC(O)C(O)C(O)C=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O OCC(O)C(O)C(O)CO>>OCC1(O)OCC(O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Arabitol dehydrogenase (Ribulose-forming) NC(CCCNC(=N)N)C(=O)O>[Mg+2]>NC(CCCNC(=N)NP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Arginine kinase NC(CCCNC(=N)N)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>NC(=N)NCCCC(=O)N.O.O=C=O Arginine 2-monooxygenase NC(CCCNC(=N)N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCCCNC(=N)N.O=C=O Arginine decarboxylase NC(CCCNC(=N)N)C(=O)O>>[NH4+].NC(CCCNC(=O)N)C(=O)O Arginine deiminase NC(CCCNC(=N)N)C(=O)O>>NC(CCCNC(=N)NC(CC(=O)O)C(=O)O)C(=O)O Argininosuccinate lyase NC(CCCNC(=N)N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCNC(=N)N)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O L-Arginyl-tRNA ligase NC(CCCNC(=N)N)C(=O)O>[Co+2]>NCCCC(N)C(=O)O.NC(=O)N Arginase NC(CCCNC(=N)N)C(=O)O>>NCCCC(N)C(=O)O.NC(=N)NCC(=O)O Glycine amidinotransferase NC(CCCNC(=N)N)C(=O)O.NC(CCCNC(=N)N)C(=O)O>CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>[N]=O.[N]=O.O.O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(CCCNC(=O)N)C(=O)O.NC(CCCNC(=O)N)C(=O)O Nitric oxide synthase NC(CCCNC(=N)NC(CC(=O)O)C(=O)O)C(=O)O>[Mg+2]>NC(CCCNC(=O)N)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.NC(CC(=O)O)C(=O)O Argininosuccinate synthetase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCNC(=N)N)C1O>>* OCC(O)C1OC(=O)C(=C1O)O>>OCC(O)C1OC(=O)C(=O)C1O non-enzymatic OCC(O)C1OC(=O)C(=C1O)O>[Cu+2]>OCC(O)C1OC(=O)C(=O)C1=O.O Ascorbate oxidase OCC(O)C1OC(=O)C(=C1O)O>[Fe+2]>OCC(O)C(O)C(=O)O.OC(=O)C(=O)O Ascorbate-2,3-dioxygenase NC(CC(=O)N)C(=O)O>>NC(CC(=O)O)C(=O)O.N Asparaginase NC(CC(=O)N)C(=O)O>>NC(=O)CC(=O)C(=O)O.NCC(=O)O Asparagine-oxo acid transaminase NC(CC(=O)O)C(=O)O>>NC(CCC(=O)O)C(=O)O.OC(=O)CC(=O)C(=O)O Aspartate transaminase NC(CC(=O)O)C(=O)O>[Co+2]>OC(=O)C=CC(=O)O.N Aspartate ammonia-lyase NC(CC(=O)O)C(=O)O>[Mg+2]>NC(CC(=O)N)C(=O)O.OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Aspartate ammonialigase NC(CC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(N)C(=O)O.O=C=O Aspartate-4-decarboxylase NC(CC(=O)O)C(=O)O>>NC(=O)NC(CC(=O)O)C(=O)O.OP(=O)(O)O Aspartate carbamoyltransferase NC(CC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)CC(=O)C(=O)O.NC(CCC(=O)O)C(=O)O Aspartate transaminase NC(CC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCC(=O)O.O=C=O Aspartate-1-decarboxylase NC(CC=O)C(=O)O>>OC(=O)C1CC=CC(=N1)C(=O)O.O.O (Dihydrodipicolinate synthase) NC(CC=O)C(=O)O>[K+]>NC(CCO)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Homoserine dehydrogenase NC(CC=O)C(=O)O>[K+]>NC(CCO)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Homoserine dehydrogenase NC(CCSCC(N)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCS)C(=O)O.N.CC(=O)C(=O)O Cystathionine beta-lyase NC(CS(=O)(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCS(=O)(=O)O.O=C=O Sulfinoaniline decarboxylase NC(CS)C(=O)O>[Fe+2].NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>NC(CS(=O)O)C(=O)O Cysteine dioxygenase NC(CS)C(=O)O>>OC(=O)C(=O)CS.NC(CCC(=O)O)C(=O)O Cysteine transaminase NC(CS)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCSCC(N)C(=O)O)C(=O)O.OC(=O)CCC(=O)O O-Succinylhomoserine (thiol)-lyase NC(CS)C(=O)O>>NC(CS(=O)(=O)O)C(=O)O.S Cysteine lyase NC(CS)C(=O)O>>CC(=O)C(=O)O.N.S Cystathionine beta-lyase NC(CSSCC(N)C(=O)O)C(=O)O>>CC(=O)C(=O)O.NC(CSS)C(=O)O.N Cystathionine beta-lyase OCC(O)C1OC(=O)C(=O)C1=O>>OCC(O)C(O)C(=O)C(=O)C(=O)O NC(Cc1ccc(O)c(O)c1)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>NCCc1ccc(O)c(O)c1.O=C=O (DOPA decarboxylase) aromatic L-amino acid decarboxylase CNCC(O)c1ccc(O)c(O)c1>>COc1cc(ccc1O)C(O)C(=O)O Catechol methyltransferase NC(CCC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>NCCCC(=O)O.O=C=O Glutamate decarboxylase NC(CCC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O Alanine transaminase NC(CCC(=O)O)C(=O)O>[Mg+2]>NC(CCC(=O)N)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutamate ammonia ligase NC(CCC(=O)O)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCC(=O)O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutamate-tRNA ligase NC(CCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CS)C(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutamatecysteine ligase NC(CCC(=O)O)C(=O)O>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>CC(C(N)C(=O)O)C(=O)O Methylaspartate mutase NC(CCC(=O)O)C(=O)O>>CC(=O)NC(CCC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Aminoacid acetyltransferase NC(CCC=O)C(=O)O>>OC(=O)C1CCC=N1.O non-enzymatic NC(CCC(=O)N)C(=O)O>>NC(CCC(=O)O)C(=O)O.N Glutaminase NC(CCC(=O)OP(=O)(O)O)C(=O)O>>NC(CCC=O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)O Glutamate-5-semialdehyde dehydrogenase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCC(=O)O)C1O>>NC1CCC(=O)OC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.*C1OC(COP(=O)(O)OC2C(O)C(*)OC2COP(=O)(O)OC3C(O)C(*)OC3CO)C(O)C1O (Glutamyl-tRNA(Glu) reductase) *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCC(=O)O)C1O>>* OCC(O)C1OC(=O)C(O)C1O>>OCC(O)C1OC(=O)C(=O)C1O.OO L-Gulonolactone oxidase OCC(O)C1OC(=O)C(O)C1O>>OCC(O)C(O)C(O)C(O)C(=O)O Glucono-3-lactonase NC(Cc1c[nH]cn1)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCc1cnc[nH]1.O=C=O Histidine decarboxylase NC(Cc1c[nH]cn1)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4cnc[nH]4)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O NC(Cc1c[nH]cn1)C(=O)O>[Zn+2]>OC(=O)C=Cc1cnc[nH]1.N Histidine ammonia lyase NC(CO)Cc1cnc[nH]1>>NC(Cc1c[nH]cn1)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+] Histidinol dehydrogenase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4cnc[nH]4)C1O>>* NC(CCS)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.[K+]>NC(CCSCC(N)C(=O)O)C(=O)O.O Cystathionine beta-synthase NC(CCS)C(=O)O>C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23.[Mg+2]>CSCCC(N)C(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 5-Methyl-THF-homocysteine methyltransferase NC(CCS)C(=O)O>OP(=O)(O)O.[Mg+2]>CSCCC(N)C(=O)O.CC(OC(=O)C(N)CCC(=O)O)C(OC(=O)C(N)CCC(=O)O)C1=CNc2nc(N)nc(OC(=O)C(N)CCC(=O)O)c2N1 5-Methyltetrahydropteroyl-(Glu)3-homocysteine methyltransferase NC(CCS)C(=O)O>>CSCCC(N)C(=O)O.CN(C)CC(=O)O.[H+] Betaine-homocysteine methyltransferase NC(CCS)C(=O)O>>NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.O Adenosylhomocysteinase NC(CCO)C(=O)O>>NC(CCOC(=O)CCC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS (Homoserine succinyltransferase) CCC(C)C(N)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CCC(C)C(=O)C(=O)O.N.OO L-Amino acid oxidase CCC(C)C(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CCC(C)C(=O)C(=O)O.NC(CCC(=O)O)C(=O)O Branched-chain-amino acid transaminase CCC(C)C(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)CC)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Isoleucyl-tRNA ligase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)CC)C1O>>* NC(CC(=O)c1ccccc1N)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>NC(CC(=O)c1cccc(O)c1N)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Kynurenine 3-monooxygenase NC(CC(=O)c1ccccc1N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>Nc1ccccc1C(=O)O.CC(N)C(=O)O Kynureninase NC(CC(=O)c1ccccc1N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)c1cc(O)c2ccccc2n1.NC(CCC(=O)O)C(=O)O.O Kynurenine transaminase CC(O)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>CC(=O)O.O=C=O.O Lactate 2-monooxygenase CC(O)C(=O)O>>CC(O)C(=O)O Lactate racemase CC(O)C(=O)O>>CC(=O)C(=O)O.[*H][Fe+2].[*H][Fe+2] Lactate dehydrogenase (cytochrome) CC(C)CC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CC(C)C)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Leucyl-tRNA ligase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CC(C)C)C1O>>* NCCCCC(N)C(=O)O>>NCCCCCN.O=C=O Lysine decarboxylase NCCCCC(N)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O NCCCCC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCCN)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Lysine-tRNA ligase NCCCCC(N)C(=O)O>>CC(=O)NCCCCC(N)C(=O)O.OP(=O)(O)O epsilon-Lysine acetyltransferase NCCCCC(N)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Saccharopine dehydrogenase (NAD+, L-Lysine forming) NCCCCC(N)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Saccharopine dehydrogenase (NADP+, L-Lysine forming) *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCCN)C1O>>*NC(=O)C(CCCCN)NC(=O)*.