First page Back Continue Last page Overview Graphics
Basic principle of medicinal chemistry
Similar structures exhibit similar behaviour
- If interaction with 5-HT receptors needed, design ‘5-HT-like’ molecule
While it is not surprising when two very similar molecules show very similar activity, when they do NOT, one have possibly found the famous ‘methyl’ substituent that made uM hit into nM lead (or most likely the other way around)
- or check experimental data
Notes: