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Toxicity Prediction
Torsades de Point: A dangerous side effect of drugs which commonly act at ion channels in the heart to cause arrythmia
A common feature of many compounds is activity at the HERG channel (K+)
Commonly, this is observed as an elongation of the so-called QT interval in an electrocardiogram of the heart (LQT)
We have applied this methodology to the detection of molecules with TdP
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