*C1OC(COP(=O)(O)OC2C(O)C(*)OC2COP(=O)(O)OC3C(O)C(*)OC3CO)C(O)C1O OCC(O)C(O)C(O)C(=O)O>>OCC1OC(=O)C(=C1O)O.O.O CS(=O)CCC(N)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*>CSCCC(N)C(=O)O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Mehionine S-oxide reductase CSCCC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCSC)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Methionine-tRNA ligase CSCCC(N)C(=O)O>[Mg+2].[K+]>C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)O Methionine adenosyltranferase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCSC)C1O>[Mg+2]>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(CCSC)NC=O)C1O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Methionyl-tRNA formyltransferase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCSC)C1O>>* NCC(O)c1ccc(O)c(O)c1>>CNCC(O)c1ccc(O)c(O)c1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] (Phenylethanolamine N-methyltransferase) NCC(O)c1ccc(O)c(O)c1>>COc1cc(ccc1O)C(O)C(=O)O NCCCC(N)C(=O)O>>NC(CCCNC(=O)N)C(=O)O.OP(=O)(O)O Ornithine carbamoyltransferase NCCCC(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCC=O)C(=O)O.NC(CCC(=O)O)C(=O)O Ornithineoxoacid transaminase NCCCC(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCCCN.O=C=O Ornithine decarboxylase NC(=O)CC(=O)C(=O)O>>OC(=O)CC(=O)C(=O)O.N omega-Amidase NC(Cc1ccccc1)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccccc4)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O NC(Cc1ccccc1)C(=O)O>[Fe+2]>NC(Cc1ccc(O)cc1)C(=O)O.O.CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O Phenylalanine 4-monooxygenase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccccc4)C1O>>* OC(=O)C1CCCCN1>>OC(=O)C1CCCC=N1.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C (L-Pipecolate dehydrogenase) OC(=O)C1CCCN1>>OC(=O)C1CCC=N1.[*H2] L-Proline dehydrogenase OC(=O)C1CCCN1>OCC(O)C1OC(=O)C(=C1O)O>OC1CNC(C1)C(=O)O.O=C=O.OC(=O)CCC(=O)O Procollagenproline-2-oxoglutarate dioxygenase OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O Ribulose-P 3-epimerase OCC1(O)OCC(O)C1O>[Mg+2]>OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Ribulokinase NC(CO)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCC(=O)O.Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.O Glycine (Serine) Hydroxymethyl transferase NC(CO)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CCCCCCCCCCCCCCCC(=O)C(N)CO.O=C=O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Serine palmitoyl transferase NC(CO)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OCC(=O)C(=O)O.CC(N)C(=O)O Alanine-oxoacid transaminase NC(CO)C(=O)O>[Mg+2]>*C(=O)OCC(COP(=O)(O)OCC(N)C(=O)O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 CDP-Diacylglycerol-serine phosphatidyltransferase NC(CO)C(=O)O>>CC(=O)C(=O)O.N 2-Serine dehydratase OCC(O)C(O)C(=O)O>>OCC(=O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Threonate dehydrogenase CC(O)C(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.O>CCC(=O)C(=O)O.N Threonine dehydratase CC(O)C(N)C(=O)O>>CC(=O)C(N)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Threonine 3-dehydrogenase NC(Cc1c[nH]c2ccccc12)C(=O)O>[Fe+2]>NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O.O.CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O Tryptophan 5-monooxygenase NC(Cc1c[nH]c2ccccc12)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.[K+]>c1cc2ccccc2[nH]1.CC(=O)C(=O)O.N Tryptophanase NC(Cc1c[nH]c2ccccc12)C(=O)O>>OC(=O)C(=O)Cc1c[nH]c2ccccc12.OO.N L-Amino acid oxidase NC(Cc1c[nH]c2ccccc12)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(=O)C(=O)Cc1c[nH]c2ccccc12.NC(CCC(=O)O)C(=O)O Tryptophan transaminase NC(Cc1c[nH]c2ccccc12)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4c[nH]c5ccccc45)C1O.OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O NC(Cc1c[nH]c2ccccc12)C(=O)O>>NC(CC(=O)c1ccccc1NC=O)C(=O)O Tryptophan 2,3-dioxygenase)-pyrrolase NC(Cc1c[nH]c2ccccc12)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O>NCCc1c[nH]c2ccccc12.O=C=O Aromatic L-amino acid decarboxylase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4c[nH]c5ccccc45)C1O>>* NC(Cc1ccc(O)cc1)C(=O)O>[Fe+2]>NC(Cc1ccc(O)c(O)c1)C(=O)O.CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O.O Tyrosine 3-monooxygenase NC(Cc1ccc(O)cc1)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccc(O)cc4)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O NC(Cc1ccc(O)cc1)C(=O)O>[Cu+2]>NC(Cc1ccc(O)c(I)c1)C(=O)O.I Iodide peroxidase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccc(O)cc4)C1O>>* *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)C)C1O>>* OCC(O)C(O)C(O)C(=O)O>>OCC1OC(=O)C(=C1O)O.O.O OCC(O)C(O)C(=O)CO>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O L-Xylulose reductase OCC(O)C(O)C(=O)CO>[Mg+2]>OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O L-Xylulokinase OCC(=O)C(O)C(O)COP(=O)(O)O>Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.[Mg+2]>OC(COP(=O)(O)O)C=O.CC(=O)OP(=O)(O)O.O Phosphoketolase OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O Ribulose-P-4-epimerase NC(CC(O)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>OC(CC(=O)C(=O)O)C(=O)O.NC(CCC(=O)O)C(=O)O Aspartate transaminase NC(CCC(=O)NC(CS)C(=O)O)C(=O)O>>NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutathione synthase CC(C(N)C(=O)O)C(=O)O>[Mg+2].[K+]>CC(=CC(=O)O)C(=O)O.N Methylaspartate ammonia lyase NC(CCCC(N)C(=O)O)C(=O)O>>NC(CCCC(N)C(=O)O)C(=O)O Diaminopimelate epimerase OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O beta-Galactosidase CC(O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=C.O Lactoyl-CoA dehydratase CC(O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Lactoyl-CoA dehydrogenase CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3>NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3.OC=O *C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*>>*C(=O)OCC(CO)OC(=O)*.C[N+](C)(C)CCOP(=O)(O)O Phospholipase C *C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*>>*C(=O)OCC(COP(=O)(O)O)OC(=O)*.C[N+](C)(C)CCO Phospholipase D CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2C(=CCCC2(C)C)C.[H].[H] CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2=C(C)CCCC2(C)C.[H].[H] CC1C(CCC(=O)O)C2=CC3=[N+]4[Mg+2][N+]5=C(C=C1N2)C(=C(C=C)C5=Cc6[nH]c(C=C4C(=C3CCC(=O)O)C)c(C=C)c6C)C>>COC(=O)CCC1=C(C)C2=Cc3[nH]c(C=C4C(=C(C)C5=[N+]4[Mg+2][N+]2=C1C=C6NC(=C5)C(C)C6CCC(=O)O)C=C)c(C)c3C=C.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] Magnesium protoporphyrin methyltransferase NC(=O)C=CC(=O)O>>OC(=O)C=CC(=O)O.N OC(=O)C=CC(=O)O>>OC(=O)C=CC(=O)O OC(=O)CC=O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malonate semialdehyde dehydrogenase (acetylating) OC(=O)CC=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malonate semialdehyde dehydrogenase (acylating) OC(=O)CC=O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase (acetylating) OC(=O)CC=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malonate semialdehyde dehydrogenase (acylating) OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase OC(=O)CC=O>>NCCC(=O)O.OC(=O)CCC(=O)C(=O)O 4-Aminobutyrate transaminase OC(=O)CC=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCC(=O)O.CC(=O)C(=O)O beta-Alanine-puruvate transaminase OC(=O)CC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O.CC(=O)O Malonyl-CoA transferase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O Malonyl-CoA decarboxylase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.OC(=O)CC(=O)O Malonate-CoA transferase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O Malonyl-CoA decarboxylase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12.[H+] (active) Acetyl-CoA carboxylase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.O=C=O OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O alpha-Glucosidase (maltase) OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O Maltose phosphorylase CC(=CCCC(=CCc1c(C)c(O)c2ccccc2c1O)C)C>>CC(=CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C)C.[H].[H] CC(=CC(=O)O)C(=O)O>[Fe+2]>CC(O)(CC(=O)O)C(=O)O (S)-2-Methylmalate dehydratase CC(=C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(CO)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Enoyl-CoA hydratase C>[Cu+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CO.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Methane monooxygenase NCc1cc(COc2ccc(CCNC(=O)CCC(NC(=O)CCC(NC(=O)CCC(C(CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)O)cc2)co1>OS(=O)(=O)CCS>OC(=O)CCC(C(CCC(=O)NC(CCC(=O)NC(CCC(=O)NCCc1ccc(OCc2coc(CNC=O)c2)cc1)C(=O)O)C(=O)O)C(=O)O)C(=O)O.O CO>>C=O.OC(=O)c1cc2c(O)c(O)c3nc(cc(C(=O)O)c3c2[nH]1)C(=O)O Alcohol dehydrogenase (Acc) CSCCS(=O)(=O)O>CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2nc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>C.CC(OP(=O)(O)O)C(NC(=O)CCCCCCSSCCS(=O)(=O)O)C(=O)O Methyl-CoenzymeM reductase CC(=O)C=O>>CC(O)C(=O)SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O Lactoyl-glutathione lyase (glyoxylase I) CC(C(=O)O)C(=O)C(=O)O>>CCC(=O)C(=O)O.O=C=O CC(C(=O)O)C(=O)C(=O)O>>CC(C(N)C(=O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O CC(O)(CCO)CC(=O)O>[Mg+2]>CC(O)(CCOP(=O)(O)O)CC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Mevalonate kinase CC(O)(CCOP(=O)(O)OP(=O)(O)O)CC(=O)O>[Mg+2]>CC(=C)CCOP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O.O=C=O Diphosphomevalonate decarboxylase CC(O)(CCOP(=O)(O)O)CC(=O)O>[Mg+2]>CC(O)(CCOP(=O)(O)OP(=O)(O)O)CC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Phosphomevalonate kinase COC(=O)C1C(=O)C2=C(C)C3=Cc4[nH]c(C=C5C(=C(C)C6=[N+]5[Mg+2][N+]3=C2C1=C7NC(=C6)C(C)C7CCC(=O)O)C=C)c(C)c4C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Protochlorophyllide reductase (2 steps) COC(=O)C1C(=O)C2=C(C)C3=Cc4[nH]c(C=C5C(=C(C)C6=[N+]5[Mg+2][N+]3=C2C1=C7NC(=C6)C(C)C7CCC(=O)O)C=C)c(C)c4C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Protochlorophyllide reductase (2 steps) COC(=O)CCC1=C(C)C2=Cc3[nH]c(C=C4C(=C(C)C5=[N+]4[Mg+2][N+]2=C1C=C6NC(=C5)C(C)C6CCC(=O)O)C=C)c(C)c3C=C>>COC(=O)C1C(=O)C2=C(C)C3=Cc4[nH]c(C=C5C(=C(C)C6=[N+]5[Mg+2][N+]3=C2C1=C7NC(=C6)C(C)C7CCC(=O)O)C=C)c(C)c4C=C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O NC(Cc1ccc(O)c(I)c1)C(=O)O>[Cu+2]>NC(Cc1cc(I)c(O)c(I)c1)C(=O)O.I Iodide peroxidase OC1C(O)C(Nc2ccccc2C(=O)O)OC1COP(=O)(O)O>>OC(COP(=O)(O)O)C(O)C(=O)CNc1ccccc1C(=O)O Phosphoribosylanthranilate isomerase CC(=O)NC(CCCN)C(=O)O>>NCCCC(N)C(=O)O.CC(=O)O Acetylornithine deacetylase CC(=O)NC(CCCN)C(=O)O>>NCCCC(N)C(=O)O.CC(=O)NC(CCC(=O)O)C(=O)O Glutamate acetyltransferase CC(=O)NC(CCCN)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)NC(CCC=O)C(=O)O.NC(CCC(=O)O)C(=O)O Acetylornithine transaminase CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)O>[Mg+2]>CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O.OP(=O)(O)OP(=O)(O)O UDP-N-Acetylglucosamine pyrophosphorylase NC1C(O)OC(CO)C(O)C1O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Glucosamine acetyltransferase CC(=O)NC1C(O)OC(CO)C(O)C1O>>NC1C(O)OC(CO)C(O)C1O.CC(=O)O CC(=O)NC1C(O)OC(CO)C(O)C1O>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3>CC(=O)NC1C(O)OC(CO)C(O)C1O N-Acylglucosamine 2-epimerase CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O N-Acylglucosamine 6-P 2-epimerase CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)O Phoshoacetylglucosamine mutase CC(=O)NC1C(O)OC(CO)C(O)C1O>[Mg+2]>CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O.OP(=O)(O)O N-Acetylneuraminate synthase CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)COP(=O)(O)O)C(=O)O.OP(=O)(O)O N-Acyl neuraminate 9-P-synthase CC(=O)NC(CCC(=O)O)C(=O)O>>CC(=O)NC(CCC(=O)OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O N-Acetylglutamate kinase CC(=O)NC(CCC(=O)OP(=O)(O)O)C(=O)O>>CC(=O)NC(CCC=O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)O N-Acetyl-gamma-glutamyl-P reductase CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O>>CC(=O)NC1C(O)CC(OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(N)nc3=O)(OC1C(O)C(O)CO)C(=O)O.OP(=O)(O)OP(=O)(O)O Acylneuraminate cytidylyltransferase CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.CC(=O)C(=O)O N-Acetylneuraminate lyase NC(=O)NC(CC(=O)O)C(=O)O>>OC(=O)C1CC(=O)NC(=O)N1.O Dihydroorotase NC(=O)NC(CC(=O)O)C(=O)O>>NC(CC(=O)O)C(=O)O.O=C=O.N Ureidosuccinate CN(CC(=O)O)C(=O)N>>CNCC(=O)O.O=C=O.N N-Carbamoylsarcosine amidase NC(=O)NC(CCC(=O)O)C(=O)O>>NC(CCC(=O)O)C(=O)O.N.O=C=O OC(=O)CCC(NC=N)C(=O)O>>NC(CCC(=O)O)C(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1 Glutamate formiminotransferase *C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(CCSC)NC=O)C1O>>* NC(CC(=O)c1ccccc1NC=O)C(=O)O>>NC(CC(=O)c1ccccc1N)C(=O)O.OC=O Formamidase CN1CC(=O)NC1=O>>CN(CC(=O)O)C(=O)N.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O N-Methylhydantoinase (ATP hydrolyzing) CC(C)(CO)C(O)C(=O)NCCC(=O)NC(CS)C(=O)O>>CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS.O=C=O Pantothenoylcysteine decarboxylase OC(=O)CCC(=O)NC(CCCC(=O)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCCC(NC(=O)CCC(=O)O)C(=O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O Succinyl-diaminopimelate transaminase NC(CCCC(NC(=O)CCC(=O)O)C(=O)O)C(=O)O>[Co+2]>NC(CCCC(N)C(=O)O)C(=O)O.OC(=O)CCC(=O)O Succinyl-diaminopimelate desuccinylase CC(=O)NCCCCC(N)C(=O)O>>CC(=O)NCCCCC(=O)C(=O)O.NC(CCC(=O)O)C(=O)O N6-Acetyl-beta-L-lysine transaminase NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dehydrogenases NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1cccnc1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(O)C(O)C4O)C(O)C3O.[H+] NAD(P) nucleosidase NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O.O NADH peroxidase NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dehydrogenases NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O NAD(P) transhydrogenase NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O>[Mg+2]>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)OP(=O)(O)O NMN-Adenyltransferase NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(CO)C(O)C2O.OP(=O)(O)O NC(=O)c1ccc[n+](c1)C2OC(CO)C(O)C2O>>NC(=O)c1cccnc1.OCC1OC(O)C(O)C1O.[H+] NC(=O)c1cccnc1>[Mg+2]>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O.OP(=O)(O)OP(=O)(O)O OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(c2)C(=O)O>[Mg+2]>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)[n+]5cccc(c5)C(=O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Nicotinamide nucleotide adenylyltransferase OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(c2)C(=O)O>[Mg+2]>OC(=O)c1cccnc1.OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.[H+] Nicotinate phosphoribosyltransferase OC(=O)c1cccnc1>>OC(=O)c1ccc(O)nc1 N#N>>[NH4+].[NH4+].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.*.*.*.*.*.* Nitrogenase CC(=O)OCC[N+](C)(C)C>>C[N+](C)(C)CCO.CC(=O)O Acetylcholin esterase CC(=O)OCC(N)C(=O)O>>NC(CS)C(=O)O.CC(=O)O O-Acetylserine (thiol)lyase CC(=O)OCC(N)C(=O)O>>NC(CO)C(=O)O.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Serine acetyltransferase C[N+](C)(C)CCOP(=O)(O)O>[Mg+2]>C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O.OP(=O)(O)OP(=O)(O)O Phosphorylcholine cytidylyltransferase NCCOP(=O)(O)O>[Mg+2]>NCCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O.OP(=O)(O)OP(=O)(O)O Ethanolamine-P cytidylyltransferase NC(CCOC(=O)CCC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(CCS)C(=O)O.OC(=O)CCC(=O)O O-Succinylhomoserine (thiol)-lyase *C(=O)OCC(COP(=O)(O)OCC(N)C(=O)O)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*.O=C=O Phosphatidylserine decarboxylase OC1C(CC(=CC1OP(=O)(O)O)C(=O)O)OC(=C)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O.OP(=O)(O)O Chorismate synthase OC(=O)c1cc(=O)[nH]c(=O)[nH]1>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)O)n2c(cc(=O)[nH]c2=O)C(=O)O.OP(=O)(O)OP(=O)(O)O Orotate P-ribosyltransferase OC1C(O)C(OC1COP(=O)(O)O)n2c(cc(=O)[nH]c2=O)C(=O)O>>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.O=C=O Orotidine-5'-P decarboxylase OC(=O)C(=O)O>>OC=O.O=C=O Oxalate decarboxylase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C(=O)O>>OC(=O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O Oxalate CoA-transferase OC(=O)CCC(C(=O)O)C(=O)C(=O)O>[Mg+2]>OC(=O)CCCC(=O)C(=O)O.O=C=O (Homoisocitrate dehydrogenase) OC(=O)CC(C(=O)O)C(=O)C(=O)O>>OC(=O)CCC(=O)C(=O)O.O=C=O Isocitrate dehydrogenase (NADP) CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC=O.O=C=O Oxalyl-CoA decarboxylase OC1C(O)C(O)C(O)C(O)C1O>[Fe+2]>OC1OC(C(O)C(O)C1O)C(=O)O myo-Inositol oxygenase OC1C(O)C(O)C(O)C(O)C1O>[Fe+2]>OC1OC(C(O)C(O)C1O)C(=O)O myo-Inositol oxygenase OP(=O)(O)OP(=O)(O)O>[Mg+2]>OP(=O)(O)O.OP(=O)(O)O Pyrophosphatase OC(=O)c1cc2c(O)c(O)c3nc(cc(C(=O)O)c3c2[nH]1)C(=O)O>>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O.