OC(=O)CCC1NC=NC1=O>>OC(=O)CCC(NC=N)C(=O)O Imidazolone propionase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Dephospho-CoA kinase
CC(C)C(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)C)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Valyl-tRNA ligase
*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*>>*C(=O)OCC(O)COP(=O)(O)OCC[N+](C)(C)C.*C(=O)O Phospholipase A2
OCC(O)COP(=O)(O)O>>OCC(=O)COP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glycerol 3-P dehydrogenase
OCC(O)COP(=O)(O)O>>OCC(=O)COP(=O)(O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Glycerol 3-P dehydrogenase
CC(=O)OC(CC(=O)O)C[N+](C)(C)C>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.C[N+](C)(C)CC(O)CC(=O)O Carnitine acetyltransferase
OC(COP(=O)(O)O)C(O)c1c[nH]c2ccccc12>>c1cc2ccccc2[nH]1.OC(COP(=O)(O)O)C=O Tryptophan synthase
*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(CO)OC(=O)*.NCCOP(=O)(O)O Phospholipase C
*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(COP(=O)(O)O)OC(=O)*.NCCO Phospholipase D
*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(O)COP(=O)(O)OCCN.*C(=O)O Phospholipase A2
*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+] Phosphatidylethanolamine methyltransferase
*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(O)C(O)C1O)OC(=O)*_[Mg+2]_*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O)OC(=O)*.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 1-Phosphatidylinositol kinase
Nc1ccc(CC(O)C(O)C(O)CO)cc1>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3=Nc4c(NC3C)nc(N)[nH]c4=O.OP(=O)(O)OP(=O)(O)O.O
CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NC(CS)C(=O)O>>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS.O=C=O P-Pantothenoylcysteine decarboxylase
CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)O>>CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NC(CS)C(=O)O.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1.OP(=O)(O)OP(=O)(O)O P-Pantothenatecysteine ligase
CC(O)C(=O)C>>CC(O)C(C)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (R,R)-Butanediol dehydrogenase
CC(C)(CO)C(O)C(=O)O>>CC(C)(CO)C(O)C(=O)NCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Pantothenate-beta-alanine ligase
CC(C)(CO)C(O)C(=O)NCCC(=O)O_[Mg+2]_CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Pantothenate kinase
CC(C)(CO)C(O)C(=O)NCCC(=O)O>>CC(C)(CO)C(O)C(=O)O.NCCC(=O)O Pantothenase
CC(=O)C(C)(O)C(=O)O>>CC(O)C(=O)C.O=C=O Acetolactate decarboxylase
CC(=O)C(C)(O)C(=O)O_[Mg+2]_CC(C)(O)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Ketol-acid reductoisomerase
CC(CO)C(=O)O>>CC(C=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxyisobutyrate dehydrogenase
CC(CO)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(CO)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 3-Hydroxyisobutyryl-CoA hydrolase
OC(=O)C1CC(=O)NC(=O)N1_[Fe+2].[Zn+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C_OC(=O)c1cc(=O)[nH]c(=O)[nH]1.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dihydro-orotate dehydrogenase
OC(=O)C1CC(=O)NC(=O)N1_[Fe+2].[Zn+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C_OC(=O)c1cc(=O)[nH]c(=O)[nH]1.OO Dihydro-orotate dehydrogenase
NC1CCC(=O)OC1O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCC(=O)CCC(=O)O Glutamate-1-semialdehyde-2,1-aminomutase
CC(C=O)C(=O)O>>CC(CN)C(=O)O.CC(=O)C(=O)O beta-Alanine-(=3-aminoisobutyrate)-pyruvate transaminase
CC(C=O)C(=O)O>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase (acylating)
CC(C=O)C(=O)O>>CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Methylmalonate semialdehyde dehydrogenase (acylating)
CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1OC1(C)C)C)C)C>>CC(CCC=C(C)C)C1CCC2(C)C3CCC4C5(CC35CCC12C)CCC(O)C4(C)C Cycloarterenol synthase
CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1OC1(C)C)C)C)C>>CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 Lanosterol synthase
*O>>*OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 3-Methyl-2-oxobutanoate dehydrogenase kinase
*OP(=O)(O)O_[Mg+2]_*O.OP(=O)(O)O Glycogen synthase D phosphatase
*OP(=O)(O)OP(=O)(O)O>>*O.OP(=O)(O)O.OP(=O)(O)O 3-Methyl-2-oxobutanoate dehydrogenase phosphatase
*O_[Mg+2]_*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase A (Phosphorylase kinase kinase)
*C(=O)OCC(O)COP(=O)(O)OCC[N+](C)(C)C>>*C(=O)O.C[N+](C)(C)CCOP(=O)(O)OCC(O)CO Lysophospholipase
OC(COP(=O)(O)O)C(=O)OP(=O)(O)O_[Mg+2]_OC(=O)C(COP(=O)(O)O)OP(=O)(O)O Bisphosphoglycerate mutase
OC(=O)c1cc(O)c2ccccc2c1O>>CC(=CCCC(=CCc1c(C)c(O)c2ccccc2c1O)C)C.OP(=O)(O)OP(=O)(O)O.O=C=O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]
CCCCCC(=O)OCC(O)CO>>OCC(O)CO.CCCCCC(=O)O Lipases
CCCCCC(=O)OCC(O)CO>>CCCCCC(=O)OCC(CO)OC(=O)CCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acylglycerol acyltransferase
OC(COP(=O)(O)O)C(O)C(=O)CNc1ccccc1C(=O)O>>OC(COP(=O)(O)O)C(O)c1c[nH]c2ccccc12.O=C=O.O Indole 3-glycerol P-synthase
*C(=O)OCC(O)COP(=O)(O)OCC[N+](C)(C)C>>*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CCCCCC(=O)OCC(O)CO_[Mg+2]_CCCCCC(=O)OCC(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Acylglycerol kinase
CCCCCCO>>CCCCCC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Alcohol dehydrogenase
CCCCCCO_OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O_CCCCCC=O.[*H2] Alkan-1-ol dehydrogenase (acceptor)
OC(=O)C1=NCCC1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-2-carboxylate reductase
OC(=O)C1=NCCC1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-2-carboxylate reductase
OC1CN=C(C1)C(=O)O>>NCC(O)CC(=O)C(=O)O non-enzymatic
OC1CN=C(C1)C(=O)O>>OC(=O)C(=O)CCC=O.N 1-Pyrroline-4-hydroxy-2-carboxylate deaminase 
OC1CN=C(C1)C(=O)O>>OC(=O)c1ccc[nH]1.O non-enzymatic
Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.O Methenyl-THF-cyclohydrolase
Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.OC=O Formyl-THF-deformylase
Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1NC=O P-Ribosylaminoimidazolecarboxamide formyltransferase
CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.* 3-Oxo-5beta-steroid delta4 dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase 
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase 
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO_*.*_CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.O.* Steroid 11beta-monooxygenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO_*.*_CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.O.* Steroid 11beta-monooxygenase
CC(=CC=O)C=CC=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C
CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C_*_CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C.O.* Steroid 17alpha-monooxygenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C_*.*_CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.O.* Steroid 21-monooxygenase
CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3>>CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)CC4CC3.O=C=O.O=C=O.O.O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CC(O)C1=O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O.OC=O
CC12CCC3C(CC=C4CC(O)CCC34C)C2CC(O)C1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Steroid-delta-isomerase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CC(O)C1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Steroid-delta-isomerase
CC(C)CCCC(C)(O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C_*.*_CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.CC(C)CCC=O.O
CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O.O.CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.O.* Steroid 21-monooxygenase
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase 
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase 
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C>>CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C_*.*_CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O.CC=O 17alpha-Hydroxyprogesterone aldolase
CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CO)CC(O)C31>>CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.[H].[H]
CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1=O_*_CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OC=O.O
CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O.OC=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C=O)C2CCC1=O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O>>*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O active Phosphorylase kinase 
Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2>>Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O
Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)O)O2>>Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O
Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3>>Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)O)O3.*O
Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3>>Nc1ncnc2[nH]cnc12.OCC1OC(CC1O)OP(=O)(O)O Purine nucleoside phosphorylase
Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3>>Nc1ncnc2[nH]cnc12.OCC1OC(CC1O)OP(=O)(O)O Purine nucleoside phosphorylase
Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)O)O3_[Mg+2].[Co+2].[Ca+2]_Nc1ncnc2n(cnc12)C3CC(O)C(CO)O3.OP(=O)(O)O 5'-Nucleotidase
Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>>Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1.OP(=O)(O)O
Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1_Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]_*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4ccc(N)nc4=O)O1.OP(=O)(O)OP(=O)(O)O DNA-directed DNA polymerase
Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>>Nc1nc(=O)n(cc1CO)C2CC(O)C(COP(=O)(O)O)O2.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Deoxycytidylate hydroxymethyltransferase
Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>>OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.N Deoxycytidilate deaminase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3>>Nc1nc2[nH]cnc2c(=O)[nH]1.OCC1OC(CC1O)OP(=O)(O)O Purine nucleoside phosphorylase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3>>Nc1nc2[nH]cnc2c(=O)[nH]1.Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O Nucleoside deoxyribosyltransferase
OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O_[Mg+2]_OC1CC(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside monophosphate kinase
OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O_[Mg+2]_Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O Thymidylate synthase
OC1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OC1CC(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.OP(=O)(O)OP(=O)(O)O (Deoxy-UTP-pyrophosphatase)
OC(=O)C1CC=CC(=N1)C(=O)O>>OC(=O)C1CCCC(=N1)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrodipicolinate reductase
CCC(C)(O)C(O)C(=O)O_[Mg+2]_CCC(C)C(=O)C(=O)O.O Dihydroxyacid dehydratase
CC(C)(O)C(O)C(=O)O_[Mg+2]_CC(C)C(=O)C(=O)O.O Dihydroxyacid dehydratase
OCC(O)C(O)C(=O)C(=O)C(=O)O>>OCC(O)C(O)C(O)C(=O)O.O=C=O
OCC(O)C(O)C(=O)C(=O)C(=O)O>>OCC(O)C(O)C(O)C(=O)O.O=C=O
Nc1nc(NCC(=O)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(N)c(=O)[nH]1>>Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O.O
Nc1nc(NCC(=O)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(N)c(=O)[nH]1>>CC1Nc2nc(N)[nH]c(=O)c2N=C1C(C)(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O.O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+]
Oc1ccc(O)nc1>>NC(=O)C=CC(=O)O.OC=O
*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC=O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N Pyruvate decarboxylase
*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS Pyruvate dehydrogenase
*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(C)(O)C(=O)O>>*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O
*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>*.CC(=O)SC(CCS)CCCCC(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N Pyruvate dehydrogenase (lipoamide) complex
CCC(O)(C(=O)C)C(=O)O_[Mg+2]_CCC(C)(O)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Ketol-acid reductoisomerase
NC(=C(C=CC=O)C(=O)O)C(=O)O>>NC(=CC=CC=O)C(=O)O.O=C=O Aminocarboxymuconate semialdehyde decarboxylase
NC(C(=O)O)C(=O)CCC(=O)O>>NCC(=O)CCC(=O)O.O=C=O 5-Aminolevulinate synthase
NC(CCCC=O)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Saccharopine dehydrogenase (NAD+, L-glutamate forming)
NC(CCCC=O)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Saccharopine dehydrogenase (NADP+, L-glutamate forming)
NC(CCCC=O)C(=O)O>>OC(=O)C1CCCC=N1.O non-enzymatic
NC(=CC=CC=O)C(=O)O>>NC(=CC=CC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 2-Aminomuconate semialdehyde dehydrogenase
NC(=CC=CC=O)C(=O)O>>OC(=O)c1ccccn1.O non-enzymatic
CC(C)(CO)C(=O)C(=O)O>>CC(C)(CO)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 2-Dehydropantoate reductase
CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1O>>COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]
CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1=O>>COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]
COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1O>>COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1OC5OC(C(O)C(O)C5O)C(=O)O
COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1O>>COc1cc2C3CCC4(C)C(O)CCC4C3CCc2cc1OS(=O)(=O)O
COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1O>>COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1OC5OC(C(O)C(O)C5O)C(=O)O
COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1O>>COc1cc2C3CCC4(C)C(CCC4=O)C3CCc2cc1OS(=O)(=O)O
CC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxyacyl-CoA dehydrogenase
CCC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC=C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenase
CCC(C)C(=O)C(=O)O>>*.CCC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O 3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)
NCCCC(=O)C(=O)O>>OC(=O)C1=NCCC1.O non-enzymatic
CC(=O)NCCCCC(=O)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O
CC(=O)NCCCCC(=O)C(=O)O>>NCCCCC(=O)C(=O)O.CC(=O)O Acyl-lysine deacylase 
CCC(=O)C(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[Mg+2]_CCC(O)(C(=O)C)C(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N Acetolactate synthase
CCC(=O)C(=O)O>>CCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O L-Lactate dehydrogenase
NC(=O)CCC(=O)C(=O)O>>OC(=O)CCC(=O)C(=O)O.N omega-Amidase
OC(=O)CCC(=O)C(=O)O>>NC(CCC(=O)O)C(=O)O.NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glutamate synthase (NADPH)
OC(=O)C(=O)CCC=O>>OC(=O)CCC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] (2-Oxoglutarate semialdehyde dehydrogenase)
OC(=O)CCC(=O)C(=O)O>>OC(CCC(=O)O)C(=O)O.* 2-Hydroxyglutairate dehydrogenase
OC(=O)CCC(=O)C(=O)O>>OC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Malate dehydrogenase
OC(=O)CCC(=O)C(=O)O>>OC(=O)CCC(O)(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Homocitrate synthase
OC(=O)CCC(=O)C(=O)O_[Zn+2].Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Glutamate dehydrogenase 
OC(=O)CCC(=O)C(=O)O_[Zn+2].Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Glutamate dehydrogenase 
OC(=O)CCC(=O)C(=O)O_Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N_OC(=O)CCC=O.O=C=O Oxoglutarate decarboxylase
CC(C)CC(=O)C(=O)O>>CC(C)CC(N)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O L-Leucine dehydrogenase
CC(C)CC(=O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(C)CC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O Branched-chain-amino-acid transaminase
CC(C)CC(=O)C(=O)O>>*.CC(C)CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O 3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)
CC(C)C(=O)C(=O)O>>CC(C)(CO)C(=O)C(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 3-Methyl-2-oxobutanoate hydroxymethyltransferase
CC(C)C(=O)C(=O)O_[K+]_CC(C)C(O)(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 2-Isopropylmalate synthase
CC(C)C(=O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(C)C(N)C(=O)O.OC(=O)CCC(=O)C(=O)O Branched-chain-amino acid transaminase
CC(C)C(=O)C(=O)O>>*.CC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O 3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)
OC(=O)C(=O)CC=C>>CC(O)CC(=O)C(=O)O 2-Oxopent-4-enoate hydratase
OCC(OP(=O)(O)O)C(=O)O_[Zn+2].[Mg+2]_OC(=O)C(=C)OP(=O)(O)O.O Enolase
CC(=CCCC(=CCc1ccccc1O)C)C>>CC(=CCCC(=CCc1cccc(O)c1O)C)C
OC(=O)CCC(=O)c1ccccc1C(=O)O_CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS_OC(=O)c1cc(O)c2ccccc2c1O.OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O
NC(=C(C=CC=O)C(=O)O)C(=O)O>>OC(=O)c1cccnc1C(=O)O.O non-enzymatic
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)CO>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CO.OCC=O Dihydroneopterin aldolase
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)CO>>Nc1nc(=O)c2nc(cnc2[nH]1)C(O)C(O)CO
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O_[Mg+2]_CC(=O)C(=O)C1CNc2nc(N)[nH]c(=O)c2N1.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O (6-Pyruvoyltetrahydropterin synthase)
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O_[Mg+2]_Nc1nc2NC3OC(COP(=O)(O)O)C(=C(S)C3Nc2c(=O)[nH]1)S.OP(=O)(O)O.OP(=O)(O)O
Nc1nc2NCC(=Nc2c(=O)[nH]1)CO_[Mg+2]_Nc1nc2NCC(=Nc2c(=O)[nH]1)COP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O 2-Amino-4-hydroxy-6-hydroxymetyldihydropteridine pyrophosphokinase
Nc1nc2NCC(=Nc2c(=O)[nH]1)COP(=O)(O)OP(=O)(O)O>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)O.OP(=O)(O)OP(=O)(O)O Dihydropteroate synthase
NC(=CC=CC(=O)O)C(=O)O>>OC(=O)CCCC(=O)C(=O)O.N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
NC(=CC=CC(=O)O)C(=O)O>>OC(=O)CCCC(=O)C(=O)O.N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
OCC(O)C(O)CC(=O)C(=O)O_[Mg+2]_OC(COP(=O)(O)O)C(O)CC(=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 2-Dehydro-3-deoxygluconokinase
CC(O)CC(=O)C(=O)O>>CC(=O)C(=O)O.CC=O 4-Hydroxy-2-oxovalerate aldolase
NC(CC(=O)c1cccc(O)c1N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OC(=O)c1cc(O)c2cccc(O)c2n1.O.NC(CCC(=O)O)C(=O)O Kynurenine transaminase
OC(=O)C(=CC=CC=O)O>>OC(=O)C(=O)CC=C.OC=O (Hydroxymuconate semialdehyde hydrolase)
CC(O)C=O>>CC(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aldehyde dehydrogenase
OC(=O)CCCC(=O)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O.O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 2-Oxoglutarate dehydrogenase
NC(=O)CCC(=O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CCC(=O)N)C(=O)O.*C(=O)C(=O)O Glutamine-oxoacid transaminase
OC(=O)CCC(=O)C(=O)O_[Mg+2]_*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(O)(CCC(=O)O)C(=O)O
CC(C)CCC(O)C(C)(O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C_*.*_CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.CC(C)CCC=O.*.O.O Cholesterol monooxygenase (side-chain cleaving)
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC21C_*.*_CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.O.* Steroid 21-monooxygenase
CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C_*.*_CC(C)CCCC(C)(O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid 17alpha-monooxygenase
CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCC(O)C(C)(O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.O.* Cholesterol monooxygenase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O.*OS(=O)(=O)O Estrone sulfotransferase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O_*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_OS(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O (Phosphoadenylsulfate reductase)
*C(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)*>>*C(N)C(=O)OCC(O)COP(=O)(O)OCC(COC(=O)*)OC(=O)*.*C1OC(COP(=O)(O)OC2C(O)C(*)OC2COP(=O)(O)OC3C(O)C(*)OC3CO)C(O)C1O
*C(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)*>>*C(=O)CC(COP(=O)(O)OCC(O)COP(=O)(O)OCC(COC(=O)*)OC(=O)*)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1
OC1CC(O)(CC(=O)C1O)C(=O)O>>OC1CC(=CC(=O)C1O)C(=O)O.O 3-Dehydroquinate dehydratase
OC1CC(O)(CC(=O)C1O)C(=O)O>>OC1CC(O)(CC(O)C1O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Quinate dehydrogenase
OC1CC(=CC(=O)C1O)C(=O)O>>OC1CC(=CC(O)C1O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Shikimate dehydrogenase
OCCC(=O)O>>OC(=O)CC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxypropionate dehydrogenase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCO>>OCCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 3-hydroxyisobutyryl-CoA hydrolase
CC(C)C(C(O)C(=O)O)C(=O)O>>CC(C)CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O 3-Isopropylmalate dehydrogenase
CC(C)C(C(O)C(=O)O)C(=O)O>>CC(C)C(=CC(=O)O)C(=O)O.O
OC(=O)C(=O)CS>>CC(=O)C(=O)O.SC#N 3-Mercaptopyruvate sulfurtransferase
OC(=O)C(=O)CS>>CC(=O)C(=O)O.OS(=O)(=O)S 3-Mercaptopyruvate sulfurtransferase
CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C>>CC(C)(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Enoyl-CoA hydratase
CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C>>CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)CC(=O)O.[*H].OC(=O)CCCCC1SCC2NC(=O)NC12 Methylcrotonyl-CoA carboxylase
CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)CC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O 3-Methylglutaconyl-CoA hydratase
CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Acetyl-CoA acyltransferase
OC(=O)CCC(=O)CC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(=O)O.OC(=O)CCC(=O)O 3-Oxoadipate-CoA transferase
OC(=O)CC1=CCC(=O)O1>>OC(=O)CCC(=O)CC(=O)O 3-Oxoadipate enol-lactonase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23
OC(COP(=O)(O)O)C(=O)O>>OCC(OP(=O)(O)O)C(=O)O Phosphoglyceromutase
OC(COP(=O)(O)O)C(=O)O>>OCC(OP(=O)(O)O)C(=O)O Phosphoglycerate phosphomutase
OC(COP(=O)(O)O)C(=O)O>>OC(=O)C(=O)COP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] D-3-Phosphoglycerate dehydrogenase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O.OS(=O)(=O)O Phosphoadenylyl sulfatase
OC(=O)C(=O)COP(=O)(O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(COP(=O)(O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O Phosphoserine transaminase
NC(COP(=O)(O)O)C(=O)O_[Mg+2]_NC(CO)C(=O)O.OP(=O)(O)O Phosphoserine phosphatase
NC(CS(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OC(=O)C(=O)CS(=O)O.NC(CCC(=O)O)C(=O)O Aspartate transaminase
NC(CS(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCS(=O)O.O=C=O Sulfinoaniline decarboxylase
NC(CS(=O)O)C(=O)O>>NC(CS(=O)(=O)O)C(=O)O
OC(=O)C(=O)CS(=O)O>>CC(=O)C(=O)O.OS(=O)O non-enzymatic?
