Linking activity to structure
Crum Brown, A., Frazer, T, 1868, Transactions of the Royal Society of Edinburgh, 24, 151, 693
Changes in biological activity were linked to small changes in structure.
A very early example of linking information in the biology domain to information in the chemical domain
Perhaps should be regarded as the birth of Chemoinformatics
? is a compoundís physiological action
C is a compoundís chemical constitution