[H+].[H+].*[Fe+2].*[Fe+2] CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS>[Mg+2]>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Pantetheine kinase *.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O>>*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O CC(C)(CO)C(O)C(=O)NCCCO>>CC(C)(CO)C(O)C(=O)NCCC(=O)O CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O>>CC1(C)SC2C(N)C(=O)N2C1C(=O)O.OC(=O)Cc1ccccc1 Penicillin amidase CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O>>CC1(C)SC(NC1C(=O)O)C(NC(=O)Cc2ccccc2)C(=O)O beta-Lactamase OC(=O)C(=O)Cc1ccccc1>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(Cc1ccccc1)C(=O)O.OC(=O)CCC(=O)C(=O)O Tyrosine transaminase OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.OP(=O)(O)O Phosphoenolpyruvate carboxylase OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.OP(=O)(O)OP(=O)(O)O Phosphoenolpyruvate carboxykinase (pyrophosphate) OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Phosphoenolpyruvate carboxykinase (ATP) OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Phosphoenolpyruvate carboxykinase (GTP) OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2cnc3c(=O)[nH]cnc23 Phosphoenolpyruvate carboxykinase (GTP) OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O>>NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N=CNC3OC(COP(=O)(O)O)C(O)C3O Phosphoribosyl-AMP cyclohydrolase NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N=CNC3OC(COP(=O)(O)O)C(O)C3O>>NC(=O)c1ncn(C2OC(OP(=O)(O)O)C(O)C2O)c1N=CNCCC(=O)C(O)C(O)COP(=O)(O)O P-Ribosylformimino-AICAR phosphoisomerase NC(=O)c1ncn(C2OC(OP(=O)(O)O)C(O)C2O)c1N=CNCCC(=O)C(O)C(O)COP(=O)(O)O>>OC(COP(=O)(O)O)C(O)c1cnc[nH]1.NC(CCC(=O)O)C(=O)O.NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3>[Mg+2]>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)O)O3>[Mg+2]>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O (Deoxy) adenylate kinase Nc1ccn(C2CC(O)C(CO)O2)c(=O)n1>[Mg+2]>Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O (Deoxycytidine kinase) Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>[Mg+2]>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>[Mg+2]>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Cytidylate kinase Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)O)O3>[K+].[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Guanylate kinase OC1CC(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase CC(=O)O>[Mg+2]>CC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Acetate kinase CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)OP(=O)(O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Phosphate acetyltransferase C[N+](C)(C)CCO>>C[N+](C)(C)CCOP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Choline kinase CN(CC(=O)O)C(=N)N>[Mg+2]>CN(CC(=O)O)C(=N)NP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Creatine kinase Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>[Mg+2]>Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Uridine kinase Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1>[Mg+2]>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Cytidylate kinase CCCCCC(=O)OCC(CO)OC(=O)CCCCC>[Mg+2]>CCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCC.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Diacylglycerol kinase OCC1OC(O)(CO)C(O)C1O>[Mg+2]>OCC1OC(O)(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Ketohexokinase OCC1OC(O)(CO)C(O)C1O>[Mg+2]>OCC1(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Fructokinase NC1C(O)OC(CO)C(O)C1O>[Mg+2]>NC1C(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hexokinase OCC1OC(O)C(O)C(O)C1O>[Mg+2]>OC1OC(COP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hexokinase OCC(O)C(=O)O>[Mg+2]>OCC(OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glycerate kinase OCC(O)C(=O)O>[Mg+2]>OC(COP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glycerate kinase OCC1OC(O)C(O)C(O)C1O>[Mg+2]>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hexokinase OCC1OC(O)C(O)C(O)C1O>[Mg+2]>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Mannokinase OCC1OC(O)C(O)C1O>[Mg+2]>OC1OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Ribokinase OCC1(O)OCC(O)C1O>[Mg+2]>OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O D-Ribulokinase CC(CCO)CCC=C(C)CCC=C(C)CCC=C(C)C>>CC(CCOP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1 Dolichyl kinase OCC(O)CO>[Mg+2]>OCC(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glycerol kinase NC(CC(=O)O)C(=O)O>[Mg+2]>NC(CC(=O)OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Aspartate kinase NC(CCC(=O)O)C(=O)O>>NC(CCC(=O)OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glutamate 5-kinase NC(CCO)C(=O)O>[Mg+2]>NC(CCOP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Homoserine kinase CC(=O)NC1C(O)OC(CO)C(O)C1O>>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O N-Acetylglucosamine kinase CC(=O)NC1C(O)OC(CO)C(O)C1O>[Mg+2].[K+]>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O N-acyl-D-Mannosamine kinase NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>[Mg+2]>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O NAD kinase NCC(O)CCC(N)C(=O)O>[Mg+2]>NCC(CCC(N)C(=O)O)OP(=O)(O)O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hydroxylysine kinase Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Thymidine kinase Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O Thymidine kinase OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Uridine kinase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>[Mg+2]>OC1C(O)C(COP(=O)(O)O)OC(OP(=O)(O)O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Phosphoglucokinase OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>[Mg+2]>OC1C(O)C(COP(=O)(O)O)OC(OP(=O)(O)O)C1O.OCC1OC(O)C(O)C(O)C1O Glucose-1-P-phosphodismutase OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>OCC1(OP(=O)(O)O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 6-Phosphofructo-2-kinase OCC1(O)OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.* 6-Phosphofructo-1-kinase CC(C)CCCC(C)CCCC(C)CCCC(=CCC12OC2(C)C(=O)c3ccccc3C1=O)C>>CC(=CCCC(=CCCC(=CCCC(=CCc1c(C)c(O)c2ccccc2c1O)C)C)C)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OC1CSSCC1O.O CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C.OP(=O)(O)OP(=O)(O)O CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C>>CC(C)CCCC(C)CCCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C.OP(=O)(O)OP(=O)(O)O CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C>>CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.OP(=O)(O)OP(=O)(O)O CCCCCC=CCC=CCC=CCC=CCCCC(=O)O>>CCCCCC(O)C=CC1C(O)CC2OC(=CCCCC(=O)O)CC12 Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]>*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4cnc5c(N)ncnc45)O1.OP(=O)(O)OP(=O)(O)O DNA-directed DNA polymerase Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]>*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4cnc5c(=O)[nH]c(N)nc45)O1.OP(=O)(O)OP(=O)(O)O DNA-directed DNA polymerase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(N)ncnc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O RNA-directed RNA polymerase Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(N)ncnc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O DNA-directed RNA polymerase CC(=O)NC1C(O)CC(OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(N)nc3=O)(OC1C(O)C(O)CO)C(=O)O>>* Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]>*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4cc(C)c(=O)[nH]c4=O)O1.OP(=O)(O)OP(=O)(O)O DNA-directed DNA polymerase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>*C1OC(C(OC2OC(C(*)C(O)C2O)C(=O)OC)C(O)C1O)C(=O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O>>*.