CC(CNC(=O)N)C(=O)O>>CC(CN)C(=O)O.O=C=O.N 3-Ureidopropionase
NC(=O)NCCC(=O)O>>NCCC(=O)O.O=C=O.N 3-Ureidopropionase
CC(C)C(O)(CC(=O)O)C(=O)O>>CC(C)C(C(O)C(=O)O)C(=O)O 3-Isopropylmalate dehydratase
CC(C)C(O)(CC(=O)O)C(=O)O>>CC(C)C(=CC(=O)O)C(=O)O.O
OCC(O)C(O)C(=O)C(O)C(=O)O>>OCC(O)C(O)C(=O)CO.O=C=O dehydro-L-Gulonate decarboxylase
CCCCCCCCCCCCCCCC(=O)C(N)CO>>CCCCCCCCCCCCCCCC(O)C(N)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3-Dehydrosphinganine reductase
Nc1c(O)cccc1C(=O)O_[Fe+2]_NC(=C(C=CC=O)C(=O)O)C(=O)O 3-Hydroxyanthranilate oxygenase
NC(CC(=O)c1cccc(O)c1N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_Nc1c(O)cccc1C(=O)O.CC(N)C(=O)O Kynureninase
CC12CCC(O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase
CC12CCC(O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase
CC12CCC(O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O)OC5OC(C(O)C(O)C5O)C(=O)O
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C
CC(CCC(=O)O)C1CCC2C3C=CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Delta6-steroid reductase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 20beta-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 11beta-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 11beta-Hydroxysteroid dehydrogenase
CC(CCCC(C)C(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C_[Mg+2]_CC(CCC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C 24-monooxygenase
CC(CCC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C_[Mg+2]_CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
CC(CCC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C_[Mg+2]_CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
CC(CO)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCCC(CO)COS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C
CC(CO)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCCC(C)C(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+] Cholestane tetraol 26-dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CO)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Cholestanetriol 26-monooxygenase
CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase
CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3beta-hydroxy-D5-Steroid dehydrogenase 
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3beta-hydroxy-D5-Steroid dehydrogenase 
CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS_[Mg+2]_CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.OP(=O)(O)OP(=O)(O)O Pantetheine-P adenylyltransferase
Nc1ccc(cc1)C(=O)O>>Nc1ccc(CC(O)C(O)C(O)CO)cc1.O=C=O.[O]
NCCCC=O>>NCCCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aminobutyraldehyde dehydrogenase
NC(CC(=O)OP(=O)(O)O)C(=O)O>>NC(CC=O)C(=O)O.OP(=O)(O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aspartate semialdehyde dehydrogenase
OC(=O)CC(=O)CC(=O)C=CC(=O)O>>CC(=O)CC(=O)O.OC(=O)C=CC(=O)O Fumarylacetoacetase
NC(=N)NCCCC(=O)N>>NC(=N)NCCCC(=O)O.N L-Guanidinobutanamide deaminase
NC(=N)NCCCC(=O)O>>NCCCC(=O)O.NC(=O)N 4-Guanidobutyrase
OC(=O)c1ccc(O)cc1_[Mg+2]_CC(=CCCC(=CCc1ccccc1O)C)C.OP(=O)(O)OP(=O)(O)O.O=C=O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCO>>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O
OC(=O)C(=O)Cc1ccc(O)cc1_OCC(O)C1OC(=O)C(=C1O)O_OC(=O)Cc1cc(O)ccc1O.O=C=O 4-Hydroxyphenylpyruvate hydroxylase
OC(=O)C(=O)Cc1ccc(O)cc1_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(Cc1ccc(O)cc1)C(=O)O.OC(=O)CCC(=O)C(=O)O Tyrosine transaminase
OC(=O)CCC1NC=NC1=O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_OC(=O)CCC1NC(=O)NC1=O Aldehyde oxidase
OC(=O)CC(=O)CC(=O)C=CC(=O)O>>OC(=O)CC(=O)CC(=O)C=CC(=O)O Maleyl-acetoacetate isomerase
OCCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCO.*O
OC1C(O)C(NC(=O)CNC=O)OC1COP(=O)(O)O>>OC1C(O)C(NC(=N)CNC=O)OC1COP(=O)(O)O.NC(CCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Phosphoribosyl-formylglycinamide synthase
OC1C(O)C(NC(=N)CNC=O)OC1COP(=O)(O)O_[K+].[Mg+2]_Nc1cncn1C2OC(COP(=O)(O)O)C(O)C2O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Phosphoribosylformylglycinamidine cyclo-ligase
NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N>>NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1NC=O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Phosphoribosyl-aminoimidazole carboxamide formyltransferase
NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1NC=O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.O IMP Cyclohydrolase
Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)NC(CC(=O)O)C(=O)O>>NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N.OC(=O)C=CC(=O)O Adenylosuccinate lyase
Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)O_[Mg+2]_Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)NC(CC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Phosphoribosyl-aminoimidazole-succinocarboxamide synthetase
Nc1cncn1C2OC(COP(=O)(O)O)C(O)C2O_[Mg+2]_Nc1c(ncn1C2OC(COP(=O)(O)O)C(O)C2O)C(=O)O Phosphoribosylaminoimidazole carboxylase
NCC(=O)NC1OC(COP(=O)(O)O)C(O)C1O_[Mg+2]_OC1C(O)C(NC(=O)CNC=O)OC1COP(=O)(O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Phosphoribosylglycineamide formyltransferase
Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Methylene-THF-dehydrogenase
Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O_NCC(=O)O_Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=O)c2c(=O)[nH]1.[H+] Aminomethyltransferase
CC1C2C(C)Nc3nc(N)[nH]c(=O)c3[N+]2=CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4>>CC1C2C(C)Nc3nc(N)[nH]c(=O)c3N2CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4.CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2cc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O.[H+] 5,10-Methylene-THMPT dehydrogenase
Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>>CN1C(CNc2ccc(cc2)C(=O)NC(CCC(=O)O)C(=O)O)CNc3nc(N)[nH]c(=O)c13.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Methylene-THF-reductase (NAD(P)+)
Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O>>CN1C(CNc2ccc(cc2)C(=O)NC(CCC(=O)O)C(=O)O)CNc3nc(N)[nH]c(=O)c13.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Methylene-THF-reductase (NAD(P)+)
CC1C2C(C)Nc3nc(N)[nH]c(=O)c3N2CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C.CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2nc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O.O 5,10-Methylene-THMPT reductase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1_[Mg+2]_Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Formate-THF ligase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CN(C=O)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NCC(=O)NC1OC(COP(=O)(O)O)C(O)C1O P-Ribosylglycinamide formyltransferase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.N.*.OC(=O)CCCCC(S)CCS Aminomethyl transferase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1.NC(CCC(=O)O)C(=O)O Glutamate formiminotransferase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1.NCC(=O)O Glutamate formiminotransferase
CC1CNC(=O)NC1=O>>CC(CNC(=O)N)C(=O)O Dihydropyrimidinase
O=C1CCNC(=O)N1>>NC(=O)NCCC(=O)O Dihydropyrimidinase
Nc1[nH]cnc1C(=O)O>>Nc1cnc[nH]1.O=C=O
NCC(=O)CCC(=O)O_[Mg+2].[Zn+2].[K+]_NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.O.O Porphobilinogen synthase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1>>Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.N Formimino-THF cyclodeaminase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=O)c2c(=O)[nH]1>>Nc1nc2NCC3CN(C=[N+]3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O 5-Formyl-THF-cycloligase
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=O)c2c(=O)[nH]1_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.OC(=O)CCC(NC=O)C(=O)O Glutamate fromiminotransferase
CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C=O>>CC1C2C(C)Nc3nc(N)[nH]c(=O)c3[N+]2=CN1c4ccc(CC(O)C(O)C(O)COC5OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C5O)cc4.O 5,10-Methenyl-THMPT cyclohydrolase
CC(=CCCC(=CCc1cccc(O)c1O)C)C>>COc1c(O)c(C)c(CC=C(C)CCC=C(C)C)c(O)c1OC.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+].[H+]
Oc1ccc2[nH]cc(CC=O)c2c1>>OC(=O)Cc1c[nH]c2ccc(O)cc12.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase
NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O>>Oc1ccc2[nH]cc(C3=CC(=C4C(=O)Nc5ccccc45)C(=O)N3)c2c1
CC(O)C(=O)SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O>>CC(O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O Hydroxyacyl-glutathione hydrolase (glyoxylase II)
CN1C(CNc2ccc(cc2)C(=O)NC(CCC(=O)O)C(=O)O)CNc3nc(N)[nH]c(=O)c13>>*C.CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Methyl-THF-B12 methyltransferase
CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C>>CSCCS(=O)(=O)O.CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3Nc4c(NC3C)nc(N)[nH]c4=O
NC1OC(COP(=O)(O)O)C(O)C1O_[Mg+2]_NCC(=O)NC1OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Phosphoribosylamine-glycine ligase
NC(=O)Nc1[nH]cnc1C(=O)O>>Nc1[nH]cnc1C(=O)O.O=C=O.N
CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC(CCCC(CO)COS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(O)C(CO)COS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C
CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1>>CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dihydropteridine reductase
CC(=O)C(=O)C1CNc2nc(N)[nH]c(=O)c2N1>>CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Sepiapterin reductase 
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1
CC1Nc2nc(N)[nH]c(=O)c2N=C1C(C)(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>>CC(O)C1=Nc2c(NC1C)nc(N)[nH]c2=O.OCC=O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O
*.CC(=O)SC(CCS)CCCCC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.OC(=O)CCCCC(S)CCS Dihydrolipoamide acetyltransferase
OC(=O)c1ccc(O)nc1>>Oc1ccc(O)nc1.O=C=O
Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase
Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase
Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O>>Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase
Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)O_[Mg+2].[K+]_Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Dihydrofolate synthase
CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C(=CC=C3CC(O)CCC3=C)CCCC12C
CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 7-Dehydrocholesterol reductase
CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 7-Dehydrocholesterol reductase
OC(COP(=O)(O)O)C(O)C(O)CC(=O)C(=O)O_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[Co+2]_OC1CC(O)(CC(=O)C1O)C(=O)O.OP(=O)(O)O 3-Dehydroquinate synthase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C.* 3-Oxo-5beta-steroid delta4 dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CC(O)C12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CC(O)C12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3-Oxo-5beta-steroid delta4 dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CC(O)C12C.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 12alpha-monooxygenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C.* 3-Oxo-5beta-steroid delta4 dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3-Oxo-5beta-steroid delta4 dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(=O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3alpha-Hydroxysteroid dehydrogenase
CC(C)CCCC(C)C1CCC2C3C(O)C=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3C(O)CC4=CC(=O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Glucose-1-P-adenylyltransferase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC4COP(=O)(O)OC4C3O.OP(=O)(O)OP(=O)(O)O Adenylate cyclase
[*H2]_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C_*.O
[*H2]>>*.O
[*H2]>>*.O
[*H2]>>*.O Choline dehydrogenase
*OS(=O)(=O)O>>*O.OS(=O)(=O)O Arylsulfatase
CC=O>>CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase
CC=O>>CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase
CC=O>>CCO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Alcohol dehydrogenase
CC(=O)O_[Mg+2]_CC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)OP(=O)(O)O Acetyl-CoA ligase
CC(=O)CC(=O)O>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)O Acetoacetyl-CoA: Acetate-CoA transferase
CC(=O)CC(=O)O>>CC(=O)C.O=C=O Acetoacetate decarboxylase
CC(=O)CC(=O)O>>CC(O)CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3-Hydroxybutyrate dehydrogenase
CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acetoacetyl-CoA hydrolase
CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O 3-Oxoacid-CoA transferase
CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Acetyl-CoA acetyltransferase
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(=O)C(N)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 5-Aminolevulinate synthase
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acetyl-CoA acetyltransferase (thiolase)
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Hydroxymethyl-glutaryl-CoA synthase
CC(=O)S*S>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.S*S Enzyme/ACP acetyltransferase
CC(=O)S*S>>CC(=O)S*S
CC(=O)S*SC(=O)CC(=O)O>>CC(=O)CC(=O)S*S.O=C=O 3-Oxoacyl-E/ACP synthase
CC(=O)S*SC(=O)CC(=O)O>>CC(=O)S*S.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O Enzyme/ACP malonyltransferase
CC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23_[Mg+2]_CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Acetate-CoA ligase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=C>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCO Enoyl-CoA hydratase
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23_[Mg+2].[K+]_CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acyl-CoA-ligases (several)
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23_[Mg+2].[K+]_CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acyl-CoA-ligases (several)
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCC(=O)OC(CC(=O)O)C[N+](C)(C)C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Carnitine palmitoyltransferase
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCC(=O)OCC(O)COP(=O)(O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS (active) Glycerol-3-phospho-acyltransferase
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC=CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.O.O (Acyl-CoA-desaturase)
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Acyl-CoA dehydroenase (NADP)
CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA-dehydrogenases (2 known)
*.CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS>>*.CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS ACP Phosphodiesterase
*C(=O)S*S>>CCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.S*S (Palmitoyl-CoA-enzyme palmitoyl transferase)
*C(=O)S*S>>*C(=O)O.S*S Oleyl-ACP hydrolase
CCCCCC(=O)OCC(O)COP(=O)(O)O>>CCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 1-Acylglycerol-3P-acyltransferase
Nc1ncnc2[nH]cnc12_[Mg+2]_Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Adenine P-ribosyltransferase
Nc1ncnc2[nH]cnc12>>O=c1[nH]cnc2[nH]cnc12.N Adenine deaminase
Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O_[Mg+2]_Nc1ncnc2[nH]cnc12.OCC1OC(O)C(O)C1O Purine nucleosidase
Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Adenosine kinase
Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O>>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23.N Adenosine deaminase
Nc1ncnc2n(cnc12)C3OC4COP(=O)(O)OC4C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O 3,5-Cyclic nucleotide phosphodiesterase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O_[Fe+2]_Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.*.O Ribonucleoside-diphosphate reductase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O_[Ca+2].[Mg+2]_Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)O Apyrase (Potato/Insects)
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.O.[H+].[H+].[H+] (Oxidative phosphorylation)
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O_[Mg+2]_Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Adenylate kinase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O_[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(N)ncnc45)C(O)C1O.OP(=O)(O)O Polyribonucleotide nucleotidyltransferase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O_[Zn+2]_Nc1ncnc2n(cnc12)C3OC(CO)C(O)C3O.OP(=O)(O)O 5'-Nucleotidase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O_[Mg+2]_Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Adenylate kinase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.N AMP deaminase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N_Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.*.O Ribonucleoside triphosphate reductase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O ATPases (several known)
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_[Ca+2].[Mg+2]_Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Apyrase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(NC(CC(=O)O)C(=O)O)ncnc23>>Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OC(=O)C=CC(=O)O Adenylosuccinate lyase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O>>OS(=O)(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Adenylsulfatase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O>>OS(=O)O.*.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Adenylsulfate reductase
NCCCCNC(=N)N>>NCCCCN.NC(=O)N Agmatinase
CCCCCC=O_OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O_CCCCCC(=O)O.[*H2] Aldehyde dehydrogenase (PQQ)
CCCCCC=O>>CCCCCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase
CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C54CC(OC5O)C31>>CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.CC12CCC(=O)CC2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O.*.* 3-Oxo-5beta-steroid delta4dehydrogenase
CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CC(O)C31)C=O>>CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C54CC(OC5O)C31 non-enzymatic
CCCCCC>>CCCCCCO.O.* Alkane-1-monooxygenase
NC(=O)NC1NC(=O)NC1=O>>NC(=O)NC(NC(=O)N)C(=O)O Allantoinase
OC(=O)CCCC(=O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CCCC(=O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O 2-Aminoadipate transaminase
OP(=O)(O)OCC(=O)Cc1cnc[nH]1_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(COP(=O)(O)O)Cc1cnc[nH]1.OC(=O)CCC(=O)C(=O)O Histidinol-P transaminase
CC(=O)CN_[K+]_CC(O)CN.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 1-Aminopropan-2-ol dehydrogenase
CC(=O)CN>>CC(=O)C=O.N.OO Monoamine oxidase
*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O>>CC(C)C(NC(=O)C(CS)NC(=O)CCCC(N)C(=O)O)C(=O)O.O.*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS d(L-2-Aminoadipyl-)L-cysteinyl-D-valinesynthase
Nc1cnc[nH]1>>OC(=O)CNC=N.N Aminoimidazolase
OCC1OC(OC2C(O)C(O)C(OCC3OC(OC4C(O)C(O)C(O)OC4CO)C(O)C(O)C3OC5OC(CO)C(O)C(O)C5O)OC2CO)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OCC1OC(OC2C(O)C(O)C(OC3C(O)C(O)C(O)OC3CO)OC2CO)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O (alpha-Glucan) phosphorylase
OCC1OC(OC2C(O)C(O)C(OCC3OC(OC4C(O)C(O)C(O)OC4CO)C(O)C(O)C3OC5OC(CO)C(O)C(O)C5O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(OC3C(O)C(O)C(O)OC3CO)OC2CO)C(O)C(O)C1O.OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O alpha-Amylase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC2OC3C(O)C(O)C(OC3CO)OC4C(O)C(O)C(OC4CO)OC5C(O)C(O)C(OC5CO)OC1C(O)C2O Cyclomaltodextrin glucanotransferase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(OCC3OC(OC4C(O)C(O)C(O)OC4CO)C(O)C(O)C3OC5OC(CO)C(O)C(O)C5O)OC2CO)C(O)C(O)C1O 1,4-alpha-Glucan branching enzyme (Q-enzyme)
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Glycogen (starch) synthases
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Starch (bacterial glycogen) synthase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O I-Form (active) Glycogen (starch) synthase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Starch (bacterial glycogen) synthase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O Glucan-1,4-alpha-glucosidase (glucoamylase)
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O alpha Amylase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O Glycogen phosphorylase a
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O_*.*_CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O.O.* Steroid 11beta-monooxygenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 19-hydroxylase)
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O.* 3-Oxo-5beta-steroid delta4 dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1=O.* 3-Oxo-5beta-steroid delta4 dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3(or 17)beta-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3(or 17)beta-Hydroxysteroid dehydrogenase
CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1=O
Nc1ccccc1C(=O)O>>Nc1ccccc1C(=O)OC2OC(C(O)C(O)C2O)C(=O)O
Nc1ccccc1C(=O)O_[Fe+2]_Oc1ccccc1O.O=C=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.N Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
Nc1ccccc1C(=O)O_[Fe+2]_Oc1ccccc1O.O=C=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.N Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
Nc1ccccc1C(=O)O>>OC1C(O)C(Nc2ccccc2C(=O)O)OC1COP(=O)(O)O.OP(=O)(O)OP(=O)(O)O Anthranilate-phosphoribosyltranferase
*_[Mg+2]_*.CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O Holo-ACP synthase
*>>*[Fe+3] Transferrin reductase
C[N+](C)(C)CC=O_OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O_C[N+](C)(C)CC(=O)O.[*H2] Choline dehydrogenase
C[N+](C)(C)CC=O_[Mg+2]_C[N+](C)(C)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Betaine aldehyde dehydrogenase
C[N+](C)(C)CC(=O)O>>CN(C)CC(=O)O.CSCCC(N)C(=O)O.[H+] Betaine-homocysteine methyltransferase
[NH4+]>>NC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Carbamoylphosphate synthase
OC(=O)[O-]>>NC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Carbamoylphosphate synthase
CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)OC5OC(C(O)C(O)C5O)C(=O)O)c(CCC(=O)OC6OC(C(O)C(O)C6O)C(=O)O)c2C)NC1=O>>CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C.OC1OC(C(O)C(O)C1O)C(=O)O.OC1OC(C(O)C(O)C1O)C(=O)O beta-Glucuronidase + further reactions
CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)OC5OC(C(O)C(O)C5O)C(=O)O)c(CCC(=O)OC6OC(C(O)C(O)C6O)C(=O)O)c2C)NC1=O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Glucuronosyltransferase
CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O.O Bilirubin oxidase
CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Biliverdin reductase
CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CC1=C(C=C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Biliverdin reductase
CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CCC1=C(C)C(=CC2=NC(=Cc3[nH]c(C=C4NC(=O)C(C)C4=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O>>CCC1=C(C)C(=CC2=NC(=Cc3[nH]c(C=C4NC(=O)C(C)C4=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O.*.*
CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)OP(=O)(O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Phosphate butyryl-transferase
*C(=O)S*S>>*C(=O)S*SC(=O)CC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
*C(=O)S*SC(=O)CC(=O)O>>*C(=O)CC(=O)S*S.O=C=O
*C(=O)OCC(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCC(O)COP(=O)(O)O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 CDP-Diacylglycerolglycerol-3P 3-phosphatidyltransferase
*C(=O)OCC(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O)OC(=O)*_[K+].[Mg+2]_*C(=O)OCC(COP(=O)(O)O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1 Phosphatidate cytidyltransferase
C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O_[Mg+2]_*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 Choline phosphotransferase
NCCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O_[Mg+2]_*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 Ethanolamine-phosphotransferase
O=C=O>>*.[C-]#[O+].*.O CO-dehydrogenase
OC(=O)[O-]_[Mg+2]_NC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.O Carbamate kinase
OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O P-Gluconate dehydrogenase (decarboxylating)
OCC(O)C(O)C(O)CO>>OCC1(O)OCC(O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Ribitoldehydrogenase
NCCC(=O)NC(Cc1cnc[nH]1)C(=O)O_[Zn+2]_NCCC(=O)O.NC(Cc1c[nH]cn1)C(=O)O Carnosinase
Oc1ccccc1O_[Fe+2]_OC(=O)C(=CC=CC=O)O Catechol 2,3-dioxygenase
Oc1ccccc1O_[Fe+2]_OC(=O)C=CC=CC(=O)O Catechol 1,2-dioxygenase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O beta-Glucosidase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O Cellobiose phosphorylase
OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.O Cellulose-1,4-cellobiosidase
OCC1OC(O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Cellulose synthase (UDP-forming)
*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O (N-Acylsphingosine glucosyltransferase)
*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(COP(=O)(O)OCC[N+](C)(C)C)C(O)C=CCCCCCCCCCCCCC.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 Ceramide cholinephosphotransferase
*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC>>CCCCCCCCCCCCCC=CC(O)C(N)CO.*C(=O)O Acylsphingosine deacylase
CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C>>CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C
CC(=O)NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2NC(=O)C)C1O>>CC(=O)NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2NC(=O)C)C1O
CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C>>CCc1c(C=O)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C.O
CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C.CC(C)CCCC(C)CCCC(C)CCCC(=CCO)C Chlorophyllase
CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C>>CCc1c(C)c2cc3[nH]c(cc4nc(C(CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C4C)c5C(C(=O)OC)C(=O)c6c(C)c(cc1n2)[nH]c65)c(C)c3C=C.[Mg+2]
CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C>>CCC1C(C)C2=[N+]3[Mg+2][N+]4=C(C=c5[n-]c(=C2)c(C(=O)C)c5C)C(C)C(CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C4=C6C(C(=O)OC)C(=O)c7c(C)c(C=C13)[n-]c67.OP(=O)(O)OP(=O)(O)O
CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N]3[Mg+2][N]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C.OP(=O)(O)OP(=O)(O)O
CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3C=CC4CC(O)CCC4(C)C3CC(O)C12C.O 7alpha-dehydroxylase
CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Cholate-CoA ligase
CC(C)CCCC(C)C1CCC2C(=CC=C3CC(O)CCC3=C)CCCC12C>>CC(CCCC(C)(C)O)C1CCC2C(=CC=C3CC(O)CC(O)C3=C)CCCC12C
*C(=O)OC1CCC2(C)C3CCC4(C)C(CCC4C3CC=C2C1)C(C)CCCC(C)C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.*C(=O)O Cholesterol esterase
*C(=O)OC1CCC2(C)C3CCC4(C)C(CCC4C3CC=C2C1)C(C)CCCC(C)C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.*C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Cholesterol acyltransferase
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C_*.*_CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.O.* Cholesterol monooxygenase (side chain cleaving)
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C_*_CC(C)CCCC(C)C1CCC2C3C(O)C=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Cholesterol 7alpha-monooxygenase
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C.OO Cholesterol oxidase
C[N+](C)(C)CCO_OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O_C[N+](C)(C)CC=O.[*H2]
C[N+](C)(C)CCO_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_C[N+](C)(C)CC=O.O Choline oxidase
C[N+](C)(C)CCO>>CC(=O)OCC[N+](C)(C)C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Choline acetyltransferase
CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>>CC(CCC(=O)NCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Glycine-N-choloyltransferase
CC(CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C4CCC5C6C(O)CC7CC(O)CCC7(C)C6CC(O)C45C>>CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Glycine-N-choloyltransferase
OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>>Nc1ccc(cc1)C(=O)O
OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>>OC(=O)c1ccc(O)cc1.CC(=O)C(=O)O (Chorismate lyase)
OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O_[Mg+2]_Nc1ccccc1C(=O)O.NC(CCC(=O)O)C(=O)O.CC(=O)C(=O)O Anthranilate synthase
OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O>>OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O Chorismate mutase
OC(=O)CC(O)(CC(=O)O)C(=O)O_[Mg+2]_OC(=O)CC(=O)C(=O)O.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O ATP Citrate lyase
OC(=O)CC(O)(CC(=O)O)C(=O)O>>OC(C(CC(=O)O)C(=O)O)C(=O)O
CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)O
CC(O)CNC(=O)CCC1(C)C(CC(=O)N)C2N3C1=C(C)C4=[N+]5C(=CC6=[N+]7C(=C(C)C8=[N+](C2(C)C(C)(CC(=O)N)C8CCC(=O)N)[Co+2]375)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(C)C4CCC(=O)N>>CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O
CC1=C2[N+]3=C(C=C4[N+]5=C(C(CCC(=O)O)C4(C)C)C(=C6N7C(C(CC(=O)O)C6(C)CCC(=O)O)C8(C)[N+](=C1C(CCC(=O)O)C8(C)CC(=O)O)[Co+2]735)C)C(CCC(=O)O)C2(C)CC(=O)O>>CC(O)CNC(=O)CCC1(C)C(CC(=O)N)C2N3C1=C(C)C4=[N+]5C(=CC6=[N+]7C(=C(C)C8=[N+](C2(C)C(C)(CC(=O)N)C8CCC(=O)N)[Co+2]375)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(C)C4CCC(=O)N.O.O.O.O.O.O.O
CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2nc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O>>CC(OP(=O)(O)OCC(O)C(O)C(O)CN1C2NC(=O)NC(=O)C2Nc3ccc(O)cc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O Hydrogenase
OC(=O)CC(=O)C(=O)O>>OC(=O)CC(O)(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Citrate synthase
Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5C)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C>>Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(=O)O)c5C)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.[H].[H].[H].[H].[H].[H]
Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C>>Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.[H].[H].[H].[H].[H].[H]
Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C>>Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(=O)O.O=C=O.O=C=O.O.O Coproporphyrinogen oxidase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.* 3-Oxo-5beta-steroid delta4 dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO>>CC12CCC(=O)C=C2CCC3C4CCC(C(=O)CO)C4(CO)CC(O)C31.O.* Corticosterone 18-monooxygenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Cortisone beta-reductase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 11beta-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(=O)CCC43C)C2CCC1(O)C(=O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Cortisone beta-reductase
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO>>CC12CC(O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(O)CO
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO>>CC12CC(=O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(O)CO
CN(CC(=O)O)C(=N)N>>CN1CC(=O)NC1=N.O Creatininase
CN(CC(=O)O)C(=N)N>>NC(=O)N.CNCC(=O)O Creatinase
CN1CC(=O)NC1=N>>CN1CC(=O)NC1=O.N Creatinine deiminase
CC=CC(=O)S*S>>CCCC(=O)S*S.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C Enoyl-E/ACP reductase
CC=CC(=O)S*S>>CCCC(=O)S*S.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Enoyl-E/ACP reductase
CC(CCC=C(C)C)C1CCC2(C)C3CCC4C5(CC35CCC12C)CCC(O)C4(C)C>>CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)CC4CC3
Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>>Nc1cc[nH]c(=O)n1.OCC1OC(OP(=O)(O)O)C(O)C1O Pyrimidine nucleoside phosphorylase
Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>>Nc1cc[nH]c(=O)n1.OCC1OC(O)C(O)C1O Nucleosidase
Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1>>OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O.N Cytidine deaminase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1_[Fe+2]_Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.*.O Ribonucleoside-diphosphate reductase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1_[Mg+2]_Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1_[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(N)nc4=O)C(O)C1O.OP(=O)(O)O Polyribonucleotide nucleotidyltransferase
Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1>>Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1.OP(=O)(O)O 5'-Nucleotidase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1>>Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.*.O Ribonucleoside triphosphate reductase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1_OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(N)nc4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O DNA-directed RNA polymerase
Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1_OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(N)nc4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O RNA-directed DNA polymerase
Nc1cc[nH]c(=O)n1>>O=c1cc[nH]c(=O)[nH]1.N Cytosine deaminase
CCCCCC(=O)OCC(CO)OC(=O)CCCCC>>CCCCCC(=O)OCC(COC(=O)CCCCC)OC(=O)CCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Diacylglycerol acyltransferase
CCCCCC(=O)OCC(CO)OC(=O)CCCCC>>CCCCCC(=O)OCC(O)CO.CCCCCC(=O)O Lipases
*C(O)CC(=O)S*S>>*C(=O)CC(=O)S*S.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
*C(O)CC(=O)S*S>>*C(=O)CC=CCCCCCC.O.*CCC(=O)S*S
CC(O)CC(=O)S*S>>CC(=O)CC(=O)S*S.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Oxoacyl-E/ACP reductase
CC(O)CC(=O)S*S>>CC=CC(=O)S*S.O (3-Hydroxyacyl-E/ACP dehydratases)
OC(CC(=O)C(=O)O)C(=O)O>>OC(=O)C=O.CC(=O)C(=O)O 4-hydroxy-2-Oxoglutarate aldolase
OC1C(O)C(COP(=O)(O)O)OC(=O)C1O>>OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O 6-P-Gluconolactonase
OC(COP(=O)(O)O)C(O)C=O>>OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)COP(=O)(O)O
OC(COP(=O)(O)O)C(O)C=O>>OC(COP(=O)(O)O)C(O)C(O)CC(=O)C(=O)O.OP(=O)(O)O
*OP(=O)(O)O>>*O.OP(=O)(O)O Glycogen synthase D phosphatase
OCC1OC(O)C(O)C(O)C1O_[Mg+2]_OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Galactokinase
OC1OC(C(O)C(O)C1O)C(=O)O>>OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Galacturonokinase
OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C(O)CC(=O)C(=O)O
OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C1OC(=O)C(=C1O)O.O
OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1OC(C(O)C(O)C1O)C(=O)O.OP(=O)(O)O
OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O.OP(=O)(O)OP(=O)(O)O
OCC(O)C(O)C(O)C(O)C(=O)O>>OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Gluconokinase
OCC1OC(=O)C(O)C(O)C1O_[Mg+2]_OCC(O)C(O)C(O)C(O)C(=O)O Gluconolactonase
OCC1OC(=O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glucose dehydrogenase
OCC1OC(=O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glucose dehydrogenase
NC1C(O)OC(CO)C(O)C1O>>NC(C(O)C(O)C(O)CO)C(=O)O.OO
NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Glucosamine-P-acetyltranferase
OCC(=O)C(O)C(O)C(O)C=O.OP(=O)=O>>OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O myo-Inositol-1-P synthase
OCC1OC(O)C(O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O Xylose isomerase
OCC1OC(O)C(O)C(O)C1O>>OCC1OC(=O)C(O)C(O)C1O.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Glucose oxidase
OCC1OC(O)C(O)C(O)C1O>>OCC(O)C(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aldehyde reductase
OC1OC(C(O)C(O)C1O)C(=O)O>>OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glucuronokinase
OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C(O)C(O)C(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glucuronate reductase
OC1OC(C(O)C(O)C1O)C(=O)O>>OCC(O)C(O)CC(=O)C(=O)O
OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1OC(C(O)C(O)C1O)C(=O)O.OP(=O)(O)O
OC1C(O)C(OP(=O)(O)O)OC(C1O)C(=O)O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O.OP(=O)(O)OP(=O)(O)O Glucuronate 1-P Uridylyltransferase
OC(C=O)C1OC(=O)C(O)C1O>>OC(C(O)C(O)C(=O)O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase
OC(C=O)C1OC(=O)C(O)C1O>>OCC(O)C1OC(=O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glucuronolactone reductase
OC(C=O)C1OC(=O)C(O)C1O>>OC1OC(C(O)C(O)C1O)C(=O)O Uronolactonase
OC(COP(=O)(O)O)C=O>>OC(=O)c1cccnc1C(=O)O.O.O.OP(=O)(O)O
OCC(O)C=O_[Mg+2]_OC(COP(=O)(O)O)C=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Triokinase
OCC(O)C=O>>OCC(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde (NAD+) dehydrogenase
OC(COP(=O)(O)O)C=O>>OC(COP(=O)(O)O)C(=O)OP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glyceraldehyde-phosphate dehydrogenase
OC(COP(=O)(O)O)C=O>>OC(COP(=O)(O)O)C(=O)OP(=O)(O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glyceraldehyde-phosphate dehydrogenase (NADP)
OC(COP(=O)(O)O)C=O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OC1OC(COP(=O)(O)O)C(O)C1O.OCC(=O)C(O)C(O)COP(=O)(O)O Transketolase
OC(COP(=O)(O)O)C=O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OCC(=O)C(O)C(O)COP(=O)(O)O.OC(COP(=O)(O)O)C(O)C=O Transketolase
CC(O)C(=O)O>>CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] D-Lactate dehydrogenase
CC(O)C(=O)O>>CC(=O)C(=O)O.*[Fe+2].*[Fe+2] D-Lactate dehydrogenase
OCC1OC(O)C(O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O Mannose isomerase
OC(=O)C1CCCN1_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_OC(=O)C1=NCCC1.OO D-Aminoacid oxidase
OC(=O)C1CCCN1_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_NCCCCC(=O)O.OC(=O)CCCCC1CCSS1 D-Proline reductase (dithiol)
OC1OC(COP(=O)(O)O)C(O)C1O_[Mg+2]_OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Ribose-phosphate pyrophosphokinase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(O)C(=O)C(O)C(O)COP(=O)(O)O Hexulose-6-P synthase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OC1OC(COP(=O)(O)O)C(O)C1O Ribose-phosphate isomerase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O Ribose-phosphate isomerase
OCC(O)C(O)C(O)C(O)CO>>OCC1OC(O)(CO)C(O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Iditol dehydrogenase
OCC(O)C(O)C(O)C=O>>OCC1(O)OCC(O)C1O Xylose isomerase
OCC(O)C(O)C(O)C=O>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aldehyde reductase
OCC(O)C(O)C(O)C=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O
OCC1(O)OCC(O)C1O>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O D-Xylulose reductase
OCC1(O)OCC(O)C1O_[Mg+2]_OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Xylulokinase
OC(COP(=O)(O)O)C(O)c1cnc[nH]1>>OP(=O)(O)OCC(=O)Cc1cnc[nH]1.O Imidazoleglycerol-P dehydratase
NC(CCCC(=O)NC1C2SCC(=C(N2C1=O)C(=O)O)CO)C(=O)O>>CC(=O)OCC1=C(N2C(SC1)C(NC(=O)CCCC(N)C(=O)O)C2=O)C(=O)O.O
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)[n+]5cccc(c5)C(=O)O)C(O)C3O_[Mg+2]_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.NC(CCC(=O)O)C(=O)O NAD-Synthase (glutamine hydrolyzing)
NC(CCO)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CCC(=O)C(=O)O.N Cystathionine gamma-lyase
NC(CO)C(=O)O_[K+].Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(=O)C(=O)O.N L-Serine dehydratase
CC(O)C(N)C(=O)O>>CCC(=O)C(=O)O.N Threonine dehydratase
NC(=O)c1cccnc1>>OC(=O)c1cccnc1.N Nicotine amidase
NCCc1c[nH]c2ccc(O)cc12_[Cu+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_Oc1ccc2[nH]cc(CC=O)c2c1.N.OO Monoamine oxidase
NCCc1c[nH]c2ccccc12_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[Cu+2]_O=CCc1c[nH]c2ccccc12.N.OO Monoamine oxidase
NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O_OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCc1c[nH]c2ccc(O)cc12.O=C=O Aromatic L-amino acid decarboxylase
CC(=O)CC(=O)O>>CC(=O)C.O=C=O Acetoacetate decarboxylase
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23_OC(=O)CCCCC1SCC2NC(=O)NC12.[Co+2].[Zn+2]_CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.OC(=O)CC(=O)C(=O)O Methylmalonyl-CoA carboxyltransferase
CC(C(=O)C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Acetyl-CoA-acyltransferase
OC(COP(=O)(O)O)C(O)CC(=O)C(=O)O>>CC(=O)C(=O)O.OC(COP(=O)(O)O)C=O 2-dehydro-3-deoxyphospho-Gluconate aldolase
OC(CC(=O)C(=O)O)C(O)C(=O)O>>CC(=O)C(=O)O.OC(C=O)C(=O)O 2-dehydro-3-deoxy-D-Glucarate aldolase