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O>>*.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(=O)[nH]c4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O RNA-directed RNA polymerase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(=O)[nH]c4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O DNA-directed RNA polymerase NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.NCc1[nH]cc(CCC(=O)O)c1CC(=O)O>>OCc1[nH]c(Cc2[nH]c(Cc3[nH]c(Cc4[nH]cc(CCC(=O)O)c4CC(=O)O)c(CCC(=O)O)c3CC(=O)O)c(CCC(=O)O)c2CC(=O)O)c(CCC(=O)O)c1CC(=O)O.N.N.N.N Porphobilinogen deaminase CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O>>CC1(C(CCC(=O)O)C2CC34NC(=O)CC4(C)C(CCC(=O)O)C(=N3)C=C5C(CC(=O)O)C(CCC(=O)O)C(=C6C7=NC(CC1=N2)C(CC(=O)O)C7CCC6=O)N5[Ni+])C(=O)N CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O>>CC1=C2N=C(C=C3NC(=Cc4[nH]c(Cc5[nH]c1c(CC(=O)O)c5CCC(=O)O)c(CCC(=O)O)c4CC(=O)O)C(CCC(=O)O)C3(C)CC(=O)O)C(CCC(=O)O)C2(C)CC(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O>>CC1(CC(=O)O)C(CCC(=O)O)C2=CC3=[N+]4C(=Cc5c(CCC(=O)O)c(CC(=O)O)c6C=C7[N+]8=C(C=C1N2[Fe+2]84n56)C(CCC(=O)O)C7(C)CC(=O)O)C(=C3CC(=O)O)CCC(=O)O.[H].[H].[H].[H] CC1=C2N=C(C=C3NC(=Cc4[nH]c(Cc5[nH]c1c(CC(=O)O)c5CCC(=O)O)c(CCC(=O)O)c4CC(=O)O)C(CCC(=O)O)C3(C)CC(=O)O)C(CCC(=O)O)C2(C)CC(=O)O>>CC(=O)O.O=C=O.CC1=C2[N+]3=C(C=C4[N+]5=C(C(CCC(=O)O)C4(C)C)C(=C6N7C(C(CC(=O)O)C6(C)CCC(=O)O)C8(C)[N+](=C1C(CCC(=O)O)C8(C)CC(=O)O)[Co+2]735)C)C(CCC(=O)O)C2(C)CC(=O)O CC(O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 20beta-Hydroxysteroid dehydrogenase CC(O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(=O)O CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.O.* Steroid 17alpha-monooxygenase CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>*.*>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1C(=O)CO.O.* Steroid 21-monooxygenase OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O>>OC(=O)C(=O)Cc1ccc(O)cc1.O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Prephenate dehydrogenase OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O>>OC(=O)C(=O)Cc1ccc(O)cc1.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Prephenate dehydrogenase OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O>>OC(=O)C(=O)Cc1ccccc1.O=C=O.O Prephenate dehydratase OCc1[nH]c(Cc2[nH]c(Cc3[nH]c(Cc4[nH]cc(CCC(=O)O)c4CC(=O)O)c(CCC(=O)O)c3CC(=O)O)c(CCC(=O)O)c2CC(=O)O)c(CCC(=O)O)c1CC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.O Spontaneously OCc1[nH]c(Cc2[nH]c(Cc3[nH]c(Cc4[nH]cc(CCC(=O)O)c4CC(=O)O)c(CCC(=O)O)c3CC(=O)O)c(CCC(=O)O)c2CC(=O)O)c(CCC(=O)O)c1CC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.O Uroporphyrinogen III synthase NCC(O)CCC(N)C(=O)O>>NCC(CCC(N)C(=O)O)OC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Procollagen galactosyl transferase CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>*.*>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.O.* Steroid 21-monooxygenase CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>*.*>CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C.O.* Steroid 11beta-monooxygenase CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>*.*>CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C.O.* Steroid 17alpha-monooxygenase CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C.* 3-Oxo-5beta-steroid delta4 dehydrogenase CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase CCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23>[Mg+2].[K+]>CCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Acetate-CoA ligase CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=C.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenase CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O Succinate propionate CoA transferase CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acetate ligase CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.[*H].OC(=O)CCCCC1SCC2NC(=O)NC12 Propionyl-CoA carboxylase *.CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.* *NC(=O)C(CCCCN)NC(=O)*>[Fe+2].OCC(O)C1OC(=O)C(=C1O)O>NCC(O)CCC(N)C(=O)O.OC(=O)CCC(=O)O.O=C=O Procollagenlysine-2-oxoglutarate 5-dioxygenase *>>NC(CC(C(=O)O)C(=O)O)C(=O)O.CC(C)CCCC(C)CCCC(C)CCCC(=CCC12OC2(C)C(=O)c3ccccc3C1=O)C.O Phylloquinone monooxygenase CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>* CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>* CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>*SC(C)C1=C(C)C2=[N+]3C1=Cc4c(C)c(C(C)S*)c5C=C6C(=C(CCC(=O)O)C7=[N+]6[Fe+2]3(n45)n8c(=C7)c(CCC(=O)O)c(C=O)c8=C2)C Cytochrome-heme lyase CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>CC(C)CCC(C)CCC(C)CCC(O)C1=C(C)C2=[N+]3C1=Cc4c(C)c(C=C)c5C=C6C(=C(CCC(=O)O)C7=[N+]6[Fe+2]3(n45)n8c(=C7)c(CCC(=O)O)c(C=O)c8=C2)C CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*S[Fe+2]12([N+]3=C4C=c5c(CCC(=O)O)c(C)c6=CC7=[N+]2C(=Cc8c(C)c(C=C)c(C=C3C(=C4CCC(=O)O)C)n81)C(=C7C)C=C)n65 CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*.CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>CC1C(CCC(=O)O)C2=CC3=[N+]4[Mg+2][N+]5=C(C=C1N2)C(=C(C=C)C5=Cc6[nH]c(C=C4C(=C3CCC(=O)O)C)c(C=C)c6C)C.[H].[H] (Mg chelatase) Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O>>CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O>>CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C.[H+].[H+] Ferrochelatase Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(=O)O>>Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O.O.O.O Protoporphyrinogen oxidase NCCCCN>>NCCCC=O.OO.N Amine oxidase (Cu++) NCCCCN>>NCCCCNCCCN.CSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.[H+] Spermidine synthase CC(=O)C(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[Mg+2]>CC(=O)C(C)(O)C(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N Acetolactate synthase CC(=O)C(=O)O>>*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O Pyruvate dehydrogenase CC(=O)C(=O)O>>*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(C)(O)C(=O)O CC(=O)C(=O)O>>CC(=O)O.O=C=O.*[Fe+2].*[Fe+2].[H+].[H+] Pyruvate dehydrogenase (cytochrome) CC(=O)C(=O)O>Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.[*H2].O=C=O Pyruvate synthase CC(=O)C(=O)O>C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.OC=O active Formate acetyltransferase CC(=O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O Alanine transaminase CC(=O)C(=O)O>[Zn+2]>CC(N)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Alanine dehydrogenase CC(=O)C(=O)O>[Zn+2]>CC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Lactate dehydrogenase CC(=O)C(=O)O>OC(=O)CCCCC1SCC2NC(=O)NC12.[Co+2].[Zn+2]>OC(=O)CC(=O)C(=O)O.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Methylmalonyl-CoA carboxyltransferase CC(=O)C(=O)O>>OC(=O)CC(=O)C(=O)O.[*H].OC(=O)CCCCC1SCC2NC(=O)NC12 Pyruvate carboxylase OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(C(=O)O)c2C(=O)O>>OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(c2)C(=O)O.O=C=O Quinolinate phosphoribosyltransferase (decarboxylating) OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(C(=O)O)c2C(=O)O>[Mg+2]>OC(=O)c1cccnc1C(=O)O.OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.[H+] Quinolinate phosphoribosyltransferase (decarboxylating) CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Methylmalonyl-CoA-epimerase CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Methylmalonyl-CoA-epimerase CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O L-Methylmalonyl-CoA mutase CC(N)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CC(N)C(=O)O Alanine racemase OC(=O)C1CCCN1>>OC(=O)C1CCCN1 Proline racemase NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O.OCC(O)C1OC(=O)C(=C1O)O Glutathione dehydrogenase NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O.*S.*S Glutathione transhydrogenases OCC(O)C(O)C(O)C=O>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aldehyde reductase CC(=CC=CC(=CC(=O)O)C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=CC(=CC(=O)OC1OC(C(O)C(O)C1O)C(=O)O)C)C=CC2=C(C)CCCC2(C)C CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.CCCCCCCCCCCCCCCC(=O)O Retinylpalmitate esterase *>>[*H2].NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Rubredoxin-NAD reductase CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>OC(=O)CCCCC1SCC2NC(=O)NC12>CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.[Na+].O=C=O Methylmalonyl-CoA decarboxylase OC(CC(=O)O)C(=O)O>>CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malate dehydrogenase (decarboxylating)("malic enzyme") OC(CC(=O)O)C(=O)O>>CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malate dehydrogenase (decarboxylating)("malic enzyme") CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O>>CC(O)(CCO)CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Hydroxymethylglutaryl-CoA reductase (active) CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O>>CC(O)(CCO)CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Hydroxymethylglutaryl-CoA reductase (active) CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O>[Mg+2].[Mg+2]>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)CC(=O)O Hydroxymethyl-glutaryl-CoA lyase C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23>>NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.C[n+]1cccc(c1)C(=O)O Nicotinate methyltransferase and other methyltransferases C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23>>NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.Cc1c[nH]c(=O)nc1N.[H+] DNA (cytosine-5)-Methyltransferase CC(O)(CC(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>CC(=O)C(=O)O.CC(=O)O Citramalate lyase OC(CC(=O)O)C(=O)O>>OC(=O)CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malate dehydrogenase CNCC(=O)O>[Fe+2]>NCC(=O)O.[*H2].C=O Sarcosine dehydrogenase NCCc1c[nH]c2ccc(O)cc12>>CN(C)CCc1c[nH]c2ccc(O)cc12 NCCc1c[nH]c2ccc(O)cc12>>COc1ccc2[nH]cc(CCNC(=O)C)c2c1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.[H+] OC1CC(=CC(O)C1O)C(=O)O>[Mg+2]>OC1CC(=CC(OP(=O)(O)O)C1O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Shikimate kinase OC1CC(=CC(OP(=O)(O)O)C1O)C(=O)O>>OC1C(CC(=CC1OP(=O)(O)O)C(=O)O)OC(=C)C(=O)O.OP(=O)(O)O 3-P-Shikimate-1-carboxyvinyltransferase NCCCCNCCCN>>NCCCNCCCCNCCCN.CSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.[H+] Spermine synthase CCCCCCCCCCCCCCCC(O)C(N)CO>>CCCCCCCCCCCCCC=CC(O)C(N)CO.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C *C(=O)NC(COP(=O)(O)OCC[N+](C)(C)C)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC.C[N+](C)(C)CCOP(=O)(O)O Sphingomyelin phosphodiesterase CCCCCCCCCCCCCC=CC(O)C(N)CO>>*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Sphingosine acetyltransferase CCCCCCCCCCCCCC=CC(O)C(N)CO>>CCCCCCCCCCCCCC=CC(O)C(N)COC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Sphingosine galactosyltransferase CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C>>CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1OC1(C)C)C)C)C.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Squalene monooxygenase OC(=O)CCC(=O)O>>OC(=O)C=CC(=O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Succinate dehydrogenase OC(=O)CCC=O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCCC(=O)O.OC(=O)CCC(=O)C(=O)O Aminobutyrate transaminase OC(=O)CCC=O>[Zn+2]>OCCCC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 4-Hydroxybutyrate dehydrogenase OC(=O)CCC=O>>OC(=O)CCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Succinate semialdehyde dehydrogenase (NAD(P)+) OC(=O)CCC=O>>OC(=O)CCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Succinate semialdehyde dehydrogenase (NAD(P)+) OC(=O)CCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O.OP(=O)(O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2cnc3c(=O)[nH]cnc23 Succinyl-CoA ligases CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NC(C(=O)O)C(=O)CCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 5-Aminolevulinate synthase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>>OC(=O)CCC(=O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.* 2-Oxoglutarate synthase CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>>OC(=O)CCC(=O)O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Succinyl-CoA ligases CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>[Mg+2]>OC(=O)CCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Succinyl-CoA ligases CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>>OC(=O)CCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Succinyl-CoA hydrolase OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.*OCC1OC(CO)(OCC2OC(*)(CO)C(O)C2O)C(O)C1O Levansucrase OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O.*OCC1OC(OCC2OC(OCC3OC(O*)C(O)C(O)C3O)C(O)C(O)C2O)C(O)C(O)C1O Dextransucrase OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O.OCC1OC(O)C(O)C(O)C1O alpha-Glucosidase OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O Sucrose phosphorylase OCC1OC(OC2(CO)OC(COP(=O)(O)O)C(O)C2O)C(O)C(O)C1O>>OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O.OP(=O)(O)O OS(=O)(=O)O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Sulfate adenylyltransferase CC12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.OS(=O)(=O)O Arylsulfatase OS(=O)O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>S.O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Sulfite reductase (NADPH) OS(=O)O>>OS(=O)(=O)O.OO Sulfite oxidase OS(=O)O>>OS(=O)(=O)O.[*H2] Sulfite dehydrogenase NC(CS)C(=O)O>>NC(CSSCC(N)C(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Cystine reductase (NADH) NC(CS)C(=O)O>>NC(CSSCC(N)C(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O GSH-Cystine transhydrogenase *>>* CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3Nc4c(NC3C)nc(N)[nH]c4=O>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3=Nc4c(NC3C)nc(N)[nH]c4=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] OC(C=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 2-Hydroxy-3-oxopropionate reductase OC(C=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 2-Hydroxy-3-oxopropionate reductase CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NCCS(=O)(=O)O Choloylglycine hydrolase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 19-hydroxylase) CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1O.* 3-oxo-5beta-Steroid D4 dehydrogenase CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1OC5OC(C(O)C(O)C5O)C(=O)O CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase *.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc(C(O)CCC(=O)O)[n+]1Cc2cnc(C)nc2N>>*.OC(=O)CCCCC(S)CCSC(=O)CCC(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N 2-oxoglutarate dehydrogenase system [*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Thioredoxin reductase (NADP) [*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Thioredoxin reductase (NADP) [*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Thioredoxin reductase (NADP) [*H2]>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Thioredoxin reductase (NADP) Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>>Cc1c[nH]c(=O)[nH]c1=O.OCC1OC(CC1O)OP(=O)(O)O Thymidine phosphorylase Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>>Cc1c[nH]c(=O)[nH]c1=O.OCC1OC(O)CC1O Nucleosidase Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>>Cc1c[nH]c(=O)[nH]c1=O.*CC1CC(O)C(O)O1 Nucleoside deoxyribosyltransferase Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O>>Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O.OP(=O)(O)O 5'-Nucleotidase Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O>[Mg+2]>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O dTMP kinase Cc1c[nH]c(=O)[nH]c1=O>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CC1CNC(=O)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrouracil dehydrogenase (NADP) Cc1c[nH]c(=O)[nH]c1=O>>CC1C(=O)NC(=O)NC1=O.[*H2] Uracil dehydrogenase CC=C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Enoyl-CoA hydratase [Fe+3]*[Fe+3]>>*.