NC(=O)NC(NC(=O)N)C(=O)O>>NC(=O)N.NC(=O)NC(O)C(=O)O Allantoinase
O=C1CC(=O)NC(=O)N1>>OC(=O)CC(=O)O.NC(=O)N Barbiturase
CC(=O)NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2NC(=O)C)C1O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.CC(=O)NC1C(O)OC(CO)C(O)C1O N-Acetyl-beta-glucosaminidase
OC(=O)CC(O)(CC(=O)O)C(=O)O>>OC(=O)CC(=O)C(=O)O.CC(=O)O Citrate lyase
NC(CCSCC(N)C(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CCC(=O)C(=O)O.NC(CS)C(=O)O.N Cystathionine gamma-lyase
CC(O)C(N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCC(=O)O.CC=O Threonine aldolase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1cccnc1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(O)C(O)C4O)C(O)C3OP(=O)(O)O.[H+] NAD(P) nucleosidase
NC(=O)NC(O)C(=O)O>>OC(=O)C=O.NC(=O)N Ureidoglycolate lyase
*OC1OC(C(O)C(O)C1O)C(=O)O>>OC1OC(C(O)C(O)C1O)C(=O)O.*O beta-Glucuronidase
OC(C(CC(=O)O)C(=O)O)C(=O)O_[Mg+2]_OC(=O)CCC(=O)O.OC(=O)C=O Isocitrate lyase
CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O 3-hydroxybutyryl-CoA dehydratase
OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)O>>OC(COP(=O)(O)O)C(O)CC(=O)C(=O)O.O P-Gluconate dehydratase
OC(C(O)C(O)C(=O)O)C(O)C(=O)O>>OC(CC(=O)C(=O)O)C(O)C(=O)O.O D-Glucarate dehydratase
OC(C(O)C(O)C(=O)O)C(O)C(=O)O>>OC(CC(=O)C(=O)O)C(O)C(=O)O.O D-Glucarate dehydratase
OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OC1C(O)C(COP(=O)(O)O)OC(=O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glucose 6-P dehydrogenase
CC=CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCC=CCC=CCC=CCC=CCCCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CC=CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCCCCCCC(C)CCCCCCCCC(=O)O.NC(CCS)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>CC(CCOP(=O)(O)OP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C
CC12CCC3C(CC=C4CC(CCC34C)OS(=O)(=O)O)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O.OS(=O)(=O)O Sterylsulfatase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CC(O)C1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 16alpha-hydroxylase)
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3(or 17)beta-Hydroxysteroid dehydrogenase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 3(or 17)beta-Hydroxysteroid dehydrogenase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Steroid delta-isomerase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Steroid delta-isomerase
CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O>>CC12CCC3C(CC=C4CC(CCC34C)OS(=O)(=O)O)C2CCC1=O.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O Alcohol sulfotransferase
CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxybutyryl-CoA dehydrogenase
CCCCO_[Zn+2]_CCCC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Butanol dehydrogenase
CC(C)O>>CC(=O)C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] (2-Propanol dehydrogenase (NAD+))
CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Butyraldehyde dehydrogenase
CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Butyryl-CoA dehydrogenase
OCC(O)C(O)C(=O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] dehydro-L-Gulonate dehydrogenase
OCC(O)C(O)C(=O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] dehydro-L-Gulonate dehydrogenase
OCC(O)C(O)C(O)CO>>OCC(O)C(O)C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Arabinitol dehydrogenase
OCC(O)C1OC(=O)C(=C1O)O>>OCC(O)C1OC(=O)C(=O)C1=O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O Glutathione dehydrogenase (ascorbate)
OCC(O)C(O)C(O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Gulonate dehydrogenase
OCC(O)C(O)C(O)C(O)C(=O)O>>OCC(O)C(O)C(=O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Gulonate dehydrogenase
OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase
OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase
CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(=O)C12C
OC(COP(=O)(O)O)C(=O)OP(=O)(O)O_[Mg+2]_OC(COP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O 3-Phosphoglycerate kinase
OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O_[Mg+2]_OC1C(O)C(O)C(O)C(O)C1O.OP(=O)(O)O 1-L-myo-Inositol phosphatase
Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1>>Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1.OP(=O)(O)OP(=O)(O)O dCTP-Pyrophosphatase
Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1>>Nc1ccn(C2CC(O)C(CO)O2)c(=O)n1.OP(=O)(O)O 5'-Nucleotidase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)O)O3_[Mg+2].[Co+2].[Ca+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3.OP(=O)(O)O 5'-Nucleotidase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3>>Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(CO)O3.OP(=O)(O)OP(=O)(O)OP(=O)(O)O dGTPase
OC(=O)C(COP(=O)(O)O)OP(=O)(O)O>>OC(COP(=O)(O)O)C(=O)O.OP(=O)(O)O Bisphosphoglycerate phosphatase
Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O>>Nc1nc2NCC(=Nc2c(=O)[nH]1)C(O)C(O)CO.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O_[Mg+2]_Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Adenylylsulfate kinase
Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(OP(=O)(O)O)C3O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O.OP(=O)(O)O 3'-Phosphoadenylsulfate 3'-phosphatase
*C(=O)OCC(COP(=O)(O)OCC(O)COP(=O)(O)O)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)*.OP(=O)(O)O Phosphatase
CCCC(=O)OP(=O)(O)O>>CCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Butyrate kinase
OCC1(OP(=O)(O)O)OC(COP(=O)(O)O)C(O)C1O>>OCC1(O)OC(COP(=O)(O)O)C(O)C1O.OP(=O)(O)O Fructose-2,6 bisphosphatase
OCC1OC(O)(CO)C(O)C1O_[Mg+2]_OCC1(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hexokinase
NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>NC1C(O)OC(CO)C(O)C1O.OP(=O)(O)O
OC(COP(=O)(O)O)C(O)C(O)C(O)C(=O)COP(=O)(O)O_[Mg+2]_OCC(=O)C(O)C(O)C(O)C(O)COP(=O)(O)O.OP(=O)(O)O Fructose bisphosphatase
CCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCC_[Mg+2]_CCCCCC(=O)OCC(CO)OC(=O)CCCCC.OP(=O)(O)O Phosphatidate phosphatase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23_[Mg+2].[Co+2].[Ca+2]_OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23.OP(=O)(O)O 5'-Nucleotidase
NC(COP(=O)(O)O)Cc1cnc[nH]1>>NC(CO)Cc1cnc[nH]1.OP(=O)(O)O Histidinol phosphatase
CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.OP(=O)(O)O
CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)COP(=O)(O)O)C(=O)O_[Mg+2]_CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O.OP(=O)(O)O (N-Acetylneuraminate-9-phosphatase)
NC(CCOP(=O)(O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(O)C(N)C(=O)O.OP(=O)(O)O Threonine synthase
OC(=O)C(=C)OP(=O)(O)O_[Mg+2].[K+]_CC(=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Pyruvate kinase
OC(=O)C(=C)OP(=O)(O)O_[Mg+2].[K+]_CC(=O)C(=O)O.*C1OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C1O Pyruvate kinase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O.OP(=O)(O)OP(=O)(O)O Phosphoribosyl-ATP pyrophosphatase
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O>>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.OP(=O)(O)O Thymidine triphosphatase
OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O.OP(=O)(O)O 5'-Nucleotidase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23_[Mg+2].[Co+2].[Ca+2]_OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]c(=O)[nH]c23.OP(=O)(O)O 5'-Nucleotidase
OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OP(=O)(O)O Glucose-6-phosphatase
OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O_[Mg+2]_OCC1(O)OC(COP(=O)(O)O)C(O)C1O.OP(=O)(O)O Hexosediphosphatase
OCC1OC(O)(COP(=O)(O)O)C(O)C1O_[Mg+2]_OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 1-Phosphofructokinase
OCC(O)COP(=O)(O)O>>OCC(O)CO.OP(=O)(O)O Glycerol kinase
*>>OCC(O)C(O)C(O)C=O.* Xylosidases
*>>OCC(O)C(O)C(O)C=O.*
CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O>>CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Phenylalanine 4-monooxygenase
NC(Cc1cc(I)c(O)c(I)c1)C(=O)O>>NC(Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O.NC(=C)C(=O)O.O.O
NC(Cc1cc(I)c(O)c(I)c1)C(=O)O>>NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O.O.O.NC(=C)C(=O)O
CN(C)CC(=O)O_[Fe+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_CNCC(=O)O.[*H2].C=O Dimethylglycine dehydrogenase
CC(CCOP(=O)(O)OP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C>>CC(CCOP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C.OP(=O)(O)O
CC(CCOP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C>>CC(CCO)CCC=C(C)CCC=C(C)CCC=C(C)C.OP(=O)(O)O Dolichyl phosphatase
NCCc1ccc(O)c(O)c1>>CN1CCC23C4Oc5c3c(CC1C2C=CC4O)ccc5O
NCCc1ccc(O)c(O)c1_[Cu+2].OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O_NCC(O)c1ccc(O)c(O)c1.O.OCC(O)C1OC(=O)C(=O)C1=O Dopamine beta-monooxygenase
*C.CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N
[*H].OC(=O)CCCCC1SCC2NC(=O)NC12_[Mg+2].[K+]_*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Biotin carboxylase
[*H].OC(=O)CCCCC1SCC2NC(=O)NC12_[Mg+2]_*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O
*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12_[Mg+2]_[*H].OC(=O)CCCCC1SCC2NC(=O)NC12.OC(=O)[O-].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O
*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12_[Mg+2]_[*H].OC(=O)CCCCC1SCC2NC(=O)NC12.OC(=O)[O-].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dihydrolipoamide dehydrogenase
*.OC(=O)CCCCC1CCSS1>>*.OC(=O)CCCCC(S)CCS.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Dihydrolipoamide dehydrogenase
*.OC(=O)CCCCC(S)CCSC(=O)CCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O.*.OC(=O)CCCCC(S)CCS Dihydrolipoamide succinyltransferase
*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(O)(CCC(=O)O)C(=O)O>>*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc(C(O)CCC(=O)O)[n+]1Cc2cnc(C)nc2N.O=C=O 2-Oxoglutarate decarboxylase
*.OC(=O)CCCCC(S)CCS>>*.OC(=O)CCCCC1CCSS1.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Dihydrolipoamide dehydrogenase
*.OC(=O)CCCCC(S)CCS>>*.OC(=O)CCCCC1CCSS1.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.O=C=O Acetyl-CoA acyltransferase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O_OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O UDPG-4-epimerase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O UDP-Glucuronate-4-epimerase
CC(C)C(=C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)C(C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C
CC(C)C(C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)C(C)C=CC(C)C1CCC2C(=CC=C3CC(O)CCC3=C)CCCC12C
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Estriol 2-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Estriol 2-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CCC1O
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(=O)O)ccc34)C2CC(O)C1O
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 16a-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Estradiol 17beta-dehydrogenase
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Estradiol 17beta-dehydrogenase
CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(OC5OC(C(O)C(O)C5O)C(=O)O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Glucuronosyltransferase
CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Estradiol 17beta-dehydrogenase
CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Estradiol 17beta-dehydrogenase
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)ccc34)C2CC(O)C1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 16a-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Estriol 2-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)c(O)cc34)C2CCC1=O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Estriol 2-hydroxylase)
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(=O)O)ccc34)C2CCC1=O
CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CCC1=O.Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)O)C(OP(=O)(O)O)C3O Estrone sulfotransferase
NCCO>>NCCOP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Ethanolamine kinase
CC12CCC3C(CCC4CC(O)CCC43C)C2CCC1=O>>CC12CCC3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1=O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.O=O 2-Hydroxyacid dehydrogenase
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.* Acyl-CoA dehydrogenase
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.* Acyl-CoA dehydrogenases (2 known) 
*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.OO
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[*H2] Glycerol 3-P dehydrogenase
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[*H2]
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.OO (S)-2-Hydroxyacid oxidase
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.OO
*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C>>*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.OO
CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C_[Mg+2]_CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)OP(=O)(O)O Farnesyl-bisphospho-farnesyltransferase
CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C_[Mg+2]_CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C.OP(=O)(O)OP(=O)(O)O Farnesyl-trans-transferase
CCCCCC(=O)O>>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)OP(=O)(O)O Acyl-CoA ligases
CCCCCC(=O)O>>CCCCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)O Acyl-CoA ligases
[Fe+2]>>[Fe+3].O.[Fe+3] Ferroxidase (ceruloplasmin)
[*H2]>>*.[H][H] Hydrogenase
*[Fe+3]>>*.[Fe+2] Transferrin reductase
Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)cnc2[nH]1>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase
Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)cnc2[nH]1>>Nc1nc2NCC(=Nc2c(=O)[nH]1)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrofolate reductase
C=O>>OC=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formaldehyde dehydrogenase
OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formate dehydrogenase
OC=O_Nc1nc2NCC(Nc2c(=O)[nH]1)C3=C(S[Mo](=O)(=O)S3)C(O)COP(=O)(O)O_O=C=O.*[Fe+2].*[Fe+2].[H+].[H+] Formate dehydrogenase (cytochrome)
OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formate dehydrogenase
OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formate dehydrogenase
OC=O>>O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Formate dehydrogenase
OC(=O)CNC=N>>NCC(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1 Glycine formimino transferase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC=O>>OC=O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Formyl-CoA hydrolase
OC(=O)CCC(C(CCC(=O)NC(CCC(=O)NC(CCC(=O)NCCc1ccc(OCc2coc(CNC=O)c2)cc1)C(=O)O)C(=O)O)C(=O)O)C(=O)O>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3C(C)Nc4nc(N)[nH]c(=O)c4N3C=O.NCc1cc(COc2ccc(CCNC(=O)CCC(NC(=O)CCC(NC(=O)CCC(C(CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)O)cc2)co1 Formylmethanofuran-THMPT formyltransferase
OC(=O)C=CC(=O)O>>OC(CC(=O)O)C(=O)O Fumarate hydratase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Cellulose synthase (GDP-forming)
CC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C_[Mg+2]_CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C.OP(=O)(O)OP(=O)(O)O Geranyl-trans-transferase
NC(C(O)C(O)C(O)CO)C(=O)O_O_OCC(O)C(O)CC(=O)C(=O)O.N Aminodeoxygluconate dehydratase
*C(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC.OCC1OC(O)C(O)C(O)C1O Glucosylceramidase
*C(=O)NC(COC1OC(CO)C(O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC>>CCCCCCCCCCCCCCCCCC(=O)NCC(OC1OC(CO)C(OC2OC(CO)C(OC3OC(CO)C(O)C(OC4OC(CO)C(O)C(O)C4O)C3NC(=O)C)C(OC5(CC(O)C(N)C(O5)C(O)C(O)CO)C(=O)O)C2O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=CCC(=O)O_OC(=O)CCCCC1SCC2NC(=O)NC12_CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O Glutaryl-CoA dehydrogenase
OC(=O)CCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutarate-CoA ligase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=CCC(=O)O.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Glutaryl-CoA dehydrogenase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=CCC(=O)O.[*H2] Glutaryl-CoA dehydrogenase
NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Glutathione reductase
NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>>*SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O.*SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O.[H+].[H+] Glutathione transferases (Detoxification reactions)
NCCOP(=O)(O)OCC(O)CO>>OCC(O)COP(=O)(O)O.NCCO Glycerophosphocholine phosphodiesterase
OCC(O)CO>>CC(O)C=O.O Glycerol dehydratase
OCC(O)CO>>OCC(O)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glycerol hydrogenase (NADP+) 
OCC(O)CO>>OCC(O)C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glycerol hydrogenase (NADP+) 
OCC(=O)COP(=O)(O)O>>OC(COP(=O)(O)O)C=O Triose-P isomerase
NCC(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_*.NCSC(CCS)CCCCC=O.O=C=O Glycine dehydrogenase (decarboxylating)
NCC(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)CN)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Glycine-tRNA ligase
NCC(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_OC(=O)C=O.OO.N D-Amino acid oxidase
NCC(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_OC(=O)C=O.N.OO D-Aminoacid oxidase
NCC(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OC(=O)C=O.NC(CCC(=O)O)C(=O)O Glycine transaminase
NCC(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OC(=O)C=O.CC(N)C(=O)O Glycine transaminase
NCC(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CO)C(=O)O.OC(=O)C=O Serineglyoxylate transaminase
CC(CCC(=O)NCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NCC(=O)O Choloylglycine hydrolase
*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O>>*.*.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O Phosphorylase phosphatase
OCC(=O)O>>OC(=O)C=O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C (S)-2-Hydroxy-acid oxidase
OCC(=O)O>>OC(=O)C=O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C (S)-2-Hydroxyacid oxidase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)CN)C1O>>*
OC(=O)C=O>>OCC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glyoxylate reductase
OC(=O)C=O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCC(=O)O.OC(=O)CCC(=O)C(=O)O.CC(=O)C(=O)O Alanine glyoxylate transaminase
OC(=O)C=O>>OCC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Glyoxylate reductase
OC(=O)C=O>>OC(=O)C(=O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C (S)-3-Hydroxyacid ester dehydrogenase
OC(=O)C=O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Glyoxylate dehydrogenase (acylating)
OC(=O)C=O>>OC(CC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Malate synthase
OC(=O)C=O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.[Mg+2]_OC(C=O)C(=O)O.O=C=O Tartronate-semialdehyde synthase
NC(=N)NCC(=O)O>>CN(CC(=O)O)C(=N)N.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] Guanidinoacetate methyl-transferase
NC(=N)NCC(=O)O>>OC(=O)CNC(=N)NP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Guanidinoacetate kinase
Nc1nc2[nH]cnc2c(=O)[nH]1>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(CO)C(O)C3O.OP(=O)(O)O Purine nucleoside phosphorylase
Nc1nc2[nH]cnc2c(=O)[nH]1_[Mg+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Hypoxanthine P-ribosyltransferase
Nc1nc2[nH]cnc2c(=O)[nH]1>>O=c1[nH]c(=O)c2nc[nH]c2[nH]1.N Guanine deaminase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(CO)C(O)C3O>>Nc1nc2[nH]cnc2c(=O)[nH]1.OCC1OC(O)C(O)C1O Purine nucleosidase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)O Nucleoside diphosphatase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O_[Mg+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O_[Mg+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.* Nucleoside diphosphate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O_[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(=O)[nH]c(N)nc45)C(O)C1O.OP(=O)(O)O Polyribonucleotide nucleotidyltransferase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O_[Zn+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3OC(CO)C(O)C3O.OP(=O)(O)O 5'-Nucleotidase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O_[K+].[Mg+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Guanylate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.N.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O GMP reductase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N.[Mg+2].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.*.O Ribonucleoside triphosphate reductase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1nc(NCC(=O)C(O)C(O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(N)c(=O)[nH]1.OC=O GTP Cyclohydrolase I