[Fe+2].NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Transferrin reductase [Fe+3]*[Fe+3]>>*.[Fe+3].[Fe+3] Transferrin reductase CCCCCC(=O)OCC(COC(=O)CCCCC)OC(=O)CCCCC>>CCCCCC(=O)OCC(CO)OC(=O)CCCCC.CCCCCC(=O)O Triacylglycerol lipase OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Lactose synthase OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O=C=O OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Sucrose synthase OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(OC2(CO)OC(COP(=O)(O)O)C(O)C2O)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Sucrose-P-synthase OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O UDPG-Hexose-1-P-uridyltransferase OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+] UDPG-dehydrogenase OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O (other Glucosyltransferases) OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>[Mg+2]>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O UTP-Glucose-1-P-uridylyltransferase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O=C=O UDP-Glucuronate decarboxylase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>*OC1OC(C(O)C(O)C1O)C(=O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Glucuronosyltransferase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O UDP-Arabinose epimerase CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(C)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O CC(OC1C(O)C(CO)OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C1NC(=O)C)C(=O)O>>* CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O UDP-N-Acetylglucosamine 4-epimerase CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O UDP-N-Acetyl-D-glucosamine-4-epimerase CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>CC(=O)NC1C(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)OC(CO)C(O)C1OC(=C)C(=O)O.OP(=O)(O)O UDP-N-Acetylglucosamine 1-carboxyvinyl transferase CC(=O)NC1C(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)OC(CO)C(O)C1OC(=C)C(=O)O>>CC(OC1C(O)C(CO)OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C1NC(=O)C)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O UDP-N-Acetylmuramate dehydrogenase CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>* CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>* COc1c(O)c(C)c(CC=C(C)CCC=C(C)C)c(O)c1OC>>COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)CCC=C(C)C.[H].[H] COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)C>>COc1c(O)c(C)c(CC=C(C)C)c(O)c1OC.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C O=c1cc[nH]c(=O)[nH]1>[Fe+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>O=C1CCNC(=O)N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrouracildehydrogenase (NADP) O=c1cc[nH]c(=O)[nH]1>>O=C1CCNC(=O)N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrouracil dehydrogenase (NAD) O=c1cc[nH]c(=O)[nH]1>>O=C1CC(=O)NC(=O)N1.[*H2] Uracil dehydrogenase O=c1cc[nH]c(=O)[nH]1>>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.OP(=O)(O)OP(=O)(O)O Uracil phosphoribosyltransferase O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1>[Cu+2]>NC(=O)NC1NC(=O)NC1=O.OO.O=C=O Urate oxidase NC(=O)N>>[NH4+].OC(=O)[O-].[NH4+] Urease OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O>>O=c1cc[nH]c(=O)[nH]1.OCC1OC(OP(=O)(O)O)C(O)C1O Uridine phosphorylase OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O>>O=c1cc[nH]c(=O)[nH]1.OCC1OC(O)C(O)C1O Uridine nucleosidase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Fe+2]>OC1CC(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.*.O Ribonucleoside-diphosphate reductase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(=O)[nH]c4=O)C(O)C1O.OP(=O)(O)O Polyribonucleotide nucleotidyltransferase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.OP(=O)(O)O Nucleoside diphosphatase OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Cytidylate kinase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OC1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.*.O Ribonucleoside triphosphate reductase OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.NC(CCC(=O)O)C(=O)O CTP synthase OC(=O)C=Cc1cnc[nH]1>>OC(=O)CCC1NC=NC1=O Urocanate hydratase CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (R) 20beta-Hydroxysteroid dehydrogenase CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(=O)CO CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (R) 20beta-Hydroxysteroid dehydrogenase CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(=O)CO OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5C)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.O=C=O.O=C=O.O=C=O.O=C=O Uroporphyrinogen decarboxylase OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.[H].[H].[H].[H].[H].[H] OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.O=C=O.O=C=O.O=C=O.O=C=O Uroporphyrinogen decarboxylase OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O Uroporphyrinogen III methyltransferase OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.[H].[H].[H].[H].[H].[H] O=c1[nH]c(=O)c2nc[nH]c2[nH]1>>NC(=O)Nc1[nH]cnc1C(=O)O O=c1[nH]c(=O)c2nc[nH]c2[nH]1>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1.OO Xanthine oxidase O=c1[nH]c(=O)c2nc[nH]c2[nH]1>>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]c(=O)[nH]c23.OP(=O)(O)O Purine nucleoside phosphorylase O=c1[nH]c(=O)c2nc[nH]c2[nH]1>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23.OP(=O)(O)OP(=O)(O)O Hypoxanthine P-ribosyltransferase OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]c(=O)[nH]c23>>O=c1[nH]c(=O)c2nc[nH]c2[nH]1.OCC1OC(O)C(O)C1O Purine nucleosidase OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O GMP synthase OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.NC(CCC(=O)O)C(=O)O GMP synthase *O>[Mg+2]>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase A (+others?) *O>[Mg+2]>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase *O>>*OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O [Hydroxymethylglutaryl-CoA reductase] kinase *O>>*OP(=O)(O)OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O [Pyruvate dehydrogenase (lipoamide)] kinase *O>[Mg+2]>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase A CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>CC1(CCCC2(C)C3CCC4CC3(CC4(O)CO)CCC12)C(=O)O CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>[Mg+2]>CC(=CCCC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C)C.OP(=O)(O)OP(=O)(O)O (Polyprenyl-cis-transferases) e.g.Di-trans-poly-cis-decarpenyl transferase CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)C.CC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C Polyprenyl-trans-transferases CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>[Mg+2]>CC(C)CCCC(=CCCC(=CCCC(=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)OP(=O)(O)O Geranylgeranyl-bisphospho-geranylgeranyltransferase CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=O)C=CC=CC=C(C)C=CC1=C(C)CCCC1(C)C Retinene isomerase CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=CC(=CC(=O)O)C)C=CC1=C(C)CCCC1(C)C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Retinal dehydrogenase CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Retinol dehydrogenase CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Retinol fattyacyltransferase OC1CNC(C1)C(=O)O>>OC1CN=C(C1)C(=O)O.OO D-Aminoacid oxidase CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2C(=CCCC2(C)C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CC(O)CC1(C)C)C=CC=C(C)C=CC2C(=CC(O)CC2(C)C)C OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O>[Mg+2]>NC1OC(COP(=O)(O)O)C(O)C1O.NC(CCC(=O)O)C(=O)O.OP(=O)(O)OP(=O)(O)O Amido-P-ribosyltransferase OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O>[Mg+2]>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O.OP(=O)(O)OP(=O)(O)O ATP-Phosphoribosyl transferase OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.OP(=O)(O)OP(=O)(O)O UTP-Hexose-1-P uridylyltransferase OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O.OP(=O)(O)OP(=O)(O)O Galactose-1-P-thymidylyltransferase OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>[Mg+2]>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Glucose-1-P-guanylyl-transferase OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>[Mg+2]>OC1OC(COP(=O)(O)O)C(O)C(O)C1O Phosphoglucomutase OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O.OP(=O)(O)OP(=O)(O)O Glucose-1-P-thymidylyltransferase OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OC1OC(COP(=O)(O)O)C(O)C(O)C1O OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O UDPG-Hexose-1-P-uridyltransferase OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OCC(=O)C(O)C(O)C(O)C=O.OP(=O)=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] myo-Inositol-1-P synthase OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OCC1(O)OC(COP(=O)(O)O)C(O)C1O Glucosephosphate isomerase OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OCC1(O)OC(COP(=O)(O)O)C(O)C1O Mannose-6-P isomerase OC1OC(COP(=O)(O)O)C(O)C1O>[Mg+2]>OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Ribose-P-pyrophosphokinase *OC1OC(CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.