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O ATPases (several known)
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(=O)[nH]c(N)nc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O DNA-directed RNA polymerase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(=O)[nH]c(N)nc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O RNA-directed RNA polymerase
Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O_[Fe+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.*.O Ribonucleoside-diphosphate reductase
OS(=O)(=O)S>>SC#N.OS(=O)=O Thiosulfate sulfurtransferase
*>>CC1=C(C=C)C(=Cc2[nH]c(C=C3N=C(C=C4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O.CCC1=C(C)C(=CC2=NC(=Cc3[nH]c(C=C4NC(=O)C(C)C4=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O.O.O.O.[C-]#[O+].*.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.* Heme oxygenase (decycling)
*S[Fe+2]12([N+]3=C4C=c5c(CCC(=O)O)c(C)c6=CC7=[N+]2C(=Cc8c(C)c(C=C)c(C=C3C(=C4CCC(=O)O)C)n81)C(=C7C)C=C)n65>>* Heme oxygenase (decycling)
*S[Fe+2]12([N+]3=C4C=c5c(CCC(=O)O)c(C)c6=CC7=[N+]2C(=Cc8c(C)c(C=C)c(C=C3C(=C4CCC(=O)O)C)n81)C(=C7C)C=C)n65>>*
NCCc1cnc[nH]1_[Cu+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_O=CCc1c[nH]cn1.N.OO Amine oxidase (Cu++)
NCCc1cnc[nH]1>>CNCCc1c[nH]cn1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] Histamine methyltransferase
OC(=O)CCC(=CC(=O)O)C(=O)O>>OC(C(CCC(=O)O)C(=O)O)C(=O)O Homoaconitate hydratase
OC(=O)CCC(O)(CC(=O)O)C(=O)O>>OC(=O)CCC(=CC(=O)O)C(=O)O.O
OC(=O)Cc1cc(O)ccc1O_[Fe+2]_OC(=O)CC(=O)CC(=O)C=CC(=O)O Homogentisate 1,2-dioxygenase
OC(=O)Cc1cc(O)ccc1O>>CC(=CCCC(=CCC1=CC(=O)C(=C(C)C1=O)C)C)C
OC(=O)Cc1cc(O)ccc1O>>CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.OP(=O)(O)OP(=O)(O)O.O=C=O.[H+].[H+]
OC(C(CCC(=O)O)C(=O)O)C(=O)O_[Mg+2]_OC(=O)CCC(C(=O)O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] (Homoisocitrate dehydrogenase)
OC(=O)CCC1NC(=O)NC1=O>>NC(=O)NC(CCC(=O)O)C(=O)O
I>>II.O.O Iodide peroxidase
I>>II.O.O Iodide peroxidase
OCC(=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Hydroxypuruvate reductase
OCC(=O)C(=O)O>>OCC(O)C(=O)O.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C 2-Hydroxyacid dehydrogenase
OCC(=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Hydroxypuruvate reductase
NCCS(=O)O>>NCCS(=O)(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Hypotaurine dehydrogenase
O=c1[nH]cnc2[nH]cnc12>>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23.OP(=O)(O)O Purine nucleoside phosphorylase
O=c1[nH]cnc2[nH]cnc12_[Mg+2]_OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23.OP(=O)(O)OP(=O)(O)O Hypoxanthine P-ribosyltransferase
O=c1[nH]cnc2[nH]cnc12_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_O=c1[nH]c(=O)c2nc[nH]c2[nH]1.OO Xanthine oxidase
*O>>*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase A
O=CCc1c[nH]c2ccccc12>>OC(=O)Cc1c[nH]c2ccccc12.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aldehyde dehydrogenase
OC(=O)C(=O)Cc1c[nH]c2ccccc12>>O=CCc1c[nH]c2ccccc12.O=C=O
OC(=O)C(=O)Cc1c[nH]c2ccccc12>>OC(O)C(=O)Cc1c[nH]c2ccccc12
c1cc2ccccc2[nH]1_Cc1ncc(COP(=O)(O)O)c(C=O)c1O.[NH4+]_NC(Cc1c[nH]c2ccccc12)C(=O)O.O Tryptophan synthase
OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]cnc23>>O=c1[nH]cnc2[nH]cnc12.OCC1OC(O)C(O)C1O Nucleosidase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23>>OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(NC(CC(=O)O)C(=O)O)ncnc23.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Adenylosuccinate synthase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]cnc23_[K+].NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O_OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] IMP dehydrogenase
CC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenase
OC1C(OC(=C)C(=O)O)C=CC=C1C(=O)O_Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N_OC(=O)CCC(=O)c1ccccc1C(=O)O.CC(=O)C(=O)O.O=C=O.O
OC1C(OC(=C)C(=O)O)C=CC=C1C(=O)O>>OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O Isochorismate synthase
CC1(C)SC2C(NC(=O)CCCC(N)C(=O)O)C(=O)N2C1C(=O)O>>NC(CCCC(=O)NC1C2SCC(=C(N2C1=O)C(=O)O)CO)C(=O)O.O.OC(=O)CCC(=O)O.OC(=O)CCC(=O)O.O=C=O.O=C=O (Expandase + hydroxylase)
CC1(C)SC2C(NC(=O)CCCC(N)C(=O)O)C(=O)N2C1C(=O)O>>CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O.NC(CCCC(=O)O)C(=O)O
CC(C)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenase
OC(=O)c1cc(O)c2ccccc2n1>>OC(=O)CCC(=O)C(=O)O.OC(=O)CC(=O)C(=O)O
*C(=O)OCC(O)COP(=O)(O)OCCN>>*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
*C(=O)OCC(O)COP(=O)(O)OCCN>>NCCOP(=O)(O)OCC(O)CO.*C(=O)O Lysophospholipase
C[N+](C)(C)CCOP(=O)(O)OCC(O)CO>>OCC(O)COP(=O)(O)O.C[N+](C)(C)CCO Glycerophosphocholine phosphodiesterase
OC1CC(N=C1)C(=O)O>>OC1CNC(C1)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-5-carboxylate reductase
OC1CC(N=C1)C(=O)O>>OC1CNC(C1)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-5-carboxylate reductase
OC1CC(N=C1)C(=O)O>>NC(CC(O)C(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 1-Pyrroline-5-carboxylate dehydrogenase
OC1CC(N=C1)C(=O)O>>NC(CC(O)C(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 1-Pyrroline-5-carboxylate dehydrogenase
OC(=O)C1CCC=N1>>NC(CCC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 1-Pyrroline-5-carboxylate dehydrogenase
OC(=O)C1CCC=N1>>NC(CCC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 1-Pyrroline-5-carboxylate dehydrogenase
OC(=O)C1CCC=N1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-5-carboxylate reductase
OC(=O)C1CCC=N1>>OC(=O)C1CCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Pyrroline-5-carboxylate reductase
CC(=O)C(N)C(=O)O>>CC(=O)CN.O=C=O 5-Aminolevulinate synthase
NC(CCCC(=O)O)C(=O)O_NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O_NC(CCCC=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (2-Aminoadipate reductase)
NC(CCCC(=O)O)C(=O)O>>NC(CCCC=O)C(=O)O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aminoadipate semialdehyde dehydrogenase
NC(CCCC=O)C(=O)O>>NC(CCCC(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Aminoadipate semialdehyde dehydrogenase
NC(CCCC(=O)O)C(=O)O>>NC(CCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.OP(=O)(O)OP(=O)(O)O
CCCC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3-Hydroxyacyl-CoA dehydrogenase
OC1CNC(C1)C(=O)O>>OC1CC(N=C1)C(=O)O.[*H2] L-Proline dehydrogenase
OC1CNC(C1)C(=O)O>>OC1CNC(C1)C(=O)O 4-Hydroxyproline epimerase
OC1CC(N=C1)C(=O)O>>NC(CC(O)C=O)C(=O)O non-enzymatic
CC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(C)N)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Alanine tRNA ligase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(C)N)C1O>>*
NC(CCCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O>>*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O
OCC(O)C(O)C(O)C=O>>OCC1(O)OCC(O)C1O L-Arabinose isomerase
OCC(O)C(O)C(O)C=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O
OCC(O)C(O)C(O)CO>>OCC1(O)OCC(O)C1O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Arabitol dehydrogenase (Ribulose-forming)
NC(CCCNC(=N)N)C(=O)O_[Mg+2]_NC(CCCNC(=N)NP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Arginine kinase
NC(CCCNC(=N)N)C(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_NC(=N)NCCCC(=O)N.O.O=C=O Arginine 2-monooxygenase
NC(CCCNC(=N)N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCCCNC(=N)N.O=C=O Arginine decarboxylase
NC(CCCNC(=N)N)C(=O)O>>[NH4+].NC(CCCNC(=O)N)C(=O)O Arginine deiminase
NC(CCCNC(=N)N)C(=O)O>>NC(CCCNC(=N)NC(CC(=O)O)C(=O)O)C(=O)O Argininosuccinate lyase
NC(CCCNC(=N)N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCNC(=N)N)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O L-Arginyl-tRNA ligase
NC(CCCNC(=N)N)C(=O)O_[Co+2]_NCCCC(N)C(=O)O.NC(=O)N Arginase
NC(CCCNC(=N)N)C(=O)O>>NCCCC(N)C(=O)O.NC(=N)NCC(=O)O Glycine amidinotransferase
NC(CCCNC(=N)N)C(=O)O.NC(CCCNC(=N)N)C(=O)O_CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_[N]=O.[N]=O.O.O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(CCCNC(=O)N)C(=O)O.NC(CCCNC(=O)N)C(=O)O Nitric oxide synthase
NC(CCCNC(=N)NC(CC(=O)O)C(=O)O)C(=O)O_[Mg+2]_NC(CCCNC(=O)N)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.NC(CC(=O)O)C(=O)O Argininosuccinate synthetase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCNC(=N)N)C1O>>*
OCC(O)C1OC(=O)C(=C1O)O>>OCC(O)C1OC(=O)C(=O)C1O non-enzymatic
OCC(O)C1OC(=O)C(=C1O)O_[Cu+2]_OCC(O)C1OC(=O)C(=O)C1=O.O Ascorbate oxidase
OCC(O)C1OC(=O)C(=C1O)O_[Fe+2]_OCC(O)C(O)C(=O)O.OC(=O)C(=O)O Ascorbate-2,3-dioxygenase
NC(CC(=O)N)C(=O)O>>NC(CC(=O)O)C(=O)O.N Asparaginase
NC(CC(=O)N)C(=O)O>>NC(=O)CC(=O)C(=O)O.NCC(=O)O Asparagine-oxo acid transaminase
NC(CC(=O)O)C(=O)O>>NC(CCC(=O)O)C(=O)O.OC(=O)CC(=O)C(=O)O Aspartate transaminase
NC(CC(=O)O)C(=O)O_[Co+2]_OC(=O)C=CC(=O)O.N Aspartate ammonia-lyase
NC(CC(=O)O)C(=O)O_[Mg+2]_NC(CC(=O)N)C(=O)O.OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Aspartate ammonialigase
NC(CC(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(N)C(=O)O.O=C=O Aspartate-4-decarboxylase
NC(CC(=O)O)C(=O)O>>NC(=O)NC(CC(=O)O)C(=O)O.OP(=O)(O)O Aspartate carbamoyltransferase
NC(CC(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OC(=O)CC(=O)C(=O)O.NC(CCC(=O)O)C(=O)O Aspartate transaminase
NC(CC(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCC(=O)O.O=C=O Aspartate-1-decarboxylase
NC(CC=O)C(=O)O>>OC(=O)C1CC=CC(=N1)C(=O)O.O.O (Dihydrodipicolinate synthase)
NC(CC=O)C(=O)O_[K+]_NC(CCO)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Homoserine dehydrogenase
NC(CC=O)C(=O)O_[K+]_NC(CCO)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Homoserine dehydrogenase
NC(CCSCC(N)C(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CCS)C(=O)O.N.CC(=O)C(=O)O Cystathionine beta-lyase
NC(CS(=O)(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCS(=O)(=O)O.O=C=O Sulfinoaniline decarboxylase
NC(CS)C(=O)O_[Fe+2].NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O_NC(CS(=O)O)C(=O)O Cysteine dioxygenase
NC(CS)C(=O)O>>OC(=O)C(=O)CS.NC(CCC(=O)O)C(=O)O Cysteine transaminase
NC(CS)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CCSCC(N)C(=O)O)C(=O)O.OC(=O)CCC(=O)O O-Succinylhomoserine (thiol)-lyase
NC(CS)C(=O)O>>NC(CS(=O)(=O)O)C(=O)O.S Cysteine lyase
NC(CS)C(=O)O>>CC(=O)C(=O)O.N.S Cystathionine beta-lyase
NC(CSSCC(N)C(=O)O)C(=O)O>>CC(=O)C(=O)O.NC(CSS)C(=O)O.N Cystathionine beta-lyase
OCC(O)C1OC(=O)C(=O)C1=O>>OCC(O)C(O)C(=O)C(=O)C(=O)O
NC(Cc1ccc(O)c(O)c1)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O_NCCc1ccc(O)c(O)c1.O=C=O (DOPA decarboxylase) aromatic L-amino acid decarboxylase
CNCC(O)c1ccc(O)c(O)c1>>COc1cc(ccc1O)C(O)C(=O)O Catechol methyltransferase
NC(CCC(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O_NCCCC(=O)O.O=C=O Glutamate decarboxylase
NC(CCC(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O Alanine transaminase
NC(CCC(=O)O)C(=O)O_[Mg+2]_NC(CCC(=O)N)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutamate ammonia ligase
NC(CCC(=O)O)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCC(=O)O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutamate-tRNA ligase
NC(CCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CS)C(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutamatecysteine ligase
NC(CCC(=O)O)C(=O)O_CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N_CC(C(N)C(=O)O)C(=O)O Methylaspartate mutase
NC(CCC(=O)O)C(=O)O>>CC(=O)NC(CCC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Aminoacid acetyltransferase
NC(CCC=O)C(=O)O>>OC(=O)C1CCC=N1.O non-enzymatic
NC(CCC(=O)N)C(=O)O>>NC(CCC(=O)O)C(=O)O.N Glutaminase
NC(CCC(=O)OP(=O)(O)O)C(=O)O>>NC(CCC=O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)O Glutamate-5-semialdehyde dehydrogenase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCC(=O)O)C1O>>NC1CCC(=O)OC1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.*C1OC(COP(=O)(O)OC2C(O)C(*)OC2COP(=O)(O)OC3C(O)C(*)OC3CO)C(O)C1O (Glutamyl-tRNA(Glu) reductase)
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCC(=O)O)C1O>>*
OCC(O)C1OC(=O)C(O)C1O>>OCC(O)C1OC(=O)C(=O)C1O.OO L-Gulonolactone oxidase
OCC(O)C1OC(=O)C(O)C1O>>OCC(O)C(O)C(O)C(O)C(=O)O Glucono-3-lactonase
NC(Cc1c[nH]cn1)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCc1cnc[nH]1.O=C=O Histidine decarboxylase
NC(Cc1c[nH]cn1)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4cnc[nH]4)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O
NC(Cc1c[nH]cn1)C(=O)O_[Zn+2]_OC(=O)C=Cc1cnc[nH]1.N Histidine ammonia lyase
NC(CO)Cc1cnc[nH]1>>NC(Cc1c[nH]cn1)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+] Histidinol dehydrogenase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4cnc[nH]4)C1O>>*
NC(CCS)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O.[K+]_NC(CCSCC(N)C(=O)O)C(=O)O.O Cystathionine beta-synthase
NC(CCS)C(=O)O_C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23.[Mg+2]_CSCCC(N)C(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 5-Methyl-THF-homocysteine methyltransferase
NC(CCS)C(=O)O_OP(=O)(O)O.[Mg+2]_CSCCC(N)C(=O)O.CC(OC(=O)C(N)CCC(=O)O)C(OC(=O)C(N)CCC(=O)O)C1=CNc2nc(N)nc(OC(=O)C(N)CCC(=O)O)c2N1 5-Methyltetrahydropteroyl-(Glu)3-homocysteine methyltransferase
NC(CCS)C(=O)O>>CSCCC(N)C(=O)O.CN(C)CC(=O)O.[H+] Betaine-homocysteine methyltransferase
NC(CCS)C(=O)O>>NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.O Adenosylhomocysteinase
NC(CCO)C(=O)O>>NC(CCOC(=O)CCC(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS (Homoserine succinyltransferase)
CCC(C)C(N)C(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_CCC(C)C(=O)C(=O)O.N.OO L-Amino acid oxidase
CCC(C)C(N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CCC(C)C(=O)C(=O)O.NC(CCC(=O)O)C(=O)O Branched-chain-amino acid transaminase
CCC(C)C(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)CC)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Isoleucyl-tRNA ligase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)CC)C1O>>*
NC(CC(=O)c1ccccc1N)C(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_NC(CC(=O)c1cccc(O)c1N)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Kynurenine 3-monooxygenase
NC(CC(=O)c1ccccc1N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_Nc1ccccc1C(=O)O.CC(N)C(=O)O Kynureninase
NC(CC(=O)c1ccccc1N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OC(=O)c1cc(O)c2ccccc2n1.NC(CCC(=O)O)C(=O)O.O Kynurenine transaminase
CC(O)C(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C_CC(=O)O.O=C=O.O Lactate 2-monooxygenase
CC(O)C(=O)O>>CC(O)C(=O)O Lactate racemase
CC(O)C(=O)O>>CC(=O)C(=O)O.[*H][Fe+2].[*H][Fe+2] Lactate dehydrogenase (cytochrome)
CC(C)CC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CC(C)C)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Leucyl-tRNA ligase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CC(C)C)C1O>>*
NCCCCC(N)C(=O)O>>NCCCCCN.O=C=O Lysine decarboxylase
NCCCCC(N)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)O
NCCCCC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCCN)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Lysine-tRNA ligase
NCCCCC(N)C(=O)O>>CC(=O)NCCCCC(N)C(=O)O.OP(=O)(O)O epsilon-Lysine acetyltransferase
NCCCCC(N)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Saccharopine dehydrogenase (NAD+, L-Lysine forming)
NCCCCC(N)C(=O)O>>NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Saccharopine dehydrogenase (NADP+, L-Lysine forming)
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCCCN)C1O>>*NC(=O)C(CCCCN)NC(=O)*.*C1OC(COP(=O)(O)OC2C(O)C(*)OC2COP(=O)(O)OC3C(O)C(*)OC3CO)C(O)C1O
OCC(O)C(O)C(O)C(=O)O>>OCC1OC(=O)C(=C1O)O.O.O
CS(=O)CCC(N)C(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.*_CSCCC(N)C(=O)O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Mehionine S-oxide reductase
CSCCC(N)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCSC)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Methionine-tRNA ligase
CSCCC(N)C(=O)O_[Mg+2].[K+]_C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)O Methionine adenosyltranferase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCSC)C1O_[Mg+2]_*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(CCSC)NC=O)C1O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)Nc2c(=O)[nH]1 Methionyl-tRNA formyltransferase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)CCSC)C1O>>*
NCC(O)c1ccc(O)c(O)c1>>CNCC(O)c1ccc(O)c(O)c1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] (Phenylethanolamine N-methyltransferase)
NCC(O)c1ccc(O)c(O)c1>>COc1cc(ccc1O)C(O)C(=O)O
NCCCC(N)C(=O)O>>NC(CCCNC(=O)N)C(=O)O.OP(=O)(O)O Ornithine carbamoyltransferase
NCCCC(N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CCC=O)C(=O)O.NC(CCC(=O)O)C(=O)O Ornithineoxoacid transaminase
NCCCC(N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCCCN.O=C=O Ornithine decarboxylase
NC(=O)CC(=O)C(=O)O>>OC(=O)CC(=O)C(=O)O.N omega-Amidase
NC(Cc1ccccc1)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccccc4)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O
NC(Cc1ccccc1)C(=O)O_[Fe+2]_NC(Cc1ccc(O)cc1)C(=O)O.O.CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O Phenylalanine 4-monooxygenase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccccc4)C1O>>*
OC(=O)C1CCCCN1>>OC(=O)C1CCCC=N1.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C (L-Pipecolate dehydrogenase)
OC(=O)C1CCCN1>>OC(=O)C1CCC=N1.[*H2] L-Proline dehydrogenase
OC(=O)C1CCCN1_OCC(O)C1OC(=O)C(=C1O)O_OC1CNC(C1)C(=O)O.O=C=O.OC(=O)CCC(=O)O Procollagenproline-2-oxoglutarate dioxygenase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O Ribulose-P 3-epimerase
OCC1(O)OCC(O)C1O_[Mg+2]_OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Ribulokinase
NC(CO)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCC(=O)O.Nc1nc2NCC3CN(CN3c2c(=O)[nH]1)c4ccc(cc4)C(=O)NC(CCC(=O)O)C(=O)O.O Glycine (Serine) Hydroxymethyl transferase
NC(CO)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CCCCCCCCCCCCCCCC(=O)C(N)CO.O=C=O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Serine palmitoyl transferase
NC(CO)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OCC(=O)C(=O)O.CC(N)C(=O)O Alanine-oxoacid transaminase
NC(CO)C(=O)O_[Mg+2]_*C(=O)OCC(COP(=O)(O)OCC(N)C(=O)O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 CDP-Diacylglycerol-serine phosphatidyltransferase
NC(CO)C(=O)O>>CC(=O)C(=O)O.N 2-Serine dehydratase
OCC(O)C(O)C(=O)O>>OCC(=O)C(O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Threonate dehydrogenase
CC(O)C(N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O.O_CCC(=O)C(=O)O.N Threonine dehydratase
CC(O)C(N)C(=O)O>>CC(=O)C(N)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] L-Threonine 3-dehydrogenase
NC(Cc1c[nH]c2ccccc12)C(=O)O_[Fe+2]_NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O.O.CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O Tryptophan 5-monooxygenase
NC(Cc1c[nH]c2ccccc12)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O.[K+]_c1cc2ccccc2[nH]1.CC(=O)C(=O)O.N Tryptophanase
NC(Cc1c[nH]c2ccccc12)C(=O)O>>OC(=O)C(=O)Cc1c[nH]c2ccccc12.OO.N L-Amino acid oxidase
NC(Cc1c[nH]c2ccccc12)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OC(=O)C(=O)Cc1c[nH]c2ccccc12.NC(CCC(=O)O)C(=O)O Tryptophan transaminase
NC(Cc1c[nH]c2ccccc12)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4c[nH]c5ccccc45)C1O.OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O
NC(Cc1c[nH]c2ccccc12)C(=O)O>>NC(CC(=O)c1ccccc1NC=O)C(=O)O Tryptophan 2,3-dioxygenase)-pyrrolase
NC(Cc1c[nH]c2ccccc12)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O.OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O_NCCc1c[nH]c2ccccc12.O=C=O Aromatic L-amino acid decarboxylase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4c[nH]c5ccccc45)C1O>>*
NC(Cc1ccc(O)cc1)C(=O)O_[Fe+2]_NC(Cc1ccc(O)c(O)c1)C(=O)O.CC(O)C(O)C1=Nc2c(NC1)nc(N)[nH]c2=O.O Tyrosine 3-monooxygenase
NC(Cc1ccc(O)cc1)C(=O)O>>*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccc(O)cc4)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O
NC(Cc1ccc(O)cc1)C(=O)O_[Cu+2]_NC(Cc1ccc(O)c(I)c1)C(=O)O.I Iodide peroxidase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)Cc4ccc(O)cc4)C1O>>*
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(N)C(C)C)C1O>>*
OCC(O)C(O)C(O)C(=O)O>>OCC1OC(=O)C(=C1O)O.O.O
OCC(O)C(O)C(=O)CO>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O L-Xylulose reductase
OCC(O)C(O)C(=O)CO_[Mg+2]_OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O L-Xylulokinase
OCC(=O)C(O)C(O)COP(=O)(O)O_Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.[Mg+2]_OC(COP(=O)(O)O)C=O.CC(=O)OP(=O)(O)O.O Phosphoketolase
OCC(=O)C(O)C(O)COP(=O)(O)O>>OCC(=O)C(O)C(O)COP(=O)(O)O Ribulose-P-4-epimerase
NC(CC(O)C(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_OC(CC(=O)C(=O)O)C(=O)O.NC(CCC(=O)O)C(=O)O Aspartate transaminase
NC(CCC(=O)NC(CS)C(=O)O)C(=O)O>>NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O Glutathione synthase
CC(C(N)C(=O)O)C(=O)O_[Mg+2].[K+]_CC(=CC(=O)O)C(=O)O.N Methylaspartate ammonia lyase
NC(CCCC(N)C(=O)O)C(=O)O>>NC(CCCC(N)C(=O)O)C(=O)O Diaminopimelate epimerase
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O beta-Galactosidase
CC(O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=C.O Lactoyl-CoA dehydratase
CC(O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Lactoyl-CoA dehydrogenase
CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3_NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O_CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3.OC=O
*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*>>*C(=O)OCC(CO)OC(=O)*.C[N+](C)(C)CCOP(=O)(O)O Phospholipase C
*C(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)*>>*C(=O)OCC(COP(=O)(O)O)OC(=O)*.C[N+](C)(C)CCO Phospholipase D
CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2C(=CCCC2(C)C)C.[H].[H]
CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2=C(C)CCCC2(C)C.[H].[H]
CC1C(CCC(=O)O)C2=CC3=[N+]4[Mg+2][N+]5=C(C=C1N2)C(=C(C=C)C5=Cc6[nH]c(C=C4C(=C3CCC(=O)O)C)c(C=C)c6C)C>>COC(=O)CCC1=C(C)C2=Cc3[nH]c(C=C4C(=C(C)C5=[N+]4[Mg+2][N+]2=C1C=C6NC(=C5)C(C)C6CCC(=O)O)C=C)c(C)c3C=C.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+] Magnesium protoporphyrin methyltransferase
NC(=O)C=CC(=O)O>>OC(=O)C=CC(=O)O.N
OC(=O)C=CC(=O)O>>OC(=O)C=CC(=O)O
OC(=O)CC=O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malonate semialdehyde dehydrogenase (acetylating)
OC(=O)CC=O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malonate semialdehyde dehydrogenase (acylating)
OC(=O)CC=O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase (acetylating)
OC(=O)CC=O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malonate semialdehyde dehydrogenase (acylating)
OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase
OC(=O)CC=O>>OC(=O)CC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malonate semialdehyde dehydrogenase
OC(=O)CC=O>>NCCC(=O)O.OC(=O)CCC(=O)C(=O)O 4-Aminobutyrate transaminase
OC(=O)CC=O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCC(=O)O.CC(=O)C(=O)O beta-Alanine-puruvate transaminase
OC(=O)CC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O.CC(=O)O Malonyl-CoA transferase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O Malonyl-CoA decarboxylase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.OC(=O)CC(=O)O Malonate-CoA transferase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.O=C=O Malonyl-CoA decarboxylase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*C(=O)[O-].OC(=O)CCCCC1SCC2NC(=O)NC12.[H+] (active) Acetyl-CoA carboxylase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)O>>CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.O=C=O
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O alpha-Glucosidase (maltase)
OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O Maltose phosphorylase
CC(=CCCC(=CCc1c(C)c(O)c2ccccc2c1O)C)C>>CC(=CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C)C.[H].[H]
CC(=CC(=O)O)C(=O)O_[Fe+2]_CC(O)(CC(=O)O)C(=O)O (S)-2-Methylmalate dehydratase
CC(=C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(CO)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Enoyl-CoA hydratase
C_[Cu+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_CO.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Methane monooxygenase
NCc1cc(COc2ccc(CCNC(=O)CCC(NC(=O)CCC(NC(=O)CCC(C(CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)O)cc2)co1_OS(=O)(=O)CCS_OC(=O)CCC(C(CCC(=O)NC(CCC(=O)NC(CCC(=O)NCCc1ccc(OCc2coc(CNC=O)c2)cc1)C(=O)O)C(=O)O)C(=O)O)C(=O)O.O
CO>>C=O.OC(=O)c1cc2c(O)c(O)c3nc(cc(C(=O)O)c3c2[nH]1)C(=O)O Alcohol dehydrogenase (Acc)
CSCCS(=O)(=O)O_CC(OP(=O)(O)OCC(O)C(O)C(O)Cn1c2cc(O)ccc2nc3c(=O)[nH]c(=O)nc13)C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_C.CC(OP(=O)(O)O)C(NC(=O)CCCCCCSSCCS(=O)(=O)O)C(=O)O Methyl-CoenzymeM reductase
CC(=O)C=O>>CC(O)C(=O)SCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O Lactoyl-glutathione lyase (glyoxylase I)
CC(C(=O)O)C(=O)C(=O)O>>CCC(=O)C(=O)O.O=C=O
CC(C(=O)O)C(=O)C(=O)O>>CC(C(N)C(=O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O
CC(O)(CCO)CC(=O)O_[Mg+2]_CC(O)(CCOP(=O)(O)O)CC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Mevalonate kinase
CC(O)(CCOP(=O)(O)OP(=O)(O)O)CC(=O)O_[Mg+2]_CC(=C)CCOP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O.O=C=O Diphosphomevalonate decarboxylase
CC(O)(CCOP(=O)(O)O)CC(=O)O_[Mg+2]_CC(O)(CCOP(=O)(O)OP(=O)(O)O)CC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Phosphomevalonate kinase
COC(=O)C1C(=O)C2=C(C)C3=Cc4[nH]c(C=C5C(=C(C)C6=[N+]5[Mg+2][N+]3=C2C1=C7NC(=C6)C(C)C7CCC(=O)O)C=C)c(C)c4C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Protochlorophyllide reductase (2 steps)
COC(=O)C1C(=O)C2=C(C)C3=Cc4[nH]c(C=C5C(=C(C)C6=[N+]5[Mg+2][N+]3=C2C1=C7NC(=C6)C(C)C7CCC(=O)O)C=C)c(C)c4C=C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)O)C=C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Protochlorophyllide reductase (2 steps)
COC(=O)CCC1=C(C)C2=Cc3[nH]c(C=C4C(=C(C)C5=[N+]4[Mg+2][N+]2=C1C=C6NC(=C5)C(C)C6CCC(=O)O)C=C)c(C)c3C=C>>COC(=O)C1C(=O)C2=C(C)C3=Cc4[nH]c(C=C5C(=C(C)C6=[N+]5[Mg+2][N+]3=C2C1=C7NC(=C6)C(C)C7CCC(=O)O)C=C)c(C)c4C=C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O
NC(Cc1ccc(O)c(I)c1)C(=O)O_[Cu+2]_NC(Cc1cc(I)c(O)c(I)c1)C(=O)O.I Iodide peroxidase
OC1C(O)C(Nc2ccccc2C(=O)O)OC1COP(=O)(O)O>>OC(COP(=O)(O)O)C(O)C(=O)CNc1ccccc1C(=O)O Phosphoribosylanthranilate isomerase
CC(=O)NC(CCCN)C(=O)O>>NCCCC(N)C(=O)O.CC(=O)O Acetylornithine deacetylase
CC(=O)NC(CCCN)C(=O)O>>NCCCC(N)C(=O)O.CC(=O)NC(CCC(=O)O)C(=O)O Glutamate acetyltransferase
CC(=O)NC(CCCN)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(=O)NC(CCC=O)C(=O)O.NC(CCC(=O)O)C(=O)O Acetylornithine transaminase
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)O_[Mg+2]_CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O.OP(=O)(O)OP(=O)(O)O UDP-N-Acetylglucosamine pyrophosphorylase
NC1C(O)OC(CO)C(O)C1O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Glucosamine acetyltransferase
CC(=O)NC1C(O)OC(CO)C(O)C1O>>NC1C(O)OC(CO)C(O)C1O.CC(=O)O
CC(=O)NC1C(O)OC(CO)C(O)C1O_Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3_CC(=O)NC1C(O)OC(CO)C(O)C1O N-Acylglucosamine 2-epimerase
CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O N-Acylglucosamine 6-P 2-epimerase
CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O>>CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)O Phoshoacetylglucosamine mutase
CC(=O)NC1C(O)OC(CO)C(O)C1O_[Mg+2]_CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O.OP(=O)(O)O N-Acetylneuraminate synthase
CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O_[Mg+2]_CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)COP(=O)(O)O)C(=O)O.OP(=O)(O)O N-Acyl neuraminate 9-P-synthase
CC(=O)NC(CCC(=O)O)C(=O)O>>CC(=O)NC(CCC(=O)OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O N-Acetylglutamate kinase
CC(=O)NC(CCC(=O)OP(=O)(O)O)C(=O)O>>CC(=O)NC(CCC=O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)O N-Acetyl-gamma-glutamyl-P reductase
CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O>>CC(=O)NC1C(O)CC(OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(N)nc3=O)(OC1C(O)C(O)CO)C(=O)O.OP(=O)(O)OP(=O)(O)O Acylneuraminate cytidylyltransferase
CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(=O)O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.CC(=O)C(=O)O N-Acetylneuraminate lyase 
NC(=O)NC(CC(=O)O)C(=O)O>>OC(=O)C1CC(=O)NC(=O)N1.O Dihydroorotase
NC(=O)NC(CC(=O)O)C(=O)O>>NC(CC(=O)O)C(=O)O.O=C=O.N Ureidosuccinate
CN(CC(=O)O)C(=O)N>>CNCC(=O)O.O=C=O.N N-Carbamoylsarcosine amidase
NC(=O)NC(CCC(=O)O)C(=O)O>>NC(CCC(=O)O)C(=O)O.N.O=C=O
OC(=O)CCC(NC=N)C(=O)O>>NC(CCC(=O)O)C(=O)O.Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)N(C=N)c2c(=O)[nH]1 Glutamate formiminotransferase
*C1OC(CO)C(OP(=O)(O)OCC2OC(*)C(O)C2OP(=O)(O)OCC3OC(*)C(O)C3OC(=O)C(CCSC)NC=O)C1O>>*
NC(CC(=O)c1ccccc1NC=O)C(=O)O>>NC(CC(=O)c1ccccc1N)C(=O)O.OC=O Formamidase
CN1CC(=O)NC1=O>>CN(CC(=O)O)C(=O)N.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O N-Methylhydantoinase (ATP hydrolyzing)
CC(C)(CO)C(O)C(=O)NCCC(=O)NC(CS)C(=O)O>>CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS.O=C=O Pantothenoylcysteine decarboxylase
OC(=O)CCC(=O)NC(CCCC(=O)C(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CCCC(NC(=O)CCC(=O)O)C(=O)O)C(=O)O.OC(=O)CCC(=O)C(=O)O Succinyl-diaminopimelate transaminase
NC(CCCC(NC(=O)CCC(=O)O)C(=O)O)C(=O)O_[Co+2]_NC(CCCC(N)C(=O)O)C(=O)O.OC(=O)CCC(=O)O Succinyl-diaminopimelate desuccinylase
CC(=O)NCCCCC(N)C(=O)O>>CC(=O)NCCCCC(=O)C(=O)O.NC(CCC(=O)O)C(=O)O N6-Acetyl-beta-L-lysine transaminase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dehydrogenases
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1cccnc1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(O)C(O)C4O)C(O)C3O.[H+] NAD(P) nucleosidase
NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O.O NADH peroxidase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Dehydrogenases
NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O NAD(P) transhydrogenase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O_[Mg+2]_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OP(=O)(O)OP(=O)(O)O NMN-Adenyltransferase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O>>NC(=O)c1ccc[n+](c1)C2OC(CO)C(O)C2O.OP(=O)(O)O
NC(=O)c1ccc[n+](c1)C2OC(CO)C(O)C2O>>NC(=O)c1cccnc1.OCC1OC(O)C(O)C1O.[H+]
NC(=O)c1cccnc1_[Mg+2]_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)O)C(O)C2O.OP(=O)(O)OP(=O)(O)O
OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(c2)C(=O)O_[Mg+2]_Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)[n+]5cccc(c5)C(=O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Nicotinamide nucleotide adenylyltransferase
OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(c2)C(=O)O_[Mg+2]_OC(=O)c1cccnc1.OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.[H+] Nicotinate phosphoribosyltransferase
OC(=O)c1cccnc1>>OC(=O)c1ccc(O)nc1
N#N>>[NH4+].[NH4+].Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.*.*.*.*.*.* Nitrogenase
CC(=O)OCC[N+](C)(C)C>>C[N+](C)(C)CCO.CC(=O)O Acetylcholin esterase
CC(=O)OCC(N)C(=O)O>>NC(CS)C(=O)O.CC(=O)O O-Acetylserine (thiol)lyase
CC(=O)OCC(N)C(=O)O>>NC(CO)C(=O)O.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Serine acetyltransferase
C[N+](C)(C)CCOP(=O)(O)O_[Mg+2]_C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O.OP(=O)(O)OP(=O)(O)O Phosphorylcholine cytidylyltransferase
NCCOP(=O)(O)O_[Mg+2]_NCCOP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1O)n2ccc(N)nc2=O.OP(=O)(O)OP(=O)(O)O Ethanolamine-P cytidylyltransferase
NC(CCOC(=O)CCC(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(CCS)C(=O)O.OC(=O)CCC(=O)O O-Succinylhomoserine (thiol)-lyase
*C(=O)OCC(COP(=O)(O)OCC(N)C(=O)O)OC(=O)*>>*C(=O)OCC(COP(=O)(O)OCCN)OC(=O)*.O=C=O Phosphatidylserine decarboxylase
OC1C(CC(=CC1OP(=O)(O)O)C(=O)O)OC(=C)C(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O_OC1C=CC(=CC1OC(=C)C(=O)O)C(=O)O.OP(=O)(O)O Chorismate synthase
OC(=O)c1cc(=O)[nH]c(=O)[nH]1_[Mg+2]_OC1C(O)C(OC1COP(=O)(O)O)n2c(cc(=O)[nH]c2=O)C(=O)O.OP(=O)(O)OP(=O)(O)O Orotate P-ribosyltransferase
OC1C(O)C(OC1COP(=O)(O)O)n2c(cc(=O)[nH]c2=O)C(=O)O>>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.O=C=O Orotidine-5'-P decarboxylase
OC(=O)C(=O)O>>OC=O.O=C=O Oxalate decarboxylase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C(=O)O>>OC(=O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O Oxalate CoA-transferase
OC(=O)CCC(C(=O)O)C(=O)C(=O)O_[Mg+2]_OC(=O)CCCC(=O)C(=O)O.O=C=O (Homoisocitrate dehydrogenase)
OC(=O)CC(C(=O)O)C(=O)C(=O)O>>OC(=O)CCC(=O)C(=O)O.O=C=O Isocitrate dehydrogenase (NADP)
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC=O.O=C=O Oxalyl-CoA decarboxylase
OC1C(O)C(O)C(O)C(O)C1O_[Fe+2]_OC1OC(C(O)C(O)C1O)C(=O)O myo-Inositol oxygenase
OC1C(O)C(O)C(O)C(O)C1O_[Fe+2]_OC1OC(C(O)C(O)C1O)C(=O)O myo-Inositol oxygenase
OP(=O)(O)OP(=O)(O)O_[Mg+2]_OP(=O)(O)O.OP(=O)(O)O Pyrophosphatase
OC(=O)c1cc2c(O)c(O)c3nc(cc(C(=O)O)c3c2[nH]1)C(=O)O>>OC(=O)c1cc2C(=O)C(=O)c3nc(cc(C(=O)O)c3-c2[nH]1)C(=O)O.[H+].[H+].*[Fe+2].*[Fe+2]
CC(C)(CO)C(O)C(=O)NCCC(=O)NCCS_[Mg+2]_CC(C)(COP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Pantetheine kinase
*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O>>*.CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)C(=O)O
CC(C)(CO)C(O)C(=O)NCCCO>>CC(C)(CO)C(O)C(=O)NCCC(=O)O
CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O>>CC1(C)SC2C(N)C(=O)N2C1C(=O)O.OC(=O)Cc1ccccc1 Penicillin amidase
CC1(C)SC2C(NC(=O)Cc3ccccc3)C(=O)N2C1C(=O)O>>CC1(C)SC(NC1C(=O)O)C(NC(=O)Cc2ccccc2)C(=O)O beta-Lactamase
OC(=O)C(=O)Cc1ccccc1_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(Cc1ccccc1)C(=O)O.OC(=O)CCC(=O)C(=O)O Tyrosine transaminase
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.OP(=O)(O)O Phosphoenolpyruvate carboxylase
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.OP(=O)(O)OP(=O)(O)O Phosphoenolpyruvate carboxykinase (pyrophosphate)
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Phosphoenolpyruvate carboxykinase (ATP)
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Phosphoenolpyruvate carboxykinase (GTP)
OC(=O)C(=C)OP(=O)(O)O>>OC(=O)CC(=O)C(=O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2cnc3c(=O)[nH]cnc23 Phosphoenolpyruvate carboxykinase (GTP)
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O>>NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N=CNC3OC(COP(=O)(O)O)C(O)C3O Phosphoribosyl-AMP cyclohydrolase
NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N=CNC3OC(COP(=O)(O)O)C(O)C3O>>NC(=O)c1ncn(C2OC(OP(=O)(O)O)C(O)C2O)c1N=CNCCC(=O)C(O)C(O)COP(=O)(O)O P-Ribosylformimino-AICAR phosphoisomerase
NC(=O)c1ncn(C2OC(OP(=O)(O)O)C(O)C2O)c1N=CNCCC(=O)C(O)C(O)COP(=O)(O)O>>OC(COP(=O)(O)O)C(O)c1cnc[nH]1.NC(CCC(=O)O)C(=O)O.NC(=O)c1ncn(C2OC(COP(=O)(O)O)C(O)C2O)c1N
Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3_[Mg+2]_Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase
Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)O)O3_[Mg+2]_Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O (Deoxy) adenylate kinase
Nc1ccn(C2CC(O)C(CO)O2)c(=O)n1_[Mg+2]_Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O (Deoxycytidine kinase)
Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1_[Mg+2]_Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase
Nc1ccn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)n1_[Mg+2]_Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Cytidylate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3_[Mg+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)O)O3_[K+].[Mg+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)O)O3.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Guanylate kinase
OC1CC(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O_[Mg+2]_OC1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase
CC(=O)O_[Mg+2]_CC(=O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Acetate kinase
CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)OP(=O)(O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Phosphate acetyltransferase
C[N+](C)(C)CCO>>C[N+](C)(C)CCOP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Choline kinase
CN(CC(=O)O)C(=N)N_[Mg+2]_CN(CC(=O)O)C(=N)NP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Creatine kinase
Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1_[Mg+2]_Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Uridine kinase
Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1_[Mg+2]_Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Cytidylate kinase
CCCCCC(=O)OCC(CO)OC(=O)CCCCC_[Mg+2]_CCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCC.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Diacylglycerol kinase
OCC1OC(O)(CO)C(O)C1O_[Mg+2]_OCC1OC(O)(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Ketohexokinase
OCC1OC(O)(CO)C(O)C1O_[Mg+2]_OCC1(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Fructokinase
NC1C(O)OC(CO)C(O)C1O_[Mg+2]_NC1C(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hexokinase
OCC1OC(O)C(O)C(O)C1O_[Mg+2]_OC1OC(COP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hexokinase
OCC(O)C(=O)O_[Mg+2]_OCC(OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glycerate kinase
OCC(O)C(=O)O_[Mg+2]_OC(COP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glycerate kinase
OCC1OC(O)C(O)C(O)C1O_[Mg+2]_OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hexokinase
OCC1OC(O)C(O)C(O)C1O_[Mg+2]_OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Mannokinase
OCC1OC(O)C(O)C1O_[Mg+2]_OC1OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Ribokinase
OCC1(O)OCC(O)C1O_[Mg+2]_OCC(=O)C(O)C(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O D-Ribulokinase
CC(CCO)CCC=C(C)CCC=C(C)CCC=C(C)C>>CC(CCOP(=O)(O)O)CCC=C(C)CCC=C(C)CCC=C(C)C.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1 Dolichyl kinase
OCC(O)CO_[Mg+2]_OCC(O)COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glycerol kinase
NC(CC(=O)O)C(=O)O_[Mg+2]_NC(CC(=O)OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Aspartate kinase
NC(CCC(=O)O)C(=O)O>>NC(CCC(=O)OP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Glutamate 5-kinase
NC(CCO)C(=O)O_[Mg+2]_NC(CCOP(=O)(O)O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Homoserine kinase
CC(=O)NC1C(O)OC(CO)C(O)C1O>>CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O N-Acetylglucosamine kinase
CC(=O)NC1C(O)OC(CO)C(O)C1O_[Mg+2].[K+]_CC(=O)NC1C(O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O N-acyl-D-Mannosamine kinase
NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O_[Mg+2]_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O NAD kinase
NCC(O)CCC(N)C(=O)O_[Mg+2]_NCC(CCC(N)C(=O)O)OP(=O)(O)O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Hydroxylysine kinase
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O_[Mg+2]_Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Thymidine kinase
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O_[Mg+2]_Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O Thymidine kinase
OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O_[Mg+2]_OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Uridine kinase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O_[Mg+2]_OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O_[Mg+2]_OC1C(O)C(COP(=O)(O)O)OC(OP(=O)(O)O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Phosphoglucokinase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O_[Mg+2]_OC1C(O)C(COP(=O)(O)O)OC(OP(=O)(O)O)C1O.OCC1OC(O)C(O)C(O)C1O Glucose-1-P-phosphodismutase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>OCC1(OP(=O)(O)O)OC(COP(=O)(O)O)C(O)C1O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O 6-Phosphofructo-2-kinase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O_[Mg+2]_OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.* 6-Phosphofructo-1-kinase
CC(C)CCCC(C)CCCC(C)CCCC(=CCC12OC2(C)C(=O)c3ccccc3C1=O)C>>CC(=CCCC(=CCCC(=CCCC(=CCc1c(C)c(O)c2ccccc2c1O)C)C)C)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.OC1CSSCC1O.O
CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C>>CCc1c(C)c2C=C3C(=C(C)C4=[N+]3[Mg+2][N+]5=C6C(=C(C)C5=Cc1[nH]2)C(=O)C(C(=O)OC)C6=C7NC(=C4)C(C)C7CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C=C.OP(=O)(O)OP(=O)(O)O
CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C>>CC(C)CCCC(C)CCCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C.OP(=O)(O)OP(=O)(O)O
CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C>>CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.OP(=O)(O)OP(=O)(O)O
CCCCCC=CCC=CCC=CCC=CCCCC(=O)O>>CCCCCC(O)C=CC1C(O)CC2OC(=CCCCC(=O)O)CC12
Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3_Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]_*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4cnc5c(N)ncnc45)O1.OP(=O)(O)OP(=O)(O)O DNA-directed DNA polymerase
Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3_Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]_*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4cnc5c(=O)[nH]c(N)nc45)O1.OP(=O)(O)OP(=O)(O)O DNA-directed DNA polymerase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(N)ncnc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O RNA-directed RNA polymerase
Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4cnc5c(N)ncnc45)C(O)C1O.OP(=O)(O)OP(=O)(O)O DNA-directed RNA polymerase
CC(=O)NC1C(O)CC(OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(N)nc3=O)(OC1C(O)C(O)CO)C(=O)O>>*
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O_Nc1ccn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1.Nc1ncnc2n(cnc12)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.Nc1nc2n(cnc2c(=O)[nH]1)C3CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3.[Mg+2]_*C1CC(O)C(COP(=O)(O)OC2CC(OC2COP(=O)(O)OC3CC(*)OC3CO)n4cc(C)c(=O)[nH]c4=O)O1.OP(=O)(O)OP(=O)(O)O DNA-directed DNA polymerase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>*C1OC(C(OC2OC(C(*)C(O)C2O)C(=O)OC)C(O)C1O)C(=O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O>>*.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O>>*.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O_Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(=O)[nH]c4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O RNA-directed RNA polymerase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O_Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(=O)[nH]c4=O)C(O)C1O.OP(=O)(O)OP(=O)(O)O DNA-directed RNA polymerase
NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.NCc1[nH]cc(CCC(=O)O)c1CC(=O)O.NCc1[nH]cc(CCC(=O)O)c1CC(=O)O>>OCc1[nH]c(Cc2[nH]c(Cc3[nH]c(Cc4[nH]cc(CCC(=O)O)c4CC(=O)O)c(CCC(=O)O)c3CC(=O)O)c(CCC(=O)O)c2CC(=O)O)c(CCC(=O)O)c1CC(=O)O.N.N.N.N Porphobilinogen deaminase
CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O>>CC1(C(CCC(=O)O)C2CC34NC(=O)CC4(C)C(CCC(=O)O)C(=N3)C=C5C(CC(=O)O)C(CCC(=O)O)C(=C6C7=NC(CC1=N2)C(CC(=O)O)C7CCC6=O)N5[Ni+])C(=O)N
CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O>>CC1=C2N=C(C=C3NC(=Cc4[nH]c(Cc5[nH]c1c(CC(=O)O)c5CCC(=O)O)c(CCC(=O)O)c4CC(=O)O)C(CCC(=O)O)C3(C)CC(=O)O)C(CCC(=O)O)C2(C)CC(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+]
CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O>>CC1(CC(=O)O)C(CCC(=O)O)C2=CC3=[N+]4C(=Cc5c(CCC(=O)O)c(CC(=O)O)c6C=C7[N+]8=C(C=C1N2[Fe+2]84n56)C(CCC(=O)O)C7(C)CC(=O)O)C(=C3CC(=O)O)CCC(=O)O.[H].[H].[H].[H]
CC1=C2N=C(C=C3NC(=Cc4[nH]c(Cc5[nH]c1c(CC(=O)O)c5CCC(=O)O)c(CCC(=O)O)c4CC(=O)O)C(CCC(=O)O)C3(C)CC(=O)O)C(CCC(=O)O)C2(C)CC(=O)O>>CC(=O)O.O=C=O.CC1=C2[N+]3=C(C=C4[N+]5=C(C(CCC(=O)O)C4(C)C)C(=C6N7C(C(CC(=O)O)C6(C)CCC(=O)O)C8(C)[N+](=C1C(CCC(=O)O)C8(C)CC(=O)O)[Co+2]735)C)C(CCC(=O)O)C2(C)CC(=O)O
CC(O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 20beta-Hydroxysteroid dehydrogenase
CC(O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C>>CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(=O)O
CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C_*.*_CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C.O.* Steroid 17alpha-monooxygenase
CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C_*.*_CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1C(=O)CO.O.* Steroid 21-monooxygenase
OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O>>OC(=O)C(=O)Cc1ccc(O)cc1.O=C=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Prephenate dehydrogenase
OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O>>OC(=O)C(=O)Cc1ccc(O)cc1.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Prephenate dehydrogenase
OC1C=CC(CC(=O)C(=O)O)(C=C1)C(=O)O>>OC(=O)C(=O)Cc1ccccc1.O=C=O.O Prephenate dehydratase
OCc1[nH]c(Cc2[nH]c(Cc3[nH]c(Cc4[nH]cc(CCC(=O)O)c4CC(=O)O)c(CCC(=O)O)c3CC(=O)O)c(CCC(=O)O)c2CC(=O)O)c(CCC(=O)O)c1CC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.O Spontaneously
OCc1[nH]c(Cc2[nH]c(Cc3[nH]c(Cc4[nH]cc(CCC(=O)O)c4CC(=O)O)c(CCC(=O)O)c3CC(=O)O)c(CCC(=O)O)c2CC(=O)O)c(CCC(=O)O)c1CC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.O Uroporphyrinogen III synthase
NCC(O)CCC(N)C(=O)O>>NCC(CCC(N)C(=O)O)OC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Procollagen galactosyl transferase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C_*.*_CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1C(=O)CO.O.* Steroid 21-monooxygenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C_*.*_CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C.O.* Steroid 11beta-monooxygenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C_*.*_CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C.O.* Steroid 17alpha-monooxygenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C.* 3-Oxo-5beta-steroid delta4 dehydrogenase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C>>CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Steroid delta-isomerase
CCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23_[Mg+2].[K+]_CCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O Acetate-CoA ligase
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)C=C.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenase
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O Succinate propionate CoA transferase
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCC(=O)OP(=O)(O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Acetate ligase
CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.[*H].OC(=O)CCCCC1SCC2NC(=O)NC12 Propionyl-CoA carboxylase
*.CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C(=O)CO.*
*NC(=O)C(CCCCN)NC(=O)*_[Fe+2].OCC(O)C1OC(=O)C(=C1O)O_NCC(O)CCC(N)C(=O)O.OC(=O)CCC(=O)O.O=C=O Procollagenlysine-2-oxoglutarate 5-dioxygenase
*>>NC(CC(C(=O)O)C(=O)O)C(=O)O.CC(C)CCCC(C)CCCC(C)CCCC(=CCC12OC2(C)C(=O)c3ccccc3C1=O)C.O Phylloquinone monooxygenase
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C_*SC(C)C1=C(C)C2=[N+]3C1=Cc4c(C)c(C(C)S*)c5C=C6C(=C(CCC(=O)O)C7=[N+]6[Fe+2]3(n45)n8c(=C7)c(CCC(=O)O)c(C=O)c8=C2)C Cytochrome-heme lyase
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>CC(C)CCC(C)CCC(C)CCC(O)C1=C(C)C2=[N+]3C1=Cc4c(C)c(C=C)c5C=C6C(=C(CCC(=O)O)C7=[N+]6[Fe+2]3(n45)n8c(=C7)c(CCC(=O)O)c(C=O)c8=C2)C
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*S[Fe+2]12([N+]3=C4C=c5c(CCC(=O)O)c(C)c6=CC7=[N+]2C(=Cc8c(C)c(C=C)c(C=C3C(=C4CCC(=O)O)C)n81)C(=C7C)C=C)n65
CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C>>*.CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C
Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O_Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O_CC1C(CCC(=O)O)C2=CC3=[N+]4[Mg+2][N+]5=C(C=C1N2)C(=C(C=C)C5=Cc6[nH]c(C=C4C(=C3CCC(=O)O)C)c(C=C)c6C)C.[H].[H] (Mg chelatase)
Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O>>CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C
Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O>>CC1=C(CCC(=O)O)C2=[N+]3C1=Cc4c(C=C)c(C)c5C=C6C(=C(C)C7=[N+]6[Fe+2]3(n54)n8c(=C7)c(C)c(CCC(=O)O)c8=C2)C=C.[H+].[H+] Ferrochelatase
Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(=O)O>>Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(=O)O.O.O.O Protoporphyrinogen oxidase
NCCCCN>>NCCCC=O.OO.N Amine oxidase (Cu++)
NCCCCN>>NCCCCNCCCN.CSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.[H+] Spermidine synthase
CC(=O)C(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.[Mg+2]_CC(=O)C(C)(O)C(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N Acetolactate synthase
CC(=O)C(=O)O>>*.CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N.O=C=O Pyruvate dehydrogenase
CC(=O)C(=O)O>>*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc([n+]1Cc2cnc(C)nc2N)C(C)(O)C(=O)O
CC(=O)C(=O)O>>CC(=O)O.O=C=O.*[Fe+2].*[Fe+2].[H+].[H+] Pyruvate dehydrogenase (cytochrome)
CC(=O)C(=O)O_Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N_CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.[*H2].O=C=O Pyruvate synthase
CC(=O)C(=O)O_C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23_CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.OC=O active Formate acetyltransferase
CC(=O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O Alanine transaminase
CC(=O)C(=O)O_[Zn+2]_CC(N)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O Alanine dehydrogenase
CC(=O)C(=O)O_[Zn+2]_CC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Lactate dehydrogenase
CC(=O)C(=O)O_OC(=O)CCCCC1SCC2NC(=O)NC12.[Co+2].[Zn+2]_OC(=O)CC(=O)C(=O)O.CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Methylmalonyl-CoA carboxyltransferase
CC(=O)C(=O)O>>OC(=O)CC(=O)C(=O)O.[*H].OC(=O)CCCCC1SCC2NC(=O)NC12 Pyruvate carboxylase
OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(C(=O)O)c2C(=O)O>>OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(c2)C(=O)O.O=C=O Quinolinate phosphoribosyltransferase (decarboxylating)
OC1C(O)C(OC1COP(=O)(O)O)[n+]2cccc(C(=O)O)c2C(=O)O_[Mg+2]_OC(=O)c1cccnc1C(=O)O.OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.[H+] Quinolinate phosphoribosyltransferase (decarboxylating)
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Methylmalonyl-CoA-epimerase
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Methylmalonyl-CoA-epimerase
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23_CC1C(CCCC(=O)N)C2=[N+]3C1=C(C)C4=[N+]5C(=C(C)C6=[N+]7C(C)(C8C(CC(=O)N)C9(C)CCC(=C)NCC(C)OP(=O)(O)OC%10C(O)C(OC%10CO)n%11c[n+](c%12cc(C)c(C)cc%11%12)[Co]735(CC%13OC(C(O)C%13O)n%14cnc%15c(N)ncnc%14%15)N8C9=C2)C(C)(CC(=O)N)C6CCC(=O)N)C(C)(CC(=O)N)C4CCC(=O)N_CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O L-Methylmalonyl-CoA mutase
CC(N)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_CC(N)C(=O)O Alanine racemase
OC(=O)C1CCCN1>>OC(=O)C1CCCN1 Proline racemase
NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O.OCC(O)C1OC(=O)C(=C1O)O Glutathione dehydrogenase
NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O>>NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O.*S.*S Glutathione transhydrogenases
OCC(O)C(O)C(O)C=O>>OCC(O)C(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Aldehyde reductase
CC(=CC=CC(=CC(=O)O)C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=CC(=CC(=O)OC1OC(C(O)C(O)C1O)C(=O)O)C)C=CC2=C(C)CCCC2(C)C
CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.CCCCCCCCCCCCCCCC(=O)O Retinylpalmitate esterase
*>>[*H2].NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Rubredoxin-NAD reductase
CC(C(=O)O)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23_OC(=O)CCCCC1SCC2NC(=O)NC12_CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.[Na+].O=C=O Methylmalonyl-CoA decarboxylase
OC(CC(=O)O)C(=O)O>>CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malate dehydrogenase (decarboxylating)("malic enzyme")
OC(CC(=O)O)C(=O)O>>CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Malate dehydrogenase (decarboxylating)("malic enzyme")
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O>>CC(O)(CCO)CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Hydroxymethylglutaryl-CoA reductase (active)
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O>>CC(O)(CCO)CC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Hydroxymethylglutaryl-CoA reductase (active)
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(C)(O)CC(=O)O_[Mg+2].[Mg+2]_CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)CC(=O)O Hydroxymethyl-glutaryl-CoA lyase
C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23>>NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.C[n+]1cccc(c1)C(=O)O Nicotinate methyltransferase and other methyltransferases
C[S+](CCC(N)C(=O)O)CC1OC(C(O)C1O)n2cnc3c(N)ncnc23>>NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.Cc1c[nH]c(=O)nc1N.[H+] DNA (cytosine-5)-Methyltransferase
CC(O)(CC(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_CC(=O)C(=O)O.CC(=O)O Citramalate lyase
OC(CC(=O)O)C(=O)O>>OC(=O)CC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Malate dehydrogenase
CNCC(=O)O_[Fe+2]_NCC(=O)O.[*H2].C=O Sarcosine dehydrogenase
NCCc1c[nH]c2ccc(O)cc12>>CN(C)CCc1c[nH]c2ccc(O)cc12
NCCc1c[nH]c2ccc(O)cc12>>COc1ccc2[nH]cc(CCNC(=O)C)c2c1.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.[H+]
OC1CC(=CC(O)C1O)C(=O)O_[Mg+2]_OC1CC(=CC(OP(=O)(O)O)C1O)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Shikimate kinase
OC1CC(=CC(OP(=O)(O)O)C1O)C(=O)O>>OC1C(CC(=CC1OP(=O)(O)O)C(=O)O)OC(=C)C(=O)O.OP(=O)(O)O 3-P-Shikimate-1-carboxyvinyltransferase
NCCCCNCCCN>>NCCCNCCCCNCCCN.CSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23.[H+] Spermine synthase
CCCCCCCCCCCCCCCC(O)C(N)CO>>CCCCCCCCCCCCCC=CC(O)C(N)CO.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C
*C(=O)NC(COP(=O)(O)OCC[N+](C)(C)C)C(O)C=CCCCCCCCCCCCCC>>*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC.C[N+](C)(C)CCOP(=O)(O)O Sphingomyelin phosphodiesterase
CCCCCCCCCCCCCC=CC(O)C(N)CO>>*C(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Sphingosine acetyltransferase
CCCCCCCCCCCCCC=CC(O)C(N)CO>>CCCCCCCCCCCCCC=CC(O)C(N)COC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Sphingosine galactosyltransferase
CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C>>CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1OC1(C)C)C)C)C.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Squalene monooxygenase
OC(=O)CCC(=O)O>>OC(=O)C=CC(=O)O.*.Cc1cc2Nc3c([nH]c(=O)[nH]c3=O)N(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Succinate dehydrogenase
OC(=O)CCC=O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCCC(=O)O.OC(=O)CCC(=O)C(=O)O Aminobutyrate transaminase
OC(=O)CCC=O_[Zn+2]_OCCCC(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 4-Hydroxybutyrate dehydrogenase
OC(=O)CCC=O>>OC(=O)CCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Succinate semialdehyde dehydrogenase (NAD(P)+)
OC(=O)CCC=O>>OC(=O)CCC(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Succinate semialdehyde dehydrogenase (NAD(P)+)
OC(=O)CCC(=O)O>>CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O.OP(=O)(O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2cnc3c(=O)[nH]cnc23 Succinyl-CoA ligases
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NC(C(=O)O)C(=O)CCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS 5-Aminolevulinate synthase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>>OC(=O)CCC(=O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS.* 2-Oxoglutarate synthase
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>>OC(=O)CCC(=O)O.Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Succinyl-CoA ligases
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O_[Mg+2]_OC(=O)CCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C3O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Succinyl-CoA ligases
CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O>>OC(=O)CCC(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Succinyl-CoA hydrolase
OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.*OCC1OC(CO)(OCC2OC(*)(CO)C(O)C2O)C(O)C1O Levansucrase
OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O.*OCC1OC(OCC2OC(OCC3OC(O*)C(O)C(O)C3O)C(O)C(O)C2O)C(O)C(O)C1O Dextransucrase
OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O.OCC1OC(O)C(O)C(O)C1O alpha-Glucosidase
OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O>>OCC1OC(O)(CO)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O Sucrose phosphorylase
OCC1OC(OC2(CO)OC(COP(=O)(O)O)C(O)C2O)C(O)C(O)C1O>>OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O.OP(=O)(O)O
OS(=O)(=O)O>>Nc1ncnc2n(ncc12)C3OC(COP(=O)(O)OS(=O)(=O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Sulfate adenylyltransferase
CC12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CCC1=O>>CC12CCC3C(CCc4cc(O)ccc34)C2CCC1=O.OS(=O)(=O)O Arylsulfatase
OS(=O)O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C_S.O.O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Sulfite reductase (NADPH)
OS(=O)O>>OS(=O)(=O)O.OO Sulfite oxidase
OS(=O)O>>OS(=O)(=O)O.[*H2] Sulfite dehydrogenase
NC(CS)C(=O)O>>NC(CSSCC(N)C(=O)O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Cystine reductase (NADH)
NC(CS)C(=O)O>>NC(CSSCC(N)C(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O.NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O GSH-Cystine transhydrogenase
*>>*
CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3Nc4c(NC3C)nc(N)[nH]c4=O>>CC(Nc1ccc(CC(O)C(O)C(O)COC2OC(COP(=O)(O)OC(CCC(=O)O)C(=O)O)C(O)C2O)cc1)C3=Nc4c(NC3C)nc(N)[nH]c4=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+]
OC(C=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 2-Hydroxy-3-oxopropionate reductase
OC(C=O)C(=O)O>>OCC(O)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O 2-Hydroxy-3-oxopropionate reductase
CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C>>CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.NCCS(=O)(=O)O Choloylglycine hydrolase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1O.O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Steroid 19-hydroxylase)
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4CC(=O)CCC43C)C2CCC1O.* 3-oxo-5beta-Steroid D4 dehydrogenase
CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1O>>CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1OC5OC(C(O)C(O)C5O)C(=O)O
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1C(=O)CO>>CC12CC(O)C3C(CCC4CC(=O)CCC43C)C2CCC1C(=O)CO.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] 3alpha-Hydroxysteroid dehydrogenase
*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc(C(O)CCC(=O)O)[n+]1Cc2cnc(C)nc2N>>*.OC(=O)CCCCC(S)CCSC(=O)CCC(=O)O.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N 2-oxoglutarate dehydrogenase system
[*H2]_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Thioredoxin reductase (NADP)
[*H2]_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Thioredoxin reductase (NADP)
[*H2]_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Thioredoxin reductase (NADP)
[*H2]_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_*.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Thioredoxin reductase (NADP)
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>>Cc1c[nH]c(=O)[nH]c1=O.OCC1OC(CC1O)OP(=O)(O)O Thymidine phosphorylase
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>>Cc1c[nH]c(=O)[nH]c1=O.OCC1OC(O)CC1O Nucleosidase
Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O>>Cc1c[nH]c(=O)[nH]c1=O.*CC1CC(O)C(O)O1 Nucleoside deoxyribosyltransferase
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O_[Mg+2]_Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Nucleoside diphosphate kinase
Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O>>Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O.OP(=O)(O)O 5'-Nucleotidase
Cc1cn(C2CC(O)C(COP(=O)(O)O)O2)c(=O)[nH]c1=O_[Mg+2]_Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O dTMP kinase
Cc1c[nH]c(=O)[nH]c1=O_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_CC1CNC(=O)NC1=O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrouracil dehydrogenase (NADP)
Cc1c[nH]c(=O)[nH]c1=O>>CC1C(=O)NC(=O)NC1=O.[*H2] Uracil dehydrogenase
CC=C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(O)C(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Enoyl-CoA hydratase
[Fe+3]*[Fe+3]>>*.[Fe+2].NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Transferrin reductase
[Fe+3]*[Fe+3]>>*.[Fe+3].[Fe+3] Transferrin reductase
CCCCCC(=O)OCC(COC(=O)CCCCC)OC(=O)CCCCC>>CCCCCC(=O)OCC(CO)OC(=O)CCCCC.CCCCCC(=O)O Triacylglycerol lipase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Lactose synthase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O=C=O
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Sucrose synthase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(OC2(CO)OC(COP(=O)(O)O)C(O)C2O)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Sucrose-P-synthase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O UDPG-Hexose-1-P-uridyltransferase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+] UDPG-dehydrogenase
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(CO)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O (other Glucosyltransferases)
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O_[Mg+2]_OCC1OC(OP(=O)(O)O)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O UTP-Glucose-1-P-uridylyltransferase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O_OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O.O=C=O UDP-Glucuronate decarboxylase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OC(C(O)C(O)C2O)C(=O)O)n3ccc(=O)[nH]c3=O>>*OC1OC(C(O)C(O)C1O)C(=O)O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O Glucuronosyltransferase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O>>OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OC2OCC(O)C(O)C2O)n3ccc(=O)[nH]c3=O UDP-Arabinose epimerase
CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(C)C(O)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O
CC(OC1C(O)C(CO)OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C1NC(=O)C)C(=O)O>>*
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O UDP-N-Acetylglucosamine 4-epimerase
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>CC(=O)NC1C(O)OC(CO)C(O)C1O.OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O UDP-N-Acetyl-D-glucosamine-4-epimerase
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>CC(=O)NC1C(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)OC(CO)C(O)C1OC(=C)C(=O)O.OP(=O)(O)O UDP-N-Acetylglucosamine 1-carboxyvinyl transferase
CC(=O)NC1C(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)OC(CO)C(O)C1OC(=C)C(=O)O>>CC(OC1C(O)C(CO)OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C1NC(=O)C)C(=O)O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O UDP-N-Acetylmuramate dehydrogenase
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>*
CC(=O)NC1C(O)C(O)C(CO)OC1OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O>>*
COc1c(O)c(C)c(CC=C(C)CCC=C(C)C)c(O)c1OC>>COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)CCC=C(C)C.[H].[H]
COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)C>>COc1c(O)c(C)c(CC=C(C)C)c(O)c1OC.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C
O=c1cc[nH]c(=O)[nH]1_[Fe+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_O=C1CCNC(=O)N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrouracildehydrogenase (NADP)
O=c1cc[nH]c(=O)[nH]1>>O=C1CCNC(=O)N1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Dihydrouracil dehydrogenase (NAD)
O=c1cc[nH]c(=O)[nH]1>>O=C1CC(=O)NC(=O)N1.[*H2] Uracil dehydrogenase
O=c1cc[nH]c(=O)[nH]1>>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.OP(=O)(O)OP(=O)(O)O Uracil phosphoribosyltransferase
O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1_[Cu+2]_NC(=O)NC1NC(=O)NC1=O.OO.O=C=O Urate oxidase
NC(=O)N>>[NH4+].OC(=O)[O-].[NH4+] Urease
OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O>>O=c1cc[nH]c(=O)[nH]1.OCC1OC(OP(=O)(O)O)C(O)C1O Uridine phosphorylase
OCC1OC(C(O)C1O)n2ccc(=O)[nH]c2=O>>O=c1cc[nH]c(=O)[nH]1.OCC1OC(O)C(O)C1O Uridine nucleosidase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O_[Fe+2]_OC1CC(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.*.O Ribonucleoside-diphosphate reductase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O_[Mg+2]_*C1OC(COP(=O)(O)OC2C(O)C(OC2COP(=O)(O)OC3C(O)C(*)OC3COP(=O)(O)O)n4ccc(=O)[nH]c4=O)C(O)C1O.OP(=O)(O)O Polyribonucleotide nucleotidyltransferase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O.OP(=O)(O)O Nucleoside diphosphatase
OC1C(O)C(OC1COP(=O)(O)O)n2ccc(=O)[nH]c2=O_[Mg+2]_OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Cytidylate kinase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>OC1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O.*.O Ribonucleoside triphosphate reductase
OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O>>Nc1ccn(C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1.OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.NC(CCC(=O)O)C(=O)O CTP synthase
OC(=O)C=Cc1cnc[nH]1>>OC(=O)CCC1NC=NC1=O Urocanate hydratase
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (R) 20beta-Hydroxysteroid dehydrogenase
CC12CC(O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(=O)CO
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(O)CO.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (R) 20beta-Hydroxysteroid dehydrogenase
CC12CC(=O)C3C(CCC4CC(O)CCC43C)C2CCC1(O)C(=O)CO>>CC12CC(=O)C3C(CCC4CC(CCC43C)OC5OC(C(O)C(O)C5O)C(=O)O)C2CCC1(O)C(=O)CO
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5C)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.O=C=O.O=C=O.O=C=O.O=C=O Uroporphyrinogen decarboxylase
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CC(=O)O)c5CCC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.[H].[H].[H].[H].[H].[H]
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>Cc1c(CCC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(CCC(=O)O)c3C.O=C=O.O=C=O.O=C=O.O=C=O Uroporphyrinogen decarboxylase
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>CC1(CC(=O)O)C(CCC(=O)O)C2=Cc3[nH]c(Cc4[nH]c(C=C5N=C(C=C1N2)C(CCC(=O)O)C5(C)CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CCC(=O)O)c3CC(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O Uroporphyrinogen III methyltransferase
OC(=O)CCc1c(CC(=O)O)c2Cc3[nH]c(Cc4[nH]c(Cc5[nH]c(Cc1[nH]2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O>>OC(=O)CCc1c(CC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(=O)O)c5CC(=O)O)c(CC(=O)O)c4CCC(=O)O)c(CC(=O)O)c3CCC(=O)O.[H].[H].[H].[H].[H].[H]
O=c1[nH]c(=O)c2nc[nH]c2[nH]1>>NC(=O)Nc1[nH]cnc1C(=O)O
O=c1[nH]c(=O)c2nc[nH]c2[nH]1_Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1.OO Xanthine oxidase
O=c1[nH]c(=O)c2nc[nH]c2[nH]1>>OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]c(=O)[nH]c23.OP(=O)(O)O Purine nucleoside phosphorylase
O=c1[nH]c(=O)c2nc[nH]c2[nH]1_[Mg+2]_OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23.OP(=O)(O)OP(=O)(O)O Hypoxanthine P-ribosyltransferase
OCC1OC(C(O)C1O)n2cnc3c(=O)[nH]c(=O)[nH]c23>>O=c1[nH]c(=O)c2nc[nH]c2[nH]1.OCC1OC(O)C(O)C1O Purine nucleosidase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O GMP synthase
OC1C(O)C(OC1COP(=O)(O)O)n2cnc3c(=O)[nH]c(=O)[nH]c23>>Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O.NC(CCC(=O)O)C(=O)O GMP synthase
*O_[Mg+2]_*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase A (+others?)
*O_[Mg+2]_*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase
*O>>*OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O [Hydroxymethylglutaryl-CoA reductase] kinase
*O>>*OP(=O)(O)OP(=O)(O)OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O [Pyruvate dehydrogenase (lipoamide)] kinase
*O_[Mg+2]_*OP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)OP(=O)(O)O)C(O)C3O Protein kinase A
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>CC1(CCCC2(C)C3CCC4CC3(CC4(O)CO)CCC12)C(=O)O
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C_[Mg+2]_CC(=CCCC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C)C.OP(=O)(O)OP(=O)(O)O (Polyprenyl-cis-transferases) e.g.Di-trans-poly-cis-decarpenyl transferase
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>CC(C)CCCC(C)CCCC(C)CCCC(=CCOP(=O)(O)OP(=O)(O)O)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C>>COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)C.CC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C Polyprenyl-trans-transferases
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C_[Mg+2]_CC(C)CCCC(=CCCC(=CCCC(=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C.OP(=O)(O)OP(=O)(O)O.OP(=O)(O)OP(=O)(O)O Geranylgeranyl-bisphospho-geranylgeranyltransferase
CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=O)C=CC=CC=C(C)C=CC1=C(C)CCCC1(C)C Retinene isomerase
CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CC=CC(=CC(=O)O)C)C=CC1=C(C)CCCC1(C)C.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Retinal dehydrogenase
CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O Retinol dehydrogenase
CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C>>CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS Retinol fattyacyltransferase
OC1CNC(C1)C(=O)O>>OC1CN=C(C1)C(=O)O.OO D-Aminoacid oxidase
CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2C(=CCCC2(C)C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CC(O)CC1(C)C)C=CC=C(C)C=CC2C(=CC(O)CC2(C)C)C
OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O_[Mg+2]_NC1OC(COP(=O)(O)O)C(O)C1O.NC(CCC(=O)O)C(=O)O.OP(=O)(O)OP(=O)(O)O Amido-P-ribosyltransferase
OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O_[Mg+2]_OC1C(O)C(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2cnc3c(=N)n(cnc23)C4OC(COP(=O)(O)O)C(O)C4O.OP(=O)(O)OP(=O)(O)O ATP-Phosphoribosyl transferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.OP(=O)(O)OP(=O)(O)O UTP-Hexose-1-P uridylyltransferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O.OP(=O)(O)OP(=O)(O)O Galactose-1-P-thymidylyltransferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O_[Mg+2]_Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=O)(O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Glucose-1-P-guanylyl-transferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O_[Mg+2]_OC1OC(COP(=O)(O)O)C(O)C(O)C1O Phosphoglucomutase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O.OP(=O)(O)OP(=O)(O)O Glucose-1-P-thymidylyltransferase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OC1OC(COP(=O)(O)O)C(O)C(O)C1O
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OCC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(C(O)C2O)n3ccc(=O)[nH]c3=O)C(O)C(O)C1O.OCC1OC(OP(=O)(O)O)C(O)C(O)C1O UDPG-Hexose-1-P-uridyltransferase
OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OCC(=O)C(O)C(O)C(O)C=O.OP(=O)=O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] myo-Inositol-1-P synthase
OC1OC(COP(=O)(O)O)C(O)C(O)C1O>>OCC1(O)OC(COP(=O)(O)O)C(O)C1O Glucosephosphate isomerase
OCC1OC(OP(=O)(O)O)C(O)C(O)C1O>>OCC1(O)OC(COP(=O)(O)O)C(O)C1O Mannose-6-P isomerase
OC1OC(COP(=O)(O)O)C(O)C1O_[Mg+2]_OC1C(O)C(OP(=O)(O)OP(=O)(O)O)OC1COP(=O)(O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O Ribose-P-pyrophosphokinase
*OC1OC(CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.*O alpha-Galactosidase
*OC1OC(CO)C(O)C(O)C1NC(=O)C>>CC(=O)NC1C(O)OC(CO)C(O)C1O.* N-Acetyl-beta-glucosaminidase
NCCC(=O)O>>CC(C)(CO)C(O)C(=O)NCCC(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Pantoate-beta-alanineligase
NCCC(=O)O>>NCCC(=O)NC(Cc1cnc[nH]1)C(=O)O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O.OP(=O)(O)OP(=O)(O)O Carnosine synthase
CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2=C(C)CCCC2(C)C>>CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CC(O)CC1(C)C)C=CC=C(C)C=CC2C(=CC(O)CC2(C)C)C
CC(=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C)C=CC=C(C)C=CC2=C(C)CCCC2(C)C_[Fe+2]_CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.CC(=CC=O)C=CC=C(C)C=CC1=C(C)CCCC1(C)C beta-Carotene 15.15'-dioxygenase
OC1C(O)C(O)(COP(=O)(O)O)OC1COP(=O)(O)O>>OC(COP(=O)(O)O)C=O.OCC(=O)COP(=O)(O)O Fructose bisphosphate aldolase
OCC1OC(O)(COP(=O)(O)O)C(O)C1O>>OCC(=O)COP(=O)(O)O.OCC(O)C=O Fructose bisphosphate aldolase (aldolase 6)
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>OCC(O)C(=O)C(O)C(O)COP(=O)(O)O Hexulose-6-P isomerase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>NC1C(O)OC(COP(=O)(O)O)C(O)C1O.NC(CCC(=O)O)C(=O)O Glutaminefructose-6P-transaminase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>NC1C(O)OC(COP(=O)(O)O)C(O)C1O.O Glucosamine-P isomerase
OCC1(O)OC(COP(=O)(O)O)C(O)C1O>>OCC(=O)C(O)C(O)C(O)C(O)COP(=O)(O)O.OC(COP(=O)(O)O)C=O Transaldolase
*OC1OC(CO)C(O)C(O)C1O>>OCC1OC(O)C(O)C(O)C1O.*O beta-Glucosidase
*C(=O)CC=CCCCCCC>>CCCCCCC=CCCCCCCCCCC(=O)O.*
OC(=O)CC(=CC(=O)O)C(=O)O>>OC(=O)CC(=C)C(=O)O.O=C=O Aconitate decarboxylase
OC(=O)CC(=CC(=O)O)C(=O)O>>OC(=O)CC(O)(CC(=O)O)C(=O)O Aconitate hydratase
OC(=O)CC(=CC(=O)O)C(=O)O>>OC(C(CC(=O)O)C(=O)O)C(=O)O Aconitate hydratase
CC(C)CCCC(=CCCC(=CCCC(=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_CC(=CCCC(=CCCC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C.[H].[H].[H].[H].[H].[H]
OC(=O)C=CC=CC(=O)O>>OC(=O)CC1=CCC(=O)O1 Muconate cycloisomerase
CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1=C(C)C(=O)NC1Cc2[nH]c(C=C3N=C(CC4NC(=O)C(=C4C)C=C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C.O non-enzymatically
CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O_Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O UDPG-4-epimerase
Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)OC3OC(CO)C(O)C(O)C3O)O2)c(=O)[nH]c1=O_NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O_CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(CC2O)n3cc(C)c(=O)[nH]c3=O)C(O)C(O)C1O.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
CC1OC(OP(=O)(O)OP(=O)(O)OCC2OC(CC2O)n3cc(C)c(=O)[nH]c3=O)C(O)C(O)C1O>>*OC1OC(C)C(O)C(O)C1O.Cc1cn(C2CC(O)C(COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O
CC(C)C(NC(=O)C(CS)NC(=O)CCCC(N)C(=O)O)C(=O)O_[Fe+2]_CC1(C)SC2C(NC(=O)CCCC(N)C(=O)O)C(=O)N2C1C(=O)O.O.O Isopenicillin synthase
OC(=O)C1CCCC(=N1)C(=O)O>>OC(=O)CCC(=O)NC(CCCC(=O)C(=O)O)C(=O)O.CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
OC(=O)C1=NCCCC1>>NCCCCC(=O)C(=O)O non-enzymatic
OC(=O)C1=NCCCC1>>OC(=O)C1CCCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O delta1-Piperideine-2-carboxylate reductase
OC(=O)C1=NCCCC1>>OC(=O)C1CCCCN1.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O delta1-Piperideine-2-carboxylate reductase
CC(=C)CCOP(=O)(O)OP(=O)(O)O_[Mg+2]_CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C.OP(=O)(O)OP(=O)(O)O
CC(=C)CCOP(=O)(O)OP(=O)(O)O_[Mg+2]_CC(=CCOP(=O)(O)OP(=O)(O)O)C Isopentenyldiphosphate isomerase
CC(=C)CCOP(=O)(O)OP(=O)(O)O_[Mg+2]_CC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C.OP(=O)(O)OP(=O)(O)O Dimethylallyl-trans-transferase
CC(=C)CCOP(=O)(O)OP(=O)(O)O>>*C(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C.OP(=O)(O)OP(=O)(O)O Rubber cis-polyprenyl cis-transferase
CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O (Desmosterol reductase)
CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CC(C)C(=C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].[H+].[H+]
CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C>>CCC(C=CC(C)C1CCC2C3CC=C4CC(O)CC(C)C4C3CCC12C)C(C)C.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.NC(CCSCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(=O)O.[H+].[H+]
CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.O
CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(CCC=C(C)C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C.*.O
CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
CC(C)CCCC(C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C>>CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C.OO Lathosterol oxidase
CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C4(C)CCC(O)CC4CC3>>CC(CCC=C(C)C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC12C
CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1=C(C)C(=O)NC1Cc2[nH]c(C=C3N=C(CC4NC(=O)C(=C4C)CC)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C.O non-enzymatically
CCC1=C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(=C4C)CC)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(CC)C4C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C
*OP(=O)(O)O>>*O.OP(=O)(O)O [Acetyl-CoA carboxylase] phosphatase
*_[Fe+2]_*
*OP(=O)(O)O>>*O.OP(=O)(O)O
*OP(=O)(O)OP(=O)(O)O>>*O.OP(=O)(O)O.OP(=O)(O)O [Hydroxymethylglutaryl-CoA reductase (NADPH)] phosphatase
*OP(=O)(O)OP(=O)(O)OP(=O)(O)O>>*O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O [Pyruvate dehydrogenase (lipoamide)] phosphatase
*OP(=O)(O)O>>*O.OP(=O)(O)O [Pyruvate kinase] phophatase
CCC1C(C)C(=O)NC1Cc2[nH]c(Cc3[nH]c(CC4NC(=O)C(CC)C4C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C>>CCC1C(C)C(=O)NC1Cc2[nH]c(C=C3N=C(CC4NC(=O)C(CC)C4C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C.O non-enzymatically
OCC1OC(OC2C(O)C(O)C(OC3C(O)C(O)C(O)OC3CO)OC2CO)C(O)C(O)C1O>>OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O.OCC1OC(O)C(O)C(O)C1O alpha-dextrin-endo-1,4-Glucosidase
NC(CCCC(N)C(=O)O)C(=O)O_Cc1ncc(COP(=O)(O)O)c(C=O)c1O_NCCCCC(N)C(=O)O.O=C=O Diaminopimelate decarboxylase
OC1C(O)C(O)C(O)C(O)C1O>>*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(O)C(O)C1O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 CDP-Diacylglycerolinositol-3-phosphatidyltransferase
OC1C(O)C(O)C(O)C(O)C1O>>*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(O)C(O)C1O)OC(=O)*.Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1 CDP-diacyl-glycerol-inositol phosphadyltransferase
CC(OP(=O)(O)O)C(NC(=O)CCCCCCSSCCS(=O)(=O)O)C(=O)O>>OS(=O)(=O)CCS.CC(OP(=O)(O)O)C(NC(=O)CCCCCCS)C(=O)O Heterodisulfide reductase, hydrogenase
*.CC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS
*.CC(C)CC(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CC(C)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS
CC(O)C1=Nc2c(NC1C)nc(N)[nH]c2=O_[Mg+2]_CC(OP(=O)(O)OP(=O)(O)O)C1=Nc2c(NC1C)nc(N)[nH]c2=O.Nc1ncnc2n(cnc12)C3OC(COP(=O)(O)O)C(O)C3O
*C(=O)OCC(COP(=O)(O)OC1C(O)C(O)C(OP(=O)(O)O)C(O)C1O)OC(=O)*>>OC1C(O)C(OP(=O)(O)O)C(O)C(O)C1OP(=O)(O)O.*C(=O)OCC(CO)OC(=O)* Phospholipase C
OC(C(CC(=O)O)C(=O)O)C(=O)O>>OC(=O)CC(C(=O)O)C(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+] Isocitrate dehydrogenase (NADP)
OC(C(CC(=O)O)C(=O)O)C(=O)O>>OC(=O)CCC(=O)C(=O)O.NC(=O)C1=CN(C=CC1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O.[H+].O=C=O Isocitrate dehydrogenase (NAD+)
*.CCC(C)C(O)c1sc(CCOP(=O)(O)OP(=O)(O)O)c(C)[n+]1Cc2cnc(C)nc2N>>CCC(C)C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1c(CCOP(=O)(O)OP(=O)(O)O)sc[n+]1Cc2cnc(C)nc2N.*.OC(=O)CCCCC(S)CCS
CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23
CC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C Acyl-CoA dehydrogenases (2 known) 
CCCC=CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23>>CCCC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(C(O)C1OP(=O)(O)O)n2cnc3c(N)ncnc23 Enoyl-CoA hydratase
*C=CC(=O)S*S>>*C(=O)S*S.*.Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)O)c2cc1C
*C=CC(=O)S*S>>*C(=O)S*S.NC(=O)c1ccc[n+](c1)C2OC(COP(=O)(O)OP(=O)(O)OCC3OC(C(OP(=O)(O)O)C3O)n4cnc5c(N)ncnc45)C(O)C2O
*C=CC(=O)S*S>>*C(O)CC(=O)S*S
CC(=CCCC(=CCCC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C_[Mg+2].Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)c2cc1C_CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C.[H].[H]