*O alpha-Galactosidase *OC1OC(CO)C(O)C(O)C1NC(=O)C>>CC(=O)NC1C(O)OC(CO)C(O)C1O.* N-Acetyl-beta-glucosaminidase NCCC(=O)O>>CC(C)(CO)C(O)C(=O)NCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Pantoate-beta-alanineligase NCCC(=O)O>>NCCC(=O)NC(Cc1cnc[nH]1)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Carnosine synthase CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2=C(C)CCCC2(C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CC(O)CC1(C)C)C=CC=C(C)C=CC2C(=CC(O)CC2(C)C)C CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2=C(C)CCCC2(C)C>[Fe+2]>CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C beta-Carotene 15.15'-dioxygenase OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O>>OC(COP(=O)(O)O)C=O.OCC(=O)COP(=O)(O)O Fructose bisphosphate aldolase OCC1OC(O)(COP(=O)(O)O)C(O)C1O>>OCC(=O)COP(=O)(O)O.OCC(O)C=O Fructose bisphosphate aldolase (aldolase 6) OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>OCC(O)C(=O)C(O)C(O)COP(=O)(O)O Hexulose-6-P isomerase OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>NC1C(O)OC(COP(=O)(O)O)C(O)C1O.NC(CCC(=O)O)C(=O)O Glutaminefructose-6P-transaminase OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>NC1C(O)OC(COP(=O)(O)O)C(O)C1O.O Glucosamine-P isomerase OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>OCC(=O)C(O)C(O)C(O)C(O)COP(=O)(O)O.OC(COP(=O)(O)O)C=O Transaldolase *OC1OC(CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.*O beta-Glucosidase *C(=O)CC=CCCCCCC>>CCCCCCC=CCCCCCCCCCC(=O)O.* OC(=O)CC(=CC(=O)O)C(=O)O>>OC(=O)CC(=C)C(=O)O.O=C=O Aconitate decarboxylase OC(=O)CC(=CC(=O)O)C(=O)O>>OC(=O)CC(O)(CC(=O)O)C(=O)O Aconitate hydratase OC(=O)CC(=CC(=O)O)C(=O)O>>OC(C(CC(=O)O)C(=O)O)C(=O)O Aconitate hydratase CC(C)CCCC(=CCCC(=CCCC(=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CC(=CCCC(=CCCC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C.[H].[H].[H].[H].[H].[H] OC(=O)C=CC=CC(=O)O>>OC(=O)CC1=CCC(=O)O1 Muconate cycloisomerase CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1=C(C)C(=O)NC1Cc2[nH]c(C=C3N=C(CC4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C.O non-enzymatically CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O UDPG-4-epimerase Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(CC2O)n3cc(C)c(=O)[nH]c3=O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(CC2O)n3cc(C)c(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(C)C(O)C(O)C1O.Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O CC(C)C(NC(=O)C(CS)NC(=O)CCCC(N)C(=O)O)C(=O)O>[Fe+2]>CC1(C)SC2C(NC(=O)CCCC(N)C(=O)O)C(=O)N2C1C(=O)O.O.O Isopenicillin synthase OC(=O)C1CCCC(=N1)C(=O)O>>OC(=O)CCC(=O)NC(CCCC(=O)C(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS OC(=O)C1=NCCCC1>>NCCCCC(=O)C(=O)O non-enzymatic OC(=O)C1=NCCCC1>>OC(=O)C1CCCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O delta1-Piperideine-2-carboxylate reductase OC(=O)C1=NCCCC1>>OC(=O)C1CCCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O delta1-Piperideine-2-carboxylate reductase CC(=C)CCOP(=O)(O)OP(=O)(O)O>[Mg+2]>CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C.OP(=O)(O)OP(=O)(O)O CC(=C)CCOP(=O)(O)OP(=O)(O)O>[Mg+2]>CC(=CCOP(=O)(O)OP(=O)(O)O)C Isopentenyldiphosphate isomerase CC(=C)CCOP(=O)(O)OP(=O)(O)O>[Mg+2]>CC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C.OP(=O)(O)OP(=O)(O)O Dimethylallyl-trans-transferase CC(=C)CCOP(=O)(O)OP(=O)(O)O>>*C(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C.OP(=O)(O)OP(=O)(O)O Rubber cis-polyprenyl cis-transferase CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Desmosterol reductase) CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)C(=C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+].[H+] CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CCC(C=CC(C)C1CCC2C3CC=C4CC(O)CC(C)C4C3CCC12C)C(C)C.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+] CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.*.O CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O CC(C)CCCC(C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C.OO Lathosterol oxidase CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)CC4CC3>>CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1=C(C)C(=O)NC1Cc2[nH]c(C=C3N=C(CC4NC(=O)C(=C4C)CC)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C.O non-enzymatically CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(CC)C4C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C *OP(=O)(O)O>>*O.OP(=O)(O)O [Acetyl-CoA carboxylase] phosphatase *>[Fe+2]>* *OP(=O)(O)O>>*O.OP(=O)(O)O *OP(=O)(O)OP(=O)(O)O>>*O.OP(=O)(O)O.OP(=O)(O)O [Hydroxymethylglutaryl-CoA reductase (NADPH)] phosphatase *OP(=O)(O)OP(=O)(O)OP(=O)(O)O>>*O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O [Pyruvate dehydrogenase (lipoamide)] phosphatase *OP(=O)(O)O>>*O.OP(=O)(O)O [Pyruvate kinase] phophatase CCC1C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(CC)C4C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1C(C)C(=O)NC1Cc2[nH]c(C=C3N=C(CC4NC(=O)C(CC)C4C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C.O non-enzymatically OCC1OC(OC2C(O)C(O)C(OC3C(O)C(O)C(O)OC3CO)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O alpha-dextrin-endo-1,4-Glucosidase NC(CCCC(N)C(=O)O)C(=O)O>Cc1ncc(COP(=O)(O)O)c(C=O)c1O>NCCCCC(N)C(=O)O.O=C=O Diaminopimelate decarboxylase OC1C(O)C(O)C(O)C(O)C1O>>*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(O)C(O)C1O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 CDP-Diacylglycerolinositol-3-phosphatidyltransferase OC1C(O)C(O)C(O)C(O)C1O>>*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(O)C(O)C1O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 CDP-diacyl-glycerol-inositol phosphadyltransferase CC(OP(=O)(O)O)C(NC(=O)CCCCCCSSCCS(=O)(=O)O)C(=O)O>>OS(=O)(=O)CCS.CC(OP(=O)(O)O)C(NC(=O)CCCCCCS)C(=O)O Heterodisulfide reductase, hydrogenase *.CC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS *.CC(C)CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC(C)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS CC(O)C1=Nc2c(NC1C)nc(N)[nH]c2=O>[Mg+2]>CC(OP(=O)(O)OP(=O)(O)O)C1=Nc2c(NC1C)nc(N)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O *C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O)OC(=O)*>>OC1C(O)C(OP(=O)(O)O)C(O)C(O)C1OP(=O)(O)O.*C(=O)OCC(CO)OC(=O)* Phospholipase C OC(C(CC(=O)O)C(=O)O)C(=O)O>>OC(=O)CC(C(=O)O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Isocitrate dehydrogenase (NADP) OC(C(CC(=O)O)C(=O)O)C(=O)O>>OC(=O)CCC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Isocitrate dehydrogenase (NAD+) *.CCC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CCC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenases (2 known) CCCC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Enoyl-CoA hydratase *C=CC(=O)S*S>>*C(=O)S*S.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C *C=CC(=O)S*S>>*C(=O)S*S.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O *C=CC(=O)S*S>>*C(O)CC(=O)S*S CC(=CCCC(=CCCC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C>[Mg+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C.[H].[H]